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51. 发明专利

PL1721162T3 Sposób oceny reumatoidalnego zapalenia stawów przez pomiar anty-CCP oraz amyloidu A w surowicy 未知
公开(公告)号：PL1721162T3
公开(公告)日：2009-03-31
申请号：PL05707585
申请日：2005-02-23
申请人： HOFFMANN LA ROCHE
发明人： WILD NORBERT , KARL JOHANN , GRUNERT VEIT PETER , ZOLG WERNER
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18

52. 发明专利

ES2314621T3 PROCEDIMIENTO DE EVALUACION DE LA ARTRITIS REUMOTOIDEA, MEDIANTE LA MEDICION DE ANTI-CCP Y AMILOIDE A SERICO. 未知
公开(公告)号：ES2314621T3
公开(公告)日：2009-03-16
申请号：ES05707585
申请日：2005-02-23
申请人： HOFFMANN LA ROCHE
发明人： WILD NORBERT , KARL JOHANN , GRUNERT VEIT PETER , ZOLG WERNER
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18
摘要： Un procedimiento para evaluar la ausencia o presencia de artritis reumatoidea, in vitro, mediante marcadores bioquímicos, que comprende la medición, en una muestra, de la concentración de por lo menos a) anti-CCP y b) amiloide A sérico, y c) correlacionar las concentraciones determinadas en las etapas a) y b), a la ausencia o presencia de artritis reumatoidea.

53. 发明专利

HK1115636A1 USE OF CYFRA 21-1 AS A MARKER FOR COLORECTAL CANCER CYFRA 21-1 未知
公开(公告)号：HK1115636A1
公开(公告)日：2008-12-05
申请号：HK08106060
申请日：2008-05-30
申请人： HOFFMANN LA ROCHE
发明人： KARL JOHANN , ANDRES HERBERT , GRUNERT VEIT , ROLLINGER WOLFGANG , ZOLG WERNER
IPC分类号： G01N20060101
摘要： The present invention relates to the assessment of colorectal cancer. It discloses the use of the CYFRA 21-1 assay in the assessment of colorectal cancer. It also relates to a method for assessing colorectal cancer in vitro using a liquid sample, derived from an individual by measuring CYFRA 21-1 in said sample. Measurement of CYFRA 21-1 can, e.g., be used in the early detection or in the follow-up of patients with colorectal cancer.

54. 发明专利

ES2297521T3 METODO PARA LA EVALUACION DE LA ARTRITIS REUMATOIDE MEDIANTE LA MEDICION DE ANTI-PCC E INTERLEUQUINA 6. 未知
公开(公告)号：ES2297521T3
公开(公告)日：2008-05-01
申请号：ES04804125
申请日：2004-12-21
申请人： HOFFMANN LA ROCHE
发明人： WILD NORBERT , KARL JOHANN , GRUNERT VEIT PETER , ZOLG WERNER
IPC分类号： G01N33/68 , G01N33/564
摘要： Un método para valorar la presencia o ausencia de artritis reumatoide in vitro mediante marcadores biológicos, lo que comprende la medida en una muestra de la concentración de al menos a) anti-PCC y b) interleuquina 6, y c) la correlación de las concentraciones determinadas en los pasos a) y b) con la presencia o ausencia de artritis reumatoide.

55. 发明专利

AT359516T 未知
公开(公告)号：AT359516T
公开(公告)日：2007-05-15
申请号：AT04739585
申请日：2004-06-04
申请人： HOFFMANN LA ROCHE
发明人： PESTLIN GABRIELE , ANDRES HERBERT , BERNDT PETER , HAGMANN MARIE-LUISE , KARL JOHANN , LANGEN HANNO , ZOLG WERNER
IPC分类号： G01N33/574

56. 发明专利

CA2623167A1 ANTI-CCP AND ANTINUCLEAR ANTIBODIES IN DIAGNOSIS OF RHEUMATOID ARTHRITIS 未知
公开(公告)号：CA2623167A1
公开(公告)日：2007-04-12
申请号：CA2623167
申请日：2006-10-04
申请人： HOFFMANN LA ROCHE
发明人： KLAUSE URSULA , LEHMANN HANS-PETER , SCHMOLKE SUSANNE , ZOLG WERNER
IPC分类号： G01N33/564
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of antinuclear antibodies (ANA) correlating the concentrations determined to the diagnosis of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and ANA and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and ANA in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.

57. 发明专利

HK1088947A1 USE OF NICOTINAMIDE N-METHYLTRANSFERASE AS A MARKER FOR COLORECTAL CANCER 未知
公开(公告)号：HK1088947A1
公开(公告)日：2006-11-17
申请号：HK06109234
申请日：2006-08-21
申请人： HOFFMANN LA ROCHE
发明人： BERNDT PETER , HAGMANN MARIE-LUISE , LANGEN HANNO , PALME STEFAN , ROESSLER MARKUS , ROLLINGER WOLFGANG , TACKE MICHAEL , ZOLG WERNER , KARL JOHANN , KOTT THERESA
IPC分类号： C12Q1/48 , G01N20090101 , G01N33/574
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

58. 发明专利

BRPI0412668A 未知
公开(公告)号：BRPI0412668A
公开(公告)日：2006-09-26
申请号：BRPI0412668
申请日：2004-07-30
申请人： HOFFMANN LA ROCHE
发明人： BERNTENIS NIKOLAOS , BUURMAN GERRIT , KROPSHOFER HARALD , MUELLER BERND CHRISTIAN , SPINDELDREHER SEBASTIAN THOMAS , VOGT ANNE , ZOLG WERNER
IPC分类号： C07K14/47 , C07K14/74 , C07K1/22 , C07K1/32 , G01N33/569 , A61K38/00 , A61K39/00
摘要： The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-gamma-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plas-minogen activator, immunoglobulin heavy chain V-III region (V H 26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-AT-Pase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-alpha-trypsin inhibitor heavy chain H4, complement C4, complement C3 (alpha-chain), complement C3 (beta-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein, invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly-alpha-2.8-sialyltrans-ferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.

59. 发明专利

CA2585788A1 USE OF CYFRA 21-1 AS A MARKER FOR COLORECTAL CANCER 未知
公开(公告)号：CA2585788A1
公开(公告)日：2006-06-29
申请号：CA2585788
申请日：2005-12-22
申请人： HOFFMANN LA ROCHE
发明人： ZOLG WERNER , ROLLINGER WOLFGANG , GRUNERT VEIT , ANDRES HERBERT , KARL JOHANN
IPC分类号： G01N33/574
摘要： The present invention relates to the assessment of colorectal cancer. It discloses the use of the CYFRA 21-1 assay in the assessment of colorectal cancer. It also relates to a method for assessing colorectal cancer in vitro using a liquid sample, derived from an individual by measuring CYFRA 21-1 in said sample. Measurement of CYFRA 21-1 can, e.g., be used in the early detection or in the follow-up of patients with colorectal cancer.

60. 发明专利

CA2532866A1 USE OF PROTEIN SAHH AS A MARKER FOR COLORECTAL CANCER 未知
公开(公告)号：CA2532866A1
公开(公告)日：2005-02-17
申请号：CA2532866
申请日：2004-08-05
申请人： HOFFMANN LA ROCHE
发明人： BERNDT PETER , HAGMANN MARIE-LUISE , KARL JOHANN , ZOLG WERNER , ROESSLER MARKUS , TACKE MICHAEL , PALME STEFAN , LANGEN HANNO , ROLLINGER WOLFGANG
IPC分类号： G01N33/574
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein SAHH (S-adenosylhomocysteine hydrolase) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuri ng SAHH in said sample. Measurement of SAHH can, e.g. be used in the early detection or diagnosis of colorectal cancer.

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