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    • 53. 发明申请
    • POLYMER-CONJUGATED MALONIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS AND DIAGNOSTIC AGENTS
    • 聚合物结合丙二酸及其作为ARZNEITMITTEL并作为诊断
    • WO1995024437A1
    • 1995-09-14
    • PCT/EP1995000844
    • 1995-03-07
    • HOECHST AKTIENGESELLSCHAFTTOEPFER, AlexanderKRETZSCHMAR, GerhardBARTNIK, EckartSCHMIDT, WolfgangHÖRSCH, Brigitte
    • HOECHST AKTIENGESELLSCHAFT
    • C08G69/10
    • C07H3/04C07H3/06C07H15/207C07H17/04C08G73/0611
    • The present invention concerns polymer-based polyvalent malonic acid derivatives having anti-adhesive properties and consisting of a polyamino acid which is linked in each case by a spacer of formula (I) -[-Q -CH2)p-Q -]r-, in which Q means -CH2- or (i), Q means -NH- or (ii), p is a number from 1 to 6 and r means 0 to 1, with at least one radical of formula (II) in which R and R together from a six-member carbo or heterocycle with at least one of the cycle substituents R , R and R , and R means H, (CH2)mX or CH2O(CH2)mX , A and B, independently of each other, mean O, S, NH, HN-CO, OC-NH, 0-CO, OC-O, NH-CO-O, O-CO-NH, S-CO, SC-O, O-CS-O, S-CS-S, NH-CS-S, S-CS-NH or CH2, and Z means a pyranose, a furanose, an open-chain polyalcohol or Y-X , Y is -O- (CX , X )n is -O- (CX , X )n, - (CH , X )n -CH2- (CX , X ) -n or a saturated or unsaturated, six-member carbo or heterocycle with at least one substituent R or a combination of the chain -O- (CX , X )n, - (CX , X3)n and the carbo or heterocycle, in which R , R and R , independently of each other, mean H, OH, -O- (CH2)qX , CH2O(CH2)qX or HNC (O)CH3 and X, X , X and X , independently of one another, mean H, NH2, COOH, OH, CH2OH, CH2NH2, C1-C20 alkyl or C6-C10 aryl, X and X , independently of one another, mean -NH- or -O- and X means OH or (iii), and m, n and q, independently of one another, mean a number between 1 to 20, by one of the cycle substituents R , R or R . In vivo these derivatives do not cause intolerance reactions either when whole or when in the form of decomposition products. The invention further relates to a process for preparing these derivatives and their use as medicaments or in diagnostic agent.
    • 本发明涉及具有抗粘附性能多价丙二酸衍生物聚合物为基础的,由聚氨基酸,其经由式(I)相应的间隔件 - [ - Q <1> - (CH 2)户Q <2> - ] R-,其中Q < 意味着1> -CH 2 - 或(i)问<2>是-NH-或(ii)p是从1到6和r为0或1,具有至少一个式的基团(II),其中R <1> 且R <2>一起形成六元碳环或杂环与环取代基R形式中的至少一个<4> - [R <5>和R <6>和R <3>为H,(CH 2)MX或CH 2 O(CH 2)MX < 1>装置A和B独立地是O,S,NH,HN-CO,OC-NH,O-CO,OC-O,NH-CO-O,O-CO-NH,S-CO,SC-O 平均-O-CS-S,S-CS-O,NH-CS-S,S-CS-NH或CH 2,并且Z表示一吡喃糖,呋喃糖,开链多元醇或YX <6>,Y为-O- (CX <2>中,X <3>)N, - (CX <2>中,X <3>)N,-CH 2(CX <2>中,X <3>) - ,或饱和或不饱和 六元碳环或具有至少一个取代基R <9> OD杂环 他链-O-的组合(CX <2>中,X <3>)N - 表示(CX <2>中,X <3>)n和碳环或杂环,其中R <4>,R <5>和R <6>独立地是H,OH,-O-(CH 2)QX <4> CH 2 O(CH 2)QX <5>或HNC(O)CH 3和X,X <1>,X <2 >和X <3>独立地是H,NH 2,COOH,OH,CH 2 OH,CH 2 NH 2,C1-C20烷基或C6-C10芳基,X <4>和X <5>独立地是-NH-或-O- 和X <6>是OH或(iii),并且m,n和q彼此独立地,通过环取代基R <4>,R <5>或R <6>连接,一个数从1到20时,在体内的一个 导致无论是在整体或降解产物不耐受反应,它们的制备方法和它们作为药物或诊断用途的方法的形式。
    • 54. 发明申请
    • 6-FLUOROBENZOTHIAZOLES AND THEIR USE IN LIQUID CRYSTAL MIXTURES
    • 6 FLUORBENZTHIAZOLE和它们在的液晶混合物
    • WO1995011890A1
    • 1995-05-04
    • PCT/EP1994003375
    • 1994-10-13
    • HOECHST AKTIENGESELLSCHAFTSCHLOSSER, HubertJUNGBAUER, Dietmar
    • HOECHST AKTIENGESELLSCHAFT
    • C07D277/64
    • C07D277/68C07D277/64C07D277/66C09K19/3497
    • 6-fluorobenzothiazoles of the general formula (I), in which the symbols and indices have the following meanings: R1 is H, a straight-chain or branched C1-C15 alkyl (with or without an asymmetric carbon atom), it also being possible for one or two non-adjacent CH2 groups to be replaced by -O-, -S-, -CO-, -CO-O-, -O-CO-, -CO-S-, -S-CO-, -O-CO-O-, -CH=CH-, -CC-, cyclopropane-1,2-diyl or -Si(CH3)2-, and it also being possible for one or more hydrogen atoms of the alkyl residue to be substituted by F, Cl or CN; A , A , A , which may be identical or different, represent 1,4-phenylene, pyrazine-2,5-diyl, pyridine-2,5-diyl, pyrimidine-2,5-diyl, in which one or two hydrogen atoms can be replaced by fluorine, trans-1,4-cyclohexylene, (1,3,4)-thiadiazole-2,5-diyl, 1,3-dioxane-2,5-diyl, naphthaline-2,6-diyl, bicyclo[2.2.2] octane-1,4-diyl or 1,3-dioxaborinane-2,5 diyl; M , M , which may be identical or different, represent -CH2CH2-, -CH=CH-, -CC-, -CH2CH2CH2CH2-, -CH2CH2CH2-O-, -O-CH2CH2CH2-, -CH2CH2CO-O-, -O-CO-CH2CH2-, -CH2-O-, -O-CH2-, -CO-O- or -O-CO-; M is -CH2CH2-, -CC-, -CH2CH2CH2CH2-, -CH2CH2CH2-O-, -O-CH2CH2CH2- or -CH2-O-; k, l, m, n, o, p are zero or one, provided that the sum of k+m+o is greater than zero. The compounds according to the invention of general formula (I) are chemically and photochemically stable. They have low melting points and generally broad liquid-crystalline phases, in particular broad nematic phases.
    • 6- Fluorbenzthiazole通式(I),其中符号和指数具有以下含义:R t <1>为H,直链或支链(具有或不asymmetisches碳原子),具有1至15个碳原子,其中烷基 一个或两个不相邻的CH 2个基团可以被-O - , - S - , - CO - , - CO-O-,-O-CO - , - CO-S-,-S-CO - , - O-CO-取代 O-,-CH = CH-, - CC-,环丙烷-1,2-二基或-Si(CH 3)2 - 可被取代,并且其中所述烷基被F,Cl或CN取代的一个或多个H原子, 可能; A <1>,A <2>,A <3>是相同的或不同的1,4-亚苯基,吡嗪-2,5-二基,吡啶-2,5-二基,嘧啶-2,5-二基,其中 一个或两个H原子可被F所取代,反式-1,4-亚环己基,(1,3,4-)噻二唑-2,5-二基,1,3-二恶烷-2,5-二基,萘 -2,6-二基,双环[2.2.2]辛烷-1,4-二基或1,3-二氧杂硼烷-2,5-二基; 中号<1>中,M <2>是相同的或不同的-CH 2 CH 2 - , - CH = CH - , - CC-,-CH2CH2CH2CH2-,-CH2CH2CH2 - , - O-CH 2 CH 2,-CH2CH2CO-O-, -O-CO-CH 2 CH 2 -CH 2 -O-,-O-CH 2 - , - CO-O-或-O-CO-; 中号<3>是-CH2CH2 - , - CC-,-CH2CH2CH2CH2-,-CH2CH2CH2 - , - O-CH 2 CH 2或-CH 2 O-; K,L,M,N,O,P是0或1,条件是K + M + O的总和是大于零。 通式(I)的新化合物是化学和光化学稳定的。 它们具有低的熔点,并且通常具有广泛的液晶相,特别是宽的向列相。
    • 55. 发明申请
    • SOLID BODY WHICH IS SUPERCONDUCTING AT HIGH TEMPERATURES AND METHOD OF PRODUCING SUCH A BODY
    • 高温超导固体及其制备方法
    • WO1995002717A1
    • 1995-01-26
    • PCT/EP1994002206
    • 1994-07-06
    • HOECHST AKTIENGESELLSCHAFTBRAND, MarkusBROMMER, GünterELSCHNER, SteffenGAUSS, StephanASSMUS, Wolf
    • HOECHST AKTIENGESELLSCHAFT
    • C30B29/22
    • C04B35/64C04B35/4508H01L39/2419Y10S505/729
    • The invention concerns a method of producing textured solid mouldings which are superconducting at high temperatures, the mouldings being made from superconducting ceramic-oxide material comprising a phase mixture of the YBCO class by moulding, pressing and sintering and then subjected to heat treatment in the direction of the longitudinal axis of the moulding in a series of heat-treatment zones. First the moulding is heated in a first zone to a temperature in the range lying 50 to 200 K below the peritectic melting point of the phase mixture specified in the moulding. The temperature is subsequently reduced in a second zone in which the temperature gradient is in the range 10 to 250 K/cm. The temperature is then maintained in a third zone at up to 50 K above the peritectic melting point of the phase mixture specified for the moulding. The temperature is then lowered again in a fourth zone in which the temperature gradient is in the range 10 to 250 K/cm. Finally, in a fifth zone, the temperature is held in the range lying 50 to 200 K below the peritectic melting point of the phase mixture specified for the moulding. The invention calls for the zones to be moved along the longitudinal axis of the moulding at a speed of 1 to 10 mm/h.
    • 本发明涉及一种用于制造有纹理的高温超导块状形状的部件,在由该物质类YBCO的相混合物的氧化物陶瓷超导材料的第一块状成形的部分形成的过程中,挤压和烧结,并且其中再逐区段热处理发生沿纵向轴线。 在第一区中首先被加热到温度在50〜200K的下面的在模制相混合物包晶熔融温度的范围内,然后用在10至250 K /厘米的范围内的温度梯度,该温度在第二区增加, 然后,高达50K的,其在具有在在第三区10至250 K /厘米的范围内的温度梯度的第四区中冷却的温度被保持在模制混合物中的规定相的包晶Schemlztemperatur上方。 最后,在50至200 K的范围内的温度仍然可以在第五区保持在低于在Formtel相混合物的包晶熔化温度。 这些区域是按照本发明在在纵向方向上为1〜10mm / h的范围的速度移动。
    • 58. 发明申请
    • ALIGNMENT LAYER FOR LIQUID CRYSTALS
    • 液晶对准层
    • WO1994028458A1
    • 1994-12-08
    • PCT/EP1994001754
    • 1994-05-30
    • HOECHST AKTIENGESELLSCHAFTHARADA, TakamasaNOZAWA, FumieUBUKATA, MasamiITOH, Haruhiko
    • HOECHST AKTIENGESELLSCHAFT
    • G02F01/1337
    • G02F1/133711C09D183/04C09D183/10Y10T428/1014C08L2666/14
    • An alignment layer for liquid crystals is disclosed. The liquid crystal alignment layer of the present invention is excellent in adhesion to the glass substrate, has a high liquid crystal alignment angle (pretilt angle) and generates a high pretilt angle with less dependence on the type of rubbing treatment methods and processing conditions such as heating temperature. The alignment layer for liquid crystals comprises a material selected from the group consisting of: (1) at least one polymer (A) selected from the group consisting of a polyurethane, a polyester, a polyimide, a polycarbonate and a polyurea each containing a siloxane compound as a polymer constituting component; (2) a mixture (B) of a siloxane compound and at least one polymer selected from the group consisting of a polyurethane, a polyester, a polyimide, a polycarbonate and a polyurea; or (3) a mixture of the polymer (A) and the mixture (B); and (4) a mixture of the polymer (A) and at least one polymer (D) selected from the group consisting of a polyurethane, a polyester, a polyimide, a polycarbonate, a polyurea, a polyamide and a cellulose-based compound.
    • 公开了液晶取向层。 本发明的液晶取向膜与玻璃基板的粘附性优异,液晶取向角(预倾斜角)高,并且产生较高的预倾斜角,对摩擦处理方法的种类和处理条件如 加热温度。 用于液晶的取向层包括选自以下的材料:(1)选自聚氨酯,聚酯,聚酰亚胺,聚碳酸酯和聚脲中的至少一种聚合物(A),各自含有硅氧烷 作为聚合物构成成分的化合物; (2)硅氧烷化合物的混合物(B)和选自聚氨酯,聚酯,聚酰亚胺,聚碳酸酯和聚脲中的至少一种聚合物; 或(3)聚合物(A)和混合物(B)的混合物; 和(4)聚合物(A)和选自聚氨酯,聚酯,聚酰亚胺,聚碳酸酯,聚脲,聚酰胺和纤维素类化合物的至少一种聚合物(D)的混合物。