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51. 发明申请

US20060190060A1 System and apparatus for controlled activation of acute use medical devices 有权
标题翻译：用于急性用途医疗装置的受控激活的系统和装置
公开(公告)号：US20060190060A1
公开(公告)日：2006-08-24
申请号：US11343354
申请日：2006-01-31
申请人： Daniel Greeninger , David Dinsmoor , Vincent Larik , Receveur Rogier , David Thompson
发明人： Daniel Greeninger , David Dinsmoor , Vincent Larik , Receveur Rogier , David Thompson
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/378
摘要： An integrated activation system for an implantable medical device (IMD) sharing a power source, the activation system comprising a switching circuit having first and second inputs and having an output coupled to the acute use device, a gating element coupled to the first input and configured to gate power from the power source to the switching circuit, and a sensing element coupled to the second input of the switching circuit. The sensing element is configured to sense an activation condition, enable an operation interval of the switching circuit, and transmit a signal to the switching circuit during the activation condition. The switching circuit is configured to transmit power to the acute use device upon receipt of a pre-determined number of signals from the sensing element.
摘要翻译：一种用于共享电源的可植入医疗装置（IMD）的集成激活系统，所述激活系统包括具有第一和第二输入并且具有耦合到所述急性使用装置的输出的切换电路，耦合到所述第一输入并配置的门控元件从电源到开关电路的栅极电力，以及耦合到开关电路的第二输入的感测元件。感测元件被配置为感测激活条件，启用开关电路的操作间隔，并且在激活条件期间将信号发送到开关电路。开关电路被配置为在接收到来自感测元件的预定数量的信号时将功率传送到急用设备。

52. 发明申请

US20050251250A1 Stents and methods for preparing stents from wires having hydrogel coating layers thereon 失效
标题翻译：用于从其上具有水凝胶涂层的线制备支架的支架和方法
公开(公告)号：US20050251250A1
公开(公告)日：2005-11-10
申请号：US11181495
申请日：2005-07-13
申请人： Michel Verhoeven , Linda Cahalan , Patrick Cahalan , Vincent Larik
发明人： Michel Verhoeven , Linda Cahalan , Patrick Cahalan , Vincent Larik
IPC分类号： A61F2/86 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61L31/145 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.
摘要翻译：公开了其上具有水凝胶涂层的可径向扩张的支架，以及制备这种支架的方法。所述方法包括用包含溶剂和在溶剂中的水溶性聚合物的溶液涂覆线材，蒸发溶剂以在线材上提供聚合物涂层，并交联聚合物涂层以在线材上提供水凝胶涂层。涂覆的线可以制成支架，其优选地具有基本均匀的具有低表面粗糙度的涂层。优选地，涂层具有亲水性质并提供生物相容性表面。涂层还可以提供将生物活性剂递送到体内。

53. 发明授权

US06605039B2 Cell-based biosensors suitable for implantable medical device applications 有权
标题翻译：适用于可植入医疗器械应用的基于细胞的生物传感器
公开(公告)号：US06605039B2
公开(公告)日：2003-08-12
申请号：US09909999
申请日：2001-07-23
申请人： Richard Houben , Vincent Larik
发明人： Richard Houben , Vincent Larik
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/14532
摘要： A sensing methodology is used based on measuring a physical response from a living structure as a result of a chemical compound stimulating this structure on the cellular level. Measurement of the heat response (calorimetry) from a group of pancreatic islets of Langerhans stimulated by glucose is proposed as a glucose biosensor. A novel biosensor concept is proposed acquiring physical response from living cells or cell clusters. In this particular case, membrane impedance of pancreatic B-cells, as a result of glucose stimulated cellular metabolism is used as physical readout. This method of physical assessment is made possible by growing genetically engineered pancreatic beta cells onto a substrate equipped with a set of interdigitated electrodes (IDEs).
摘要翻译：基于在细胞水平上刺激该结构的化学化合物的结果，基于测量来自活体结构的物理反应的感测方法被使用。作为葡萄糖生物传感器，提出了一组由葡萄糖刺激的朗格汉斯胰岛的热响应（量热法）的测量。提出了一种新的生物传感器概念，从生物细胞或细胞簇获得物理反应。在这种特殊情况下，作为葡萄糖刺激的细胞代谢的结果，胰腺B细胞的膜阻抗用作物理读数。通过将基因工程的胰β细胞生长到配备有一组交叉电极（IDE）的基底上，这种物理评估方法成为可能。

54. 发明申请

US20120116481A1 System and Apparatus for Controlled Activation of Acute Use Medical Devices 有权
标题翻译：控制激活急性用途医疗器械的系统和装置
公开(公告)号：US20120116481A1
公开(公告)日：2012-05-10
申请号：US13226399
申请日：2011-09-06
申请人： Daniel R. Greeninger , David A. Dinsmoor , Vincent Larik , Receveur Rogier , David L. Thompson
发明人： Daniel R. Greeninger , David A. Dinsmoor , Vincent Larik , Receveur Rogier , David L. Thompson
IPC分类号： A61N1/36
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/378
摘要： An integrated activation system for an implantable medical device (IMD) sharing a power source, the activation system comprising a switching circuit having first and second inputs and having an output coupled to the acute use device, a gating element coupled to the first input and configured to gate power from the power source to the switching circuit, and a sensing element coupled to the second input of the switching circuit. The sensing element is configured to sense an activation condition, enable an operation interval of the switching circuit, and transmit a signal to the switching circuit during the activation condition. The switching circuit is configured to transmit power to the acute use device upon receipt of a pre-determined number of signals from the sensing element.
摘要翻译：一种用于共享电源的可植入医疗装置（IMD）的集成激活系统，所述激活系统包括具有第一和第二输入并且具有耦合到所述急性使用装置的输出的切换电路，耦合到所述第一输入并配置的门控元件从电源到开关电路的栅极电力，以及耦合到开关电路的第二输入的感测元件。感测元件被配置为感测激活条件，启用开关电路的操作间隔，并且在激活条件期间将信号发送到开关电路。开关电路被配置为在接收到来自感测元件的预定数量的信号时将功率传送到急用设备。

55. 发明授权

US08014872B2 System and apparatus for controlled activation of acute use medical devices 有权
标题翻译：用于急性用途医疗装置的受控激活的系统和装置
公开(公告)号：US08014872B2
公开(公告)日：2011-09-06
申请号：US11343354
申请日：2006-01-31
申请人： Daniel R. Greeninger , David A. Dinsmoor , Vincent Larik , Receveur Rogier , David L. Thompson
发明人： Daniel R. Greeninger , David A. Dinsmoor , Vincent Larik , Receveur Rogier , David L. Thompson
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/378
摘要： An integrated activation system for an implantable medical device (IMD) sharing a power source, the activation system comprising a switching circuit having first and second inputs and having an output coupled to the acute use device, a gating element coupled to the first input and configured to gate power from the power source to the switching circuit, and a sensing element coupled to the second input of the switching circuit. The sensing element is configured to sense an activation condition, enable an operation interval of the switching circuit, and transmit a signal to the switching circuit during the activation condition. The switching circuit is configured to transmit power to the acute use device upon receipt of a pre-determined number of signals from the sensing element.
摘要翻译：一种用于共享电源的可植入医疗装置（IMD）的集成激活系统，所述激活系统包括具有第一和第二输入并且具有耦合到所述急性使用装置的输出的切换电路，耦合到所述第一输入并配置的门控元件从电源到开关电路的栅极电力，以及耦合到开关电路的第二输入的感测元件。感测元件被配置为感测激活条件，启用开关电路的操作间隔，并且在激活条件期间将信号发送到开关电路。开关电路被配置为在接收到来自感测元件的预定数量的信号时将功率传送到急用设备。

56. 发明申请

US20080161703A1 Method and Apparatus for Atrial Arrhythmia Detection 有权
标题翻译：心律失常检测方法与装置
公开(公告)号：US20080161703A1
公开(公告)日：2008-07-03
申请号：US11616993
申请日：2006-12-28
申请人： Richard P.M. Houben , Vincent Larik , Tim D.J. Jongen
发明人： Richard P.M. Houben , Vincent Larik , Tim D.J. Jongen
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/02405 , A61N1/3624
摘要： A medical device performs a method for detecting atrial arrhythmias. A signal including ventricular cycle length information is sensed in a patient and used to determine each difference between successive ventricular cycle lengths occurring during a predetermined time period. Each succeeding difference is stored as a data point in a histogram, and a metric of variability of the data points of the histogram is determined. An atrial arrhythmia is detected in response to the metric crossing a threshold. The threshold is determined in response to the number of ventricular cycle lengths occurring during the predetermined time period.
摘要翻译：医疗器械执行检测心房心律失常的方法。在患者中检测包括心室周长信息的信号，并且用于确定在预定时间段内发生的连续心室周期长度之间的每个差异。每个后续差异作为数据点存储在直方图中，并且确定直方图的数据点的变化度量。响应于穿过阈值的度量来检测心房心律失常。响应于在预定时间段期间发生的心室周期长度的数量来确定阈值。

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