专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明专利

IN849KON2014A SUBSTITUTED PYRAZOLYL BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN O CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS 未知
公开(公告)号：IN849KON2014A
公开(公告)日：2015-10-02
申请号：IN849KON2014
申请日：2014-04-17
申请人： GRUENENTHAL GMBH
发明人： FRANK FOLTYN ROBERT , CHRISTOPH THOMAS , SCHIENE KLAUS , DE VRY JEAN , DAMANN NILS , LESCH BERNHARD , BAHRENBERG GREGOR , SAUNDERS DEREK JOHN , STOCKHAUSEN HANNELORE , KIM YONG SOO , KIM MYEONG SEOP , LEE JEEWOO
IPC分类号： C07D231/12 , A61K31/415 , C07D407/12
摘要： The invention relates to substituted pyrazolyl based carboxamide and urea derivatives of formula (Q) as vanilloid receptor ligands to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

52. 发明专利

BRPI0714764A2 未知
公开(公告)号：BRPI0714764A2
公开(公告)日：2014-12-30
申请号：BRPI0714764
申请日：2007-09-27
申请人： GRUENENTHAL GMBH
发明人： OBERBOERSCH STEFAN , SCHUNK STEFAN , REICH MELANIE , HEES SABINE , JOSTOCK RUTH , ENGELS MICHAEL , KLESS ACHIN , CHRISTOPH THOMAS , SCHIENE KLAUS , GERMANN TIENO , BIJSTERVELD EDWARD
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： N-heterocyclic sulfonamide derivatives with aminocarbonyl-methoxymethyl or aminocarbonyl-methoxyethyl groups on the ring carbon adjacent to the sulfonamide nitrogen atom are new. Substituted sulfonamide derivatives of formula (I) in the form of racemates, enantiomers or diastereoisomers of the bases, mixtures of the last two, and/or their salts with physiologically-tolerable acids are new. n : 0, 1, 2 or 3; m : 1 or 2; R 1>aryl or heteroaryl; R 2a-c>, R 3>, R 4>H, or these groups plus an adjacent group may form a 5- or 6-membered ring (saturated or unsaturated, optionally substituted and containing N or O as hetero-atoms; R 5> and R 6> together form (a) a 4- to 8-membered non-aromatic ring (optionally condensed with a 4- to 10-membered aromatic, saturated or unsaturated ring, with either or both rings being substituted or condensed with a basic residue and optionally substituted with other basic residues selected from 1-6C alkyl, 1-3C alkoxy, 3-8C cycloalkyl, : O, aralkyl or aryl), or (b) a 4- to 8-membered ring containing another N or O atom and optionally substituted with a basic or non-basic residue, the ring N-atom being optionally substituted also with 1-6C alkyl, aryl or aralkyl if the basic or non-basic residue is not attached to the ring via the hetero-atom, or (c) R 5>= H, 1-6C alkyl, 3-8C cycloalkyl, aryl or aralkyl and R 6>= aryl 3-8C cycloalkyl or an aryl or 3-8C cycloalkyl group linked via a 1-3C alkyl chain, the aryl or cycloalkyl group being optionally condensed with a 5- to 10-membered optionally unsaturated ring (optionally containing hetero-atom(s)) and substituted with a basic residue (or this alkyl substitution may be on the 1-3C alkyl bridge), or (d) R 5>= H, 1-6C alkyl, 3-8C cycloalkyl, aryl or aralkyl and R 6>= 4-8C heterocyclyl (optionally linked via a 1-3C alkyl chain), optionally substituted on one or two ring members with a basic or non-basic residue, or (e) R 5>, R 6>= H, aralkyl or optionally branched, optionally substituted 1-10C alkyl containing 1-3 N atoms (R 5> and R 6> cannot both be H), or (f) R 5>= H, alkyl, cycloalkyl, aryl or aralkyl as above and R 6>= a basic heteroaryl group, optionally linked via 1-4C alkylene and optionally substituted, in which the 1-4C chain may also be substituted with a basic residue; . Independent claims are also included for (1) a method for the production of (I) by reacting carboxylic acids of formula (L) with prim. or sec. amines of formula R 5>R 6>NH (M) in presence of dehydrating agents such as sodium or magnesium sulfate, phosphorus pentoxide or reagents such as CDI, DCC, TBTU and EDCI, and in presence of HOAt or HOBt and an organic base, e.g. DIPEA or pyridine, in a solvent such as THF, dichloromethane, diethyl ether, dioxan, DMF or acetonitrile (2) drugs containing (I), optionally with suitable additives, auxiliary substances and/or other active ingredients. [Image] [Image].

53. 发明专利

BRPI0715298A2 未知
公开(公告)号：BRPI0715298A2
公开(公告)日：2014-10-29
申请号：BRPI0715298
申请日：2007-10-16
申请人： GRUENENTHAL GMBH
发明人： MERLA BEATRIX , CHRISTOPH THOMAS , OBERBOESCH STEFAN , SCHIENE KLAUS , BAHRENBERG GREGOR , FRANK ROBERT , KUEHNERT SVEN , SCHROEDER WOLFGANG
IPC分类号： C07D487/04 , A61K31/4985 , A61P25/00 , A61P25/06 , A61P25/08
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.

54. 发明专利

HRP20140663T1 FARMACEUTSKA KOMBINACIJA 3(3-DIMETILAMINO-1-ETIL-2-METIL-PROPIL)-FENOLA I ANTIEPILEPTIÄŚKOG SREDSTVA\n 未知
$FARMACEUTSKA KOMBINACIJA 3(3-DIMETILAMINO-1-ETIL-2-METIL-PROPIL)-FENOLA I ANTIEPILEPTIÄŚKOG SREDSTVA\n$
公开(公告)号：HRP20140663T1
公开(公告)日：2014-10-10
申请号：HRP20140663
申请日：2014-07-14
申请人： GRUENENTHAL GMBH
发明人： BLOMS-FUNKE PETRA , SCHIENE KLAUS , CHRISTOPH THOMAS
IPC分类号： A61K31/137 , A61K45/06 , A61P25/04

55. 发明专利

PT2331210E COMBINAÇÃO FARMACÊUTICA DE 3-(3-DIMETILAMINO-1-ETIL-2- METILPROPIL)FENOL E UM ANTIEPILÉPTICO 未知
公开(公告)号：PT2331210E
公开(公告)日：2014-08-25
申请号：PT09778335
申请日：2009-09-04
申请人： GRUENENTHAL GMBH
发明人： CHRISTOPH THOMAS , BLOMS-FUNKE PETRA , SCHIENE KLAUS
IPC分类号： A61K31/137 , A61K45/06 , A61P25/04

56. 发明专利

CA2650423C PHARMACEUTICAL COMBINATION COMPRISING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL AND PARACETAMOL 未知
公开(公告)号：CA2650423C
公开(公告)日：2014-08-12
申请号：CA2650423
申请日：2007-04-25
申请人： GRUENENTHAL GMBH
发明人： BLOMS-FUNKE PETRA , SCHIENE KLAUS
IPC分类号： A61K31/137 , A61K31/167 , A61P29/00
摘要： The present invention relates to a combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) Paracetamol or a derivative thereof, a pharmaceutical formulation and a dosage form comprising said combination as well as a method of treating pain, e.g. chronic or acute pain, characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.

57. 发明专利

SG10201401455WA USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING RHEUMATOID PAIN 未知
公开(公告)号：SG10201401455WA
公开(公告)日：2014-07-30
申请号：SG10201401455W
申请日：2010-04-26
申请人： GRUENENTHAL GMBH
发明人： JAHNEL ULRICH , SCHIENE KLAUS
摘要： The invention relates to the use of 1-phenyl-3-dimethylaminopropane compounds, such as tapentadol, for the production of medicaments for treating rheumatoid, preferably rheumatoid arthritic, very preferably chronic rheumatoid arthritic pain.

58. 发明专利

CA2649459C PHARMACEUTICAL COMBINATION COMPRISING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL AND AN NSAID 未知
公开(公告)号：CA2649459C
公开(公告)日：2014-07-22
申请号：CA2649459
申请日：2007-04-25
申请人： GRUENENTHAL GMBH
发明人： SCHIENE KLAUS , BLOMS-FUNKE PETRA
IPC分类号： C07C219/28 , A61K31/137 , A61P29/00 , C07C229/42 , C07D231/48
摘要： The invention provides a combination comprising as components: (a) at least one 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol of formula (I), (see formula I) an enantiomer thereof, a diastereomer thereof, a racemate thereof, a mixture of enantiomers thereof, a mixture of diastereomers thereof, an acid addition salt thereof or a solvate thereof; and (b) one or more non-steroidal anti-inflammatory drugs (NSAIDs) selected from the group consisting of Diclofenac, Diclofenac-Sodium, Dipyrone (Metamizol), Metamizol-Sodium, Ibuprofen, Ketoprofen, (+)-Ibuprofen and (-)-Ibuprofen.

59. 发明专利

ES2400407T3 Compuestos de nicotinamida sustituidos y su utilización en medicamentos 未知
公开(公告)号：ES2400407T3
公开(公告)日：2013-04-09
申请号：ES08802179
申请日：2008-09-15
申请人： GRUENENTHAL GMBH
发明人： MERLA BEATRIX , KUEHNERT SVEN , FRANK ROBERT , KAULARTZ DAGMAR , SCHROEDER WOLFGANG , BAHRENBERG GREGOR , SCHIENE KLAUS
IPC分类号： C07D213/82 , A61K31/33 , A61P25/06 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Compuestos de nicotinamida sustituidos de fórmula general I, donde n >= 0, 1 o 2; p >= 0 o 1; q >= 0 o 1; R1 representa arilo o heteroarilo, sustituido de forma simple o múltiple o no sustituido; alquilo(C1-6),cicloalquilo(C3-10) o heterociclilo, sustituido de forma simple o múltiple o no sustituido; R2 representa H; alquilo(C1-6) sustituido de forma simple o múltiple o no sustituido; R3 representa arilo o heteroarilo, sustituido de forma simple o múltiple o no sustituido; alquilo(C1-6) o cicloalquilo(C3-10), en cada caso sustituido de forma simple o múltiple o no sustituido; R4, R5, R6 y R7 representan, independientemente entre sí, H; alquilo(C1-6) sustituido de forma simple o múltipleo no sustituido; R8, R9 y R10 representan, independientemente entre sí, H, F, Cl, Br, O-alquilo(C1-6), CF3, OCF3, SCF3,alquilo(C1-6); con la condición de que, cuando R3 representa 3-trifluorometilfenilo o 4-trifluorometil-2-piridilo, R2, R4 y R5 son H y n es igual a 0,entonces R1 no es 2-piridilo ni 2-tienilo; y cuando R3 representa fenilo o metilo, R2, R4 y R5 son H y n es igual a 0, entonces R1 no es 2-tienilo; incluyendoel concepto "alquilo(C1-6)" grupos hidrocarburo acíclicos saturados o insaturados, e incluyendo el concepto"cicloalquilo" y "cicloalquilo(C3-10)" hidrocarburos cíclicos saturados o insaturados, pero no aromáticos,en forma de racematos, de enantiómeros, diastereoisómeros, mezclas de enantiómeros o diastereoisómeros ode un enantiómero o diastereoisómero individual; en forma de bases y/o sales de ácidos fisiológicamentecompatibles.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式