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51. 发明专利

HK1151305A1 用於治療癌症的針對密蛋白- 的單克隆抗體未知
公开(公告)号：HK1151305A1
公开(公告)日：2012-01-27
申请号：HK11105552
申请日：2008-12-08
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TRECI ZLEM , USENER DIRK , FRITZ STEFAN , UHEREK CHRISTOPH , BRANDENBURG GUNDA , GEPPERT HARALD-GERHARD , SCHRDER ANJA KRISTINA , THIEL PHILIPPE
IPC分类号： A61K20060101 , C07K20060101 , A61P20060101 , C12N20060101

52. 发明专利

BRPI0618920A2 未知
公开(公告)号：BRPI0618920A2
公开(公告)日：2011-09-27
申请号：BRPI0618920
申请日：2006-11-24
申请人： GANYMED PHARMACEUTICALS AG , UNIV MAINZ JOHANNES GUTENBERG
发明人： SAHIN UGUR , TUERECI IZLEM , USENER DIRK , FRITZ STEFAN , UHEREK CHRISTOPH , BRANDENBURG GUNDA , GEPPERT HARALD-GERHARD , SCHROEDER ANJA KRISTINA , THIEL PHILIPPE
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , A61P35/00 , C12N5/12
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

53. 发明专利

CA2628126A1 MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER 未知
公开(公告)号：CA2628126A1
公开(公告)日：2007-05-31
申请号：CA2628126
申请日：2006-11-24
申请人： GANYMED PHARMACEUTICALS AG , JOHANNES GUTENBERG UNI MAINZ V
发明人： SCHROEDER ANJA KRISTINA , FRITZ STEFAN , GEPPERT HARALD-GERHARD , UHEREK CRISTOPH , TUERECI OEZLEM , SAHIN UGUR , THIEL PHILIPPE , USENER DIRK , BRANDENBURG GUNDA
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , A61P35/00 , C12N5/12
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

54. 发明专利

DE102004024617A1 未知
公开(公告)号：DE102004024617A1
公开(公告)日：2005-12-29
申请号：DE102004024617
申请日：2004-05-18
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TUERECI OEZLEM , KOSLOWSKI MICHAEL , FRITZ STEFAN , GEPPERT HARALD-GERHARD
IPC分类号： C07K14/47 , C07K14/705 , C07K16/30 , C12N9/88 , G01N33/574 , A61K48/00 , A61K39/395 , C12Q1/68
摘要： Pharmaceutical composition comprising nucleic acid with specific sequence, useful for inhibiting expression or activity of tumor-associated antigen, where the tumor associated antigen has a fully defined nucleic acid sequence. The nucleic acid is alternatively one which, under stringent conditions hybridizes, is degenerated with respect to, or is complementary to the foregoing. Pharmaceutical composition comprising nucleic acid with specific sequence, useful for inhibiting expression or activity of tumor-associated antigen, where the tumor associated antigen has a nucleic acid-coded sequence selected from the group comprising sequence identification numbers 1-8, 41-44, 51-59, 84, 117, 119 and 138, a part or derivative of them. The nucleic acid is alternatively one which, under stringent conditions hybridizes, is degenerated with respect to, or is complementary to the foregoing. The composition or agent so determined, is selective for cells which exhibit expression or abnormal expression of a tumor-associated antigen. The agent induces cell death, reduction of cell growth, damage to the cell membrane or secretion of cytokines. Numerous developments and variations in accordance with the foregoing principles are elaborated. Independent claims are included for the following: (1) a method of disease diagnosis; (2) a kit for the purpose of disease diagnosis; (3) a nucleic acid or associated recombinant DNA or RNA molecule; (4) a host cell; (5) a protein, polypeptide; and (6) an immunogenic fragment, antibody or conjugate. ACTIVITY : Cytostatic. MECHANISM OF ACTION : Tumor associated antigen inhibitor.

55. 发明专利

CA2886580C MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER 未知
公开(公告)号：CA2886580C
公开(公告)日：2019-12-10
申请号：CA2886580
申请日：2006-11-24
申请人： GANYMED PHARMACEUTICALS AG , JOHANNES GUTENBERG UNIV MAINZ VERTRETEN DURCH DEN PRASIDENTEN
发明人： SAHIN UGUR , TURECI OZLEM , USENER DIRK , FRITZ STEFAN , UHEREK CHRISTOPH , BRANDENBURG GUNDA , GEPPERT HARALD-GERHARD , SCHRODER ANJA KRISTINA , THIEL PHILIPPE
IPC分类号： C07K16/28 , C07K16/30 , C12N5/16 , C12P21/08
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor- related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

56. 发明专利

CY1119290T1 ΜΟΝΟΚΛΩΝΑ ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΛΑΟΥΔΙΝΗΣ-18 ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΚΑΡΚΙΝΟΥ 未知
公开(公告)号：CY1119290T1
公开(公告)日：2018-02-14
申请号：CY171100941
申请日：2017-09-06
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TUERECI OEZLEM , USENER DIRK , FRITZ STEFAN , UHEREK CHRISTOPH , BRANDENBURG GUNDA , GEPPERT HARALD GERHARD , SCHROEDER ANJA KRISTINA , THIEL PHILIPPE
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06 , A61K51/10 , A61P35/00 , C07K16/18 , C07K16/30 , C12N5/12
摘要： Ηπαρούσαεφεύρεσηπαρέχειαντισώματαχρήσιμαωςθεραπευτικάγιατηθεραπείαή/καιπρόληψηασθενειώνπουσχετίζονταιμεκύτταραπουεκφράζουν CLD18, συμπεριλαμβανομένωντωνασθενειώνπουσχετίζονταιμεόγκουςόπωςο γαστρικόςκαρκίνος, οκαρκίνοςτοοισοφάγου, καρκίνοςτουπαγκρέατος, καρκίνοςτουπνεύμονα, καρκίνοςτωνωοθηκών, καρκίνοςτουήπατος, καρκίνοςτηςκεφαλής-αυχένακαικαρκίνοςτηςχοληδόχουκύστης.

57. 发明专利

PL1749027T3 Różnie ekspresjonowane w guzach produkty genów i ich zastosowanie 未知
公开(公告)号：PL1749027T3
公开(公告)日：2017-01-31
申请号：PL05745559
申请日：2005-05-18
申请人： GANYMED PHARMACEUTICALS AG
发明人： TÜRECI ÖZLEM , SAHIN UGUR , KOSLOWSKI MICHAEL , FRITZ STEFAN , GEPPERT HARALD-GERHARD
IPC分类号： C07K14/47 , A61K39/395 , A61P35/00 , C07K14/705 , C07K16/30 , C12N9/88 , G01N33/574

58. 发明专利

DK1749027T3 GENPRODUKTER, DER UDTRYKKES DIFFERENTIELT I TUMORER OG ANVENDELSE DERAF 未知
公开(公告)号：DK1749027T3
公开(公告)日：2016-12-05
申请号：DK05745559
申请日：2005-05-18
申请人： GANYMED PHARMACEUTICALS AG
发明人： TÜRECI ÖZLEM , SAHIN UGUR , FRITZ STEFAN , GEPPERT HARALD-GERHARD , KOSLOWSKI MICHAEL
IPC分类号： C07K14/47 , A61K39/395 , A61P35/00 , C07K14/705 , C07K16/30 , C12N9/88 , G01N33/574

59. 发明专利

CY1114050T1 ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΕΝΑΝΤΙ CLAUDIN-18 ΣΤΗΝ ΑΓΩΓΗ ΕΝΑΝΤΙ ΚΑΡΚΙΝΟΥ 未知
公开(公告)号：CY1114050T1
公开(公告)日：2016-07-27
申请号：CY131100474
申请日：2013-06-12
申请人： GANYMED PHARMACEUTICALS AG
发明人： SAHIN UGUR , TÜRECI ÖZLEM , USENER DIRK , FRITZ STEFAN , UHEREK CHRISTOPH , BRANDENBURG GUNDA , GEPPERT HARALD - GERHARD , SCHRÖDER ANJA KRISTINA , THIEL PHILIPPE
IPC分类号： A61K39/395 , A61K51/10 , A61P35/00 , C12N5/12
摘要： Ηπαρούσαεφεύρεσηπαρέχειαντισώματαχρήσιμαωςθεραπευτικάμέσαστηναγωγήκαι/ήπρόληψηασθενειώνπουσχετίζονταιμεκύτταραταοποίαεκφράζουν CLD18, συμπεριλαμβανομένωνασθενειώνόγκουόπωςο καρκίνοςτουγαστρικού, οκαρκίνοςτουοισοφάγου, οκαρκίνοςτουπαγκρέατος, οκαρκίνοςτωνπνευμόνων, οκαρκίνοςωοθηκών, οκαρκίνοςστοκόλον, οκαρκίνοςτουήπατος, οκαρκίνοςκεφαλήςκαιαυχένα, καιο καρκίνοςχοληδόχουκύστης.

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