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51. 发明申请

US20140205612A1 HUMAN IMMUNODEFICIENCY VIRUS (HIV)-NEUTRALIZING ANTIBODIES 有权
标题翻译：人类免疫缺陷病毒（HIV） - 抗精神病药物
公开(公告)号：US20140205612A1
公开(公告)日：2014-07-24
申请号：US13780776
申请日：2013-02-28
申请人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
IPC分类号： C07K16/10 , A61K39/21
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译：本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物种的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。所得到的单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染的能力。提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。此外，提供了使用合适表位的疫苗接种方法。

52. 发明申请

US20140201795A1 Methods, a Client and a Server for Handling an MPEG Transport Stream 有权
标题翻译：方法，客户端和处理MPEG传输流的服务器
公开(公告)号：US20140201795A1
公开(公告)日：2014-07-17
申请号：US13993687
申请日：2010-12-15
申请人： Michael Huber , Hans Byström , Mats Cedervall , Johan Kwarnmark
发明人： Michael Huber , Hans Byström , Mats Cedervall , Johan Kwarnmark
IPC分类号： H04N21/6375 , H04N21/234 , H04N21/643 , H04N21/44 , H04N21/438 , H04N21/236 , H04N21/434
CPC分类号： H04N21/23418 , H04L65/4076 , H04L65/4084 , H04L65/607 , H04L65/608 , H04L65/80 , H04N21/23605 , H04N21/23617 , H04N21/4343 , H04N21/4349 , H04N21/4384 , H04N21/44004 , H04N21/6375 , H04N21/64322
摘要： A method for re-transmitting missing packets in an improved manner in association with transmitting an MPEG transport stream between a client and a server of a communication network is provided. New type of customized control packets are introduced which are periodically embedded into the transport stream at the server from which the MPEG transport stream is distributed, wherein each of the embedded control packets is provided with package identification data. A client receiving the MPEG transport stream, including the embedded customized control packets, will, on the basis of the package identification data obtained from a customized control packet be able to identify each of n packets which were inserted by the server into the transport stream subsequent to the respective customized control packet.
摘要翻译：提供了一种与在通信网络的客户端和服务器之间传输MPEG传输流相关联地以改进的方式重新发送丢失分组的方法。引入了新型的定制控制分组，其周期性地嵌入在分发MPEG传输流的服务器处的传输流中，其中每个嵌入式控制分组被提供有包标识数据。接收包括嵌入式定制控制分组的MPEG传输流的客户端将根据从定制的控制分组获得的包标识数据能够将服务器插入的n个分组中的每一个标识到传输流中到相应的定制控制分组。

53. 发明授权

US08670966B2 Methods and systems for performing oilfield production operations 有权
标题翻译：执行油田生产作业的方法和系统
公开(公告)号：US08670966B2
公开(公告)日：2014-03-11
申请号：US12534962
申请日：2009-08-04
申请人： Kashif Rashid , Daniel Colin-Nesbitt Lucas-Clements , Aron Edward Hallquist , Michael Huber , Trevor Graham Tonkin , Andrew Michael Shand
发明人： Kashif Rashid , Daniel Colin-Nesbitt Lucas-Clements , Aron Edward Hallquist , Michael Huber , Trevor Graham Tonkin , Andrew Michael Shand
IPC分类号： G06G7/48 , G06G7/50 , G01N15/08 , E21B43/00
CPC分类号： G06Q10/04 , E21B43/122
摘要： Methods and systems for performing well network production optimizations are described. For example, in one embodiment, a method of allocating an applied resource throughout a well network includes receiving topological data into an analytical model of a well network having one or more wells. The topological data includes a plurality of performance curves that relate well performance to one or more levels of an applied resource. The method also includes determining an optimum allocation of the applied resource using the analytical model to maximize an operating parameter of the well network, including converting a portion the analytical model having one or more wells and a linear inequality relationship to a modified portion having a single variable and a linear equality constraint.
摘要翻译：描述了用于执行良好网络生产优化的方法和系统。例如，在一个实施例中，在整个井网络中分配应用资源的方法包括将拓扑数据接收到具有一个或多个井的井网络的分析模型中。拓扑数据包括将井性能与应用资源的一个或多个级别相关联的多个性能曲线。该方法还包括使用分析模型来确定应用资源的最佳分配，以最大化井网络的运行参数，包括将具有一个或多个井的分析模型和线性不等式关系的部分转换为具有单个变量和线性等式约束。

54. 发明授权

US08408973B2 Finishing apparatus with resiliently mountable finishing belt guide 有权
标题翻译：具有弹性安装的精整带导向装置的整理装置
公开(公告)号：US08408973B2
公开(公告)日：2013-04-02
申请号：US12869412
申请日：2010-08-26
申请人： Peter Grabsch , Michael Huber , Simon Wolber , Johannes Herrmann , Oliver Hildebrandt
发明人： Peter Grabsch , Michael Huber , Simon Wolber , Johannes Herrmann , Oliver Hildebrandt
IPC分类号： B24B21/00 , B24B21/16
CPC分类号： B24B35/00
摘要： The disclosure relates to a finishing apparatus for finish machining of rotationally symmetric workpiece surfaces having a finish belt guide which has a guiding body for guiding the finish belt, wherein the guiding body comprises a shell-like guiding surface along which the finish belt can be guided or is guided between an insertion end of the finish belt and a withdrawal end of the finish belt, wherein the guiding surface is mounted in a resiliently elastic manner in the radial direction, wherein, when seen in the circumferential direction, the guiding surface extends in a continuous manner between the insertion end of the finish belt and the withdrawal end of the finish belt over at least a part of the width of said guiding surface and is mounted in a resiliently elastic manner.
摘要翻译：本发明涉及一种用于精加工旋转对称的工件表面的精加工装置，其具有精密带导向件，该精密带导向件具有用于引导精加工带的导向主体，其中，导向体包括壳形导向表面，精加工带沿该引导体可被引导或者在精加工带的插入端和精加工带的退出端之间被引导，其中，引导表面沿径向方向以弹性弹性方式安装，其中当从圆周方向看时，引导表面在精加工带的插入端和精加工带的退出端之间的连续方式在所述引导表面的宽度的至少一部分上，并以弹性弹性方式安装。

55. 发明授权

US08127512B2 Roofing system 有权
标题翻译：屋顶系统
公开(公告)号：US08127512B2
公开(公告)日：2012-03-06
申请号：US11100145
申请日：2005-04-06
申请人： John L. Pierson , Michael Huber , Jerome Thomson
发明人： John L. Pierson , Michael Huber , Jerome Thomson
IPC分类号： E04D13/14 , E04C5/07
CPC分类号： E04D3/365 , E04D3/366
摘要： A roofing system formed of a plurality of support members secured to a load bearing roof deck. A plurality of roofing panels are positioned on the support members and are oriented to form overlapping joints between the panels. Sealant is positioned within the overlapping joints of the panels. A compression bar is positioned over the overlapping joints and is secured to the overlapping joints and support member by a fastener arrangement.
摘要翻译：一种屋顶系统，其由固定到承重屋顶甲板上的多个支撑构件形成。多个屋顶板被定位在支撑构件上并且被定向成在板之间形成重叠的接头。密封剂位于面板的重叠接头内。压缩杆定位在重叠接头上方，并通过紧固件装置固定到重叠接头和支撑构件。

56. 发明申请

US20120041773A1 COMPUTERIZED SYSTEM FOR ADAPTIVE RADIATION THERAPY 审中-公开
标题翻译：用于自适应放射治疗的计算机系统
公开(公告)号：US20120041773A1
公开(公告)日：2012-02-16
申请号：US12855126
申请日：2010-08-12
申请人： Patrik Kunz , Michael Huber
发明人： Patrik Kunz , Michael Huber
IPC分类号： G06Q50/00
CPC分类号： G06F19/3481 , G06Q50/22 , G16H50/70
摘要： In one embodiment of the invention, a computerized method for producing a treatment decision for adaptive radiation therapy (ART) is disclosed. The method comprises several steps. First, patient specific input data regarding a patient and general patient population data are input into a treatment decision engine. Next, this data is analyzed in order to adjust a set of interrelationships and thresholds to fit the ART regimen for which a decision is being processed. In a third step, the interrelationships and thresholds are applied to the data using a processing module which formulates a decision regarding the current ART regimen, and metadata regarding the medical condition of the patient. Finally, the decision and metadata are outputted such that they are accessible to a user. Using such a method, a treatment decision for ART is produced.
摘要翻译：在本发明的一个实施例中，公开了一种用于产生用于自适应放射治疗（ART）的治疗决定的计算机化方法。该方法包括几个步骤。首先，关于患者和一般患者群体数据的患者特定输入数据被输入到治疗决策引擎中。接下来，分析这些数据以便调整一组相互关系和阈值以适应正在处理决定的ART方案。在第三步骤中，使用处理模块将相关关系和阈值应用于数据，所述处理模块制定关于当前ART方案的决定以及关于患者的医疗状况的元数据。最后，输出决定和元数据，使得它们可被用户访问。使用这种方法，产生用于ART的治疗决定。

57. 发明申请

US20100193307A1 HYDRODYNAMIC RETARDER WITH A TANGENTIAL INFLOW AND OUTFLOW PRINCIPLE 审中-公开
标题翻译：具有横向流入和流出原理的水力拖车
公开(公告)号：US20100193307A1
公开(公告)日：2010-08-05
申请号：US12665101
申请日：2008-06-19
申请人： Thomas Meid , Andreas Ulmer , Michael Huber , Peter Weissenrieder , Stefan Krause
发明人： Thomas Meid , Andreas Ulmer , Michael Huber , Peter Weissenrieder , Stefan Krause
IPC分类号： F16D57/04 , F16D57/00
CPC分类号： B60T10/02 , F16D57/005 , F16D57/04
摘要： A hydrodynamic retarder with tangential inflow and outflow is formed with at least one radial recess (3), in the stator, which extends radially outward when viewed in the radial direction. The at least one radial recess (3) is arranged so as to enable one of back-feed and back-filling of the oil, emerging through the tangential outlet, into the pressure space.
摘要翻译：具有切向流入和流出的流体动力学延迟器在定子中形成有至少一个径向凹槽（3），当沿径向方向观察时，定子中径向向外延伸。所述至少一个径向凹部（3）被布置成使得通过切向出口出现的油的反向进料和后填充中的一个进入压力空间。

58. 发明申请

US20100175958A1 Hydrodynamic Retarder 有权
标题翻译：流体动力学缓凝剂
公开(公告)号：US20100175958A1
公开(公告)日：2010-07-15
申请号：US12602608
申请日：2008-05-19
申请人： Thomas Meid , Kirk Huhn , Michael Ptock , Michael Huber , Christian Selinka , Reinhold Mayer
发明人： Thomas Meid , Kirk Huhn , Michael Ptock , Michael Huber , Christian Selinka , Reinhold Mayer
IPC分类号： F16D57/04 , B60T10/02
CPC分类号： B60T10/02 , F16D57/04
摘要： A hydrodynamic retarder having a first blade wheel and second blade wheel concentric thereto, forming a hydrodynamic circuit grouped about a common rotary axis. Each blade wheel includes a base body and a blade arrangement fixed thereto including a plurality of blades each connected to receptacles in the base body. A first ring segment of at least one blade wheel includes at least one first blade having a flow edge facing the other blade wheel in each case, said edge having at least one extension running in a substantially straight line between the radial outer end thereof and the radial inner end thereof, and at least one second blade is provided in a second ring segment of the blade wheel, the blade having a retraction both opposite the flow edge facing the other blade wheel in each case, and opposite a protrusion protruding in the direction of the other blade wheel.
摘要翻译：一种流体动力学延迟器，其具有与其同心的第一叶轮和第二叶轮，形成围绕公共旋转轴组合的流体动力学回路。每个叶轮包括基体和固定到其上的叶片装置，其包括多个叶片，每个叶片各自连接到基体中的插座。至少一个叶轮的第一环段包括至少一个第一叶片，其在每种情况下具有面向另一叶轮的流动边缘，所述边缘具有至少一个在其径向外端和并且至少一个第二叶片设置在所述叶轮的第二环段中，所述叶片在每种情况下都具有与所述另一个叶轮相对的流动边缘相对的缩回，并且与所述叶片的方向的另一个叶轮。

59. 发明申请

US20090000128A1 Hand-Guided Power Tool with a Cooling Apparatus 审中-公开
标题翻译：具有冷却装置的手动导向电动工具
公开(公告)号：US20090000128A1
公开(公告)日：2009-01-01
申请号：US12160273
申请日：2007-05-04
申请人： Hans Kaiser , Stefano Delfini , Michael Huber , Martin Affolter
发明人： Hans Kaiser , Stefano Delfini , Michael Huber , Martin Affolter
IPC分类号： B27B19/09
CPC分类号： B23D49/162 , B25F5/008
摘要： A portable electric power tool is specified, having a metal housing (10), at least a region of which is covered with at least one plastic part (26, 27). To cool that region of the metal housing (10) which gets very warm due to the plastic cover, means are provided which produce Can air flow (28) which is supplied from outside and sweeps over the metal housing (10) in the region of the plastic part (26).
摘要翻译：规定了一种便携式电动工具，其具有金属壳体（10），其至少一个区域被至少一个塑料部件（26,27）覆盖。为了冷却由于塑料盖而变得非常温暖的金属壳体（10）的区域，提供了产生可从外部供应并在金属壳体（10）上扫过金属壳体（10）的罐空气流（28）的装置，塑料部分（26）。

60. 发明授权

US06313524B1 Chip module with a plurality of flat contact elements mountable on either an external printed circuit board or an external circuit board substrate 失效
标题翻译：芯片模块具有可安装在外部印刷电路板或外部电路板基板上的多个平面接触元件
公开(公告)号：US06313524B1
公开(公告)日：2001-11-06
申请号：US09274506
申请日：1999-03-23
申请人： Frank Pueschner , Michael Huber , Peter Stampka , Jürgen Fischer , Josef Heitzer
发明人： Frank Pueschner , Michael Huber , Peter Stampka , Jürgen Fischer , Josef Heitzer
IPC分类号： H01L2328
CPC分类号： G06K19/07747 , G06K19/07743 , H01L23/49855 , H01L24/48 , H01L24/49 , H01L2224/05554 , H01L2224/48091 , H01L2224/48227 , H01L2224/49171 , H01L2924/00014 , H01L2924/01078 , H01L2924/01079 , H01L2924/10161 , H01L2924/14 , H01L2924/1532 , H01L2924/181 , H05K1/181 , H05K3/284 , H05K3/3426 , H05K2201/10977 , H05K2203/1316 , Y02P70/611 , Y02P70/613 , Y10T29/49146 , Y10T29/49172 , H01L2924/00 , H01L2224/45015 , H01L2924/207 , H01L2924/00012 , H01L2224/45099 , H01L2224/05599 , H01L2224/85399
摘要： A chip module has a contact area disposed on its outer side formed of a plurality of essentially flat contact elements of electrically conductive material insulated from one another. At least one semiconductor chip having one or more integrated semiconductor circuits that are electrically connected to the contact elements of the contact area via bonding wires. The contact elements of the chip module are formed by a prefabricated lead frame for supporting the at least one semiconductor chip and have on two opposing sides of the chip module outwardly offset terminals arranged in rows next to one another. The outwardly offset terminals are provided for surface mounting the chip module on the mounting surface of an external printed circuit board or an external circuit board substrate.
摘要翻译：芯片模块具有设置在其外侧上的接触区域，该接触区域由彼此绝缘的导电材料的多个基本平坦的接触元件形成。至少一个具有一个或多个集成半导体电路的半导体芯片，其通过接合线与接触区域的接触元件电连接。芯片模块的接触元件由用于支撑至少一个半导体芯片的预制引线框架形成，并且在芯片模块的两个相对侧上向外偏移端子排列成彼此相邻的行。外部偏移端子用于将芯片模块表面安装在外部印刷电路板或外部电路板基板的安装表面上。

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