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51. 发明申请

US20080279900A1 GEL USEFUL FOR THE DELIVERY OF COSMETIC ACTIVE INGREDIENTS 有权
标题翻译：凝胶用于输送化妆品活性成分
公开(公告)号：US20080279900A1
公开(公告)日：2008-11-13
申请号：US11938001
申请日：2007-11-09
申请人： Antonio Longo , Mose Santaniello , Paola Risi
发明人： Antonio Longo , Mose Santaniello , Paola Risi
IPC分类号： A61K31/195 , A61K9/14 , A61K36/16 , A61K36/48 , A61K36/232 , A61K31/7016 , A61K31/56 , A61K31/12 , A61Q19/06 , A61K31/35 , A61K31/704 , A61K31/522 , A61K36/53 , A61K36/73 , A61K31/20
CPC分类号： A61K8/44 , A61K8/042 , A61K8/8147 , A61Q17/04 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： A gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles is described.
摘要翻译：描述了用于化妆品使用的凝胶，其由形成凝胶的聚合物，表面活性剂和丙酸L-肉碱甘氨酸盐酸盐盐酸盐的混合物组成，其用于治疗皮肤的干扰，如脂肪团和皱纹。

52. 发明申请

US20070249989A1 Diagnostic Device 有权
标题翻译：诊断设备
公开(公告)号：US20070249989A1
公开(公告)日：2007-10-25
申请号：US11662032
申请日：2005-06-16
申请人： Antonio Longo , Jesse Kuhns , Federico Bilotti , Michele D'Arcangelo , Christopher Hess , William Weisenburgh
发明人： Antonio Longo , Jesse Kuhns , Federico Bilotti , Michele D'Arcangelo , Christopher Hess , William Weisenburgh
IPC分类号： A61B17/22
CPC分类号： A61B1/0008 , A61B1/31 , A61B1/32
摘要： A diagnostic device (10) for pathologies of tubular anatomical structures comprises a tubular elongated structure (12, 28) developing between a proximal end and a distal end and is suitable to be inserted in the tubular anatomical structure, means (22, 32) for locally dilating the walls of the tubular anatomical structure that are associated with the distal end of said elongated structure, said means for locally dilating being movable between a closed position for introducing the device and at least one open position for viewing and evaluating the pathology, and control means being associated with the proximal end of the elongated structure, said control means being operatively connected to said means for locally dilating, in order to move them between the closed position and the open position, and vice versa.
摘要翻译：用于管状解剖结构病理的诊断装置（10）包括在近端和远端之间形成的管状细长结构（12,28），并且适合于插入管状解剖结构中，用于局部扩张与所述细长结构的远端相关联的管状解剖结构的壁，所述用于局部扩张的装置可在用于引入装置的关闭位置和用于观察和评估病理的至少一个打开位置之间移动，以及控制装置与细长结构的近端相关联，所述控制装置可操作地连接到所述用于局部扩张的装置，以便在关闭位置和打开位置之间移动它们，反之亦然。

53. 发明申请

US20070185508A1 Method for performing trans-anal resection with a curved cutter stapler 有权
标题翻译：用弯曲切割订书机执行肛门切除术的方法
公开(公告)号：US20070185508A1
公开(公告)日：2007-08-09
申请号：US11348544
申请日：2006-02-07
申请人： Donna Korvick , William Bernie , Antonio Longo
发明人： Donna Korvick , William Bernie , Antonio Longo
IPC分类号： A61B17/08
CPC分类号： A61B17/0293 , A61B1/31 , A61B17/0469 , A61B17/072 , A61B17/105 , A61B17/320016 , A61B17/32053 , A61B2017/00353 , A61B2017/07221 , A61B2017/3452
摘要： A method for performing trans-anal resection is achieved by applying a first stitch about the rectum, wherein deep bites of the first stitch capture and fold a rectum wall, creating a longitudinal staple line in the rectal wall at a position adjacent the first stitch, positioning a curved surgical stapler instrument in the rectum for capturing the rectal wall held by the first stitch, firing the surgical stapler instrument creating a circumferential first staple line approximately along the arc defined by the first stitch, and repeating the procedure about the circumference of the rectum until a predetermined portion of the rectum is fully resected.
摘要翻译：通过在直肠周围施加第一针迹来实现反肛门切除的方法，其中第一针迹的深咬合捕获并折叠直肠壁，在与第一针迹相邻的位置处在直肠壁中产生纵向缝合线，将弯曲的外科缝合器器械定位在直肠中，用于捕获由第一针迹保持的直肠壁，点燃外科缝合器器械，沿着由第一针迹限定的圆弧形成周向的第一缝合线，并且重复围绕第直肠直到直肠的预定部分被完全切除。

54. 发明申请

US20060144898A1 Surgical stapling instrument 审中-公开
标题翻译：手术吻合器械
公开(公告)号：US20060144898A1
公开(公告)日：2006-07-06
申请号：US11362405
申请日：2006-02-24
申请人： Federico Bilotti , Antonio Longo
发明人： Federico Bilotti , Antonio Longo
IPC分类号： A61B17/04
CPC分类号： A61B17/1114 , A61B17/072 , A61B17/115 , A61B17/1155 , A61B2017/07221
摘要： A surgical stapling instrument (1) comprises a body portion (2, 3), a handle (4) and a staple fastening assembly (8). The staple fastening assembly (8) includes a curved cartridge (10), which comprises at least one curved open row of staples, and a curved anvil (22), which is adapted to cooperate with the cartridge (10) for forming the ends of the staples exiting from the cartridge (10). The staple fastening assembly (8) is adapted to allow unobstructed access towards the concave inner faces of the cartridge (10) and the anvil (22). The cartridge (10) can be moved towards the anvil (22) from a spaced position for positioning tissue therebetween to a closed position for clamping the tissue. Preferably, a knife is contained within the cartridge (10) and is positioned such that there is at least one row of staples on at least one side of the knife.
摘要翻译：外科缝合器械（1）包括主体部分（2,3），手柄（4）和钉紧固组件（8）。缝钉紧固组件（8）包括弯曲的盒（10），其包括至少一个弯曲的开放排的钉和弯曲的砧座（22），其适于与所述盒（10）协作以形成订书钉从盒（10）离开。缝合钉紧固组件（8）适于允许朝向盒（10）和砧座（22）的凹内表面畅通无阻。药筒（10）可以从间隔位置移动到砧座（22），用于将组织定位到用于夹紧组织的关闭位置。优选地，刀被容纳在盒（10）内并且被定位成使得在刀的至少一侧上存在至少一排钉。

55. 发明授权

US06335342B1 Azaindole derivatives, process for their preparation, and their use as antitumor agents 失效
标题翻译： Azaindole衍生物，其制备方法及其作为抗肿瘤剂的用途
公开(公告)号：US06335342B1
公开(公告)日：2002-01-01
申请号：US09597274
申请日：2000-06-19
申请人： Antonio Longo , Maria Gabriella Brasca , Paolo Orsini , Gabriella Traquandi , Valeria Pittalà , Anna Vulpetti , Mario Varasi , Paolo Pevarello
发明人： Antonio Longo , Maria Gabriella Brasca , Paolo Orsini , Gabriella Traquandi , Valeria Pittalà , Anna Vulpetti , Mario Varasi , Paolo Pevarello
IPC分类号： A61K41435
CPC分类号： C07D471/04
摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I): wherein R is a hydrogen or halogen atom or a group selected from —CN, —OH, —OCOR4, —(CH2)nNH2, —(CH2)nNHR4, —(CH2)nNHCOR4, —(CH2)nNHCONR4R5, —(CH2)nNHCOOR4, or —(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R2 is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from —CONR4R5, —COOR4, —CONHOR4, —SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed. These compounds are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.
摘要翻译：由式（I）表示的新颖的1H-吡咯并[2,3-b]吡啶：其中R是氢或卤素原子或选自-CN，-OH，-OCOR 4， - （CH 2）n NH 2，（CH2）nNHR4， - （CH2）nNHCOR4， - （CH2）nNHCONR4R5， - （CH2）nNHCOOR4或 - （CH2）nNHSO2R4，其中n为0或1，R4和R5如说明书所述; R1是氢或任选取代的烷基; R2是任选取代的选自烷基或芳基的基团; R3是氢或选自-CONR4R5，-COOR4，-CONHOR4，-SO2NHR4，烷基磺酰基氨基羰基或全氟化烷基磺酰基氨基羰基的基团; 或其药学上可接受的盐。这些化合物可用于治疗与改变的细胞依赖性激酶活性相关的细胞增殖性疾病。

56. 发明授权

US6102271A Circular stapler for hemorrhoidal surgery 有权
标题翻译：用于痔疮手术的圆形订书机
公开(公告)号：US6102271A
公开(公告)日：2000-08-15
申请号：US197805
申请日：1998-11-23
申请人： Antonio Longo , John R. Bittner , Randall L. Hacker , Federico Bilotti
发明人： Antonio Longo , John R. Bittner , Randall L. Hacker , Federico Bilotti
IPC分类号： A61B17/02 , A61B17/11 , A61B17/115 , A61B17/068
CPC分类号： A61B17/0293 , A61B17/115 , A61B17/1155 , A61B2017/1142 , A61B2017/3452
摘要： A circular sapling instrument for the removal of hemorrhoids has a stapling end effector having a casing, a hollow staple driver within the casing, an annular blade having an open distal end is located within the staple driver, and a elongated interior drive shaft is reciprocable within the staple driver and the annular blade. A first inner chamber is defined between the staple driver and the interior drive shaft, and a second inner chamber is defined between the annular blade and the drive shaft. The first chamber communicates with the second chamber. The casing has an exterior surface and a substantially unobstructed passageway extends within the casing surface, into the first inner chamber, into the second inner chamber, and through the open distal end of the second inner chamber for insertion and withdrawal of a surgical instrument therethrough.
摘要翻译：用于去除痔疮的圆形树皮仪器具有缝合端部执行器，其具有壳体，壳体内的中空缝钉驱动器，具有敞开的远端的环形刀片位于钉驱动器内，并且细长的内部驱动轴可在内订书钉驱动器和环形刀片。第一内腔被限定在钉驱动器和内部驱动轴之间，并且在环形刀片和驱动轴之间限定第二内腔。第一室与第二室连通。壳体具有外表面，并且基本上无障碍的通道在壳体表面内延伸到第一内室中，进入第二内室，并且穿过第二内室的敞开的远端，用于插入和取出外科器械。

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