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51. 发明授权

US5110587A Immunogenic composition comprising synthetically modified vaccinia virus 失效
标题翻译：包含合成修饰的痘苗病毒的免疫原性组合物
公开(公告)号：US5110587A
公开(公告)日：1992-05-05
申请号：US537882
申请日：1990-06-14
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： A61K39/00 , C07K14/035 , C07K14/11 , C12N15/863
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： Vaccines containing vaccinia virus synthetically modified to contain DNA sequences not naturally occurring in vaccinia virus and provoking an immunological response thereto in host animals inoculated with said vaccines.
摘要翻译：含有痘苗病毒的疫苗被合成修饰以含有不是天然存在于痘苗病毒中的DNA序列，并在用所述疫苗接种的宿主动物中引发免疫应答。

52. 发明授权

US4603112A Modified vaccinia virus 失效
标题翻译：改良痘苗病毒
公开(公告)号：US4603112A
公开(公告)日：1986-07-29
申请号：US446824
申请日：1982-12-08
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C07H21/04 , C07K14/035 , C07K14/11 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/863 , C12P21/00 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
摘要翻译：公开的是用于修饰痘苗病毒基因组以产生痘苗突变体的方法，特别是通过引入外源DNA的痘苗基因组; 通过这种方法制备的改良牛痘; 某些DNA序列和未修饰的和遗传修饰的微生物作为中间体参与这些方法; 以及用这种痘苗突变体感染细胞和宿主动物的方法，以引发由所述细胞和宿主动物扩增由外源DNA（包括抗原蛋白）编码的外源DNA和蛋白质。

53. 发明授权

US07144578B2 Poxvirus-rabies recombinants and compositions and methods employing the recombinants 有权
标题翻译：痘病毒狂犬病重组体，以及采用重组体的组合物和方法
公开(公告)号：US07144578B2
公开(公告)日：2006-12-05
申请号：US09951061
申请日：2001-09-13
申请人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
发明人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
IPC分类号： A61K39/275 , A61K39/285 , C12N7/01 , C12N15/863 , C12N15/47
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/33 , C07K2319/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122
摘要： Recombinant viruses containing DNA coding for a rabies virus antigen, such as rabies virus G are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom are useful for eliciting an immunological against rabies virus, and, the gene products and antibodies elicited thereby are useful in assays.
摘要翻译：含有编码狂犬病病毒抗原的DNA的狂犬病病毒G的重组病毒被公开并要求保护。重组病毒可以是NYVAC或ALVAC重组病毒。重组病毒及其基因产物可用于引发针对狂犬病病毒的免疫学，并且由此引发的基因产物和抗体可用于测定。

54. 发明授权

US06780407B1 Pox virus comprising DNA sequences encoding CEA and B7 antigen 失效
标题翻译：痘病毒包含编码CEA和B7抗原的DNA序列
公开(公告)号：US06780407B1
公开(公告)日：2004-08-24
申请号：US09663667
申请日：2000-09-15
申请人： Enzo Paoletti , James Tartaglia , William I. Cox
发明人： Enzo Paoletti , James Tartaglia , William I. Cox
IPC分类号： A01N6300
CPC分类号： A61K39/17 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/285 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/525 , C07K14/535 , C07K14/5406 , C07K14/5434 , C07K14/55 , C07K14/57 , C07K14/705 , C07K14/70532 , C07K14/82 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/20122 , C12N2760/20134 , C12N2770/24022 , C12N2770/24122
摘要： Attenutated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wiltype or mutant; human melanoma-associated antigen; IL-2; IFN&ggr;; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
摘要翻译：包含编码细胞因子和/或肿瘤相关抗原的DNA的弱化重组病毒以及使用该病毒的方法和组合物被公开并要求保护。重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码以下至少一种：人肿瘤坏死因子; 核磷蛋白p53，wiltype或突变体; 人黑素瘤相关抗原; IL-2; IFNgamma; IL-4; GMCSF; IL-12; B7; erb-B-2和癌胚抗原。重组病毒及其基因产物可用于癌症治疗。

55. 发明授权

US06632438B2 Recombinant poxvirus cytomegalovirus, compositions, and uses 失效
标题翻译：重组痘病毒巨细胞病毒，组合物和用途
公开(公告)号：US06632438B2
公开(公告)日：2003-10-14
申请号：US09916963
申请日：2001-07-26
申请人： Enzo Paoletti , Steven E. Pincus , William I. Cox , Elizabeth K. Kauffmann
发明人： Enzo Paoletti , Steven E. Pincus , William I. Cox , Elizabeth K. Kauffmann
IPC分类号： A61K3912
CPC分类号： A61K35/76 , A61K39/12 , A61K39/245 , A61K2039/5254 , A61K2039/5256 , A61K2039/55505 , A61K2039/55577 , C12N2710/16134 , C12N2710/24143
摘要： Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA of the recombinant viruses can be used as probes or for generating PCR primers.
摘要翻译：公开并要求保护含有编码HCMV抗原的DNA的减毒重组病毒，以及使用病毒，来自其的表达产物和由病毒或表达产物产生的抗体的方法和组合物。重组病毒可以是NYVAC或ALVAC重组病毒。来自其的重组病毒和基因产物以及由病毒和基因产物产生的抗体具有几种预防，治疗和诊断用途。重组病毒的DNA可用作探针或产生PCR引物

56. 发明授权

US06265189B1 Pox virus containing DNA encoding a cytokine and/or a tumor associated antigen 失效
标题翻译：痘病毒含有编码细胞因子和/或肿瘤相关抗原的DNA
公开(公告)号：US06265189B1
公开(公告)日：2001-07-24
申请号：US08460736
申请日：1995-06-02
申请人： Enzo Paoletti , James Tartaglia , William I. Cox
发明人： Enzo Paoletti , James Tartaglia , William I. Cox
IPC分类号： C12P2104
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/17 , A61K39/205 , A61K39/275 , A61K39/285 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/525 , C07K14/535 , C07K14/5406 , C07K14/5434 , C07K14/55 , C07K14/57 , C07K14/705 , C07K14/70532 , C07K14/82 , C07K2319/00 , C12N7/00 , C12N15/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/16134 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20022 , C12N2760/20122 , C12N2760/20134 , C12N2770/20022 , C12N2770/24022 , C12N2770/24122
摘要： Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least on of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN&ggr;; IL-4; GNCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
摘要翻译：包含编码细胞因子和/或肿瘤相关抗原的DNA的减毒重组病毒以及采用病毒的方法和组合物被公开和要求保护。重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码至少一种：人类肿瘤坏死因子; 核磷蛋白p53，野生型或突变体; 人黑素瘤相关抗原; IL-2; IFNgamma; IL-4; GNCSF; IL-12; B7; erb-B-2和癌胚抗原。重组病毒及其基因产物可用于癌症治疗。

57. 发明授权

US06214353B1 Malaria recombinant poxvirus vaccine 失效
标题翻译：疟疾重组痘病毒疫苗
公开(公告)号：US06214353B1
公开(公告)日：2001-04-10
申请号：US09083366
申请日：1998-05-21
申请人： Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim A. Siddigui
发明人： Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim A. Siddigui
IPC分类号： A61K39285
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/00 , C12N2799/023 , Y02A50/412
摘要： What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译：描述的是重组痘病毒，例如痘苗病毒，其含有来自裂殖酵母表面抗原的外源DNA 1.还描述了含有重组痘病毒的疫苗，用于在接种疫苗的宿主动物中诱导免疫应答。

58. 发明授权

US06183750B2 Avipox virus containing DNA sequences encoding herpesvirus glycoproteins 失效
标题翻译：含有编码疱疹病毒糖蛋白的DNA序列的Avipox病毒
公开(公告)号：US06183750B2
公开(公告)日：2001-02-06
申请号：US08476500
申请日：1995-06-07
申请人： Enzo Paoletti
发明人： Enzo Paoletti
IPC分类号： A61K3912
CPC分类号： C12N15/86 , A61K38/00 , A61K39/00 , A61K2039/5256 , C07K14/005 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24043 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2760/16122 , C12N2760/18122 , C12N2760/20122 , C12N2770/20022
摘要： What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpesvirus. In one embodiment, the foreign DNA is expressed in a host by the production of a herpesvirus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two, particularly two or three, herpesvirus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, the barrier of maternal immunity in a newborn offspring can be overcome or avoided.
摘要翻译：描述的是重组痘病毒，例如痘苗病毒，禽痘病毒和金丝雀痘病毒，其含有疱疹病毒的外源DNA。在一个实施方案中，外源DNA通过产生疱疹病毒糖蛋白在宿主中表达。在另一个实施方案中，外源DNA通过产生至少两种，特别是两种或三种疱疹病毒糖蛋白在宿主中表达。还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。通过本发明，可以克服或避免新生儿中孕产妇免疫的障碍。

59. 发明授权

US6130066A Vectors having enhanced expression and methods of making and uses thereof 失效
标题翻译：具有增强表达的载体及其制备方法和用途
公开(公告)号：US6130066A
公开(公告)日：2000-10-10
申请号：US79587
申请日：1998-05-15
申请人： James Tartaglia , William I. Cox , Russell Robert Gettig , Hector Martinez , Enzo Paoletti , Steven E. Pincus
发明人： James Tartaglia , William I. Cox , Russell Robert Gettig , Hector Martinez , Enzo Paoletti , Steven E. Pincus
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P37/04 , C12N15/67 , C12N15/85 , C12N15/863 , C12P21/06
CPC分类号： C12N15/86 , A61K48/00 , C12N15/67 , C12N15/85 , C12N2710/24043 , C12N2710/24143 , C12N2830/00 , C12N2830/60 , C12N2840/00
摘要： Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a transcription factor or a translation factor or a transcription factor and a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector, or at different loci. The second nucleic acid molecule can encode: one transcription factor or more than one transcription factor; or one translation factor or more than one translation factor; or at least one transcription factor and at least one translation factor. The transcription factor can be from vaccinia H4L, D6, A7, G8R, A1L, A2L, H5R, or combinations thereof. The translation factor can be from a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus, e.g., NYVAC, or ALVAC.
摘要翻译：披露和要求保护的是具有增强的表达的载体和用于制备和使用它们的方法。表达的增强来自至少一种第一核酸分子和至少一种第二核酸分子的基本上同时表达。第二核酸分子编码转录因子或翻译因子或转录因子和翻译因子。同时表达可以是将第一和第二核酸分子可操作地连接到单个启动子，或者可操作地将第一核酸分子与第一启动子连接，而将第二核酸分子可操作地连接到第二启动子，其中第一和第二启动子基本同时起作用。因此，第一和第二核酸分子可以在载体中的相同基因座处或在不同的基因座处。第二核酸分子可编码：一种转录因子或多于一种转录因子; 或一个翻译因子或多于一个翻译因子; 或至少一个转录因子和至少一个翻译因子。转录因子可以来自牛痘H4L，D6，A7，G8R，A1L，A2L，H5R或其组合。翻译因子可以来自K3L开放阅读框，E3L开放阅读框，VAI RNA，EBER RNA，西格玛3开放阅读框，TRBP开放阅读框或其组合。载体可以是痘病毒，例如减毒痘病毒，例如NYVAC或ALVAC。

60. 发明授权

US5843456A Alvac poxvirus-rabies compositions and combination compositions and uses 失效
标题翻译：阿尔瓦克痘病毒狂犬病的组合物和组合组合物和用途
公开(公告)号：US5843456A
公开(公告)日：1998-12-01
申请号：US486969
申请日：1995-06-07
申请人： Enzo Paoletti , Joanne Maki
发明人： Enzo Paoletti , Joanne Maki
IPC分类号： C12N15/09 , A61K39/00 , A61K39/175 , A61K39/205 , A61K39/235 , A61K39/275 , A61K39/295 , A61K39/35 , A61P31/12 , A61P37/04 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N15/863
CPC分类号： C07K14/005 , C07K14/33 , C12N15/86 , A61K2039/5254 , A61K2039/70 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122 , Y10S530/826
摘要： Attenuated recombinant viruses containing DNA encoding a rabies virus antigen in a "cocktail" or combination or multivalent compositions well as methods for making and using the compositions, expression products therefrom, and antibodies generated, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The compositions and products therefrom and antibodies generated have several preventive, therapeutic and diagnostic uses.
摘要翻译：公开和要求保护含有编码狂犬病病毒抗原的“混合物”或组合或多价组合物的DNA的减毒重组病毒，以及制备和使用组合物，表达产物及产生的抗体的方法。重组病毒可以是NYVAC或ALVAC重组病毒。其组合物和产物及其产生的抗体具有几种预防，治疗和诊断用途。

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