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51. 发明授权

US09504774B2 Intraatrial ventricular assist device 有权
标题翻译：心房内心室辅助装置
公开(公告)号：US09504774B2
公开(公告)日：2016-11-29
申请号：US12243256
申请日：2008-10-01
申请人： Oscar H. Frazier , William E. Cohn
发明人： Oscar H. Frazier , William E. Cohn
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/101 , A61M1/1008 , A61M1/122 , A61M1/125
摘要： A medical device comprises a pump adapted to fit within an atrium of a heart, said pump comprising an inlet and an outlet. The device further comprises a flexible outflow conduit coupled to said outlet. A method of assisting ventricular function of a heart of a patient comprises: a) inserting a continuous flow pump having an inlet and an outlet into the heart via a subclavian or jugular vein; b) attaching the outlet of the continuous flow pump to an atrial septum, wherein the inlet of the continuous flow pump is directed into a heart atrium; c) attaching the distal end of the outflow conduit to an artery; and d) operating the pump at a volumetric rate ranging from about 2 L/min to about 3 L/min.
摘要翻译：医疗装置包括适于装配在心脏心房内的泵，所述泵包括入口和出口。该装置还包括耦合到所述出口的柔性流出导管。辅助患者心脏的心室功能的方法包括：a）通过锁骨下静脉或颈静脉将具有入口和出口的连续流动泵插入心脏; b）将连续流动泵的出口连接到心房隔膜，其中连续流动泵的入口被引导进入心房; c）将流出管道的远端连接到动脉; 和d）以约2L / min至约3L / min的体积速率操作泵。

52. 发明申请

US20160129599A1 ISOLATION BOX FOR PROTECTING READING MATERIAL 审中-公开
标题翻译：用于保护阅读材料的隔离盒
公开(公告)号：US20160129599A1
公开(公告)日：2016-05-12
申请号：US14740527
申请日：2015-06-16
申请人： Elizabeth E. Cohn , William E. Cohn
发明人： Elizabeth E. Cohn , William E. Cohn
IPC分类号： B25J21/02 , A47G29/00 , B65D85/00 , B65D43/02
CPC分类号： B25J21/02 , A45C11/22 , A45C13/02 , A47G29/00 , A61G10/005 , A61G11/009 , A61L2/26 , B65D43/02 , B65D85/70
摘要： A portable reverse isolation box (PRIB) for protecting an object from the environment and/or protecting a user from the object, the PRIB comprising: a housing comprising a container and a lid, wherein the container has structural integrity and at least a portion of the lid is transparent, and further wherein the housing forms an airtight and watertight isolation bay when the lid is mounted on the container; a port formed in the container; and a disposable flexible element mounted in the port in an airtight and watertight relationship, the flexible element being capable of assuming a concave configuration so as to permit a user to manipulate the object within the isolation bay without opening the lid.
摘要翻译：一种便携式反向隔离箱（PRIB），用于将物体从环境中保护和/或保护使用者免受物体侵害，所述PRIB包括：壳体，包括容器和盖子，其中所述容器具有结构完整性和至少一部分所述盖是透明的，并且进一步其中当所述盖安装在所述容器上时，所述壳体形成气密和水密隔离隔间; 在容器中形成的端口; 以及以气密和水密关系安装在端口中的一次性柔性元件，柔性元件能够呈现凹形构造，以允许使用者在隔离隔间内操纵物体而不打开盖。

53. 发明授权

US09271819B2 Apparatus and method for the ligation of tissue 有权
标题翻译：用于结扎组织的装置和方法
公开(公告)号：US09271819B2
公开(公告)日：2016-03-01
申请号：US12124023
申请日：2008-05-20
申请人： John R. Liddicoat , William E. Cohn , Roger Laham
发明人： John R. Liddicoat , William E. Cohn , Roger Laham
IPC分类号： A61F2/01 , A61B17/12 , A61B17/00 , A61B19/00
CPC分类号： A61B17/12013 , A61B17/00234 , A61B17/0467 , A61B17/12009 , A61B17/30 , A61B2017/00243 , A61B2017/00867 , A61B2017/00876 , A61B2017/12018 , A61B2017/308 , A61B2090/0811 , A61B2090/3966 , A61B2576/023 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0108 , A61M25/0127 , A61M25/10 , A61M29/02
摘要： A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.
摘要翻译：一种新颖的基于导管的系统，其将心脏外侧的左心耳（LAA）结合，优选地使用导管和/或器械的组合，例如位于左心耳内的引导导管，其可以协助定位左心耳和/或辅助将附件最佳放置在附肢的外侧，以及在心包空间内的心脏外的结扎导管和/或器械，以将结扎元件设置在左心耳的颈部。

54. 发明申请

US20150150762A1 BABY NIPPLE ASSEMBLY FOR USE WITH FLEXIBLE DRINK POUCHES 审中-公开
标题翻译： BABY NIPPLE装配使用灵活的饮料袋
公开(公告)号：US20150150762A1
公开(公告)日：2015-06-04
申请号：US14321005
申请日：2014-07-01
申请人： William E. Cohn
发明人： William E. Cohn
IPC分类号： A61J11/04 , A61J9/00 , B65D75/58 , A61J11/00
CPC分类号： A61J11/045 , A61J9/005 , A61J11/002 , A61J11/0095 , A61J11/04 , B65D75/008 , B65D75/5877
摘要： A novel baby nipple assembly for use with a flexible drink pouch, wherein the baby nipple assembly generally comprises a mount subassembly (sometimes hereinafter referred to as simply “the mount” or “the disk”) for attachment to the flexible drink, pouch, and a nipple subassembly (sometimes hereinafter referred to as simply “the nipple”) for connection to the mount subassembly, wherein the mount subassembly comprises a relatively large fiat element for adhesion to an outside surface of the flexible drink pouch, and the nipple subassembly comprises (1) means for connection to the mount subassembly, (ii) a sharp tube for extending through the mount subassembly and puncturing the side all of the flexible drink pouch, and (iii) a soft nipple in fluid communication with the sharp tube, whereby a baby or young child can suckle on the nipple and receive the beverage from the flexible drink pouch.
摘要翻译：一种用于柔性饮料袋的新颖的婴儿奶头组合件，其中婴儿乳头组件通常包括用于附接到柔性饮料，小袋和安装子组件的安装子组件（有时在下文中简称为“安装件”或“盘”），用于连接到安装子组件的乳头子组件（有时在下文中简称为“接头”），其中安装子组件包括用于粘附到柔性饮料袋的外表面的相对大的法兰元件，并且接头组件包括 1）用于连接到安装子组件的装置，（ii）用于延伸通过安装子组件并将所有柔性饮料袋刺入一侧的尖锐管，以及（iii）与尖管流体连通的软接头，婴儿或幼儿可以在乳头上吸吮并从柔性饮料袋接收饮料。

55. 发明授权

US08951280B2 Cardiac valve procedure methods and devices 有权
标题翻译：心脏瓣膜手术方法和装置
公开(公告)号：US08951280B2
公开(公告)日：2015-02-10
申请号：US12797283
申请日：2010-06-09
申请人： William E. Cohn , Gregory H. Lambrecht , John R. Liddicoat , Robert Kevin Moore , Richard B. Streeter , Todd F. Davenport
发明人： William E. Cohn , Gregory H. Lambrecht , John R. Liddicoat , Robert Kevin Moore , Richard B. Streeter , Todd F. Davenport
IPC分类号： A61M29/00 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/2427 , A61F2220/0016 , A61F2250/0059
摘要： Devices and methods for performing intravascular procedures without cardiac bypass include embodiments of temporary filter devices, temporary valves, and prosthetic valves. The temporary filter devices have a cannula which provides access for surgical tools for effecting repair of cardiac valves. The cannula may have filters which prevent embolitic material from entering the coronary arteries and aorta. The valve devices may also have a cannula for insertion of the valve into the aorta. The valve devices expand in the aorta to occupy the entire flow path of the vessel and operate to prevent blood flow and to permit flow through the valve. The prosthetic valves include valve fixation devices which secure the prosthetic valve to the wall of the vessel. The prosthetic valves are introduced into the vascular system in a compressed state, advanced to the site of implantation, and expanded and secured to the vessel wall.
摘要翻译：不用心脏旁路进行血管内手术的装置和方法包括临时过滤装置，临时阀和人工瓣膜的实施例。临时过滤装置具有套管，该套管为进行心脏瓣膜修复的外科手术工具提供通路。套管可以具有防止栓塞材料进入冠状动脉和主动脉的过滤器。瓣膜装置还可以具有用于将瓣膜插入主动脉的插管。瓣膜装置在主动脉中膨胀以占据血管的整个流动路径，并且操作以防止血液流动并允许流过瓣膜。假体瓣膜包括固定假体瓣膜至血管壁的瓣膜固定装置。假体瓣膜以压缩状态引入血管系统中，前进到植入部位，并且扩张并固定到血管壁。

56. 发明授权

US08740970B2 System and method for attaching a vessel in a vascular environment 失效
标题翻译：将血管附着在血管环境中的系统和方法
公开(公告)号：US08740970B2
公开(公告)日：2014-06-03
申请号：US12629656
申请日：2009-12-02
申请人： Baron L. Hamman , William E. Cohn , Devin S. Dobie , Kirk S. Honour , Dana Ray Mester
发明人： Baron L. Hamman , William E. Cohn , Devin S. Dobie , Kirk S. Honour , Dana Ray Mester
IPC分类号： A61F2/06
CPC分类号： A61B17/0293 , A61B2017/1103 , A61B2017/1107 , A61B2017/1135
摘要： An apparatus is provided in one example embodiment and includes a body section having an upper surface, a lower surface, and an inner edge circumferentially arranged around at least a portion of an open area. The apparatus also includes a tool extending from the body section into the open area for holding a graft vessel. The lower surface of the body section opposes a receiving vessel when the tool is positioned to transfer the graft vessel to the receiving vessel, such that the graft vessel is axially accessible through the open area to be attached to the receiving vessel. In more specific embodiments, the body section has first and second opposing ends defining a gap sized to permit the vessel to pass through.
摘要翻译：在一个示例性实施例中提供了一种装置，并且包括具有上表面，下表面和围绕开口区域的至少一部分周向布置的内边缘的主体部分。该装置还包括从身体部分延伸到用于保持移植血管的开放区域的工具。当工具被定位成将移植物容器移动到接收容器时，主体部分的下表面与接收容器相对，使得移植容器可以通过待连接到接收容器的敞开区域轴向容纳。在更具体的实施例中，主体部分具有第一和第二相对端部，其限定尺寸允许容器通过的间隙。

57. 发明授权

US08623077B2 Apparatus for replacing a cardiac valve 有权
标题翻译：用于更换心脏瓣膜的装置
公开(公告)号：US08623077B2
公开(公告)日：2014-01-07
申请号：US13311139
申请日：2011-12-05
申请人： William E. Cohn
发明人： William E. Cohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2427
摘要： A prosthetic heart valve in combination with a delivery assembly that includes a first elongate component that is movably disposed to a second elongate component. The delivery assembly has a temporary valve location relative to the delivery assembly to which the prosthetic heart valve can be releasably mounted in position and a spaced implantation location relative to the delivery assembly to which the prosthetic heart valve can also be releasably mounted in position. The prosthetic heart valve and delivery assembly combination is configurable with movement of the first elongate component relative to the second elongate component from a delivery state with the prosthetic heart valve mounted in the temporary location to an implantation state with the prosthetic heart valve repositioned from the temporary, location to the implantation location so that the prosthetic heart valve can subsequently be deployed from the implantation location.
摘要翻译：一种假体心脏瓣膜与输送组件组合，其包括可移动地设置在第二细长部件上的第一细长部件。输送组件相对于输送组件具有暂时的阀位置，假体心脏瓣膜可以释放地安装在该位置上，并且相对于输送组件的间隔的植入位置，假体心脏瓣膜也可释放地安装在该输送组件上。假体心脏瓣膜和输送组件组合可配置成使得第一细长部件相对于第二细长部件从输送状态的运动，其中假体心脏瓣膜安装在临时位置到植入状态，其中假体心脏瓣膜从临时位置重新定位，位置到植入位置，使得可以随后从植入位置展开假体心脏瓣膜。

58. 发明授权

US08226712B1 Total artificial heart system for auto-regulating flow and pressure 失效
标题翻译：全人工心脏系统用于自动调节流量和压力
公开(公告)号：US08226712B1
公开(公告)日：2012-07-24
申请号：US12485015
申请日：2009-06-15
申请人： Oscar H. Frazier , William E. Cohn
发明人： Oscar H. Frazier , William E. Cohn
IPC分类号： A61M1/12
CPC分类号： A61F2/064 , A61F2/06 , A61M1/101 , A61M1/1086 , A61M1/12 , A61M2205/3334 , A61M2206/11
摘要： The present invention is TAH system for auto-regulating blood flow and maintaining the asymmetric pressure balance in the mammalian cardiovascular system by decreasing the resistance in blood flow and minimizing the pressure gradients to exploit the in-flow pressure sensitivities of continuous flow pumps. The system further includes laminar flow generating manifolds connected to the atrium at one end and attached to pumps linked to the great vessels at the other, such that the in-let flow sensitivities of the pumps are maximized to auto-regulate blood flow, providing adequate pulmonary and systemic arterial flow to support normal metabolism and end-organ function and maintain the appropriate asymmetric physiologic pressure balance between the systemic and pulmonary systems of the mammalian cardiovascular system.
摘要翻译：本发明是通过降低血液流动阻力并使压力梯度最小化以利用连续流量泵的入口压力灵敏度来自动调节血液流动并维持哺乳动物心血管系统中的不对称压力平衡的TAH系统。该系统还包括在一端连接到心房的层流发生歧管并且附接到另一端连接到大血管的泵，使得泵的入口流动灵敏度最大化以自动调节血流量，提供足够的肺和全身动脉血流以支持正常代谢和末端器官功能，并维持哺乳动物心血管系统的系统和肺系统之间适当的不对称生理压力平衡。

59. 发明申请

US20120143324A1 Aortic Valve Devices 审中-公开
标题翻译：主动脉瓣装置
公开(公告)号：US20120143324A1
公开(公告)日：2012-06-07
申请号：US13250720
申请日：2011-09-30
申请人： J. Scott Rankin , Al Beavan , William E. Cohn
发明人： J. Scott Rankin , Al Beavan , William E. Cohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0008 , A61F2230/0054 , A61F2250/0087
摘要： The present disclosure provides aortic valve prosthetic devices that are constructed in an elliptical shape, or are expandable to an elliptical shape for improved results in the repair of defective aortic valves. The devices can be surgically implanted, or they can be implanted percutaneously through an insertion catheter. The expandable devices can be self-expanding or expanded by an inflatable balloon to an elliptical cross section geometry.
摘要翻译：本公开提供了主动脉瓣假体装置，其构造为椭圆形，或者可扩展成椭圆形，用于改进有缺陷的主动脉瓣的修复结果。该装置可以手术植入，也可以通过插入导管经皮植入。可膨胀装置可以自膨胀或者通过可充气气囊膨胀到椭圆形截面几何形状。

60. 发明申请

US20110172690A1 Balloon Catheter for Use with a Surgical Coring System 审中-公开
标题翻译：用于手术取心系统的气球导管
公开(公告)号：US20110172690A1
公开(公告)日：2011-07-14
申请号：US12836513
申请日：2010-07-14
申请人： William E. Cohn
发明人： William E. Cohn
IPC分类号： A61B17/32
CPC分类号： A61M25/1002 , A61B17/32053 , A61B17/34 , A61B17/3415 , A61B2017/3419 , A61B2017/3425 , A61B2017/3486 , A61B2017/3488 , A61M25/04 , A61M2025/1072
摘要： A balloon catheter for use with a surgical coring system for off pump surgery, includes various shaped balloon portions which are adapted to seal an apical hole in the left ventricle of a patient's heart.
摘要翻译：用于与外科手术取芯系统进行脱水手术的气囊导管包括适于密封患者心脏左心室中的顶孔的各种成形气囊部分。

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