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51. 发明申请

US20060155483A1 System and process for validating, aligning and reordering one or more genetic sequence maps using at least one ordered restriction map 有权
标题翻译：使用至少一个有序限制图来验证，对准和重新排序一个或多个遗传序列图的系统和过程
公开(公告)号：US20060155483A1
公开(公告)日：2006-07-13
申请号：US10432766
申请日：2001-09-28
申请人： Marco Antoniotti , Bhubaneswar Mishra , Thomas Anantharaman , Salvatore Paxia , David Schwartz
发明人： Marco Antoniotti , Bhubaneswar Mishra , Thomas Anantharaman , Salvatore Paxia , David Schwartz
IPC分类号： G06F19/00
CPC分类号： G06F19/22
摘要： A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map and/or the second DNA map. In particular, the first and second DNA maps can be received (the first DNA map corresponding to a sequence DNA map, and the second DNA map corresponding to a genomic consensus DNA map as provided in an optical DNA map). Then, the accuracy of the first DNA map and/or the second DNA map is validated based on information associated with the first and second DNA maps. In addition, a method and system are provided for aligning a plurality of DNA sequences with a ordered DNA restriction map. The DNA sequences and the DNA map are received (the DNA sequences being fragments of a genome and the DNA map corresponding to a genomic consensus DNA map which relates to an optical ordered DNA map). Then, a level of accuracy of the DNA sequences and the DNA map is obtained based on information associated with the DNA sequences and the DNA map by means of the method and system described above. The locations of the DNA map at which the DNA sequences are capable of being associated with particular segments of the DNA map are located. Furthermore, it is possible to obtain locations of the DNA map (without the validation) by locating an optimal one of the locations for each of the DNA sequences for each of the locations.
摘要翻译：提供了一种方法和系统，用于将第一DNA限制性图谱的有序区段与第二DNA限制图谱的有序区段进行比较，以确定第一DNA图谱和/或第二DNA图谱的准确度。特别地，可以接收第一个和第二个DNA图谱（对应于序列DNA图谱的第一个DNA图谱，和对应于光学DNA图谱中提供的基因组共有DNA图谱的第二个DNA图谱）。然后，基于与第一和第二DNA图相关联的信息来验证第一DNA图和/或第二DNA图的准确性。此外，提供了用于使多个DNA序列与有序DNA限制图对齐的方法和系统。接受DNA序列和DNA图谱（DNA序列是基因组的片段，DNA图谱对应于涉及光学有序DNA图谱的基因组共有DNA图谱）。然后，通过上述方法和系统，基于与DNA序列和DNA图谱相关的信息，获得DNA序列和DNA图谱的准确度。 DNA序列的DNA图谱位置可以与DNA图谱的特定片段相关联。此外，通过为每个位置定位每个DNA序列的最佳位置之一，可以获得DNA图谱的位置（无需验证）。

52. 发明申请

US20060029951A1 Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis 有权
公开(公告)号：US20060029951A1
公开(公告)日：2006-02-09
申请号：US11133949
申请日：2005-05-20
申请人： Marc Caron , Xiaodong Zhang , Martin Beaulieu , Raul Gainetdinov , Tatiana Sotnikova , Ranga Krishnan , David Schwartz , Lauranell Burch , Redford Williams
发明人： Marc Caron , Xiaodong Zhang , Martin Beaulieu , Raul Gainetdinov , Tatiana Sotnikova , Ranga Krishnan , David Schwartz , Lauranell Burch , Redford Williams
IPC分类号： C12Q1/68
CPC分类号： A61K45/06 , A61K31/137 , A61K31/14 , A61K31/343 , A61K31/405 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.

53. 发明申请

US20050021502A1 Data federation methods and system 审中-公开
标题翻译：数据联合方法和系统
公开(公告)号：US20050021502A1
公开(公告)日：2005-01-27
申请号：US10850826
申请日：2004-05-20
申请人： Benjamin Chen , Jason Oliver , David Schwartz , William Lindsey , Angus MacDonald
发明人： Benjamin Chen , Jason Oliver , David Schwartz , William Lindsey , Angus MacDonald
IPC分类号： G06F20060101 , G06F7/00 , G06F17/30
CPC分类号： G06F16/2471 , G06F16/84
摘要： A method is provided for processing tree like data structures in a streaming manner. An initial context of name/value bindings is set up. A tree of objects is constructed. Each element in the tree of objects is represented as a function object that accepts a context parameter and a target parameter that it can send a stream of start, content, and end events to represent tree output. The parse tree of objects is examined for element names that are recognized as commands. The commands are converted to special function objects that implement command's semantics. Other elements, that are not recognized as commands, are mapped to a default function object.
摘要翻译：提供了一种以流式方式处理树状数据结构的方法。设置名称/值绑定的初始上下文。建立一个对象树。对象树中的每个元素都表示为接受上下文参数和目标参数的函数对象，它可以发送开始，内容和结束事件流来表示树输出。检查被识别为命令的元素名称的对象的解析树。命令转换为实现命令语义的特殊功能对象。未被识别为命令的其他元素被映射到默认的功能对象。

54. 发明授权

US06562798B1 Immunostimulatory oligonucleotides with modified bases and methods of use thereof 失效
标题翻译：具有修饰碱基的免疫刺激性寡核苷酸及其使用方法
公开(公告)号：US06562798B1
公开(公告)日：2003-05-13
申请号：US09324191
申请日：1999-06-01
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： A01N4304
CPC分类号： A61K31/7115 , A61K39/39 , A61K47/54 , A61K2039/55561 , A61K2039/57 , C07H21/00 , C12N15/117 , C12N2310/18 , C12N2310/334
摘要： Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.
摘要翻译：公开了免疫调节寡核苷酸组合物。这些寡核苷酸包含包含修饰的胞嘧啶的免疫刺激性六核苷酸序列。这些寡核苷酸可以与免疫调节肽或抗原结合施用。还公开了在施用包含修饰的免疫刺激序列的寡核苷酸时调节免疫应答的方法。

55. 发明授权

US06448012B1 Method for mapping a nucleic acid 有权
标题翻译：映射核酸的方法
公开(公告)号：US06448012B1
公开(公告)日：2002-09-10
申请号：US09713016
申请日：2000-11-16
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： C12Q168
CPC分类号： C12Q1/683 , C12Q1/68 , C12Q1/6841 , G01N15/02 , G01N15/10 , G01N27/44704 , G01N27/44721 , G01N27/44773 , G01N2015/0038 , G01N2015/0288 , G01N2015/1062 , G01N2015/1081 , G01N2015/1486 , G01N2015/149 , G01N2015/1495 , G01N2015/1497 , Y10T436/143333
摘要： A method for observing and determining the size of individual molecules and for determining the weight distribution of a sample containing molecules of varying size, which involves placing a deformable or nondeformable molecule, in a medium, subjecting the molecule to an external force, thereby causing conformational and/or positional changes, and then measuring these changes. Preferred ways to measure conformational and positional changes include: (1) determining the rate at which a deformable molecule returns to a relaxed state after termination of the external force, (2) determining the rate at which a molecule becomes oriented in a new direction when the direction of the perturbing force is changed, (3) determining the rate at which a molecule rotates, (4) measuring the length of a molecule, particularly when it is at least partially stretched, or (5) measuring at least one diameter of a spherical or ellipsoidal molecule. Measurements of relaxation, reorientation, and rotation rates, as well as length and diameter can be made using a light microscope connected to an image processor. Molecule relaxation, reorientation and rotation also can be determined using a microscope combined with a spectroscopic device. The invention is particularly useful for measuring polymer molecules, such as nucleic acids, and can be used to determine the size and map location of restriction digests. Breakage of large polymer molecules mounted on a microscope slide is prevented by condensing the molecules before mounting and unfolding the molecules after they have been placed in a matrix.
摘要翻译：一种用于观察和确定单个分子的尺寸并确定含有不同大小的分子的样品的重量分布的方法，其包括将可变形或不可变形的分子置于介质中，使分子受到外力，由此引起构象和/或位置变化，然后测量这些变化。测量构象和位置变化的优选方法包括：（1）确定可变形分子在外力终止后恢复到松弛状态的速率，（2）确定分子在新方向上取向的速率，当扰动力的方向发生变化，（3）确定分子转动的速度，（4）测量分子的长度，特别是至少部分拉伸时，或（5）测量至少一个直径的球形或椭圆形分子。可以使用连接到图像处理器的光学显微镜来进行放松，重新定向和旋转速率以及长度和直径的测量。也可以使用与分光装置结合的显微镜来确定分子松弛，重新取向和旋转。本发明特别可用于测量聚合物分子，例如核酸，并且可用于确定限制性消化物的大小和图谱位置。通过在将分子置于基质中之前将分子凝结并分解开来，使分子冷凝，可以防止在显微镜载片上安装大分子的破裂。

56. 发明授权

US06237534B1 Litter box assembly 失效
标题翻译：垃圾箱装配
公开(公告)号：US06237534B1
公开(公告)日：2001-05-29
申请号：US09596022
申请日：2000-06-15
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： A01K2900
CPC分类号： A01K1/0125 , A01K1/0107
摘要： A litter box assembly is described that comprises a box for containing litter, having a base, rigid side walls, an opening in one of the side walls, and a removable lid atop the side walls; and a flexible tunnel, preferably made of an accordion plastic. The tunnel allows for the ingress and egress of a small animal, preferably a “so-called” indoor pet such as a cat, and supports the weight of the small animal during its ingress and egress to and from the litter box. The tunnel is preferably suspended above the ground via removable attachments to the opening in the litter box, the to an opening in a residence. The litter box is not fixed in a particular orientation relative to the opening in the residence, even when connected to the tunnel. The litter box is preferably substantially divided, by an interior wall, into a waste chamber for containing litter and an interior passageway. The interior passageway may comprises holes on the floor to allow the passage of litter through the holes during ingress and egress of the animal, but small enough to prevent passage of the feet of the animal through the holes. The rigid side walls of the litter box may also comprise wall holes, which may be covered by overhangs, where the wall holes are of a size to permit the free flow of air and gases into and out of the litter box, and small enough to prevent passage of the animal from the litter box through the holes.
摘要翻译：描述了一种垃圾箱组件，其包括用于容纳垃圾的箱体，其具有基部，刚性侧壁，一个侧壁中的开口和在侧壁顶部的可移除盖; 以及优选由手风琴塑料制成的柔性隧道。该隧道允许小型动物，优选地是所谓的“猫”等室内宠物的入口和出口，并且在进入和离开垃圾箱的过程中支撑小动物的重量。隧道优选通过可移除的附件悬挂在地面上的垃圾箱中的开口，到居住地的开口处。即使连接到隧道，垃圾箱也不会相对于住宅内的开口以特定方向固定。垃圾箱优选地通过内壁大体分成用于容纳垃圾和内部通道的废物室。内部通道可以包括在地板上的孔，以允许垃圾在进入和移出动物期间通过孔，但足够小以防止动物的脚通过孔。垃圾箱的刚性侧壁还可以包括壁孔，其可以被悬垂物覆盖，其中壁孔的大小允许空气和气体自由流入和排出垃圾箱，并且足够小到防止动物从垃圾箱通过孔。

57. 发明授权

US6150089A Method and characterizing polymer molecules or the like 失效
标题翻译：表征聚合物分子等的方法
公开(公告)号：US6150089A
公开(公告)日：2000-11-21
申请号：US128996
申请日：1993-09-30
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： G01B11/08 , C12N15/09 , C12Q1/68 , G01N15/02 , G01N15/10 , G01N15/14 , G01N27/447 , G01N33/44 , G01N33/50 , G01N27/26
CPC分类号： C12Q1/683 , C12Q1/68 , C12Q1/6841 , G01N15/02 , G01N15/10 , G01N27/44704 , G01N27/44721 , G01N27/44773 , G01N2015/0038 , G01N2015/0288 , G01N2015/1062 , G01N2015/1081 , G01N2015/1486 , G01N2015/149 , G01N2015/1495 , G01N2015/1497 , Y10T436/143333
摘要： A method for observing and determining the size of individual molecules and for determining the weight distribution of a sample containing molecules of varying size, which involves placing a deformable or nondeformable molecule in a medium, subjecting the molecule to an external force, thereby causing conformational and/or positional changes, and then measuring these changes. Preferred ways to measure conformational and positional changes include: (1) determining the rate at which a deformable molecule returns to a relaxed state after termination of the external force, (2) determining the rate at which a molecule becomes oriented in a new direction when the direction of the perturbing force is changed, (3) determining the rate at which a molecule rorates, (4) measuring the length of a molecule, particularly when it is at least partially stretched, or (5) measuring at least one diameter of a spherical or ellipsoidal molecule. Measurements of relaxation, reorientation, and rotation rates, as well as length and diameter can be made using a light microscope connected to an image processor. Molecule relaxation, reorientation and rotation also can be determined using a microscope combined with a spectroscopic device. The invention is particularly useful for measuring polymer molecules, such as nucleic acids, and can be used to determine the size and map location of restriction digests. Breakage of large polymer molecules mounted on a microscope slide is prevented by condensing the molecules before mounting and unfolding the molecules after they have been placed in a matrix.
摘要翻译：一种用于观察和确定单个分子的尺寸并确定含有不同大小分子的样品的重量分布的方法，其包括将可变形或不可变形的分子置于介质中，使分子受到外力，由此引起构象和 /或位置变化，然后测量这些变化。测量构象和位置变化的优选方法包括：（1）确定可变形分子在外力终止后恢复到松弛状态的速率，（2）确定分子在新方向上取向的速率，当扰动力的方向发生变化，（3）确定分子的速率，（4）测量分子的长度，尤其是至少部分拉伸时，或（5）测量至少一个直径的球形或椭圆形分子。可以使用连接到图像处理器的光学显微镜来进行放松，重新定向和旋转速率以及长度和直径的测量。也可以使用与分光装置结合的显微镜来确定分子松弛，重新取向和旋转。本发明特别可用于测量聚合物分子，例如核酸，并且可用于确定限制性消化物的大小和图谱位置。通过在将分子置于基质中之前将分子凝结并分解开来，使分子冷凝，可以防止在显微镜载片上安装大分子的破裂。

58. 发明申请

US20140296612A1 Brachytherapy Assist Device 审中-公开
标题翻译：近距离放射治疗辅助装置
公开(公告)号：US20140296612A1
公开(公告)日：2014-10-02
申请号：US13941264
申请日：2013-07-12
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： A61N5/10
CPC分类号： A61N5/1007 , A61N2005/1094
摘要： A lightweight, portable, interchangeable and effective overlay plate that will increase the efficiency of brachytherapy radiation treatment and reduce the duration of the radiation exposure during the radioactive seed insertion and positioning in brachytherapy. The overlay plate has a limited number of apertures specific to the treatment of a particular patient and is attached to the matrix used to position and guide the needles with the radioactive seeds. The apertures of the overlay plate may further be truncated-cone-shaped, with the narrow ends aligned with corresponding apertures in the matrix and the flared ends facing the user. The overlay plate minimizes the radiation exposure as much as reasonably possible because any amount of radiation exposure carries a risk to the exposed individual, and the overlay plate may also be manufactured from radiation-protective material to further minimize the radiation exposure.
摘要翻译：轻便，便携，可互换和有效的覆盖板，将提高近距离放射治疗的效率，并减少放射性种子插入和近距离放射治疗期间放射线暴露的持续时间。覆盖板具有特定于特定患者的治疗特定的有限数量的孔，并且附接到用于定位和引导针与放射性种子的基质。覆盖板的孔可以进一步是截锥形的，其中窄端与矩阵中的相应孔对准，并且扩张端面向使用者。覆盖板最大限度地减少了辐射暴露的可能性，因为任何数量的辐射暴露都会对暴露的个体带来风险，并且覆盖板也可以由辐射防护材料制成，以进一步最小化辐射暴露。

59. 发明申请

US20130240688A1 Adjustable Foot for Furniture 有权
标题翻译：家具可调脚
公开(公告)号：US20130240688A1
公开(公告)日：2013-09-19
申请号：US13423939
申请日：2012-03-19
申请人： David Schwartz , Larry Hale
发明人： David Schwartz , Larry Hale
IPC分类号： A47B91/02
CPC分类号： A47B91/024
摘要： This invention relates to an adjustable foot support including a mount housing and lower housing. The mount housing is configured to be externally mounted to a piece of furniture and includes an internal, threaded column. The lower housing also includes an internal threaded column with the column configured to mate with the mount housing.
摘要翻译：本发明涉及一种包括安装壳体和下部壳体的可调式支脚。安装壳体被构造成外部安装到一件家具并且包括内部的螺纹柱。下壳体还包括内螺纹柱，柱具有与安装壳体配合的配置。

60. 发明授权

US08091587B1 Tamper-resistant water flow restriction system 有权
标题翻译：防篡改水流量限制系统
公开(公告)号：US08091587B1
公开(公告)日：2012-01-10
申请号：US12657838
申请日：2010-01-28
申请人： David Schwartz
发明人： David Schwartz
IPC分类号： F15D1/04
CPC分类号： F15D1/04 , Y10T137/0402 , Y10T137/7256 , Y10T137/7927 , Y10T137/8593
摘要： A system and method for installing and removing a flow restrictor assembly in a shower, while prevents tampering with the flow restriction system thus installed. Tampering is prevented by concealing the flow restrictor assembly behind a shower wall, attached directly to a water supply line. The system further prevents tampering by concealing the tool-hole necessary for its removal behind a flow restrictor disk, so that there are no visible means of removing the flow restrictor assembly. The flow restrictor assembly threads onto a showerhead arm and the flow restrictor assembly with the attached showerhead arm threads directly into the water line. When the showerhead arm is unthreaded, the flow restrictor assembly remains connected to the water line by an external screw thread. The flow restrictor must be removed to reveal the tool-hole which may only then be engaged by a tool for removal.
摘要翻译：一种用于在淋浴器中安装和拆卸限流器组件的系统和方法，同时防止对如此安装的流动限制系统的篡改。通过将节流器组件隐藏在淋浴壁后面，直接连接到供水管线来防止篡改。该系统进一步通过隐藏在流量限制器盘的后面所需的工具孔来防止篡改，使得没有可见的除去限流器组件的手段。流量限制器组件螺纹连接到喷头臂上，并且限流器组件具有附接的喷头臂直接进入水管线。当喷头臂无螺纹时，限流器组件通过外部螺纹保持连接到水管线。必须拆卸限流器以露出工具孔，该工具孔只能由用于拆卸的工具接合。

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