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51. 发明授权

US06979829B2 Devices and methods for determining the amount of energy absorbed during irradiation 失效
标题翻译：用于确定照射期间吸收能量的装置和方法
公开(公告)号：US06979829B2
公开(公告)日：2005-12-27
申请号：US10420932
申请日：2003-04-23
申请人： Glenn Calvert , David Clark , Martin J. MacPhee , Randall Kent , Anna L. McBain , Bryant O. Pearce
发明人： Glenn Calvert , David Clark , Martin J. MacPhee , Randall Kent , Anna L. McBain , Bryant O. Pearce
IPC分类号： A61L2/00 , A61L2/08 , A61L2/28 , G01T20060101 , G01T1/02
CPC分类号： A61L2/28 , A61L2/0035 , A61L2/08 , A61L2202/22
摘要： Devices and methods are disclosed for determining the amount of energy absorbed during irradiation. Such devices comprise a material that absorbs radiation in a quantifiable manner and a cooling agent to maintain the temperature of that material within a predetermined range, and may be used to determine the amount of energy absorbed during irradiation, for example during sterilization of a biological material.
摘要翻译：公开了用于确定在照射期间吸收的能量的量的装置和方法。这样的装置包括以可量化的方式吸收辐射的材料和将该材料的温度保持在预定范围内的冷却剂，并且可以用于确定在照射期间吸收的能量的量，例如在生物材料的灭菌期间。

52. 发明申请

US20050183159A1 Floral organ tissue-specific expression of isopentenyl transferase 失效
标题翻译：花生器官组织特异性表达异戊烯基转移酶
公开(公告)号：US20050183159A1
公开(公告)日：2005-08-18
申请号：US11043328
申请日：2005-01-26
申请人： David Clark , Holly Loucas
发明人： David Clark , Holly Loucas
IPC分类号： C07H21/04 , C12N9/10 , C12N15/82 , A01H1/00 , C12N5/04
CPC分类号： C12N9/1085 , C07H21/04 , C12N15/8233 , C12N15/8261 , C12N15/827 , C12N15/8295 , Y02A40/146
摘要： The invention provides methods and compositions for the production of transgenic plants, plant cells, embryos, and seeds that produce plants with floral organs that have increased mass and/or size as compared to wild-type plants.
摘要翻译：本发明提供用于生产具有与野生型植物相比具有增加的质量和/或尺寸的具有花器官的植物的转基因植物，植物细胞，胚胎和种子的方法和组合物。

53. 发明申请

US20050169913A1 Compositions comprising antibodies to human FgI2 审中-公开
标题翻译：包含人FgI2抗体的组合物
公开(公告)号：US20050169913A1
公开(公告)日：2005-08-04
申请号：US10997920
申请日：2004-11-29
申请人： Gary Levy , David Clark
发明人： Gary Levy , David Clark
IPC分类号： A61K45/00 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P7/02 , A61P13/12 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07K16/40 , C12N9/64 , C12N15/55 , G01N33/68 , G01N33/86
CPC分类号： C12N9/647 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C07K2317/70 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N33/574 , G01N33/6893 , G01N33/86 , G01N2800/224 , G01N2800/24 , G01N2800/245
摘要： Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.
摘要翻译：描述了使用新型抗体和化合物介导免疫凝血的方法。已经鉴定了具有直接凝血酶原酶活性的蛋白Fgl2。 Fgl2的抑制剂可用于预防和治疗需要减少免疫凝血的疾病，包括细菌和病毒感染，同种异体移植物和异种移植物排斥反应，肾小球肾炎，癌症，许多胃肠道疾病和胎儿丧失。

54. 发明申请

US20050124676A1 EP4 receptor antagonists 失效
标题翻译： EP4受体拮抗剂
公开(公告)号：US20050124676A1
公开(公告)日：2005-06-09
申请号：US10964831
申请日：2004-10-15
申请人： David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
发明人： David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
IPC分类号： A61K31/34 , A61K31/41 , C07D307/68 , C07D45/02
CPC分类号： C07D307/68
摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译：式（I）化合物或其盐，溶剂合物和化学保护形式，其中R 2和R 5中的一个为：（i）H或任选地取代的C 1-4烷基; 或（ii）任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1，m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3， SUP>是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5〜20 其中R 3，N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N， 1-4个C 1-4烷基; 或（iv）四唑-5-基。

55. 发明申请

US20050124600A1 Quinazoline(di)ones for invertebrate pest control 失效
标题翻译：喹唑啉（二）用于无脊椎害虫防治
公开(公告)号：US20050124600A1
公开(公告)日：2005-06-09
申请号：US10496724
申请日：2003-01-16
申请人： David Clark , George Lahm
发明人： David Clark , George Lahm
IPC分类号： A01N43/56 , C07D239/90 , C07D239/96 , C07D243/14 , C07D401/06 , C07D401/14 , C07D403/06 , A61K31/553 , A61K31/517 , A61K31/519 , A61K31/554
CPC分类号： C07D401/06 , A01N43/56 , C07D239/90 , C07D239/96 , C07D243/14 , C07D401/14 , C07D403/06
摘要： Compounds of Formula I including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof, are disclosed which are useful as invertebrate pest control agents, (I) wherein A, B, J, K, L and R3 are as defined in the disclosure. Also disclosed are compositions for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I an N-oxide thereof or a suitable salt thereof and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, its N-oxide or a suitable salt of the compound (e.g., as a composition described herein).
摘要翻译：公开了包含所有几何和立体异构体，N-氧化物和农业上合适的盐的式I化合物，其可用作无脊椎害虫防治剂，（I）其中A，B，J，K，L和R 3 如本公开中所定义。还公开了用于控制无脊椎害虫的组合物，其包含生物有效量的式I化合物及其N-氧化物或其合适的盐和至少一种选自表面活性剂，固体稀释剂和液体稀释剂的另外的组分。还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式I化合物，其N-氧化物或该化合物的合适盐（例如本文所述的组合物）接触。

56. 发明申请

US20050108076A1 System for routing and tracking deliverables 审中-公开
标题翻译：用于路由和跟踪可交付成果的系统
公开(公告)号：US20050108076A1
公开(公告)日：2005-05-19
申请号：US10712983
申请日：2003-11-13
申请人： Curtis Carrender , Ronald Gilbert , Jeffrey Scott , David Clark
发明人： Curtis Carrender , Ronald Gilbert , Jeffrey Scott , David Clark
IPC分类号： G06K17/00 , G06F17/60
CPC分类号： G06K19/07758 , G06K17/00 , G06K19/0776 , G06Q10/0833
摘要： A system for routing and tracking deliverables, the system including a flexible label having a flexible transponder associated therewith or formed therein for association with a respective deliverable, at least one transceiver configured to communicate with the transceivers to receive control signals; and a routing device coupled to the transceiver and configured to route and sort deliverables in response to control signals received at the transceiver from the transponder.
摘要翻译：一种用于路由和跟踪可交付物的系统，所述系统包括具有与其相关联或在其中形成的灵活的应答器的灵活标签，用于与相应的可递送的至少一个收发器相关联，所述收发器经配置以与收发器通信以接收控制信号; 以及路由设备，其耦合到所述收发器并且被配置为响应于在所述收发器处从所述应答器接收的控制信号来路由和分类可交付物。

57. 发明授权

US06881554B2 Apparatus and methods for chemiluminescent assays 失效
公开(公告)号：US06881554B2
公开(公告)日：2005-04-19
申请号：US10346625
申请日：2003-01-17
申请人： Joseph L. DiCesare , John T. McCaffrey , David Clark , Michael I. Crockett
发明人： Joseph L. DiCesare , John T. McCaffrey , David Clark , Michael I. Crockett
IPC分类号： B01L3/00 , C12Q1/66 , G01N1/02 , G01N21/76 , G01N33/52 , C12Q1/24
CPC分类号： G01N33/52 , B01L3/5029 , B01L2300/0672 , B01L2300/0832 , B01L2300/087 , B01L2400/0478 , B01L2400/0683 , C12Q1/66 , G01N1/02 , G01N21/76 , G01N2001/028 , G01N2201/0221 , Y10T436/16 , Y10T436/25375 , Y10T436/2575
摘要： Disclosed is a device and methods for the rapid chemiluminescence assay of surfaces to detect the presence of microbial contamination. The device and methods are suitable for use by untrained personnel under the relatively harsh and variable conditions found in the field, for example in fast food restaurants and other food preparation areas. The chemiluminescence reaction that is the source of the analytical signal in the disclosed assay device and method is preferably based on a luciferase/luciferin system.

58. 发明申请

US20050070556A1 3-B-D-ribofuranosylthiazolo [4,5-d] pyridimine nucleosides and uses thereof 有权
标题翻译： 3-B-D-呋喃核糖基噻唑并[4,5-d]哒嗪亚胺核苷及其用途
公开(公告)号：US20050070556A1
公开(公告)日：2005-03-31
申请号：US10861430
申请日：2004-06-07
申请人： Devron Averett , Stephen Webber , Joseph Lennox , Erik Rueden , David Clark , Alan Xiang
发明人： Devron Averett , Stephen Webber , Joseph Lennox , Erik Rueden , David Clark , Alan Xiang
IPC分类号： C07H19/24 , A61K31/519 , C07D498/02
CPC分类号： C07H19/24
摘要： The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
摘要翻译：本发明涉及含有具有免疫调节活性的化合物的3-β-D-呋喃核糖基噻唑并[4,5-d]哒嗪亚胺核苷和药物组合物。本发明还涉及通过施用有效量的这种化合物来治疗或预防使用这些化合物和组合物，以及本文所述的疾病和病症的治疗方法。

59. 发明申请

US20050020644A1 Bicyclic fused pyridinyl amides and advantagesous compositons thereof for use as fungicides 审中-公开
标题翻译：双环稠合吡啶基酰胺和其有用的组合物用作杀真菌剂
公开(公告)号：US20050020644A1
公开(公告)日：2005-01-27
申请号：US10501258
申请日：2003-02-20
申请人： John Bisaha , James Hay , Stephen Foor , Michael Walker , David Clark
发明人： John Bisaha , James Hay , Stephen Foor , Michael Walker , David Clark
IPC分类号： A01N37/44 , A01N43/42 , A01N43/76 , A01N47/04 , A01N47/14 , A01N47/34 , A01N55/02 , A01N57/18 , C07D401/12 , C07D491/04 , C07D495/04 , C07D213/56 , A01N43/40
CPC分类号： C07D401/12 , C07D491/04 , C07D495/04
摘要： Compounds of Formula I, including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof: (Formula I); wherein X and either Y or Z are a linking chain 3 or 4 atoms in length attached to contiguous carbon atoms and are taken together with said carbon atoms to form a fused phenyl ring, a fused 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring optionally including one or two ring members selected from the group consisting of C(═O), SO or S(O)2, or a fused 5- or 6-membered heteroaromatic ring, each fused ring optionally substituted with one to three substituents independently selected from R7; and R1, R2, R5, R6R7, m and p are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of a compound of Formula I.
摘要翻译：式I的化合物，包括所有几何和立体异构体，N-氧化物及其农业上合适的盐：（式I）; 其中X和Y或Z是连接在连接碳原子上的长度为3或4个原子的连接链，并与所述碳原子一起形成稠合苯环，稠合的5或6元非芳族碳环或杂环任选地包括一个或两个选自C（= O），SO或S（O）2的环成员或稠合的5或6元杂芳环，每个稠环任选被一至三个取代基独立地取代选自R 7; 和R 1，R 2，R 5，R 6 R 7，m和p如本公开所定义。还公开了含有式I化合物的组合物和用于控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。

60. 发明授权

US06433187B1 Certain polycyclic compounds useful as tubulin-binding agents 失效
标题翻译：某些多环化合物可用作微管蛋白结合剂
公开(公告)号：US06433187B1
公开(公告)日：2002-08-13
申请号：US09464217
申请日：1999-12-15
申请人： David Clark , Walter Frankmoelle , Jonathan Houze , Juan C. Jaen , Julio C. Medina
发明人： David Clark , Walter Frankmoelle , Jonathan Houze , Juan C. Jaen , Julio C. Medina
IPC分类号： C07D33708
CPC分类号： C07D401/06 , A61K31/382 , C07C311/20 , C07C311/21 , C07C2603/30 , C07C2603/32 , C07D409/06 , C07D409/14 , C07D493/04
摘要： Derivatives of known tubulin-binding compounds are provided in which a (poly)fluorobenzene, a fluoropyridine, or a fluoronitrobenzene moiety is incorporated or added to the structure. These derivatives can be used as antimitotic agents and can be considered covalent modifiers of tubulin. The strategy developed for each of the compounds is to i) append a fluorinated electrophile (e.g., pentafluorophenylsulfonamido, 2-fluoropyridyl, or 3,5-dinitro-4-fluorophenyl) to an existing functional group in a natural product, ii) replace an aromatic ring in a natural product with a fluorinated electrophile, or iii) attach a fluorinated electrophile to an open valence in a portion of the molecule that will not interfere with recognition and binding to the tubulin site. Derivatives are provided based on colchicine, steganacin, podophyllotoxin, nocodazole, combretastatin, curacin A, vinblastine, vincristine, dolastatin, 2-methoxyestradiol, dihydroxy-pentamethoxyflavanone and others.
摘要翻译：提供了已知的微管蛋白结合化合物的衍生物，其中（聚）氟苯，氟代吡啶或氟硝基苯部分被结合或添加到该结构中。这些衍生物可用作抗有丝分裂剂并且可以被认为是微管蛋白的共价修饰剂。为每种化合物制定的策略是i）将天然产物中的现有官能团上的氟化亲电体（例如五氟苯基磺酰胺基，2-氟吡啶基或3,5-二硝基-4-氟苯基）具有氟化亲电体的天然产物中的芳香环，或iii）在分子的一部分中将氟化亲电体连接至开放价态，其不会干扰识别和结合微管蛋白位点。衍生物基于秋水仙碱，steganacin，鬼臼毒素，诺考达唑，考布他汀，curacin A，长春花碱，长春新碱，多卡他汀，2-甲氧基雌二醇，二羟基 - 五甲氧基黄酮等。

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