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51. 发明授权

US5675687A Seamless multi-section visual display system 失效
标题翻译：无缝多段视觉显示系统
公开(公告)号：US5675687A
公开(公告)日：1997-10-07
申请号：US560189
申请日：1995-11-20
申请人： Anthony B. Wood
发明人： Anthony B. Wood
IPC分类号： G02F1/1333 , G06F1/16 , G09F9/35 , G02B6/04
CPC分类号： G06F1/1679 , G06F1/1616 , G06F1/1624 , G06F1/1641 , G09F9/35 , G02F1/13336
摘要： A multi-section visual display system (20) for producing visual images that appear seamless to the user comprising at least two visual displays (26, 28), a light pipe (54, 56), which includes a plurality of parallel fiber optic segments having a polished surface or an integrated polymeric structure that guides light, disposed in parallel to each of the visual displays (26, 28) and an assembly (44) for mounting the visual displays (26, 28) adjacent to one another such that adjacent light pipes (54, 56) bend light toward one another to provide a seamless visual image.
摘要翻译：一种多部分视觉显示系统（20），用于产生对用户无缝显示的视觉图像，包括至少两个视觉显示器（26,28），光管（54,56），其包括多个平行光纤段具有抛光表面或整体聚合物结构，其引导与每个视觉显示器（26,28）平行布置的光，以及用于将视觉显示器（26,28）彼此相邻地安装的组件（44），使得相邻光管（54,56）将光朝向彼此弯曲以提供无缝的视觉图像。

52. 发明授权

US5095447A Color overlay of scanned and reference images for display 失效
标题翻译：扫描和参考图像的颜色叠加显示
公开(公告)号：US5095447A
公开(公告)日：1992-03-10
申请号：US617446
申请日：1990-11-21
申请人： William G. Manns , Anthony B. Wood
发明人： William G. Manns , Anthony B. Wood
IPC分类号： G01R31/308 , H04N1/04
CPC分类号： G01R31/308 , H04N1/04 , H04N2201/0426 , Y10S715/965
摘要： A laser pattern inspection and/or writing system which writes or inspects a pattern on a target on a stage, by raster scanning the target pixels. Inspection can also be done by substage illumination with non-laser light. A database, organized into frames and strips, represents an ideal pattern as one or more polygons. Each polygon's data description is contained within a single data frame. The database is transformed into a turnpoint polygon representation, then a left and right vector representation, then an addressed pixel representation, then a bit-mapped representation of the entire target. Most of the transformations are carried out in parallel pipelines. Guardbands around polygon sides are used for error filtering during inspection. Guardbands are polygons, and frames containing only guardband information are sent down dedicated pipelines. Error filtering also is done at the time of pixel comparisons of ideal with real patterns, and subsequently during defect area consolidation. Defect areas are viewed as color overlays of ideal and actual target areas, from data generated during real time. Defect areas can be de-zoomed to allow larger target areas to be viewed. An autofocus keeps the scanning laser beam in focus on the target. The inspection system is used to find fiducial marks to orient the target prior to raster scanning. IC bars are provided with alignment marks for locating each IC bar. Interferometers or glass scale encoders allow the stage position to be known.
摘要翻译：激光图案检查和/或写入系统，其通过光栅扫描目标像素来写入或检查在舞台上的目标上的图案。检查也可以通过非激光的分层照明进行。组织成框架和条带的数据库表示作为一个或多个多边形的理想模式。每个多边形的数据描述都包含在单个数据帧中。将数据库转换为转折点多边形表示，然后转换为左和右向量表示，然后转换为寻址像素表示，然后是整个目标的位映射表示。大多数转换是在并行管道中进行的。多边形周围的保护带用于检查过程中的错误过滤。保卫带是多边形，仅包含保护带信息的帧被发送到专用管道。在理想与实际图案的像素比较时，随后在缺陷区域合并期间，也进行误差滤波。缺陷区域被视为理想和实际目标区域的颜色叠加，从实时生成的数据。缺陷区域可以去放大，以允许查看较大的目标区域。自动对焦将扫描激光束保持在目标上。检查系统用于在光栅扫描之前找到基准标记来定向目标。 IC条具有用于定位每个IC条的对准标记。干涉仪或玻璃刻度尺可以让舞台位置知道。

53. 发明授权

US09492404B2 Compositions and methods for treatment of taupathy 有权
标题翻译：用于治疗甲状腺炎的组合物和方法
公开(公告)号：US09492404B2
公开(公告)日：2016-11-15
申请号：US13209201
申请日：2011-08-12
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K38/21 , A61P25/28 , A61K9/00 , A61K31/46 , A61K31/47 , A61K31/137 , A61P29/00 , A61K31/58 , A61K31/56 , A61K31/167 , A61K31/44 , A61K31/436 , A61K31/136 , A61P25/00 , A61K39/395 , A61K38/13 , A61K41/00
CPC分类号： A61K31/136 , A61K31/137 , A61K31/167 , A61K31/436 , A61K31/44 , A61K31/46 , A61K31/47 , A61K31/56 , A61K31/58 , A61K38/13 , A61K38/21 , A61K41/0004 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient for treating an inflammatory neurodegenerative condition or disease (e.g., a taupathy) or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for modulating phosphorylation of tau protein. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membrane potential and/or conductance, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译：提供了包含电荷稳定的含氧纳米结构的离子水溶液的电动改变的流体（例如，电动改变的富含气体的流体和溶液），其量足以治疗炎症性神经变性病症或疾病（例如，甲状腺炎）或其至少一种症状。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供了调节tau蛋白的磷酸化。特定方面提供通过调节细胞膜电位和/或电导中的至少一种来调节或调节与所述炎症反应相关的细胞内信号转导，膜蛋白例如膜受体，包括但不限于G-蛋白偶联受体（GPCR），和细胞间结（例如，紧密连接处，间隙连接处，zona adherins和desmasomes）。其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。

54. 发明授权

US09198929B2 Compositions and methods for enhancing physiological performance and recovery time 有权
标题翻译：用于增强生理性能和恢复时间的组合物和方法
公开(公告)号：US09198929B2
公开(公告)日：2015-12-01
申请号：US13102930
申请日：2011-05-06
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K33/00 , A23L1/30 , A23L2/54 , A61K41/00
CPC分类号： A61K33/00 , A23L2/54 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/08 , A61K33/14 , A61K41/0004 , A23V2200/25 , A23V2200/33 , A23V2250/126
摘要： Provided are methods for enhancing exercise (e.g., intense, eccentric, elevated temperature, repetitive, aerobic, and high altitude) performance, comprising administering electrokinetically-altered aqueous fluids comprising an ionic aqueous solution of stably configured charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than 100 nanometers. In certain aspects, enhancing exercise performance comprises at least one of: reducing plasma inflammatory cytokines (e.g., IFN-alpha, ENA-78 and BDNF); ameliorating muscle/tendon damage or enhancing muscle/tendon recovery; reducing biomarkers of exercise-induced muscle injury (e.g., CK-, plasma myoglobin); ameliorating exercise induced tendinosis, tendonitis, tenosynovitis, avulsion, and tendon strain associated with chronic repetitive movement or enhancing recovering therefrom; increasing VO2 max; decreasing RPE; reducing blood lactate; preserving muscle contractile function (e.g., maximal force, joint ROM); reducing muscle soreness; ameliorating onset of fatigue in an exercising subject. Improved methods for producing electrokinetically altered aqueous fluids (including sports beverages) are also provided.
摘要翻译：提供了用于增强运动（例如，强烈，偏心，升高的温度，重复，有氧和高海拔）性能的方法，包括施用电动改变的含水流体，其包含稳定配置的电荷稳定的含氧纳米结构的离子水溶液，其主要具有平均直径小于100纳米。在某些方面，增强运动性能包括降低血浆炎性细胞因子（例如IFN-α，ENA-78和BDNF）中的至少一种; 改善肌肉/肌腱损伤或增强肌肉/肌腱恢复; 减少运动性肌肉损伤的生物标志物（例如，CK-，血浆肌红蛋白）; 改善运动诱导的腱鞘炎，腱炎，腱鞘炎，撕脱和与慢性重复运动相关的肌腱菌株或增强其从其中的恢复; 增加VO2 max; 减少RPE; 减少血液乳酸盐保持肌肉收缩功能（例如，最大力，关节ROM）; 减轻肌肉酸痛; 改善运动受试者的疲劳发作。还提供了用于生产电动改变的含水流体（包括运动饮料）的改进的方法。

55. 发明授权

US08591957B2 Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution 失效
标题翻译：使用富氧溶液治疗眼睛和其他人体组织的方法
公开(公告)号：US08591957B2
公开(公告)日：2013-11-26
申请号：US11924601
申请日：2007-10-25
申请人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
发明人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
IPC分类号： A01N39/00
CPC分类号： A61K9/0014 , A61K9/0048 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , B29D11/00096 , A61K2300/00
摘要： Particular embodiments disclosed herein relate to electrokinetically altered gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for eye related conditions and/or diseases. In certain embodiments, the electrokinetically altered gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.
摘要翻译：本文公开的具体实施方案涉及电动改变的富含气体的流体，其制备方法，制备其的系统和/或利用富含气体的流体用于眼睛相关病症和/或疾病的治疗方法。在某些实施方案中，电动改变的富含气体的流体是富氧水。某些实施方案涉及使用流体处理与眼睛条件和/或疾病相关的化妆品和/或治疗症状的化妆品和/或治疗流体和/或治疗方法。

56. 发明授权

US08410182B2 Mixing device 有权
标题翻译：混合装置
公开(公告)号：US08410182B2
公开(公告)日：2013-04-02
申请号：US12433741
申请日：2009-04-30
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： B01F3/04 , C02F1/46
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.
摘要翻译：提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种。进一步提供制备电动改性的离子水性液体组合物的方法。特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。其它实施方案包括产生电动改变的流体的特定方法。电动改变的流体组合物和制备流体的方法包括任选地以分子氧稳定的溶剂化电子的形式的电动改变的离子水性流体。

57. 发明申请

US20120015083A1 DIFFUSER/EMULSIFIER FOR AQUACULTURE APPLICATIONS 有权
标题翻译：用于水产养殖应用的扩散器/乳化器
公开(公告)号：US20120015083A1
公开(公告)日：2012-01-19
申请号：US13028058
申请日：2011-02-15
申请人： Anthony B. Wood
发明人： Anthony B. Wood
IPC分类号： A23L2/54 , A23L2/76 , A23L2/50 , A23L2/72
CPC分类号： C02F1/20 , A01K63/042 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F3/0857 , B01F7/00758 , B01F7/00783 , B01F7/008 , B01F7/00825 , B01F2003/04687 , B01F2003/04872 , B01F2003/04879 , B01F2215/0052 , B01J19/008 , C02F1/001 , C02F1/34 , C02F1/68 , C02F1/685 , C02F1/727 , C02F1/74 , C02F1/78 , C02F3/205 , C02F9/00 , C02F2101/322 , C02F2303/04 , E21B43/121
摘要： A method of treatment of water in an aquatic environment. Water is first pumped from a reservoir to a first mixing station. An inert gas is introduced into the pumped water at the first mixing station to provide inert gas saturated water, which inert gas saturated water will displace undesired gasses in the water in the reservoir. The inert gas saturated water is then pumped to a sparging column such that the inert gas and undesired gasses will be released from the inert gas saturated water to provide depleted water.
摘要翻译：一种在水生环境中处理水的方法。首先将水从储存器泵送到第一混合站。将惰性气体引入第一混合站的泵送水中以提供惰性气体饱和水，该惰性气体饱和水将置换储存器中的水中不期望的气体。然后将惰性气体饱和水泵送到鼓泡塔，使得惰性气体和不需要的气体将从惰性气体饱和水中释放以提供耗尽的水。

58. 发明申请

US20110008462A1 SYSTEM AND METHOD FOR THERAPEUTIC APPLICATION OF DISSOLVED OXYGEN 审中-公开
标题翻译：溶解氧气治疗应用的系统与方法
公开(公告)号：US20110008462A1
公开(公告)日：2011-01-13
申请号：US12697846
申请日：2010-02-01
申请人： Anthony B. Wood , Richard A. Klena , Gregory Archambeau
发明人： Anthony B. Wood , Richard A. Klena , Gregory Archambeau
IPC分类号： A61K33/00 , A01N1/02 , C02F1/72 , C02F1/36 , C02F1/78
CPC分类号： A01K63/042 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F3/0857 , B01F7/00758 , B01F7/00783 , B01F7/008 , B01F7/00825 , B01F2215/0052 , C02F1/001 , C02F1/20 , C02F1/34 , C02F1/68 , C02F1/685 , C02F1/727 , C02F1/78 , C02F9/00 , C02F2101/322 , C02F2303/04 , Y10S514/912
摘要： A system and method for generating an oxygen enriched aqueous solution for therapeutic application includes a diffuser comprising a first diffusing member having a surface incorporating surface disturbances, and a second diffusing member positioned relative to the first diffusing member to form a channel through which an aqueous solution and oxygen gas may flow. A reservoir containing the aqueous solution is connected to a pump that draws the aqueous solution from the reservoir and inputs the aqueous solution into the diffuser. The aqueous solution is moved through the channel relative to the surface disturbances to create cavitation in the aqueous solution to diffuse the oxygen gas into the aqueous solution to produce an oxygen enriched aqueous solution.
摘要翻译：用于产生用于治疗应用的富氧水溶液的系统和方法包括扩散器，其包括具有包含表面干扰的表面的第一扩散构件和相对于第一扩散构件定位的第二扩散构件，以形成通道，水溶液氧气可能流过。含有水溶液的储存器连接到泵，其从储存器抽取水溶液并将水溶液输入到扩散器中。水溶液相对于表面扰动移动通过通道，以在水溶液中产生气蚀，以将氧气扩散到水溶液中以产生富氧水溶液。

59. 发明申请

US20100310665A1 BACTERIOSTATIC OR BACTERIOCIDAL COMPOSITIONS AND METHODS 审中-公开
标题翻译： BACTERIOSTATIC或BACTERIOCIDAL组合物和方法
公开(公告)号：US20100310665A1
公开(公告)日：2010-12-09
申请号：US12773743
申请日：2010-05-04
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K38/02 , A61K31/431 , A61P31/04
CPC分类号： A61K31/137 , A61K9/0019 , A61K9/0078 , A61K31/58 , A61K2300/00
摘要： Particular aspects provide compositions and methods for treating bacterial infection or at least one symptom related to bacterial infection in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically-altered fluid (including gas-enriched electrokinetically altered fluids) which comprise an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. The electrokinetically-altered ionic fluid compositions are sufficient to provide for modulation of intracellular signal transduction, wherein treating bacterial infection or at least one symptom related to bacterial infection is thereby afforded. In particular embodiments, the fluids are gas-enriched fluids or therapeutic compositions and methods, and include oxygen-enriched ionic aqueous solutions optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the gas-enriched therapeutic compositions.
摘要翻译：具体方面提供了用于治疗有需要的受试者的细菌感染或与细菌感染相关的至少一种症状的组合物和方法，其通过施用包含至少一种电动改变的流体（包括富含气体的电动改变的流体）的治疗组合物，其包含电荷稳定的含氧纳米结构的离子水溶液的量足以在与细胞接触时提供细胞膜电位和细胞膜电导率中的至少一种的调节。电动改变的离子液体组合物足以提供细胞内信号转导的调节，由此提供治疗细菌感染或至少一种与细菌感染相关的症状。在具体实施方案中，流体是富含气体的流体或治疗组合物和方法，并且包括任选地与其它治疗剂组合的富氧离子水溶液。其它实施方案包括用于富含气体的治疗组合物的特定给药途径或制剂。

60. 发明申请

US20100303871A1 COMPOSITIONS AND METHODS FOR MODULATING CELLULAR MEMBRANE-MEDIATED INTRACELLULAR SIGNAL TRANSDUCTION 审中-公开
公开(公告)号：US20100303871A1
公开(公告)日：2010-12-02
申请号：US12773546
申请日：2010-05-04
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/00 , C12N5/07 , A61K39/395 , A61K33/00 , A61P29/00 , A61P11/06 , A61P25/28 , A61P25/00 , A61P5/00 , A61P19/08 , A61P27/02 , A61P3/00 , A61P11/00 , A61P11/08
CPC分类号： C12N13/00 , A61K33/00 , A61K45/06 , G01N33/5008 , G01N33/6872 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Particular aspects of the present invention provide compositions and methods suitable for modulation of at least one of cellular membrane potential and cellular membrane conductivity. Additional aspects provide compositions and methods suitable for modulating intracellular signal transduction, including modulation of at least one of membrane structure, membrane potential or membrane conductivity, membrane proteins or receptors, ion channels, and calcium dependant cellular messaging systems, comprising use of the inventive electrokinetically altered solutions to impart electrochemical and/or conformational changes in membranous structures (e.g., membrane proteins, receptors and/or other components) including G-protein coupled receptors (GPCRs), G-proteins, and/or intracellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes).

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