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51. 发明授权

US06246901B1 Detecting, localizing, and targeting internal sites in vivo using optical contrast agents 失效
标题翻译：使用光学造影剂在体内检测，定位和定位内部位点
公开(公告)号：US06246901B1
公开(公告)日：2001-06-12
申请号：US09690195
申请日：2000-10-16
申请人： David A. Benaron
发明人： David A. Benaron
IPC分类号： A61B600
CPC分类号： G01N33/57434 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4381 , A61B5/6848 , A61B2562/0238 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N33/57415 , Y10S977/869 , Y10S977/904
摘要： A system for detecting, localizing and targeting a medical instrument toward a target tissue within the body using an optical contrast agent in which a light source (102) is optically coupled to the tissue to be diagnosed (135), a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue, and either one or both of the light source and light detector are coupled to a medical instrument (130) used in a medical procedure. A contrast locator engine (184) receives a signal from the detector and provides an target tissue output signal (195) based upon the localization and distribution of the contrast agent, allowing the target tissue to be detected, located, or imaged, and for the medical instrument to positioned or targeted relative to the target tissue, and for allowing the accuracy of placement or the progress of a procedure to be assessed in real time. A method for the system is also described.
摘要翻译：一种用于使用其中光源（102）光学耦合到要诊断的组织（135）的光学造影剂来检测，定位和瞄准医疗器械朝向身体内的目标组织的系统（135），光检测器（174）光学耦合到组织以检测穿过组织的一部分光，并且光源和光检测器中的一个或两者耦合到医疗过程中使用的医疗器械（130）。对比度定位器引擎（184）从检测器接收信号，并基于造影剂的定位和分布提供目标组织输出信号（195），允许检测，定位或成像目标组织，并且对于医疗器械相对于目标组织定位或靶向，并且用于允许实时评估放置的准确性或程序的进展。还描述了该系统的方法。

52. 发明授权

US6167297A Detecting, localizing, and targeting internal sites in vivo using optical contrast agents 失效
标题翻译：使用光学造影剂在体内检测，定位和定位内部位点
公开(公告)号：US6167297A
公开(公告)日：2000-12-26
申请号：US305855
申请日：1999-05-05
申请人： David A. Benaron
发明人： David A. Benaron
IPC分类号： A61B5/06 , A61B5/00 , A61B6/00
CPC分类号： G01N33/57434 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4381 , A61B5/6848 , A61B2562/0238 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N33/57415 , Y10S977/869 , Y10S977/904
摘要： A system for detecting, localizing and targeting a medical instrument toward a target tissue within the body using an optical contrast agent in which a light source (102) is optically coupled to the tissue to be diagnosed (135), a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue, and either one or both of the light source and light detector are coupled to a medical instrument (130) used in a medical procedure. A contrast locator engine (184) receives a signal from the detector and provides an target tissue output signal (195) based upon the localization and distribution of the contrast agent, allowing the target tissue to be detected, located, or imaged, and for the medical instrument to positioned or targeted relative to the target tissue, and for allowing the accuracy of placement or the progress of a procedure to be assessed in real time. A method for the system is also described.
摘要翻译：一种用于使用其中光源（102）光学耦合到要诊断的组织（135）的光学造影剂来检测，定位和瞄准医疗器械朝向身体内的目标组织的系统（135），光检测器（174）光学耦合到组织以检测穿过组织的一部分光，并且光源和光检测器中的一个或两者耦合到医疗过程中使用的医疗器械（130）。对比度定位器引擎（184）从检测器接收信号，并基于造影剂的定位和分布提供目标组织输出信号（195），允许检测，定位或成像目标组织，并且对于医疗器械相对于目标组织定位或靶向，并且用于允许实时评估放置的准确性或程序的进展。还描述了该系统的方法。

53. 发明授权

US5785658A In vivo tissue analysis methods and apparatus 失效
标题翻译：体内组织分析方法和装置
公开(公告)号：US5785658A
公开(公告)日：1998-07-28
申请号：US473004
申请日：1995-06-07
申请人： David A. Benaron , Daniel S. Goldberger
发明人： David A. Benaron , Daniel S. Goldberger
IPC分类号： A61B5/00 , A61B17/00 , A61B17/068 , A61B17/28 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , G01N21/47 , A61B6/00
CPC分类号： A61B17/3417 , A61B17/3494 , A61B18/00 , A61B5/0084 , A61B5/0086 , A61B5/6848 , G01N21/4795 , A61B17/068 , A61B17/29 , A61B17/3474 , A61B18/14 , A61B2017/00022 , A61B2017/00057 , A61B2017/00061 , A61B2017/00119 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2090/3614 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , A61B5/0075
摘要： A tool for nondestructive interrogation of the tissue including a light source emitter and detector which may be mounted directly on the surgical tool in a tissue contacting surface for interrogation or mounted remotely and guided to the surgical field with fiber optic cables. The light source may be broadband and wavelength differentiation can be accomplished at the detector via filters or gratings, or using time, frequency, or space resolved methods. Alternatively, n discrete monochromatic light sources may be provided which are subsequently multiplexed into a single detector by time or by frequency multiplexing. The optical sensing elements can be built into a surgical tool end effector tip such as a tissue grasping tool which has cooperating jaws (bivalve or multi-element). In the preferred embodiment the light source (or the fiber optic guide) is mounted on one jaw and the detector (or fiber optic guide) is mounted in the opposing jaw so that the light emitter and detector are facing one another either directly (i.e., on the same optical axis when the tool is closed) or acutely (i.e., with intersecting optical axes so that the light emitted is detected). In this case, the sensor is working in a transmission modality. Arrangements with the optical components mounted on the same member of a single member or a multi member structure, operating in a reflective modality, are disclosed.
摘要翻译：一种用于非破坏性询问组织的工具，包括光源发射器和检测器，其可以直接安装在组织接触表面上的外科手术器件上用于询问或远程安装并且用光纤电缆引导到外科手术区域。光源可以是宽带的，并且可以在检测器通过滤波器或光栅，或者使用时间，频率或空间分辨的方法来实现波长分化。或者，可以提供n个离散单色光源，其随后通过时间或通过频率复用复用到单个检测器中。光学感测元件可以内置在外科工具末端执行器尖端中，例如具有配合的钳口（双壳体或多元件）的组织抓取工具。在优选实施例中，光源（或光纤引导件）安装在一个钳口上，并且检测器（或光纤引导件）安装在相对的钳口中，使得发光器和检测器直接彼此面对（即，在工具关闭时在相同的光轴上）或锐利地（即，具有相交的光轴，使得检测到发射的光）。在这种情况下，传感器以传输模式工作。公开了以反射模式操作的安装在单个构件或多构件结构的同一构件上的光学构件的布置。

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