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51. 发明授权

US5234921A Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals 失效
标题翻译：咪唑并吡啶羧酸的间 - 环氮杂酰胺及其类似物作为药物
公开(公告)号：US5234921A
公开(公告)日：1993-08-10
申请号：US896244
申请日：1992-06-10
申请人： Daniel L. Flynn , Alan E. Moormann , Roger Nosal
发明人： Daniel L. Flynn , Alan E. Moormann , Roger Nosal
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：含有本文所述的内消旋 - 侧链侧链的咪唑并吡啶可用作5-羟色胺5-HT 3受体的拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑症，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和/或戒断，胃肠蠕动性窒息（包括食管反流，消化不良，肠易激综合征），由化疗药引起的呕吐和内脏痛。此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

52. 发明授权

US5155110A Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition 失效
标题翻译：具有环孢菌素和5-LIPOXYGENASE抑制作用的药用酸性羟肟酸衍生物
公开(公告)号：US5155110A
公开(公告)日：1992-10-13
申请号：US248204
申请日：1988-09-26
申请人： David T. Connor , Daniel L. Flynn
发明人： David T. Connor , Daniel L. Flynn
IPC分类号： C07D209/38 , C07D209/40 , C07D239/92 , C07D239/96
CPC分类号： C07D239/92 , C07D209/38 , C07D209/40 , C07D239/96
摘要： The present invention is novel selected hydroxamic acid derivatives of fenamic acids having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.

53. 发明授权

US4943587A Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition 失效
标题翻译：所选非甾体抗炎酰基残基的羟肟酸衍生物及其对环氧合酶和5-脂氧合酶抑制的用途
公开(公告)号：US4943587A
公开(公告)日：1990-07-24
申请号：US196584
申请日：1988-05-19
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Daniel L. Flynn , Jagadish C. Sircar
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Daniel L. Flynn , Jagadish C. Sircar
IPC分类号： C07D209/12 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/395 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/535 , A61K31/5377 , A61P3/00 , A61P11/08 , A61P25/04 , A61P29/00 , A61P37/08 , C07C257/06 , C07C259/04 , C07C317/40 , C07D207/337 , C07D209/26 , C07D209/46 , C07D209/82 , C07D231/12 , C07D263/32 , C07D263/46 , C07D277/00 , C07D279/00 , C07D307/72 , C07D307/92 , C07D313/12 , C07D487/04 , C07D491/044 , C07D491/052 , C07D495/04
CPC分类号： C07C257/06 , C07C317/40 , C07D209/26 , C07C2102/08
摘要： The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.

54. 发明授权

US4933489A Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene 失效
标题翻译：制备6-氯-1,4-二乙酰氧基-2,3-二甲氧基萘的方法
公开(公告)号：US4933489A
公开(公告)日：1990-06-12
申请号：US790720
申请日：1985-10-24
申请人： Daniel L. Flynn
发明人： Daniel L. Flynn
IPC分类号： C07C69/16 , C07C46/00 , C07C50/32 , C07C67/08
CPC分类号： C07C50/32 , C07C46/00
摘要： An improved process for the manufacture of the antipsoriatic agent, 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene, is herein described which involves in situ Diels-Alder coupling of 2,3-dimethoxybenzo-1,4-quinone with a 3-chloro-1-alkoxy-1,3-butadiene; 1,4-elimination of the alcohol with aromatization of the chlorine-bearing ring, and acetylation.
摘要翻译：本文描述了制备抗氧化剂，6-氯-1,4-二乙酰氧基-2,3-二甲氧基萘的改进方法，其涉及2,3-二甲氧基苯并-1,4-醌的原位狄尔斯 - 阿尔德偶联与3-氯-1-烷氧基-1,3-丁二烯; 用含氯环芳构化的1,4-消除醇和乙酰化。

55. 发明授权

US07153959B2 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US07153959B2
公开(公告)日：2006-12-26
申请号：US10374781
申请日：2003-02-25
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
IPC分类号： C07D401/04 , C07D401/14 , C07D413/02
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是如说明书中所述。

57. 发明授权

US06794396B2 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity 失效
标题翻译：用于抑制胆固醇酯转移蛋白活性的取代的吡啶
公开(公告)号：US06794396B2
公开(公告)日：2004-09-21
申请号：US10403903
申请日：2003-03-31
申请人： Len F. Lee , Kevin C. Glenn , Daniel T. Connolly , David G. Corley , Daniel L. Flynn , Ashton T. Hamme , Shridhar G. Hegde , Michele A. Melton , Roger J. Schilling , James A. Sikorski , Nancy N. Wall , Jeffery A. Zablocki
发明人： Len F. Lee , Kevin C. Glenn , Daniel T. Connolly , David G. Corley , Daniel L. Flynn , Ashton T. Hamme , Shridhar G. Hegde , Michele A. Melton , Roger J. Schilling , James A. Sikorski , Nancy N. Wall , Jeffery A. Zablocki
IPC分类号： C07D21302
CPC分类号： A61K31/44
摘要： A class of substituted pyridines that are useful for inhibiting the activity of cholesteryl ester transfer protein, and have the structural formula (IA), wherein R2, R3, R4, R5, and R6 are defined in the claims.
摘要翻译：一类可用于抑制胆固醇酯转移蛋白活性的取代吡啶，并具有结构式（IA），其中R 2，R 3，R 4，R 5和R 6在权利要求书中定义。

58. 发明授权

US06683077B2 2-Amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并恶嗪酮用于治疗病毒感染
公开(公告)号：US06683077B2
公开(公告)日：2004-01-27
申请号：US10035433
申请日：2002-01-04
申请人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
发明人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
IPC分类号： A61K31535
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式I定义，其中R-R 4如本文所定义，或其药学上可接受的盐。

59. 发明授权

US06423713B1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US06423713B1
公开(公告)日：2002-07-23
申请号：US09918481
申请日：2001-07-31
申请人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
发明人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC分类号： A61K31496
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式IA定义，其中R1，R2，R3和R4如说明书中所述。

60. 发明授权

US5202344A N-substituted lactams useful as cholecystokinin antagonists 失效
标题翻译： N-取代的LACTAMS有用作为CHOLECYSTOKININ ANTAGONISTS
公开(公告)号：US5202344A
公开(公告)日：1993-04-13
申请号：US626590
申请日：1990-12-11
申请人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
IPC分类号： A61K31/40 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/47 , A61K31/495 , A61P43/00 , C07D205/085 , C07D207/273 , C07D207/277 , C07D207/28 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D207/28 , C07D403/12
摘要： This invention relates to novel N-substituted lactams having the following formula ##STR1## useful in the treatment and prevention of Cholecystokinin (CCK) related disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals.
摘要翻译：本发明涉及具有下式的新型N-取代内酰胺，其可用于治疗和预防哺乳动物胃肠道，中枢神经和食欲调节系统中胆囊收缩素（CCK）相关疾病。

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