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51. 发明申请

US20170298373A1 PLANT PROMOTER AND 3'UTR FOR TRANSGENE EXPRESSION 审中-公开
公开(公告)号：US20170298373A1
公开(公告)日：2017-10-19
申请号：US15453121
申请日：2017-03-08
申请人： Dow AgroSciences LLC
发明人： Manju Gupta , Sandeep Kumar , Shavell Gorman , Andrew F. Worden
IPC分类号： C12N15/82 , C12N15/65 , A01H5/12
CPC分类号： C12N15/8225 , C12N15/113 , C12N15/8223 , C12N15/8286 , Y02A40/162
摘要： This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays GRMZM2G138258 promoter. Some embodiments relate to a Zea mays GRMZM2G138258 promoter that functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a Zea mays GRMZM2G138258 3′UTR that functions in plants to terminate transcription of operably linked nucleotide sequences.

52. 发明授权

US09777286B2 Zea mays metallothionein-like regulatory elements and uses thereof 有权
公开(公告)号：US09777286B2
公开(公告)日：2017-10-03
申请号：US14505055
申请日：2014-10-02
申请人： Dow AgroSciences LLC
发明人： Manju Gupta , Sandeep Kumar , Navin Elango , Karthik Narayna Muthuraman , Jeffrey Beringer , Huixia Wu , Nagesh Sardesai
IPC分类号： C12N15/82
CPC分类号： C12N15/8227 , C12N15/8216 , C12N15/8222
摘要： Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using Zea mays metallothionein-like gene regulatory elements.

53. 发明申请

US20170081675A1 PLANT PROMOTER AND 3' UTR FOR TRANSGENE EXPRESSION 审中-公开
公开(公告)号：US20170081675A1
公开(公告)日：2017-03-23
申请号：US15266348
申请日：2016-09-15
申请人： Dow AgroSciences LLC
发明人： Manju Gupta , Sara Bennett , Andrew F. Worden
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C07K14/415 , C12N15/8205 , C12N15/8222 , C12N15/8241 , C12N15/8273 , C12N15/8274 , C12N15/8286
摘要： This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a 3′UTR from Arabidopsis thaliana Ubiquitin C9 gene. Some embodiments relate to a 3′ UTR from a Arabidopsis thaliana Ubiquitin C9 gene that functions in plants to terminate transcription of operably linked nucleotide sequences.

54. 发明授权

US09422569B2 Construct and method for synthetic bidirectional plant promoter UBI1 有权
标题翻译：合成双向植物启动子UBI1的构建和方法
公开(公告)号：US09422569B2
公开(公告)日：2016-08-23
申请号：US13674606
申请日：2012-11-12
申请人： Dow AgroSciences LLC
发明人： Sandeep Kumar , Diaa Alabed , Terry Wright , Manju Gupta
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8222 , C12N15/8286 , Y02A40/162
摘要： Provided are constructs and methods for expressing multiple genes in plant cells and/or plant tissues. The constructs provided comprise at least one bidirectional promoter link to multiple gene expression cassettes. In some embodiments, the constructs and methods provided employ a bidirectional promoter based on a minimal core promoter element from a Zea mays Ubiquitin-1 gene, or a functional equivalent thereof. In some embodiments, the constructs and methods provided allow expression of genes between three and twenty.
摘要翻译：提供了用于在植物细胞和/或植物组织中表达多个基因的构建体和方法。所提供的构建物包含至少一个与多个基因表达盒的双向启动子连接。在一些实施方案中，提供的构建体和方法使用基于来自玉米泛素-1基因的最小核心启动子元件或其功能等同物的双向启动子。在一些实施方案中，提供的构建体和方法允许在3至20个之间表达基因。

55. 发明申请

US20140090113A1 ENGINEERED TRANSGENE INTEGRATION PLATFORM (ETIP) FOR GENE TARGETING AND TRAIT STACKING 审中-公开
标题翻译：用于基因定位和路由堆栈的工程变换集成平台（ETIP）
公开(公告)号：US20140090113A1
公开(公告)日：2014-03-27
申请号：US14020575
申请日：2013-09-06
申请人： Dow AgroSciences LLC
发明人： Noel Cogan , John Forster , Matthew Hayden , Tim Sawbridge , German Spangenberg , Steven R. Webb , Manju Gupta , W. Mike Ainley , Matthew J. Henry , John Mason , Sandeep Kumar , Stephen Novak
IPC分类号： C12N15/82
摘要： An Engineered Transgene Integration Platform (ETIP) is described that can be inserted randomly or at targeted locations in plant genomes to facilitate rapid selection and detection of a GOI that is perfectly targeted (both the 5′ and 3′ ends) at the ETIP genomic location. One element in the subject disclosure is the introduction of specific double stranded breaks within the ETIP. In some embodiments, an ETIP is described using zinc finger nuclease binding sites, but may utilize other targeting technologies such as meganucleases, CRISPRs, TALs, or leucine zippers. Also described are compositions of, and methods for producing, transgenic plants wherein the donor or payload DNA expresses one or more products of an exogenous nucleic acid sequence (e.g. protein or RNA) that has been stably-integrated into an ETIP in a plant cell. In embodiments, the ETIP facilitates testing of gene candidates and plant expression vectors from ideation through Development phases.
摘要翻译：描述了可以随机或在植物基因组中的目标位置插入工程化转基因整合平台（ETIP），以便于在ETIP基因组位置上完全靶向（5'和3'末端）的GOI的快速选择和检测。主题披露中的一个要素是在ETIP内引入特定的双链断裂。在一些实施方案中，使用锌指核酸酶结合位点描述ETIP，但可以利用其它靶向技术，例如大范围核酸酶，CRISPR，TAL或亮氨酸拉链。还描述了转基因植物的组合物和生产方法，其中供体或有效载体DNA表达已经稳定整合到植物细胞中的ETIP中的外源核酸序列（例如蛋白质或RNA）的一种或多种产物。在实施方案中，ETIP有助于从构想到开发阶段测试基因候选物和植物表达载体。

56. 发明申请

US20130326725A1 TARGETED MODIFICATION OF MALATE DEHYDROGENASE 有权
标题翻译：恶性脱氢酶的目标修饰
公开(公告)号：US20130326725A1
公开(公告)日：2013-12-05
申请号：US13875992
申请日：2013-05-02
申请人： Dow AgroSciences LLC , Sangamo BioSciences, Inc.
发明人： Vipula Shukla , Manju Gupta , Fyodor Urnov , Dmitry Guschin , Michiel Jan De Both , Paul Bundock
IPC分类号： C12N15/82 , A01C14/00
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
摘要翻译：本文公开了用于靶向修饰一种或多种内源性植物苹果酸脱氢酶基因的方法和组合物。

57. 发明申请

US20130145503A1 ENGINEERED ZINC FINGER PROTEINS TARGETING 5-ENOLPYRUVYL SHIKIMATE-3-PHOSPHATE SYNTHASE GENES 有权
公开(公告)号：US20130145503A1
公开(公告)日：2013-06-06
申请号：US13766380
申请日：2013-02-13
申请人： c/o Dow AgroSciences LLC , c/o Sangamo BioSciences, Inc.
发明人： Manju Gupta , Asha M. Palta , Stephen Novak , Fyodor Urnov , Sunita Gopalan
IPC分类号： C12N15/82
CPC分类号： C12N15/8213 , C07K2319/00 , C07K2319/81 , C12N9/1092 , C12N15/8243 , C12N15/8274
摘要： The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.

58. 发明授权

US09029629B2 Altered FAD2 and FAD3 genes in Brassica and the molecular marker-assisted detection thereof 有权
标题翻译：在芸苔属中改变FAD2和FAD3基因及其分子标记辅助检测
公开(公告)号：US09029629B2
公开(公告)日：2015-05-12
申请号：US10545100
申请日：2004-02-11
申请人： Xueyi Hu , Mandy Lynne Sullivan-Gilbert , Manju Gupta , Steven Arnold Thompson
发明人： Xueyi Hu , Mandy Lynne Sullivan-Gilbert , Manju Gupta , Steven Arnold Thompson
IPC分类号： A01H1/02 , A01H1/04 , A01H5/00 , C12N9/02 , C12N15/82
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N9/0071 , C12N9/0083 , C12N15/8247 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Y114/19001
摘要： The present invention provides methods of marker-assisted selection for high oleic/low linolenic traits in canola and in other oil seed crop species, as well as isolated nucleic acids for use as molecular markers in such methods. In particular, molecular markers and Brassica nucleic acid corresponding to fad2 and fad3 gene mutations are disclosed. The markers of the present invention are highly useful for the direct selection of desirable fad2 and fad3 alleles during marker-assisted trait introgression and breeding. In one aspect of the embodiment, two single nucleotide polymorphism (SNP) markers are provided that correspond to the alleles. Thus, the present invention advantageously permits one of skill in the art to breed for the molecular markers described herein, or derivatives thereof, rather than breeding for a high oleic/low linolenic phenotype.
摘要翻译：本发明提供了油菜和其他油料种子作物中高油酸/低亚麻酸性状的标记辅助选择方法，以及分离的核酸，用作这些方法中的分子标记。特别地，公开了对应于fad2和fad3基因突变的分子标记和芸苔属核酸。本发明的标记对于在标记辅助性状渗入和育种期间直接选择期望的fad2和fad3等位基因是非常有用的。在该实施方案的一个方面，提供了对应于等位基因的两个单核苷酸多态性（SNP）标记。因此，本发明有利地允许本领域技术人员繁殖本文所述的分子标记或其衍生物，而不是育种高油酸/低亚麻酸表型。

59. 发明授权

US08952223B2 Corn event DAS-59122-7 and methods for detection thereof 有权
标题翻译：玉米事件DAS-59122-7及其检测方法
公开(公告)号：US08952223B2
公开(公告)日：2015-02-10
申请号：US11938483
申请日：2007-11-12
申请人： James Wayne Bing , Robert F. Cressman, Jr. , Manju Gupta , Salim M. Hakimi , David Hondred , Todd L. Krone , Mary E. Hartnett Locke , Abigail K. Luckring , Sandra E. Meyer , Daniel Moellenbeck , Kenneth Edwin Narva , Paul D. Olson , Craig D. Sanders , Jimei Wang , Jian Zhang , Gan-Yuan Zhong
发明人： James Wayne Bing , Robert F. Cressman, Jr. , Manju Gupta , Salim M. Hakimi , David Hondred , Todd L. Krone , Mary E. Hartnett Locke , Abigail K. Luckring , Sandra E. Meyer , Daniel Moellenbeck , Kenneth Edwin Narva , Paul D. Olson , Craig D. Sanders , Jimei Wang , Jian Zhang , Gan-Yuan Zhong
IPC分类号： C12N15/82 , C12N15/11 , C07K14/415 , C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/415 , C12N15/8277 , C12N15/8286 , C12Q1/6895 , C12Q2600/13 , Y02A40/162
摘要： The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
摘要翻译：本发明提供了与转基因抗虫玉米植物相关的DNA组合物。还提供了基于插入到玉米基因组中的重组构建体的DNA序列和插入位点侧翼的DNA序列来检测玉米DAS-59122-7事件的存在的测定。提供了用于进行测定的试剂盒和条件。

60. 发明授权

US08399218B2 Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes 有权
公开(公告)号：US08399218B2
公开(公告)日：2013-03-19
申请号：US12284888
申请日：2008-09-25
申请人： Manju Gupta , Asha M. Palta , Stephen Novak , Fyodor Urnov , Sunita Gopalan
发明人： Manju Gupta , Asha M. Palta , Stephen Novak , Fyodor Urnov , Sunita Gopalan
IPC分类号： C12P21/06 , C07H21/02 , C07K14/00
CPC分类号： C12N15/8213 , C07K2319/00 , C07K2319/81 , C12N9/1092 , C12N15/8243 , C12N15/8274
摘要： The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.

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