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51. 发明申请

US20060100706A1 Stent systems and methods for spine treatment 审中-公开
标题翻译：支架系统和脊柱治疗方法
公开(公告)号：US20060100706A1
公开(公告)日：2006-05-11
申请号：US11130843
申请日：2005-05-16
申请人： John Shadduck , Csaba Truckai
发明人： John Shadduck , Csaba Truckai
IPC分类号： A61F2/44
CPC分类号： A61B17/7098 , A61B17/1617 , A61B17/1671 , A61F2/44 , A61F2/4601
摘要： Stent systems and methods for expanding and deploying stents in hard tissue such as bone, more particularly within a vertebral body. One exemplary method includes using a stent body that is coupled to a high speed rotational motor with the stent expandable and detachable from an introducer working end. In one embodiment, the stent is a deformable metal body with zig-zag type struts in an expanded configuration that carries diamond cutting particles bonded to the strut surfaces. The “spin” stent is rotated at high rpm's to remove cancellous bone from the deployment site together with irrigation and aspiration at the end of the probe that carries the stent. The stent may be expanded asymmetrically, such as with first and second balloons or by using an interior restraint, to apply vertical distraction forces to move apart the cortical endplates and support the vertebra in the distracted condition. The cancellous bone about the expanded stent as well as the interior of the stent can be filled with a bone cement, allograft or other bone graft material. In one method of use, the spin stent is designed and adapted for (i) treating a vertebral compression fracture (VCF) or for (ii) reinforcing an osteoporotic vertebral body.
摘要翻译：用于在诸如骨骼的硬组织中扩张和展开支架的支架系统和方法，特别是在椎体内。一个示例性方法包括使用支架主体，该支架主体与高速旋转马达相连，支架能够从导引器工作端伸出和拆卸。在一个实施例中，支架是可变形的金属体，其具有处于结合到支柱表面的金刚石切割颗粒的膨胀构造中的锯齿形支柱。 “旋转”支架以高转速旋转以从部署部位移除松质骨，同时在携带支架的探针末端进行冲洗和抽吸。支架可以不对称地扩张，例如通过第一和第二气囊或通过使用内部约束装置来施加垂直牵引力以使皮质端板分开并在分心状态下支撑椎骨。关于扩张的支架以及支架的内部的松质骨可以用骨水泥，同种异体移植物或其他骨移植材料填充。在一种使用方法中，旋转支架设计和适用于（i）治疗椎体压缩性骨折（VCF）或（ii）加强骨质疏松性椎体。

52. 发明申请

US20060089715A1 Implants and methods for treating bone 有权
公开(公告)号：US20060089715A1
公开(公告)日：2006-04-27
申请号：US11146893
申请日：2005-06-07
申请人： Csaba Truckai , John Shadduck
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61F2/44
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00004 , A61F2/44 , A61F2/4455 , A61F2/4611 , A61F2002/30062 , A61F2002/30289 , A61F2002/30579 , A61F2002/30677 , A61F2210/0004 , A61F2230/0091
摘要： An orthopedic implant comprising a deformable, expandable implant body configured for treating abnormalities in bones, such as compression fractures of vertebra, necrosis of femurs and the like. An exemplary implant body comprises a small cross-section threaded element that is introduced into a bone region and thereafter is expanded into a larger cross-section, monolithic assembly to provide a bone support. In one embodiment, the implant body is at least partly fabricated of a magnesium alloy that is biodegradable to allow for later tissue ingrowth.

53. 发明申请

US20060085081A1 Implants and methods for treating bone 审中-公开
标题翻译：植入物和治疗骨的方法
公开(公告)号：US20060085081A1
公开(公告)日：2006-04-20
申请号：US11146891
申请日：2005-06-07
申请人： John Shadduck , Csaba Truckai
发明人： John Shadduck , Csaba Truckai
IPC分类号： A61F2/02
CPC分类号： A61B17/68 , A61B17/7095 , A61B2017/00004
摘要： An implant system that includes small cross-section implant elements that can be introduced into targeted bone regions wherein the elements self-assemble into a large cross-section, higher modulus monolith. The implant elements are configured with properties engage one another, such as surface features or magnetic properties. The implants and methods can be used to treat bone abnormalities such as compression fractures of vertebrae, bone necrosis, bone tumors, cysts and the like.
摘要翻译：一种植入系统，其包括可以被引入目标骨区域的小横截面植入元件，其中元件自组装成大截面，更高模量的整料。植入元件被构造成具有彼此接合的特性，例如表面特征或磁性。植入物和方法可用于治疗骨骼异常，如椎骨压缩性骨折，骨坏死，骨肿瘤，囊肿等。

54. 发明申请

US20060069388A1 Electrosurgical instrument and method 有权
公开(公告)号：US20060069388A1
公开(公告)日：2006-03-30
申请号：US11173878
申请日：2005-07-02
申请人： Csaba Truckai , John Shadduck
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61B18/14 , A61B17/32
CPC分类号： A61B18/1445 , A61B17/320016 , A61B17/3201 , A61B18/08 , A61B18/085 , A61B18/1442 , A61B18/1815 , A61B2017/00084 , A61B2017/2933 , A61B2017/2934 , A61B2017/2945 , A61B2017/320064 , A61B2018/00107 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/1432
摘要： An electrosurgical working end and method for sealing and transecting tissue. An exemplary working end provides curved jaw members that are positioned on opposing sides of the targeted anatomic structure. The working end carries a slidable extension member having flange portions with inner surfaces that slide over the jaw members to clamp tissue therebetween. The working end carries an independent slidable cutting member that is flexible to follow the curved axis of the jaws. The electrosurgical surfaces of the jaws include partially-resistive bodies for carrying a current or load which modulates ohmic heating in the engaged tissue to prevent charring and desiccation of tissue to create a high strength thermal seal.

55. 发明申请

US20060000823A1 Polymer compositions exhibiting a PTC property and methods of fabrication 有权
标题翻译：展示PTC性质的聚合物组合物和制造方法
公开(公告)号：US20060000823A1
公开(公告)日：2006-01-05
申请号：US10993210
申请日：2004-11-18
申请人： Csaba Truckai , John Shadduck
发明人： Csaba Truckai , John Shadduck
IPC分类号： H05B1/02
CPC分类号： H05B3/146 , A61B18/14 , H05B2203/02
摘要： Various embodiments of the invention provide polymeric compositions including PTC composites that exhibit highly non-linear PTC effects together with extremely rapid, repeatable switching within a predetermined temperature range. In one embodiment, the polymer composite includes a polymer base material with dispersed conductive particles that have very low densities and very low thermal conductivity properties. The conductive particle component can comprise hollow glass microspheres to provide low mass and low thermal conductivity properties together with a nanoscale conductive cladding of silver or gold. The conductively clad microspheres have a core portion with a bulk density of less than about 2.0 g/cm3 and a mean thermal conductivity of less than about 5.0 W/m-° K.
摘要翻译：本发明的各种实施方案提供了包含PTC复合材料的聚合物组合物，其在预定温度范围内显示高度非线性的PTC效应以及非常快速，可重复的切换。在一个实施方案中，聚合物复合材料包括具有分散的导电颗粒的聚合物基体材料，其具有非常低的密度和非常低的导热性能。导电颗粒组分可以包括中空玻璃微球，以提供低质量和低导热性以及银或金的纳米级导电包层。导电包覆的微球体具有堆积密度小于约2.0g / cm 3的核心部分，并且平均热导率小于约5.0W / m-°K.

56. 发明申请

US20050159745A1 Electrosurgical instrument with replaceable cartridge 有权
标题翻译：电子手术器具可更换墨盒
公开(公告)号：US20050159745A1
公开(公告)日：2005-07-21
申请号：US11038930
申请日：2005-01-18
申请人： Csaba Truckai , John Shadduck , James Baker
发明人： Csaba Truckai , John Shadduck , James Baker
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B17/32 , A61B2017/2945 , A61B2018/00619 , A61B2018/00755 , A61B2018/00791 , A61B2018/00875 , A61B2018/1432 , A61B2018/1495
摘要： Various embodiments provide an electrosurgical instrument with a disposable electrosurgical cartridge. In one embodiment, the cartridge has first and second energy-delivery surfaces that carry first and second opposing polarity conductors coupled to a voltage source, together with first and second temperature-responsive variable impedance bodies exposed partly in the respective-delivery surfaces. The cartridge further carries a slidable blade member. The temperature-responsive variable impedance bodies are coupled to the voltage source by series and parallel circuitry. In use, the variable impedance bodies are adapted to modulate current flow and ohmic heating in engaged tissue by providing controlled current paths in the tissue and through the variable impedance bodies as the temperature-responsive bodies sense the temperature of adjacent engaged tissue. The engagement surfaces are capable of highly localized modulation of Rf energy application to engaged tissue to provide high and low temperatures, voltage and current in the tissue to create high strength welds.
摘要翻译：各种实施例提供具有一次性电外科手术盒的电外科器械。在一个实施例中，盒具有第一和第二能量传递表面，其承载耦合到电压源的第一和第二相对极性导体以及部分地暴露在相应输送表面中的第一和第二温度响应可变阻抗体。该盒还带有可滑动的刀片部件。温度响应可变阻抗体通过串联和并联电路耦合到电压源。在使用中，可变阻抗体适于通过在温度响应体感测相邻接合组织的温度时通过在组织中和通过可变阻抗体中提供受控的电流路径来调制接合组织中的电流和欧姆加热。接合表面能够对接合组织进行Rf能量的高度局部调节，以在组织中提供高和低温度，电压和电流以产生高强度焊缝。

57. 发明申请

US20070142831A1 Surgical Instruments And Techniques For Treating Gastro-Esophageal Reflux Disease 有权
标题翻译：手术器械和技术治疗胃食管反流病
公开(公告)号：US20070142831A1
公开(公告)日：2007-06-21
申请号：US11469816
申请日：2006-09-01
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B18/14
CPC分类号： A61N1/326 , A61B18/1485 , A61B18/1492 , A61B90/39 , A61B2018/00047 , A61B2018/00285 , A61B2018/00482 , A61B2018/00494 , A61B2018/00553 , A61B2018/00678 , A61B2018/00726 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1861 , A61B2090/3782 , A61B2218/002
摘要： An apparatus to treat tissue in a selected wall region of an esophagus is provided. In one embodiment the apparatus inlcudes an elongate member having a circumference and is sized to be deployed in an esophagus. The apparatus further includes an energy delivery element sized to apply electrical energy to tissue in the esophagus, and to produce a pattern of treated tissue within a less than 180° circumferential portion of the esophagus. The elongate member further includes an expandable structure to stabilize the energy delivery element in physical and electrical contact with tissue.
摘要翻译：提供了一种用于治疗食道的选定壁区域中的组织的装置。在一个实施例中，装置包括具有圆周的细长构件，并且其尺寸被设计成部署在食道中。该装置还包括能量递送元件，其尺寸设置成将电能施加到食道中的组织，并且在食道的小于180°的圆周部分内产生经处理的组织的图案。细长构件还包括可膨胀结构，以稳定能量递送元件与组织的物理和电接触。

58. 发明申请

US20070299487A1 Adaptive Optic Lens and Method of Making 有权
标题翻译：自适应光学透镜及其制作方法
公开(公告)号：US20070299487A1
公开(公告)日：2007-12-27
申请号：US11849921
申请日：2007-09-04
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61F2/16 , A61N5/067
CPC分类号： G02B3/14 , A61F2/145 , A61F2/1613 , A61F2/1635 , A61F2210/0014 , G02B26/06
摘要： A lens for correcting human vision, for example an IOL, contact lens or corneal inlay or onlay, that carries and interior phase or layer comprising a pattern of individual transparent adaptive displacement structures. In the exemplary embodiments, the displacement structures are actuated by shape change polymer that adjusts a shape or other parameter in response to applied energy that in turn displaces a fluid media within the lens that actuates a flexible lens surface. The adaptive optic means of the invention can be used to create highly localized surface corrections in the lens to correct higher order aberrations-which types of surfaces cannot be fabricated into and IOL and then implanted. The system of displacement structures also can provide spherical corrections in the lens.
摘要翻译：用于矫正人类视觉的镜片，例如IOL，隐形眼镜或角膜镶嵌物或镶嵌物，其携带和内部相或包含单独的透明自适应位移结构的图案的层。在示例性实施例中，位移结构由形状变化聚合物致动，聚合物响应于所施加的能量而调节形状或其它参数，所述能量又使透镜内的流体介质移动，该流体介质致动柔性透镜表面。本发明的自适应光学装置可以用于在透镜中产生高度局部化的表面校正，以校正高阶像差 - 哪些类型的表面不能被制造和IOL然后植入。位移结构的系统也可以在透镜中提供球面校正。

59. 发明申请

US20060200173A1 Instruments and techniques for controlled removal of epidermal layers 有权
标题翻译：用于控制去除表皮层的仪器和技术
公开(公告)号：US20060200173A1
公开(公告)日：2006-09-07
申请号：US11417709
申请日：2006-05-03
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B17/50
CPC分类号： A61B17/545 , A61B17/50 , A61B17/54 , A61B2017/00761 , A61B2017/320004 , A61B2217/005 , A61B2217/007 , A61M1/0064 , A61M35/00
摘要： An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response. The method of the invention creates more normal dermal architectures in skin with limited depths of skin removal by the series of superficial treatments that may be comparable to the extent of neocollagenesis caused by a deep skin removal treatment (e.g., CO2 laser skin removal).
摘要翻译：一种利用具有工作端的手持式仪器以受控方式去除表皮层的仪器和技术，该工具包括（i）真空抽吸系统，（ii）用于将无菌流体或药物剂递送至皮肤的源 ; 和（iii）工作端中的皮肤界面表面，其具有特殊的形状结构，用于当工作端移动到患者皮肤上同时使流体快速渗透到皮肤中时，用于研磨患者表皮的表面层治疗目的。穿过皮肤的工作端的移动导致患者皮肤上的路径中的表面层的磨损。本发明的方法可用于周期性治疗以通过诱导人体的自然伤口愈合反应来去除表皮层，从而增强真皮胶原聚集体的合成。本发明的方法在皮肤中产生更正常的皮肤结构，通过一系列表面处理具有有限的皮肤去除深度，其可以与由深层皮肤去除处理引起的新胶原形成的程度相当（例如， SUP>激光皮肤去除）。

60. 发明申请

US20050021139A1 Ophthalmic devices, methods of use and methods of fabrication 审中-公开
标题翻译：眼科装置，使用方法和制造方法
公开(公告)号：US20050021139A1
公开(公告)日：2005-01-27
申请号：US10890576
申请日：2004-10-07
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61F2/16
CPC分类号： A61F2/1694 , A61F2/1648
摘要： An adaptive optic for refractive lens exchange or cataract patients. The intracapsular implant comprises an elastomeric monolith with an equilibrium memory shape that imparts to the capsular sac's periphery the natural shape of the capsule in an accommodated state. In one embodiment, the monolith carries a recessed deformable central lens portion having an ultralow modulus that allows for high accommodative amplitude in response to equatorial tensioning. In a preferred embodiment, the adaptive optic defines an anisotropic modulus with a plurality of on-axis, rotationally symmetric elastomer block portions each having a different Young's modulus. The invention further provides composite materials for enhancing deformation of lens curvature, including the use of auxetic polymeric materials and negative stiffness materials. In preferred embodiments, at least a portion of the lens is fabricated of a shape memory polymer that provides a memory shape and a temporary shape with a reduced cross-sectional shape for introduction into the patient's eye.
摘要翻译：用于折射晶状体交换或白内障患者的自适应光学镜。囊内植入物包括具有平衡记忆形状的弹性体整体，其在囊状囊的外围处于容纳状态的胶囊的自然形状。在一个实施例中，整体式承载具有超低模量的凹陷的可变形的中心透镜部分，其允许响应于赤道张力的高调节幅度。在优选实施例中，自适应光学器件限定具有各自具有不同杨氏模量的多个在轴旋转对称的弹性体块部分的各向异性模量。本发明还提供了用于增强透镜曲率变形的复合材料，包括使用辅助聚合材料和负刚度材料。在优选实施例中，透镜的至少一部分由形状记忆聚合物制成，形状记忆聚合物提供具有减小的横截面形状的记忆形状和临时形状，用于引入患者眼睛。

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