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51. 发明授权

US5145847A 14,17.alpha.-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents 失效
标题翻译： 14,17（ALPHA） - 乙酸和乙二胺，其制备这些化合物的方法，以及其用于生产药物的用途
公开(公告)号：US5145847A
公开(公告)日：1992-09-08
申请号：US558340
申请日：1990-07-27
申请人： Rolf Bohlmann , Hermann Kunzer , Rudolf Wiechert , David Henderson , Martin Schneider , Yukishige Nishino
发明人： Rolf Bohlmann , Hermann Kunzer , Rudolf Wiechert , David Henderson , Martin Schneider , Yukishige Nishino
IPC分类号： A61K31/565 , A61P35/00 , C07J1/00 , C07J53/00
CPC分类号： C07J53/002
摘要： Disclosed are novel 14,17.alpha.-etheno- and -ethanoestratrienes according to general Formula I ##STR1## wherein X is a --CH.sub.2 --CH.sub.2 or ##STR2## R.sup.1 is a hydrogen atom, a C.sub.1 - to C.sub.15 -acyl, benzoyl, C.sub.1 - to C.sub.15 -alkyl, C.sub.3 - to C.sub.9 -cycloalkyl or alkylcycloalkyl group, andR.sup.2 is the grouping ##STR3## wherein R.sup.3 and R.sup.4 independently of each other mean a hydrogen atom or a straight-chain or branched, optionally partially or completely fluorinated C.sub.1 -C.sub.8 -alkyl group,a process for their preparation, pharmaceutical preparations containing these compounds, as well as their use for the production of medicinal agents.The novel compounds exhibit strong antiestrogenic efficacy.
摘要翻译：公开了根据通式I（I）的新型14,17α-乙烯 - 和 - 乙二醇三亚甲基，其中X是-CH 2 -CH 2或者R 1是氢原子，C 1至C 15酰基，苯甲酰基，C 1至C 15 - 烷基，C 3至C 9 - 环烷基或烷基环烷基，并且R 2为分组，其中R 3和R 4彼此独立地表示氢原子或直链或支链，任选地部分或部分完全氟化的C 1 -C 8烷基，其制备方法，含有这些化合物的药物制剂，以及它们用于制备药剂的用途。新化合物表现出强的抗雌激素疗效。

52. 发明授权

US5135937A Cycloalkylene azoles and pharmaceutical preparations obtained therefrom 失效
标题翻译： CYCLOALKYLENE AZOLES和药物制剂
公开(公告)号：US5135937A
公开(公告)日：1992-08-04
申请号：US563114
申请日：1990-08-03
申请人： Rolf Bohlmann , Peter Strehlke , David Henderson , Martin Schneider , Yukishige Nishino
发明人： Rolf Bohlmann , Peter Strehlke , David Henderson , Martin Schneider , Yukishige Nishino
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4174 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61P5/32 , A61P13/00 , A61P13/02 , A61P15/00 , A61P35/00 , C07D233/56 , C07D233/58 , C07D233/64 , C07D249/04 , C07D249/08 , C07D401/08 , C07D405/08 , C07D409/06 , C07D409/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/04 , C07D249/08
摘要： The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent,X is the grouping ##STR3## an oxygen or sulfur atom, and Y and Z, independently of each other, are ##STR4## or a nitrogen atom, as well as their pharmaceutically compatible addition salts with acids as well as processes for production thereof. The compounds possess strongly aromatase-inhibiting activity and are suitable for the preparation of medicinal agents.Methods for treating estrogen induced or stimulated tumors, male infertility, and impending cardiac infarction with these compounds are also provided as well as methods for inhibiting female fertility.
摘要翻译：本公开涉及通式I的环亚烷基唑类（I），其中，IMAGE是任选携带至少一个烷基取代基的碳环或多碳环基，X是氧或硫原子的基团，Y和 Z，彼此独立地是氮原子，以及它们与酸的药学上相容的加成盐以及其制备方法。该化合物具有强烈的芳香酶抑制活性，适用于制备药剂。还提供了用于治疗雌激素诱导或刺激的肿瘤，男性不育症和即将发生的这些化合物的心肌梗塞的方法以及抑制女性生育能力的方法。

53. 发明授权

US5021434A N-substituted imidazoles, as well as their use in pharmaceutical agents 失效
标题翻译： N-取代的咪唑，以及它们在药剂中的用途
公开(公告)号：US5021434A
公开(公告)日：1991-06-04
申请号：US331320
申请日：1989-03-31
申请人： Peter Strehlke , Rolf Bohlmann , David Henderson
发明人： Peter Strehlke , Rolf Bohlmann , David Henderson
IPC分类号： C07D401/06 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P13/02 , A61P15/00 , A61P35/00 , A61P43/00 , C07D233/56 , C07D233/58 , C07D233/60 , C07D233/61 , C07D401/12 , C07D409/00 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention relates to N-substituted imidazoles, processes for their production as well as their use in pharmaceutical agents.The compounds according to the invention have aromatase-inhibiting properties.

54. 发明授权

US4591585A 1-alkyl-androsta-1,4-diene-3,17-diones their production and pharmaceutical preparations containing same 失效
标题翻译： 1-烷基 - 雄甾-1,4-二烯-3,17-将其制备和含有它们的药物制剂分离
公开(公告)号：US4591585A
公开(公告)日：1986-05-27
申请号：US621769
申请日：1984-06-18
申请人： Ulrich Kerb , Gerhard Sauer , Rudolf Wiechert , David Henderson , Yukishige Nishino , Sybille Beier
发明人： Ulrich Kerb , Gerhard Sauer , Rudolf Wiechert , David Henderson , Yukishige Nishino , Sybille Beier
IPC分类号： A61K31/565 , A61P13/02 , A61P15/00 , A61P35/00 , C07J1/00 , A61K31/56
CPC分类号： C07J1/0011
摘要： 1-Alkyl androsta-1,4-diene-3,17-diones of the formula ##STR1## wherein R.sub.1 is a methyl, ethyl, hydroxymethyl, C.sub.1 -C.sub.3 -alkoxymethyl, or C.sub.1 -C.sub.4 -alkanoyloxymethyl group, R.sub.6 is a hydrogen atom or a methyl group, and R.sub.7 is a hydrogen atom or a methyl group in the 7.alpha.- or 7.beta.-position, are useful for fertility control and for the treatment of estrogen-triggered diseases.
摘要翻译：其中R 1是甲基，乙基，羟甲基，C 1 -C 3 - 烷氧基甲基或C 1 -C 4 - 烷酰氧基甲基，R 6是氢原子的1-烷基雄甾-1,4-二烯-3,17-二酮原子或甲基，R7是7α-或7β-位中的氢原子或甲基，可用于生育调控和用于治疗雌激素引发的疾病。

55. 发明授权

US4536401A 11.beta.-aryl estradienes, processes for their production and pharmaceutical preparations containing them 失效
标题翻译： 11β-芳基雌二醇，其制备方法和含有它们的药物制剂
公开(公告)号：US4536401A
公开(公告)日：1985-08-20
申请号：US581853
申请日：1984-02-21
申请人： Guenter Neef , Gerhard Sauer , Rudolf Wiechert , Helmut Hofmeister , Ralph Rohde , Klaus Annen , Henry Laurent , Sybille Beier , Wolfgang Losert , Walter Elger , David Henderson
发明人： Guenter Neef , Gerhard Sauer , Rudolf Wiechert , Helmut Hofmeister , Ralph Rohde , Klaus Annen , Henry Laurent , Sybille Beier , Wolfgang Losert , Walter Elger , David Henderson
IPC分类号： C07J1/00 , C07J21/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J63/00 , C07J71/00 , A61K31/58
CPC分类号： C07J41/0083 , C07J1/0081 , C07J21/003 , C07J21/006 , C07J31/006 , C07J33/005 , C07J41/0088 , C07J43/003 , C07J43/006 , C07J63/008 , C07J71/001
摘要： Compounds of the formula I ##STR1## wherein R.sub.1 is ##STR2## wherein R.sup.I and R.sup.II each independently is alkyl of 1-4 carbon atoms, or R.sup.I and R.sup.II together with the connecting N-atom form a 5- or 6-membered heterocyclic ring whose remaining atoms are all C-atoms, or which also includes and additional N-atom, an additional O or S atom or a combination thereof; ##STR3## wherein R.sup.I and R.sup.II are as defined above; --SR.sup.III, wherein R.sup.III is methyl, ethyl or phenyl; or--OR.sup.IV, wherein R.sup.IV is methyl, ethyl, propyl, methoxymethyl, allyl, or .beta.-dimethylaminoethyl;R.sub.2 is hydrogen, methyl, or ethyl; ##STR4## wherein the wavy lines mean that the substituent is in the .alpha.- or .beta.-position, and ##STR5## M is Na, K or Li; and R.sup.V, R.sup.VI, R.sup.VII and R.sup.VIII each independently is alkyl of 1-4 carbon atoms, have valuable pharmacological properties, e.g., a combination of antiprogestational and antimineralocorticordal effects.
摘要翻译：式Ⅰ的化合物其中R 1是R 1，其中R 1和R 2各自独立地是1-4个碳原子的烷基，或者R 1和R II与连接的N-原子一起形成5-或6-元环，其余的原子都是C原子，或者还包括和另外的N原子，另外的O或S原子或它们的组合; 其中RI和RII如上所定义; -SRIII，其中RIII是甲基，乙基或苯基; 或-ORIV，其中RIV是甲基，乙基，丙基，甲氧基甲基，烯丙基或β-二甲基氨基乙基; R2是氢，甲基或乙基; 其中波浪线意味着取代基位于α位或β位，而图像中的取代基为< + RE M是Na，K或Li; RV，RVI，RVII和RVIII各自独立地为1-4个碳原子的烷基，具有有价值的药理学性质，例如抗孕素和抗肌钙蛋白作用的组合。

56. 发明授权

US4436214A Anti-theft picnic device 失效
标题翻译：防盗野餐装置
公开(公告)号：US4436214A
公开(公告)日：1984-03-13
申请号：US450987
申请日：1982-12-20
申请人： David Henderson
发明人： David Henderson
IPC分类号： A45C13/18 , E05G1/00 , B65D25/24 , E02D5/80
CPC分类号： A45C13/18 , E05G1/005
摘要： A secure beach picnic chest assembly includes a lockable picnic chest and a centrally-disposed anti-theft anchoring device that extends through a through opening in the floor of the chest and can be pushed downwardly to become embedded in sand or soft soil. By turning an actuator handle at the top of the anchoring device, a plurality of anchoring members thereon can be moved between first and second positions. In their first positions, the anchoring members are disposed against the outside of a peripheral wall of the member, so that the member can be inserted into or withdrawn from the sand or soft soil. In their second positions, the anchoring members are angled outwardly from the peripheral wall for anchoring the anti-theft member and the picnic chest to prevent the latter from being carried away by casual thieves. The combination is useful, for example, at a beach, where food, clothes, and valuables can be placed in the chest, and the lid thereof can be secured by a lock, permitting the entire party of picnickers or bathers to leave the chest unattended and go swimming.
摘要翻译：一个安全的海滩野餐胸部组件包括一个可锁定的野餐胸部和一个中央布置的防盗锚固装置，其延伸穿过胸部底部的通孔，并可向下推动以嵌入沙子或软土中。通过在锚定装置的顶部转动致动器手柄，其上的多个锚固构件可以在第一和第二位置之间移动。在其第一位置中，锚定构件抵靠构件的周壁的外侧设置，使得构件可以插入或从砂土或软土中取出。在其第二位置，锚固构件从周壁向外成角度，用于锚定防盗构件和野餐胸部，以防止后者被随意的盗贼携带。该组合是有用的，例如，在海滩，食物，衣服和贵重物品可以放在胸部，并且其盖可以通过锁固定，允许野餐者或沐浴者的整个一方离开胸部无人值守并去游泳。

57. 外观设计

USD709642S1 Luminaire 有权
公开(公告)号：USD709642S1
公开(公告)日：2014-07-22
申请号：US29391822
申请日：2011-05-13
申请人： Fredric S. Maxik , David Henderson , Mark Penley Boomgaarden , Addy S. Widjaja , Emilio Flores , Shane Sullivan , Wei Sun
设计人： Fredric S. Maxik , David Henderson , Mark Penley Boomgaarden , Addy S. Widjaja , Emilio Flores , Shane Sullivan , Wei Sun

58. 外观设计

USD709640S1 Luminaire 有权
公开(公告)号：USD709640S1
公开(公告)日：2014-07-22
申请号：US29391818
申请日：2011-05-13
申请人： Fredric S. Maxik , David Henderson , Mark Penley Boomgaarden , Addy S. Widjaja , Emilio Flores , Shane Sullivan , Wei Sun
设计人： Fredric S. Maxik , David Henderson , Mark Penley Boomgaarden , Addy S. Widjaja , Emilio Flores , Shane Sullivan , Wei Sun

59. 发明授权

US08608341B2 LED luminaire 有权
标题翻译： LED灯具
公开(公告)号：US08608341B2
公开(公告)日：2013-12-17
申请号：US13336216
申请日：2011-12-23
申请人： Mark Penley Boomgaarden , Shane Sullivan , Ryan Chase Kelley , David Henderson
发明人： Mark Penley Boomgaarden , Shane Sullivan , Ryan Chase Kelley , David Henderson
IPC分类号： F21S4/00
CPC分类号： F21V3/02 , F21K9/23 , F21K9/60 , F21V7/041 , F21V29/773 , F21V29/83 , F21Y2103/33 , F21Y2115/10
摘要： Disclosed is a luminaire including an electrical base, a driver circuit in electrical communication with the electrical base, a heat sink operably coupled to the electrical base, a lens coupled to the heat sink and having a first portion adjacent the heat sink and a second portion adjacent the first portion, the first portion having at least one aperture disposed therein or therethrough, the at least one aperture having a different optical transmission property from the first portion in which the at least one aperture is disposed, a reflective member between the second portion and the heat sink, and an LED light source between the reflective member and the heat sink, the LED having at least one LED member between the reflective member and the first portion to emit light towards the reflective member, each LED member being disposed in electrical communication with the driver circuit.
摘要翻译：公开了一种照明装置，其包括电气基座，与电气基座电气连通的驱动电路，可操作地耦合到电气基座的散热器，耦合到散热器的透镜，并具有与散热器相邻的第一部分和第二部分邻近第一部分，第一部分具有设置在其中或穿过其中的至少一个孔，所述至少一个孔具有与设置有至少一个孔的第一部分不同的光学透射性质;第二部分之间的反射构件和散热器，以及在反射构件和散热器之间的LED光源，LED在反射构件和第一部分之间具有至少一个LED构件，以朝向反射构件发射光，每个LED构件设置在电气与驱动电路通讯。

60. 外观设计

USD682452S1 Luminaire 有权
公开(公告)号：USD682452S1
公开(公告)日：2013-05-14
申请号：US29413981
申请日：2012-02-23
申请人： David Henderson , Zach Gibler , Kenneth Marion Bowen , Stephanie Fulton Harris , Jay F. Perkins , Mohan Bokka Rao , Ryan Robert Berger , Michael T. Kopczewski
设计人： David Henderson , Zach Gibler , Kenneth Marion Bowen , Stephanie Fulton Harris , Jay F. Perkins , Mohan Bokka Rao , Ryan Robert Berger , Michael T. Kopczewski

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