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51. 发明申请

WO2016028799A1 LEADLESS CARDIAC PACEMAKER HAVING A SENSOR WITH A LOWER POWER MODE 审中-公开
标题翻译：具有较低功率模式的传感器的无铅CARDIAC PACEMAKER
公开(公告)号：WO2016028799A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/045720
申请日：2015-08-18
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith P. , STAHMANN, Jeffrey E. , KANE, Michael J.
IPC分类号： A61N1/375 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3708 , A61B5/0031 , A61B5/0538 , A61B5/1102 , A61B5/1107 , A61B5/686 , A61B2560/0209 , A61B2562/0219 , A61N1/36514 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/37205 , A61N1/37217 , A61N1/3756
摘要： A leadless cardiac pacemaker (LCP) configured to sense and pace a patient's heart includes a sensor configured to sense a parameter related to cardiac contractility of the patient's heart and a power management unit that is operatively coupled to the sensor. The power management unit is configured to place the sensor in a higher power sense mode during times when sensing the parameter related to cardiac contractility is desired and to place the sensor in a lower power mode during times when sensing the parameter related to cardiac contractility is not desired
摘要翻译：被配置为感测和加速患者心脏的无引导心脏起搏器（LCP）包括被配置为感测与患者心脏的心脏收缩力相关的参数的传感器和可操作地耦合到传感器的功率管理单元。功率管理单元被配置为在感测与心脏收缩力相关的参数期望的时间期间将传感器放置在更高功率感测模式中，并且在感测与心脏收缩力相关的参数的时间期间将传感器置于较低功率模式期望

52. 发明申请

WO2016022394A1 COMMUNICATIONS IN A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗设备系统中的通信
公开(公告)号：WO2016022394A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042936
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith R. , KANE, Michael J. , HUELSKAMP, Paul , JUFFER, Lance E. , STAHMANN, Jeffrey E.
IPC分类号： A61N1/372 , H04L25/49
CPC分类号： A61N1/37217 , A61N1/3727 , A61N1/37288 , A61N1/3962 , H04B13/005 , H04L25/4902
摘要： Systems and methods for communicating between medical devices. In one example, an implantable medical device comprising may comprise one or more electrodes and a controller coupled to the electrodes. The controller may be configured to receive a first communication pulse at a first communication pulse time and a second communication pulse at a second communication pulse time via the one or more electrodes. The controller may further be configured to identify one of three or more symbols based at least in part on the time difference between the first communication pulse time and the second communication pulse time.
摘要翻译：用于医疗设备之间通信的系统和方法。在一个示例中，可植入医疗装置包括一个或多个电极和耦合到电极的控制器。控制器可以被配置为经由一个或多个电极在第一通信脉冲时间和第二通信脉冲时间接收第二通信脉冲。控制器还可以被配置为至少部分地基于第一通信脉冲时间和第二通信脉冲时间之间的时间差来识别三个或更多个符号中的一个。

53. 发明申请

WO2015095818A1 LEADLESS PACEMAKER WITH END-OF-LIFE PROTECTION 审中-公开
标题翻译：无终身保护者，终身保护
公开(公告)号：WO2015095818A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071714
申请日：2014-12-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , HASSL, Benjamin J. , MAILE, Keith R. , LINDER, William J.
IPC分类号： A61N1/375 , A61N1/37
CPC分类号： A61N1/3708 , A61N1/37223 , A61N1/37235 , A61N1/3756 , A61N1/3962
摘要： An implantable medical device includes operational circuitry and a power source configured to deliver energy to the operational circuitry. The operational circuitry includes, for example, a therapy circuit. The implantable medical device also includes a deactivation element configured to disable the therapy circuit. The implantable medical device also includes a power manager configured to detect an end-of-life condition of the power source and, in response to detecting the end-of-life condition, to cause the deactivation element to disable the therapy circuit.
摘要翻译：可植入医疗装置包括操作电路和被配置为向操作电路传送能量的电源。操作电路包括例如治疗电路。可植入医疗装置还包括被配置为禁用治疗电路的去激活元件。可植入医疗装置还包括功率管理器，其被配置为检测电源的寿命终止状态，并且响应于检测到寿命终止状态，使得停用元件禁用治疗电路。

54. 发明申请

WO2019136148A1 DUAL CHAMBER PACING WITHOUT BEAT-TO-BEAT COMMUNICATION 审中-公开
公开(公告)号：WO2019136148A1
公开(公告)日：2019-07-11
申请号：PCT/US2019/012182
申请日：2019-01-03
申请人： CARDIAC PACEMAKERS, INC.
发明人： KOOP, Brendan Early , STAHMANN, Jeffrey E. , SHUROS, Allan Charles , MAILE, Keith R. , HAASL, Benjamin J.
IPC分类号： A61N1/372 , A61N1/362
摘要： A ventricular implantable medical device that is configured to detect an atrial timing fiducial from the ventricle. The ventricular implantable medical is configured to deliver a ventricular pacing therapy to the ventricle based on the detected atrial timing fiducial. If the ventricular implantable medical device temporarily fails to detect atrial activity because of noise, posture, patient activity or for any other reason, an atrial implantable medical device may be configured to communicate atrial events to the ventricular implantable medical device and the ventricular implantable medical device may synchronize the ventricular pacing therapy with the atrium activity based on those communications.

55. 发明申请

WO2018009686A1 SYSTEMS AND METHODS TO DETERMINE SURROGATES OF BLOOD PRESSURE 审中-公开
标题翻译：用于确定血压的系统和方法
公开(公告)号：WO2018009686A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040930
申请日：2017-07-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , FOSTER, Arthur J. , MI, Bin , KANE, Michael J. , THAKUR, Pramodsingh H. , LINDER, William J. , AN, Qi , MAILE, Keith R.
IPC分类号： A61B5/021
CPC分类号： A61B5/7275 , A61B5/0059 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/11 , A61B7/023 , A61B7/04 , A61N1/3756 , A61N1/3925 , A61N1/3956
摘要： Embodiments of the present disclosure relate to systems and methods for determining a subject's blood pressure using one or more implantable medical devices (IMDs). In an embodiment, a medical system comprises: at least one implantable medical device configured to sense signals associated with heart sounds of a subject and a processing unit communicatively coupled to the at least one implantable medical device. The processing unit is configured to: receive heart sound signals corresponding to the signals associated with the heart sounds; and calculate a surrogate of the subject's blood pressure using at least one heart sound signal of the received heart sound signals.
摘要翻译：本公开的实施例涉及用于使用一个或多个可植入医疗设备（IMD）来确定对象的血压的系统和方法。在一个实施例中，一种医疗系统包括：至少一个可植入医疗装置，其被配置为感测与受试者的心脏音相关联的信号;以及处理单元，其可通信地耦合到所述至少一个可植入医疗装置。处理单元被配置为：接收对应于与心音相关联的信号的心音信号; 并使用接收到的心音信号中的至少一个心音信号来计算对象血压的替代值。

56. 发明申请

WO2017210055A1 SYSTEMS TO DETECT RESPIRATORY DISEASES 审中-公开
标题翻译：检测呼吸道疾病的系统
公开(公告)号：WO2017210055A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/034212
申请日：2017-05-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： THAKUR, Pramodsingh Hirasingh , STAHMANN, Jeffrey E. , KANE, Michael J. , MI, Bin , BALCZEWSKI, Ron A. , MAILE, Keith R.
IPC分类号： A61B7/00 , A61B5/08 , A61B5/02 , A61B5/11 , A61B5/00 , A61N1/365
摘要： Systems and methods for monitoring patients with respiratory diseases are described. A system may include a sensor circuit to sense a respiration signal and at least one hemodynamic signal. The system may detect a specified respiratory phase from the respiration signal, and generate from the hemodynamic signal one or more signal metrics that are correlative to at least one of a systolic blood pressure, a blood volume, or a cardiac dimension. The system may detect a restrictive or obstructive respiratory condition when the hemodynamic signal metric indicates hemodynamic deterioration during a specified respiratory phase. The system may additionally classify the detected restrictive or obstructive respiratory condition into one of two or more categories, and deliver a therapy based on the detection or the classification.
摘要翻译：描述了用于监测患有呼吸疾病的患者的系统和方法。系统可以包括感测呼吸信号和至少一个血液动力学信号的传感器电路。系统可以从呼吸信号中检测指定的呼吸相位，并且从血液动力学信号生成与收缩压，血容量或心脏尺寸中的至少一个相关的一个或多个信号度量。当血液动力学信号度量指示特定呼吸阶段期间的血液动力学恶化时，系统可检测限制性或阻塞性呼吸状况。系统可以另外将检测到的限制性或阻塞性呼吸状况分类为两个或更多个类别中的一个，并且基于检测或分类来递送治疗。

57. 发明申请

WO2017139164A1 SYSTEMS AND METHODS FOR PATIENT MONITORING 审中-公开
标题翻译：用于患者监护的系统和方法
公开(公告)号：WO2017139164A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/016150
申请日：2017-02-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , STAHMANN, Jeffrey E. , THAKUR, Pramodsingh Hirasingh , AVERINA, Viktoria A. , MAILE, Keith R.
IPC分类号： A61B5/00 , G06F19/00 , A61B5/02 , A61B5/08 , A61B5/20
CPC分类号： A61B5/686 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/08 , A61B5/201 , A61B5/4836 , A61B5/7225 , A61B5/725 , A61B5/7275 , G06F19/00 , G16H50/30
摘要： Systems and methods for monitoring patients with a chronic disease such as heart failure are disclosed. The system may include a physiological sensor circuit to sense physiological signals and generate signal metrics from the physiological signals. The system may include a health status analyzer circuit to use the signal metrics to generate one or more stability indicators of patient health status, such as stability of heart failure status. The system may additionally generate one or more health status indicators indicating patient health status such as heart failure progression. A patient disposition decision may be generated using the health status indicators and the stability indicators to provide an indication of readiness for patient discharge from or a risk of admission to a hospital.
摘要翻译：公开了用于监测诸如心力衰竭等慢性疾病的患者的系统和方法。该系统可以包括生理传感器电路以感测生理信号并且从生理信号生成信号度量。该系统可以包括健康状态分析器电路以使用信号度量来生成患者健康状态的一个或多个稳定性指标，诸如心力衰竭状态的稳定性。该系统可以另外产生一个或多个健康状态指示器，指示患者健康状态，例如心力衰竭进展。使用健康状况指标和稳定性指标可以产生患者处置决定，以提供患者从院内排出的准备情况或入院的风险。

58. 发明申请

WO2017096340A1 SYSTEM FOR ASTHMA EVENT DETECTION AND NOTIFICATION 审中-公开
标题翻译：用于哮喘事件检测和通知的系统
公开(公告)号：WO2017096340A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064879
申请日：2016-12-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael J. , THOMPSON, Julie A.
IPC分类号： A61B5/00 , A61B5/07
CPC分类号： G16H50/30 , A61B5/0031 , A61B5/076 , A61B5/4839 , A61B5/4842 , A61B5/746 , G06F19/00 , G06F19/3418 , G06F19/3456
摘要： A system, including a sensor configured to ambulatorily sense a parameter and a status unit configured to determine a change in asthma status of a patient based on the parameter.
摘要翻译：系统，包括被配置为以非环境方式感测参数的传感器和被配置成基于参数确定患者的哮喘状态的改变的状态单元。

59. 发明申请

WO2016022397A1 MEDICAL DEVICE SYSTEMS WITH MULTIPLE COMMUNICATION MODES 审中-公开
标题翻译：具有多种通信模式的医疗设备系统
公开(公告)号：WO2016022397A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042954
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , MAILE, Keith R. , KOOP, Brendan E. , KANE, Michael J. , LUDWIG, Jacob M. , HUELSKAMP, Paul
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/371 , A61N1/37205 , A61N1/37211 , A61N1/3727 , A61N1/3756
摘要： Medical device systems and methods with multiple communication modes. An example medical device system may include a first medical device and a second medical device communicatively coupled to the first medical device. The first medical device may be configured to communicate information to the second medical device in a first communication mode. The first medical device may further be configured to communicate information to the second medical device in a second communication mode after determining that one or more of the communication pulses captured the heart of the patient.
摘要翻译：具有多种通信模式的医疗设备系统和方法。示例性医疗设备系统可以包括通信地耦合到第一医疗设备的第一医疗设备和第二医疗设备。第一医疗设备可以被配置为以第一通信模式向第二医疗设备传送信息。第一医疗设备还可以被配置为在确定一个或多个通信脉冲捕获患者的心脏之后，以第二通信模式将信息传送到第二医疗设备。

60. 发明申请

WO2016007660A1 SYSTEMS AND METHODS FOR TREATING CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：用于治疗心脏病的系统和方法
公开(公告)号：WO2016007660A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039594
申请日：2015-07-08
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael J. , LINDER, William J. , SIMMS, Howard D. , MAILE, Keith R.
IPC分类号： A61N1/372 , A61N1/375 , A61N1/39 , A61N1/38 , A61N1/362
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/365 , A61N1/37205 , A61N1/37288 , A61N1/3756 , A61N1/3925 , A61N1/3987
摘要： Systems and methods for treating cardiac arrhythmias. One example medical device system for delivering electrical stimulation therapy to a heart of a patient may comprise a leadless cardiac pacemaker (LCP) implanted within a heart of a patient and configured to determine occurrences of cardiac arrhythmias, a medical device configured to determine occurrences of cardiac arrhythmias and to deliver defibrillation shock therapy to the patient, wherein the LCP and the medical device are spaced from one another and communicatively coupled, and wherein after the LCP determines an occurrence of a cardiac arrhythmia, the LCP is configured to modify the defibrillation shock therapy of the medical device.
摘要翻译：用于治疗心律失常的系统和方法。用于将电刺激治疗递送到患者心脏的一个示例性医疗装置系统可以包括植入患者心脏内的无引线心脏起搏器（LCP），并且被配置为确定心律不齐的发生，被配置为确定心脏发生的医疗装置心律失常并且向病人提供除颤休克疗法，其中所述LCP和所述医疗装置彼此间隔开并且通信耦合，并且其中在所述LCP确定心律失常的发生之后，所述LCP被配置为修改除颤休克疗法的医疗器械。

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