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51. 发明授权

US08877233B2 Porous sponge matrix medical devices and methods 有权
标题翻译：多孔海绵矩阵医疗器械及方法
公开(公告)号：US08877233B2
公开(公告)日：2014-11-04
申请号：US10184559
申请日：2002-06-28
申请人： Joseph Obermiller , Michael C. Hiles
发明人： Joseph Obermiller , Michael C. Hiles
IPC分类号： A61F13/00 , A61K9/70 , A61L15/00 , A61L15/16 , A61F2/00 , A61F2/06 , A61F13/20 , A61N1/30 , A61M31/00 , A61M5/00 , A61M5/315 , A61M35/00 , A61B17/00 , A61L27/56 , A61B17/12 , A61L31/14 , A61L26/00 , A61L31/04 , A61L27/24 , A61B10/02
CPC分类号： A61L31/146 , A61B10/0233 , A61B17/0057 , A61B17/12022 , A61B17/1219 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00898 , A61L26/0033 , A61L26/0085 , A61L27/24 , A61L27/56 , A61L31/044 , A61L2400/04
摘要： Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.
摘要翻译：描述了可用于植入活组织切片的止血装置，该装置包括高度紧密，干燥的止血海绵元件。优选的装置还包括表现出高密度和刚度的压实海绵基质，同时在润湿时具有高体积膨胀性。还描述了制造和使用这些装置的方法。

52. 发明授权

US08808352B2 Cast bioremodelable graft 有权
标题翻译：铸造生物可重复移植
公开(公告)号：US08808352B2
公开(公告)日：2014-08-19
申请号：US11054043
申请日：2005-02-09
申请人： Scott E. Eells , Michael C. Hiles , Thomas A. Osborne
发明人： Scott E. Eells , Michael C. Hiles , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61L27/3629 , A61L27/3633 , A61L27/58
摘要： A cast bioremodelable graft (22) including a cast tubular construct (33) of a bioremodelable substance (34). The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released from an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23-25) in the graft, which is then loaded on an endoluminal delivery system.
摘要翻译：包括生物可重塑物质（34）的铸造管状构造物（33）的铸塑生物可重塑移植物（22）。将生物可重塑物质浇铸或施加到形式上，然后真空压制以干燥或硬化物质。可膨胀构件（18）设置在铸造管状结构的内部，下面或周围，以在从内腔输送系统释放时膨胀移植物。第二层（39）可以施加在第一层（38）上，并且可扩展支架在其间包含支架，而不需要任何单独的附接。将移植物脱水并优选真空压制以使生物可重塑物质硬化。去除形式以在移植物中形成一个或多个腔（23-25），然后将其装载在腔内递送系统上。

53. 发明授权

US08778362B2 Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof 有权
标题翻译：抗肿瘤/癌症异源无细胞胶原制剂及其用途
公开(公告)号：US08778362B2
公开(公告)日：2014-07-15
申请号：US12880936
申请日：2010-09-13
申请人： Mark A. Suckow , Michael C. Hiles
发明人： Mark A. Suckow , Michael C. Hiles
IPC分类号： A61K9/00 , A61K9/14 , A61K9/70
CPC分类号： A61K35/22 , A61K35/13 , A61L27/3633 , A61L27/54 , A61L2300/416 , C12N5/0693
摘要： Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer.
摘要翻译：公开了具有肿瘤抑制活性的哺乳动物肿瘤和/或癌细胞调节底物制剂。在一些实施方案中，哺乳动物肿瘤和/或癌细胞调节底物制剂基本上不含细胞成分。这些制剂包括调节的异源无细胞胶原组织制剂，并且可以使用哺乳动物细胞外基质底物制备。条件底物包括许多不同的抗肿瘤和/或抗癌生物分子，例如当哺乳动物肿瘤和/或癌细胞在基质上生长时分泌和/或产生的抗肿瘤生物分子群体，从而赋予对本发明的调理底物的抗肿瘤和/或抗癌特性。本公开还提供了用于制备哺乳动物肿瘤和/或癌细胞调节底物的方法，以及使用该制剂抑制肿瘤生长的方法，例如在疫苗或伤口敷料中。还描述了用所述条件底物抑制前列腺肿瘤和黑素瘤的方法。调节的哺乳动物肿瘤和/或癌细胞底物制剂基本上不含活的和/或致癌或侵袭性肿瘤和/或癌细胞。条件底物和底物制剂包括可用于治疗癌症的制剂和制剂中的抗肿瘤和抗癌特性。

54. 发明授权

US08591930B2 Growth factor modified extracellular matrix material preparation and methods for preparation and use thereof 有权
标题翻译：生长因子修饰细胞外基质材料的制备及其制备及使用方法
公开(公告)号：US08591930B2
公开(公告)日：2013-11-26
申请号：US12110630
申请日：2008-04-28
申请人： Michael C. Hiles , Andrew Brightman , Abram D. Janis
发明人： Michael C. Hiles , Andrew Brightman , Abram D. Janis
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61L27/20 , A61L27/3604 , A61L27/50 , C08L5/10
摘要： Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.
摘要翻译：描述的是包括粘膜下层和其它外源蛋白质的细胞外基质材料的组织移植物构建体。还描述了用于制备组织移植构建体的方法，其包括从猪移植材料中剥离内源性肝素结合蛋白，然后将一种或多种人生长因子结合到保留在移植材料内的天然肝素分子。这样的移植材料可以用于治疗患者的伤口的方法中。

55. 发明申请

US20090204228A1 EXTRACELLULAR MATRIX COMPOSITE MATERIALS, AND MANUFACTURE AND USE THEREOF 有权
标题翻译：细胞基复合材料及其制造及其使用
公开(公告)号：US20090204228A1
公开(公告)日：2009-08-13
申请号：US12399635
申请日：2009-03-06
申请人： Michael C. Hiles
发明人： Michael C. Hiles
IPC分类号： A61F2/02
CPC分类号： A61L27/3641 , A61K35/22 , A61K35/37 , A61K35/44 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/48 , C08L89/00
摘要： Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material.
摘要翻译：描述了优选的细胞外基质复合物，其包括沉积在其上的第二细胞外基质材料的第一细胞外基质材料。优选的材料通过以与细胞外基质移植材料接触的方式培养细胞来制造，以使细胞在材料上生物合成和沉积细胞外基质成分。然后除去细胞以提供细胞外基质复合材料。

56. 发明授权

US07485138B2 Tubular graft construct 有权
标题翻译：管状移植物构建体
公开(公告)号：US07485138B2
公开(公告)日：2009-02-03
申请号：US10068212
申请日：2002-02-06
申请人： Neal E. Fearnot , Michael C. Hiles
发明人： Neal E. Fearnot , Michael C. Hiles
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2002/30235 , A61F2002/30428 , A61F2210/0076 , A61F2220/0025 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2310/00017 , A61F2310/00365 , A61L27/042 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/3604 , Y10S623/917 , Y10S623/921 , C08L27/18 , C08L23/12 , C08L67/00 , C08L77/06
摘要： Described are medical devices which are or can be used to form tubular medical devices, and related methods. Preferred devices include tubular grafts of biomaterial having lumen walls which present no seam edge that traverses the entire length of the lumen, illustratively including devices having lumen walls which have a discontinuous seam presenting multiple seam edges. Such a device may include a tubular structure formed by inserting a plurality of extensions of a biomaterial sheet through a plurality of corresponding apertures of the sheet.
摘要翻译：描述了可以或可以用于形成管状医疗装置的医疗装置及相关方法。优选的装置包括具有腔壁的生物材料的管状移植物，其不存在穿过管腔整个长度的接缝边缘，示例性地包括具有腔壁的装置，其具有呈现多个接缝边缘的不连续接缝。这种装置可以包括通过将片材的多个对应的孔插入生物材料片的多个延伸部而形成的管状结构。

57. 发明申请

US20120064163A1 ANTI-TUMOR/CANCER HETEROLOGOUS ACELLULAR COLLAGENOUS PREPARATIONS AND USES THEREOF 有权
标题翻译：抗肿瘤/癌症杂交细胞胶原蛋白的制备及其用途
公开(公告)号：US20120064163A1
公开(公告)日：2012-03-15
申请号：US12880936
申请日：2010-09-13
申请人： Mark A. Suckow , Michael C. Hiles
发明人： Mark A. Suckow , Michael C. Hiles
IPC分类号： A61K39/00 , A61P35/00 , C12P21/00 , A61K9/00
CPC分类号： A61K35/22 , A61K35/13 , A61L27/3633 , A61L27/54 , A61L2300/416 , C12N5/0693
摘要： Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer.
摘要翻译：公开了具有肿瘤抑制活性的哺乳动物肿瘤和/或癌细胞调节底物制剂。在一些实施方案中，哺乳动物肿瘤和/或癌细胞调节底物制剂基本上不含细胞成分。这些制剂包括调节的异源无细胞胶原组织制剂，并且可以使用哺乳动物细胞外基质底物制备。条件底物包括许多不同的抗肿瘤和/或抗癌生物分子，例如当哺乳动物肿瘤和/或癌细胞在基质上生长时分泌和/或产生的抗肿瘤生物分子群体，从而赋予对本发明的调理底物的抗肿瘤和/或抗癌特性。本公开还提供了用于制备哺乳动物肿瘤和/或癌细胞调节底物的方法，以及使用该制剂抑制肿瘤生长的方法，例如在疫苗或伤口敷料中。还描述了用所述条件底物抑制前列腺肿瘤和黑素瘤的方法。调节的哺乳动物肿瘤和/或癌细胞底物制剂基本上不含活的和/或致癌或侵袭性肿瘤和/或癌细胞。条件底物和底物制剂包括可用于治疗癌症的制剂和制剂中的抗肿瘤和抗癌特性。

58. 发明申请

US20100196480A1 GRAFT MATERIALS CONTAINING BIOACTIVE EXTRACELLULAR MATRICES AND CELLS 审中-公开
标题翻译：含有生物活性细胞基质和细胞的GRAFT材料
公开(公告)号：US20100196480A1
公开(公告)日：2010-08-05
申请号：US12762058
申请日：2010-04-16
申请人： Michael C. Hiles , Jason P. Hodde , David M. J. Ernst , Lal Ninan
发明人： Michael C. Hiles , Jason P. Hodde , David M. J. Ernst , Lal Ninan
IPC分类号： A61K9/00 , A61K35/12 , C12N5/02
CPC分类号： A61L27/54 , A61K35/38 , A61K38/1825 , A61L27/227 , A61L27/24 , A61L27/3629 , A61L27/3633 , A61L27/3687 , A61L27/50 , A61L2300/414 , A61L2400/06
摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
摘要翻译：描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

59. 发明申请

US20080181950A1 BIOFILM-INHIBITING MEDICAL PRODUCTS 有权
标题翻译：生物膜抑制医疗产品
公开(公告)号：US20080181950A1
公开(公告)日：2008-07-31
申请号：US12019477
申请日：2008-01-24
申请人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
发明人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
IPC分类号： A01N25/00 , A01N31/00 , A61P17/02
CPC分类号： A61L15/40 , A61L15/44 , A61L2300/102 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

60. 发明申请

US20070154515A1 IMPLANTABLE GRAFT MATERIAL 失效
标题翻译：可植入材料
公开(公告)号：US20070154515A1
公开(公告)日：2007-07-05
申请号：US11616159
申请日：2006-12-26
申请人： Chad E. Johnson , Michael C. Hiles
发明人： Chad E. Johnson , Michael C. Hiles
IPC分类号： A61K35/12
CPC分类号： A61F2/2415 , A61B90/90 , A61B2050/0065 , A61F2/0095 , A61F2/07 , A61F2/08 , A61F2/2412 , A61F2/2475 , A61F2/32 , A61F2/3603 , A61F2/40 , A61F2/86 , A61F2002/072 , A61F2002/30062 , A61F2002/30247 , A61F2002/3025 , A61F2002/30649 , A61F2002/30754 , A61F2002/30971 , A61F2002/4007 , A61F2210/0004 , A61F2230/0071 , A61F2240/001 , A61F2310/00365 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3804 , A61L27/3843 , A61L31/005
摘要： Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient's body.
摘要翻译：描述了适合于在患者体内植入的移植材料，包括在体腔中改造的分离的组织材料。还描述了治疗患者的方法，所述方法包括将这些材料植入，以及在患者体内包括这些材料的假体装置。

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