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51. 发明申请

US20090274693A1 Method of Treating Cancer using a cMet and AXL Inhibitor and an ErbB Inhibitor 审中-公开
标题翻译：使用cMet和AXL抑制剂和ErbB抑制剂治疗癌症的方法
公开(公告)号：US20090274693A1
公开(公告)日：2009-11-05
申请号：US12435473
申请日：2009-05-05
申请人： Tona M. Gilmer , James G. Greger, JR. , Li Liu , Hong Shi
发明人： Tona M. Gilmer , James G. Greger, JR. , Li Liu , Hong Shi
IPC分类号： A61K31/5377 , A61K31/47 , A61K39/395 , A61P35/04
CPC分类号： A61K31/5377 , A61K31/47 , A61K31/517 , A61K39/39558 , C07K16/32 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： The present invention relates to a method of treating cancer in a patient comprising administering to the patient therapeutically effective amounts of:a) a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein R1-R4, p, and q are as defined; and(b) an erbB inhibitor that inhibits erbB-1 or erbB-2 or erbB-3 receptor or a combination thereof. The method of the present invention addresses a need in the art with the discovery of a combination therapy that shows evidence of being a more effective therapy than previously disclosed therapies.
摘要翻译：本发明涉及一种治疗患者的癌症的方法，包括向患者施用治疗有效量的：a）式A化合物或其药学上可接受的盐，其中R 1 -R 4，p和q如上所定义 ; 和（b）抑制erbB-1或erbB-2或erbB-3受体的erbB抑制剂或其组合。本发明的方法解决了本领域的需要，发现了组合疗法，该组合治疗显示出比先前公开的疗法更有效的治疗的证据。

52. 发明授权

US07587000B2 Radio receiver utilizing a single analog to digital converter 有权
标题翻译：使用单个模数转换器的无线电接收机
公开(公告)号：US07587000B2
公开(公告)日：2009-09-08
申请号：US11958055
申请日：2007-12-17
申请人： Henrik T. Jensen , Hong Shi
发明人： Henrik T. Jensen , Hong Shi
IPC分类号： H04L27/00
CPC分类号： H03D3/007 , H04L27/38
摘要： A radio receiver includes a single analog to digital converter, a 1st digital mixing module, and a 2nd digital mixing module. The single analog to digital converter is coupled to convert the filtered IF signal into a digital IF signal, which includes information regarding an in-phase component and a quadrature component of a modulated RF signal. The 1st and 2nd mixing modules each receive the digital IF signal and mix the digital IF signal with an in-phase and quadrature digital local oscillation to produce a 1st baseband signal component and a 2nd baseband signal component.
摘要翻译：无线电接收机包括单个模数转换器，第一数字混合模块和第二数字混合模块。耦合单个模数转换器以将经滤波的IF信号转换成数字IF信号，该数字IF信号包括关于调制RF信号的同相分量和正交分量的信息。第一和第二混频模块各自接收数字IF信号，并将数字IF信号与同相和正交数字本地振荡混频，以产生第一基带信号分量和第二基带信号分量。

53. 发明授权

US07499680B2 Translational loop transmitter architecture employing channel power ratio measurements for modulation accuracy calibration 失效
标题翻译：平移环路发射机架构采用信道功率比测量进行调制精度校准
公开(公告)号：US07499680B2
公开(公告)日：2009-03-03
申请号：US11078148
申请日：2005-03-11
申请人： Hong Shi , Henrik Tholstrup Jensen
发明人： Hong Shi , Henrik Tholstrup Jensen
IPC分类号： H04B17/00
CPC分类号： H04B1/0475
摘要： A Radio Frequency RF transmitter includes a translational loop architecture that supports non-constant envelope modulation types and includes by adjusting the envelope of the translational loop at the translational loop output. The RF transmitter includes an Intermediate Frequency (IF) modulator, a translational loop, an envelope time delay adjust block, an envelope adjust block, and a time delay calibration block. The IF modulator receives a modulated baseband signal and produces a modulated IF signal having a non-constant envelope. The translational loop receives the modulated IF signal and produces a modulated RF signal having a constant envelope. The envelope time delay adjust block receives an envelope signal corresponding to the original modulated signal and produces a time delayed envelope signal based upon a time delay control signal. The envelope adjust block adjusts the modulated RF signal based upon the time delayed envelope signal to produce an envelope adjusted modulated RF signal. Finally, the time delay calibration block receives the envelope adjusted modulated RF signal and produces the time delay control signal.
摘要翻译：射频RF发射机包括支持非恒定包络调制类型的平移环路架构，并且包括通过调整平移环路输出端的平移环路的包络。 RF发射机包括中频（IF）调制器，平移回路，包络时间延迟调整块，包络调整块和时间延迟校准块。 IF调制器接收调制的基带信号并产生具有非恒定包络的调制IF信号。平移环路接收调制的IF信号并产生具有恒定包络线的调制RF信号。包络时间延迟调整块接收对应于原始调制信号的包络信号，并且基于时间延迟控制信号产生时间延迟包络信号。信封调整块基于时间延迟的包络信号来调整调制的RF信号，以产生包络调制的调制的RF信号。最后，延时校准块接收包络调制的调制RF信号并产生延时控制信号。

54. 发明授权

US07405473B1 Techniques for optimizing electrical performance and layout efficiency in connectors with via placement and routing 有权
标题翻译：通过放置和布线优化连接器电气性能和布局效率的技术
公开(公告)号：US07405473B1
公开(公告)日：2008-07-29
申请号：US11285912
申请日：2005-11-23
申请人： Hong Shi , Yuanlin John Xie
发明人： Hong Shi , Yuanlin John Xie
IPC分类号： H01L23/04 , H05K1/11
CPC分类号： H05K1/0222 , H01L2224/16225 , H01L2924/00011 , H01L2924/00014 , H01L2924/15311 , H05K1/112 , H05K1/115 , H05K3/4602 , H05K2201/10674 , H01L2224/0401
摘要： Techniques are provided for placing and routing vias that conduct signals through a connector between two electrical units. Vias that conduct a first set of signals are placed next to vias that provide return paths for the first set of signals to reduce cross-talk or impedance. Vias that conduct input or output signals can be placed next to vias that provide return paths for the input or output signals to reduce cross-talk. The vias that provide the return paths can conduct, for example, ground signals, power supply signals, or both. Vias that conduct power supply signals can be placed next to vias that provide return paths for the power supply signals to reduce impedance. The vias that provide the return paths for the power supply signals can conduct, for example, ground signals. The via configurations reduce cost and increase yield, and the via configurations are modular.
摘要翻译：提供技术用于放置和布置通过两个电气单元之间的连接器传导信号的通孔。进行第一组信号的通孔放置在为第一组信号提供返回路径以减少串扰或阻抗的通孔旁边。进行输入或输出信号的通道可以放置在提供输入或输出信号返回路径以减少串扰的过孔旁。提供返回路径的通孔可以导通例如接地信号，电源信号或两者。进行电源信号的通孔可以放置在提供电源信号返回路径以减少阻抗的通孔旁边。提供电源信号返回路径的通孔可以导通例如接地信号。通孔配置降低成本并提高产量，并且通孔配置是模块化的。

55. 发明申请

US20080107206A1 RADIO RECEIVER UTILIZING A SINGLE ANALOG TO DIGITAL CONVERTER 有权
标题翻译：无线电接收机将数字转换器应用于单模转换器
公开(公告)号：US20080107206A1
公开(公告)日：2008-05-08
申请号：US11958055
申请日：2007-12-17
申请人： Henrik Jensen , Hong Shi
发明人： Henrik Jensen , Hong Shi
IPC分类号： H04L27/00
CPC分类号： H03D3/007 , H04L27/38
摘要： A radio receiver includes a single analog to digital converter, a 1st digital mixing module, and a 2nd digital mixing module. The single analog to digital converter is coupled to convert the filtered IF signal into a digital IF signal, which includes information regarding an in-phase component and a quadrature component of a modulated RF signal. The 1st and 2nd mixing modules each receive the digital IF signal and mix the digital IF signal with an in-phase and quadrature digital local oscillation to produce a 1st baseband signal component and a 2nd baseband signal component.
摘要翻译：一个无线电接收机包括一个模数转换器，一个数字混合模块和一个第二个数字混合模块。耦合单个模数转换器以将经滤波的IF信号转换成数字IF信号，该数字IF信号包括关于调制RF信号的同相分量和正交分量的信息。混合模块1和3分别接收数字IF信号并混合数字IF信号与同相和正交数字本地振荡，以产生1

56. 发明申请

US20070010224A1 LNA gain adjustment in an RF receiver to compensate for intermodulation interference 有权
标题翻译： LNA增益调整在RF接收机中以补偿互调干扰
公开(公告)号：US20070010224A1
公开(公告)日：2007-01-11
申请号：US11523332
申请日：2006-09-19
申请人： Hong Shi
发明人： Hong Shi
IPC分类号： H04B17/00 , H04B1/06
CPC分类号： H03G3/3068 , H03F1/32 , H03F2200/294 , H03F2200/372 , H03G3/3052 , H03G3/3078 , H04B1/109
摘要： A Radio Frequency (RF) receiver includes a low noise amplifier (LNA) and a mixer coupled to the output of the LNA. The gain of the LNA is adjusted to maximize signal-to-noise ratio of the mixer and to force the mixer to operate well within its linear region when an intermodulation interference component is present. The RF receiver includes a first received signal strength indicator (RSSI_A) coupled to the output of the mixer that measures the strength of the wideband signal at that point. A second received signal strength indicator (RSSI_B) couples after the BPF and measures the strength of the narrowband signal. The LNA gain is set based upon these signal strengths. By altering the gain of the LNA by one step and measuring the difference between a prior RSSI_B reading and a subsequent RSSI_B′ reading will indicate whether intermodulation interference is present.
摘要翻译：射频（RF）接收机包括低噪声放大器（LNA）和耦合到LNA的输出的混频器。调整LNA的增益以使混频器的信噪比最大化，并且当存在互调干涉分量时，迫使混频器在其线性区域内良好地运行。 RF接收机包括耦合到混频器的输出的第一接收信号强度指示符（RSSI_A），该信号强度指示器测量在该点处的宽带信号的强度。第二接收信号强度指示符（RSSI_B）在BPF之后耦合并测量窄带信号的强度。基于这些信号强度设置LNA增益。通过将LNA的增益改变一步并测量先前的RSSI_B读数与随后的RSSI_B读数之间的差异将指示是否存在互调干扰。

57. 发明授权

US07120410B2 LNA gain adjustment in an RF receiver to compensate for intermodulation interference 失效
公开(公告)号：US07120410B2
公开(公告)日：2006-10-10
申请号：US09966060
申请日：2001-09-28
申请人： Hong Shi
发明人： Hong Shi
IPC分类号： H04B17/00
CPC分类号： H03G3/3068 , H03F1/32 , H03F2200/294 , H03F2200/372 , H03G3/3052 , H03G3/3078 , H04B1/109
摘要： A Radio Frequency (RF) receiver includes a low noise amplifier (LNA) and a mixer coupled to the output of the LNA. The gain of the LNA is adjusted to maximize signal-to-noise ratio of the mixer and to force the mixer to operate well within its linear region when an intermodulation interference component is present. The RF receiver includes a first received signal strength indicator (RSSI_A) coupled to the output of the mixer that measures the strength of the wideband signal at that point. A second received signal strength indicator (RSSI_B) couples after the BPF and measures the strength of the narrowband signal. The LNA gain is set based upon these signal strengths. By altering the gain of the LNA by one step and measuring the difference between a prior RSSI_B reading and a subsequent RSSI_B′ reading will indicate whether intermodulation interference is present.

58. 发明申请

US20060035595A1 Radio frequency integrated circuit 失效
公开(公告)号：US20060035595A1
公开(公告)日：2006-02-16
申请号：US11223170
申请日：2005-09-09
申请人： Hong Shi
发明人： Hong Shi
IPC分类号： H04B1/38
CPC分类号： H04B1/406 , H03L7/18
摘要： A radio frequency (RF) integrated circuit (IC) includes a local oscillation module, analog radio receiver, analog radio transmitter, digital receiver module, digital transmitter module, and digital optimization module. The local oscillation module is operably coupled to produce at least one local oscillation. The analog radio receiver is operably coupled to directly convert inbound RF signals into inbound low intermediate frequency signals based on the local oscillation. The digital receiver module is operably coupled to process the inbound low IF signals in accordance with one of a plurality of radio transceiving standards to produce inbound data. The digital transmitter is operably coupled to produce an outbound low intermediate frequency signal by processing outbound data in accordance with the one of the plurality of radio transceiving standards. The analog radio transmitter is operably coupled to directly convert the outbound low IF signals into outbound RF signals based on the local oscillation. The digital optimization module is operably coupled to the local oscillation module, the analog radio receiver and/or the analog radio transmitter to optimize performance of at least one aspect of the local oscillation module, the analog radio receiver and/or the analog radio transmitter for the given radio transceiving standard being implemented.

59. 发明申请

US20050153670A1 Translational loop transmitter architecture employing channel power ratio measurements for modulation accuracy calibration 失效
公开(公告)号：US20050153670A1
公开(公告)日：2005-07-14
申请号：US11078148
申请日：2005-03-11
申请人： Hong Shi , Henrik Jensen
发明人： Hong Shi , Henrik Jensen
IPC分类号： H04B1/04 , H03C1/62 , H04B17/00
CPC分类号： H04B1/0475
摘要： A Radio Frequency RF transmitter includes a translational loop architecture that supports non-constant envelope modulation types and includes by adjusting the envelope of the translational loop at the translational loop output. The RF transmitter includes an Intermediate Frequency (IF) modulator, a translational loop, an envelope time delay adjust block, an envelope adjust block, and a time delay calibration block. The IF modulator receives a modulated baseband signal and produces a modulated IF signal having a non-constant envelope. The translational loop receives the modulated IF signal and produces a modulated RF signal having a constant envelope. The envelope time delay adjust block receives an envelope signal corresponding to the original modulated signal and produces a time delayed envelope signal based upon a time delay control signal. The envelope adjust block adjusts the modulated RF signal based upon the time delayed envelope signal to produce an envelope adjusted modulated RF signal. Finally, the time delay calibration block receives the envelope adjusted modulated RF signal and produces the time delay control signal.

60. 发明授权

US06882831B2 Translational loop transmitter architecture employing channel power ratio measurements for modulation accuracy calibration 失效
标题翻译：平移环路发射机架构采用信道功率比测量进行调制精度校准
公开(公告)号：US06882831B2
公开(公告)日：2005-04-19
申请号：US10066843
申请日：2002-02-04
申请人： Hong Shi , Henrik Tholstrup Jensen
发明人： Hong Shi , Henrik Tholstrup Jensen
IPC分类号： H04B1/04 , H01Q11/12
CPC分类号： H04B1/0475
摘要： A Radio Frequency RF transmitter includes a translational loop architecture that supports non-constant envelope modulation types and includes by adjusting the envelope of the translational loop at the translational loop output. The RF transmitter includes an Intermediate Frequency (IF) modulator, a translational loop, an envelope time delay adjust block, an envelope adjust block, and a time delay calibration block. The IF modulator receives a modulated baseband signal and produces a modulated IF signal having a non-constant envelope. The translational loop receives the modulated IF signal and produces a modulated RF signal having a constant envelope. The envelope time delay adjust block receives an envelope signal corresponding to the original modulated signal and produces a time delayed envelope signal based upon a time delay control signal. The envelope adjust block adjusts the modulated RF signal based upon the time delayed envelope signal to produce an envelope adjusted modulated RF signal. Finally, the time delay calibration block receives the envelope adjusted modulated RF signal and produces the time delay control signal.
摘要翻译：射频RF发射机包括支持非恒定包络调制类型的平移环路架构，并且包括通过调整平移环路输出端的平移环路的包络。 RF发射机包括中频（IF）调制器，平移回路，包络时间延迟调整块，包络调整块和时间延迟校准块。 IF调制器接收调制的基带信号并产生具有非恒定包络的调制IF信号。平移环路接收调制的IF信号并产生具有恒定包络线的调制RF信号。包络时间延迟调整块接收对应于原始调制信号的包络信号，并且基于时间延迟控制信号产生时间延迟包络信号。信封调整块基于时间延迟的包络信号来调整调制的RF信号，以产生包络调制的调制的RF信号。最后，延时校准块接收包络调制的调制RF信号并产生延时控制信号。

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