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    • 60. 发明公开
    • ELEKTROCHEMISCHE HERSTELLUNG STERISCH GEHINDERTER AMINE
    • EP2041336A2
    • 2009-04-01
    • EP07786853.7
    • 2007-06-27
    • BASF SEMalkowsky, Itamar
    • GRIESBACH, UlrichWALDVOGEL, Siegfried R.KULISCH, JoergMALKOWSKY, Itamar
    • C25B3/04
    • C25B3/04C07C209/30C07C2601/14C07C211/35C07C211/40
    • The invention relates to a method for producing an amine, comprising the step of cathodic reduction of a corresponding oxime derivative of general formula (I), wherein R represents C1-6 alkyl or C2-6 alkenyl, which is optionally substituted with one or more substituents independently selected from the group consisting of phenyl, O-C1-6 alkyl, NH-C1-6 alkyl, N(C1-6 alkyl)2, OH and NH2; R1 represents H; C1-6 alkyl or C(O)-C1-6 alkyl and A represents a 5-, 6- or 7-membered hydrocarbon ring which is saturated or which has a double bond and wherein optionally at least one CH2 group is replaced by -O-, -S- -NH-, -N=, or -N(C1-6 alkyl)- and which is optionally substituted with one or more other substituents independently selected from the group consisting of phenyl, C1-6 alkyl, O-C1-6 alkyl, NH-C1-6-alkyl, N(C1-6 alkyl)2, OH and NH2; and the oxime derivative, with respect to the carbon ring having the substituent R, having an excess of the R or S form of at least 10 %.
    • 本发明涉及一种制备胺的方法,其包括通式(I)的相应肟衍生物的步骤阴极还原,其中R是C1-6 - 烷基或任选被一个 或更多取代基独立地选自苯基,O-C 1-6 - 烷基,NH-C 1-6 - 烷基,N(C 1-6 - 烷基)2,OH和NH 2; R1为H; C 1-6 - 烷基或C(O)-C 1-6 - 烷基,A是饱和或具有双键并且其中至少一个CH 2基团可以的5-,6-或7-元烃环,如果 适当地被-O - , - S - NH - , - N =或-N(C 1-6 - 烷基)取代,并且其可任选地被一个或多个另外的取代基取代,所述取代基独立地选自苯基 ,C 1-6 - 烷基,O-C 1-6 - 烷基,NH-C 1-6 - 烷基,N(C 1-6 - 烷基)2,OH和NH 2; 其中,基于带有取代基R的环碳,肟衍生物具有至少10%的R或S形式的过量。