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51. 发明公开

EP2181084A1 VERFAHREN ZUR HERSTELLUNG VON MENTHOL DURCH HYDRIERUNG VON ISOPULEGOL 有权
标题翻译：用于生产薄荷脑经氢化胡薄荷醇
公开(公告)号：EP2181084A1
公开(公告)日：2010-05-05
申请号：EP08786173.8
申请日：2008-07-16
申请人： BASF SE
发明人： GRALLA, Gabriele , HEYDRICH, Gunnar , BERGNER, Eike Johannes , EBEL, Klaus
IPC分类号： C07C29/17 , C07C35/12
CPC分类号： C07C29/172 , C07B2200/07 , C07C2601/14 , C07C35/12
摘要： PF 60020 17 The present invention relates to a process for preparing racemic or optically active menthol by catalytic hydrogenation of racemic or optically active isopulegol in the presence of hydrogen and catalysts which include nickel-, copper-, zirconium- and molybdenum-containing compounds. The present invention 10 specifically relates to a corresponding process for the continuous catalytic hydrogenation of L-isopulegol to L-menthol.

52. 发明公开

EP2059493A1 RÜCKGEWINNUNG VON PHENOL-LIGANDEN BEI DER HERSTELLUNG VON ISOPULEGOL 有权
标题翻译：苯酚配体的胡薄荷醇的生产过程中恢复
公开(公告)号：EP2059493A1
公开(公告)日：2009-05-20
申请号：EP07803135.8
申请日：2007-08-31
申请人： BASF SE
发明人： HEYDRICH, Gunnar , GRALLA, Gabriele , EBEL, Klaus , FRIEDRICH, Marko
IPC分类号： C07C29/17 , C07C29/56 , C07C29/80 , C07C35/17 , C07C35/12
CPC分类号： C07C29/80 , B01J31/0214 , B01J31/143 , B01J31/4015 , C07B2200/07 , C07C29/172 , C07C29/56 , C07C35/12 , C07C35/17 , C07C2601/14 , Y02P20/584
摘要： The invention relates to methods for preparing a reaction product containing aluminium, obtained during the production of isopulegol, by the cyclization of citronellal in the presence of complex compounds, said product containing at least one ligand of formula (I), in which: R1, R2, R3 are selected from hydrogen, halogen, nitro, C1-C8 alkyl, C1-C8 alkoxy, di(C1-C4 alkyl)amino and aryl; and R4, R5 are selected from halogen, nitro, C1-C8 alkyl, C1-C8 alkoxy, di-(C1-C4 alkyl)amino, aryl or heteroaryl. According to said method, a) the reaction product is separated by distillation into a top product enriched with isopulegol and a bottom product poor in isopulegol and b) the ligand of formula (I) is isolated from the bottom product. In addition, the invention relates to a method for producing isopulegol and to a method for producing menthol.

53. 发明公开

EP3489213A1 ZUSAMMENSETZUNG ZUR VERWENDUNG IN EINEM VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER CARBONYLVERBINDUNGEN 有权
公开(公告)号：EP3489213A1
公开(公告)日：2019-05-29
申请号：EP18206833.8
申请日：2015-12-18
申请人： BASF SE
发明人： SCHELWIES, Mathias , PACIELO, Rocco , HEYDRICH, Gunnar , WEGNER, Günter , TEBBEN, Gerd-Dieter , HAUBNER, Martin , KELLER, Andreas , BEY, Oliver , RENZ, Stephanie , SEEBER, Georg
IPC分类号： C07C45/62 , C07C47/21 , C07C47/02 , C07C29/17 , C07C29/56 , C07C35/12 , C07C35/17
摘要： Die vorliegende Erfindung betrifft ein Zusammensetzungen, enthaltend einen chiralen, zweizähnigen Bisphosphin-Liganden und zusätzlich wenigstens eine Verbindung der allgemeinen Formel (I). Diese Zusammsetzungen eignen sich in Verfahren zur Herstellung einer optisch aktiven Carbonylverbindung durch asymmetrische Hydrierung einer prochiralen α,β-ungesättigter Carbonylverbindung mit Wasserstoff in Gegenwart wenigstens eines im Reaktionsgemisch löslichen, optisch aktiven Übergangsmetall-Katalysators, der Rhodium als katalytisch aktives Übergangsmetall und einen chiralen, zweizähnigen Bisphosphin-Liganden aufweist, wobei das Reaktionsgemisch während der Hydrierung der prochiralen α,β-ungesättigter Carbonylverbindung zusätzlich wenigstens eine Verbindung der allgemeinen Formel (I) enthält:

worin
R 1 , R 2 :
gleich oder verschieden sind und für C 6 - bis C 10 -Aryl stehen, das unsubstituiert ist oder einen oder mehrere, z.B. 1, 2, 3, 4 oder 5, Substituenten trägt, die ausgewählt sind unter C 1 - bis C 6 -Alkyl, C 3 - bis C 6 -Cycloalkyl, C 6 -bis C 10 -Aryl, C 1 - bis C 6 -Alkoxy und Amino;
Z
für eine Gruppe CHR 3 R 4 oder Aryl steht, das unsubstituiert ist oder einen oder mehrere, z.B. 1, 2, 3, 4 oder 5, Substituenten trägt, die ausgewählt sind unter C 1 - bis C 6 -Alkyl, C 3 - bis C 6 -Cycloalkyl, C 6 - bis C 10 -Aryl, C 1 - bis C 6 -Alkoxy und Amino, worin R 3 und R 4 wie in den Ansprüchen und der Beschreibung definiert sind.

54. 发明公开

EP3233778A1 VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER CARBONYLVERBINDUNGEN 有权
公开(公告)号：EP3233778A1
公开(公告)日：2017-10-25
申请号：EP15817247.8
申请日：2015-12-18
申请人： BASF SE
发明人： SCHELWIES, Mathias , PACIELLO, Rocco , HEYDRICH, Gunnar , WEGNER, Günter , TEBBEN, Gerd-Dieter , HAUBNER, Martin , KELLER, Andreas , BEY, Oliver , RENZ, Stephanie , SEEBER, Georg
IPC分类号： C07C45/62 , C07C47/21 , C07C47/02 , C07C29/17 , C07C29/56 , C07C35/12 , C07C35/17
CPC分类号： C07C45/62 , C07B2200/07 , C07C29/172 , C07C29/56 , C07C2601/14 , C07C47/21 , C07C47/02 , C07C35/12 , C07C35/17
摘要： The present invention relates to a method for synthesizing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst which is soluble in the reaction mixture and comprises rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand; during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound, the reaction mixture further comprises at least one compound of the general formula (I), in which R
1 and R
2 are identical or different and are C
6 - to C
10 -aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents selected from C
1 - to C
6 -alkyl, C
3 - to C
6 -cycloalkyl, C
6 - to C
10 -aryl, C
1 - to C
6 -alkoxy and amino; Z is a group CHR
3 R
4 or aryl, which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents selected from C
1 - to C
6 -alkyl, C
3 - to C
6 -cycloalkyl, C
6 - to C
10 -aryl, C
1 - to C
6 -alkoxy and amino, in which R
3 and R
4 are as defined in the claims and the description.
摘要翻译：本发明涉及一种合成光学活性羰基化合物的方法，该方法包括在至少一种可溶于反应混合物中的光学活性过渡金属催化剂的存在下，用氢将前手性α，β-不饱和羰基化合物不对称氢化，并包含铑作为催化活性的过渡金属和手性二齿双膦配体; 在前手性α，β-不饱和羰基化合物氢化期间，反应混合物还包含至少一种通式（I）的化合物，其中R 1和R 2相同或不同并且是C 6至C 10 - 未取代的或带有一个或多个例如 1,2,3,4或5个选自C 1至C 6烷基，C 3至C 6环烷基，C 6至C 10芳基，C 1至C 6烷氧基和氨基的取代基 ; Z是基团CHR 3 R 4或芳基，其未被取代或带有一个或多个例如 1,2,3,4或5个选自C 1至C 6烷基，C 3至C 6环烷基，C 6至C 10芳基，C 1至C 6烷氧基和氨基的取代基其中R 3和R 4如权利要求和说明书中所定义。

55. 发明授权

EP2064169B1 RÜCKGEWINNUNG VON BIS(DIARYLPHENOL)-LIGANDEN BEI DER HERSTELLUNG VON ISOPULEGOL 有权
标题翻译： BIS（diarylphenol）的配体时回收生产异胡薄荷醇
公开(公告)号：EP2064169B1
公开(公告)日：2016-03-23
申请号：EP07803136.6
申请日：2007-08-31
申请人： BASF SE
发明人： HEYDRICH, Gunnar , GRALLA, Gabriele , EBEL, Klaus
IPC分类号： C07C29/17 , C07C29/56 , C07C29/80 , C07C35/12 , C07C35/17 , B01J31/02 , B01J31/14 , B01J31/40
CPC分类号： C07C29/56 , B01J31/0214 , B01J31/143 , B01J31/4015 , B01J2531/31 , C07B2200/07 , C07C29/172 , C07C29/80 , C07C2601/14 , Y02P20/584 , C07C35/12 , C07C35/17

56. 发明授权

EP2155638B1 MENTHOLSCHUPPEN UND VERFAHREN ZU DEREN HERSTELLUNG 有权
公开(公告)号：EP2155638B1
公开(公告)日：2014-11-26
申请号：EP08760702.4
申请日：2008-06-09
申请人： BASF SE
发明人： RAULS, Matthias , BAYER, Robert , HEYDRICH, Gunnar , FRYE, Lars , WISNIEWSKI, Thomas
IPC分类号： C07C29/76 , C07C35/12 , B01J2/24
CPC分类号： B01J2/24 , C07B2200/07 , C07C29/76 , C07C35/12 , C07C2601/14

57. 发明授权

EP1846353B1 VERFAHREN ZUR STEUERUNG EINER HYDRIERUNG 无效
标题翻译：一种用于控制加氢
公开(公告)号：EP1846353B1
公开(公告)日：2011-03-23
申请号：EP06707886.5
申请日：2006-01-30
申请人： BASF SE
发明人： WECK, Alexander , RÖSCH, Markus , WINDECKER, Gunther , HEYDRICH, Gunnar , PINKOS, Rolf , SCHUBERT, Olga , HARTH, Klaus
IPC分类号： C07C51/36 , C07D307/60 , B01J19/00 , C07C55/10
CPC分类号： B01J8/067 , B01J19/0006 , B01J2219/00006 , B01J2219/002 , B01J2219/00216 , B01J2219/0022 , B01J2219/00234 , B01J2219/00238 , B01J2219/30 , B01J2219/30483 , C07C51/36 , Y02P20/582 , Y10T436/22 , C07C55/10
摘要： The invention relates to a method for controlling hydrogenation of an educt in a hydrogenation reactor. According to said method, the amount of hydrogen reacted during hydrogenation is determined first, whereupon the ratio between the amount of hydrogen reacted and the amount of educt delivered is calculated, said ratio is compared to a predefined setpoint value, and finally at least one process parameter is modified if the ratio between the amount of hydrogen reacted and the amount of educt delivered deviates from the predefined setpoint value by a given value.

58. 发明公开

EP2234949A1 VERFAHREN ZUR HERSTELLUNG VON 4,4'-Ý1-(TRIFLUORMETHYL)ALKYLIDEN¨-BIS-(2,6-DIPHENYLPHENOLEN) 有权
标题翻译：用于生产4,4“ - [1-（三氟甲基）亚烷基]双（2,6-二DIPHENYLPHENOLEN）
公开(公告)号：EP2234949A1
公开(公告)日：2010-10-06
申请号：EP08863003.3
申请日：2008-12-17
申请人： BASF SE
发明人： GRALLA, Gabriele , HEYDRICH, Gunnar , EBEL, Klaus , KRAUSE, Wolfgang
IPC分类号： C07C37/07 , C07C37/62 , C07C39/15 , C07C39/367 , C07C45/74 , C07C49/613 , C07C49/653
CPC分类号： C07C45/74 , C07C37/07 , C07C37/20 , C07C37/62 , C07C49/613 , C07C49/653 , C07C39/15 , C07C39/367
摘要： The present invention relates to a method for the production of 4,4'-[1-(trifluoromethyl)alkylidene]-bis-(2,6-diphenylphenols), in particular to the production of 4,4'-[1-(trifluoromethyl)ethylidene]-bis-(2,6-diphenylphenol), comprising the self-condensation of cyclohexanone in the presence of a basic catalyst to form tricyclic condensation products, dehydration of the obtained tricyclic condensation products in the presence of a carrier-bound transition metal catalyst in condensed phase to form 2,6-diphenylphenol, and reaction of the 2,6-diphenylphenol with a trifluoromethylketone. In addition, the invention relates to an improved method for the production of 2,6-diphenylphenol by aldol self-condensation of cyclohexanone.

59. 发明公开

EP2225192A2 VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEM UND RACEMISCHEM MENTHOL 有权
标题翻译：工艺生产光学活性和消旋薄荷
公开(公告)号：EP2225192A2
公开(公告)日：2010-09-08
申请号：EP08854428.3
申请日：2008-11-13
申请人： BASF SE
发明人： HEYDRICH, Gunnar , GRALLA, Gabriele , RAULS, Matthias , SCHMIDT-LEITHOFF, Joachim , EBEL, Klaus , KRAUSE, Wolfgang , OEHLENSCHLÄGER, Steffen , JÄKEL, Christoph , FRIEDRICH, Marko , BERGNER, Eike Johannes , KASHANI-SHIRAZI, Nawid , PACIELLO, Rocco
IPC分类号： C07C29/17
CPC分类号： C07C29/56 , C07B2200/07 , C07C29/172 , C07C29/78 , C07C45/62 , C07C45/82 , C07C2601/14 , C07C2601/16 , C07C47/21 , C07C35/12 , C07C35/17
摘要： The invention relates to a particularly economic, complete method for producing menthol, especially for the production of optically active, essentially enantiomerically and diastereomerically pure L-menthol and of racemic menthol starting from the commercially accessible, inexpensive parent material citral. The method comprises the following steps: a.1 ) catalytic hydrogenation of neral and/or geranial to form citronellal, b.1 ) cyclisation of citronellal to form isopulegol in the presence of an acidic catalyst, c.1 ) purification of isopulegol by crystallisation and d.1 ) catalytic hydrogenation of isopulegol to form menthol.

60. 发明授权

EP1515932B1 VERFAHREN ZUR HERSTELLUNG VON 1,4- BUTANDIOL 有权
标题翻译：用于生产1,4丁二醇
公开(公告)号：EP1515932B1
公开(公告)日：2010-06-16
申请号：EP03757050.4
申请日：2003-06-10
申请人： BASF SE
发明人： HESSE, Michael , SCHLITTER, Stephan , BORCHERT, Holger , SCHUBERT, Markus , RÖSCH, Markus , BOTTKE, Nils , FISCHER, Rolf-Hartmuth , WECK, Alexander , WINDECKER, Gunther , HEYDRICH, Gunnar
IPC分类号： C07C29/149 , C07C31/20
CPC分类号： C07C29/149 , Y02P20/582 , C07C31/207
摘要： The invention relates to a method for producing optionally alkyl-substituted 1,4-butanediol by means of two-stage catalytic hydration in the gas phase, comprising the following steps: a) a gas stream of C4-dicarboxylic acid or a derivative thereof is fed into a first reactor and the gas phase is catalytically hydrated so as to obtain a product mainly containing optionally alkyl-substituted y-butyrolactone; b) the obtained product stream is fed into a second reactor and the gas phase is catalytically hydrated so as to obtain optionally alkyl-substituted 1,4-butanediol; c) the desired product is separated from intermediate products, by-products, and an optionally unreacted starting material. A catalyst comprising = 95 percent by weight of CuO and = 5 percent by weight of an oxidic carrier is used in each hydration stage. The product mixture obtained in the first hydration step is introduced into the second hydration stage without further cleaning said product mixture.

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