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51. 发明专利

ES2361463T3 DERIVADOS DE PIRIDINA COMO MODULADORES DEL RECEPTOR S1P1/EDG1. 未知
公开(公告)号：ES2361463T3
公开(公告)日：2011-06-17
申请号：ES08789611
申请日：2008-08-14
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LESCOP CYRILLE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , STEINER BEAT , VELKER JOERG
IPC分类号： C07D413/14 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61P37/06 , C07D417/14
摘要： Un compuesto de Fórmula (I), Fórmula (I) en la que piridina1 representa **Fórmula** en las que los asteriscos marcan el enlace con el cual el anillo de Piridina1 está unido a A; R1 representa alquilo C1-5, alcoxi C1-4, cicloalquilo C3-6, hidroximetilo, o NR1aR1b; R1a representa alquilo C1-4; R1b representa hidrógeno, o alquilo C1-3; o R1a y R1b, junto con el nitrógeno que está unido a la piridina, forman un anillo de pirrolidina; R2 representa hidrógeno, o alquilo C1-4, o en el caso en que R1 represente alquilo C1-5 o cicloalquilo C3-6, R2 puede representar además metoxi; R3 representa alquilo C1-5, alcoxi C1-4, cicloalquilo C3-6, o NR3aR3b; R3a representa alquilo C1-4; R3b representa hidrógeno, o alquilo C1-3; R4 representa alquilo C1-4, o hidrógeno; R5 representa alquilo C1-5, metoxi, o NR5aR5b; y R6 representa alquilo C1-2; R5a representa alquilo C1-4; R5b representa hidrógeno, o alquilo C1-3; o R5 representa alquilo C1-2, o metoxi; y R6 representa alquilo C1-5, o NR6aR6b; R6a representa alquilo C1-4; R6b representa hidrógeno, o alquilo C1-3; R7 representa alquilo C1-5; R8 representa alquilo C1-2, o metoxi; R9 representa alquilo C1-5; R10 representa alquilo C1-2; A representa en las que los asteriscos indican el enlace que está unido al anillo de Piridina1; Piridina2 representa en las que los asteriscos marcan el enlace con el cual el anillo de Piridina2 está unido a A; R11 representa alquilo C1-4, alcoxi C1-3, hidroximetilo, o NR11aR11b; R11a representa alquilo C1-3; R11b representa hidrógeno, o alquilo C1-2; R12 representa hidrógeno, o alquilo C1-2; R13 representa alquilo C1-4, o NR13aR13b; R13a representa alquilo C1-3; R13b representa hidrógeno, o alquilo C1-2; R14 representa alquilo C1-2; R15 representa alquilo C1-4, o NR15aR15b; y R16 representa alquilo C1-2; R15a representa alquilo C1-3; R15b representa hidrógeno, o alquilo C1-3; o R15 representa alquilo C1-2; y R16 representa alquilo C1-4, o NR16aR16b; R16a representa alquilo C1-3; R16b representa hidrógeno, o alquilo C1-2; R17 representa alquilo C1-4; R18 representa alquilo C1-2, o metoxi; R19 representa alquilo C1-4; y R20 representa alquilo C1-2; con la excepción de 3-(2-etil-4-piridil)-5-(2-etil-4-piridil)-1,2,4-oxadiazol; o una sal de dicho compuesto.

52. 发明专利

DE602008005770D1 PYRIDINDERIVATE ALS S1P1/EDG1-REZEPTORMODULATOREN 未知
公开(公告)号：DE602008005770D1
公开(公告)日：2011-05-05
申请号：DE602008005770
申请日：2008-08-14
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LESCOP CYRILLE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , STEINER BEAT , VELKER JOERG
IPC分类号： C07D413/14 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61P37/06 , C07D417/14

53. 发明专利

HK1144809A1 PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS 未知
公开(公告)号：HK1144809A1
公开(公告)日：2011-03-11
申请号：HK10111281
申请日：2010-12-03
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LESCOP CYRILLE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , STEINER BEAT , VELKER JOERG
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.

54. 发明专利

BRPI0611631A2 未知
公开(公告)号：BRPI0611631A2
公开(公告)日：2010-09-21
申请号：BRPI0611631
申请日：2006-06-20
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LEHMANN DAVID , MATHYS BORIS , MUELLER CLAUS , VELKER JOERG
IPC分类号： C07D333/22 , A61K31/381 , A61K31/397 , A61K31/4436 , A61P37/06 , C07D417/04 , C07D417/10
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

55. 发明专利

MX2010001881A DERIVADOS DE PIRIDINA COMO MODULADORES DEL RECEPTOR S1P1/EDG1. 未知
公开(公告)号：MX2010001881A
公开(公告)日：2010-03-10
申请号：MX2010001881
申请日：2008-08-14
申请人： ACTELION PHARMACEUTICALS LTD
发明人： STEINER BEAT , VELKER JOERG , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , BOLLI MARTIN , LESCOP CYRILLE
IPC分类号： C07D413/14 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61P37/06 , C07D417/14
摘要： La invención se refiere a derivados de piridina novedosos, su preparación y su utilización como compuestos farmacéuticamente activos. Dichos compuestos actúan particularmente como agentes inmunomoduladores.

56. 发明专利

DE602007003074D1 未知
公开(公告)号：DE602007003074D1
公开(公告)日：2009-12-17
申请号：DE602007003074
申请日：2007-01-23
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LEHMANN DAVID , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , STEINER BEAT , VELKER JOERG
IPC分类号： C07D409/06 , A61K31/4436 , A61K31/4439 , A61P37/00 , C07D413/14
摘要： The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

57. 发明专利

MA30717B1 DERIVES DE PYRIDIN-3-YLE EN TANT QU'AGENTS IMMUNOMODULATEURS 未知
公开(公告)号：MA30717B1
公开(公告)日：2009-09-01
申请号：MA31728
申请日：2009-03-18
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , LEHMANN DAVID , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , STEINER BEAT , VELKER JOERG
IPC分类号： C07D413/04 , A61K31/4439 , A61P19/00 , A61P35/00 , C07D417/04
摘要： DÉRIVÉS DE PYRIDIN-3-YLE DE FORMULE (I), DANS LAQUELLE R1, R2, R3, R4, R5, R6 ET A SONT TELS QUE SPÉCIFIÉS DANS LA DESCRIPTION, AINSI QUE LEUR ÉLABORATION ET LEUR UTILISATION COMME COMPOSÉS PHARMACEUTIQUEMENT ACTIFS. CES COMPOSÉS AGISSENT EN PARTICULIER COMME AGENTS IMMUNOMODULATEURS.

58. 发明专利

CA2629122A1 NOVEL THIOPHENE DERIVATIVES 未知
公开(公告)号：CA2629122A1
公开(公告)日：2007-05-31
申请号：CA2629122
申请日：2006-11-22
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , MATHYS BORIS , MUELLER CLAUS , LEHMANN DAVID , STEINER BEAT , VELKER JOERG , NAYLER OLIVER
IPC分类号： C07D333/72 , A61K31/381 , A61P37/06
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

59. 发明专利

DE60207894T2 未知
公开(公告)号：DE60207894T2
公开(公告)日：2006-07-20
申请号：DE60207894
申请日：2002-12-02
申请人： ACTELION PHARMACEUTICALS LTD
发明人： DR AISSAOUI HAMED , BINKERT CHRISTOPH , CLOZEL MARTINE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , DR SCHERZ MICHAEL , VELKER JOERG , WELLER THOMAS
IPC分类号： C07D401/12 , A61K31/4709 , A61P9/02 , C07D20060101 , C07D401/14 , C07D471/04
摘要： The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

60. 发明专利

CA2540196A1 PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS 未知
公开(公告)号：CA2540196A1
公开(公告)日：2005-04-07
申请号：CA2540196
申请日：2004-09-21
申请人： ACTELION PHARMACEUTICALS LTD
发明人： CLOZEL MARTINE , WELLER THOMAS , MATHYS BORIS , MUELLER CLAUS , SCHERZ MICHAEL , BUR DANIEL , VELKER JOERG
IPC分类号： A61K31/4545 , A61P9/00 , C07D401/12 , C07D409/14
摘要： The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

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