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51. 发明专利

ZA200306610B 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin II receptor antagonists. 未知
公开(公告)号：ZA200306610B
公开(公告)日：2004-12-14
申请号：ZA200306610
申请日：2003-08-25
申请人： ACTELION PHARMACEUTICALS LTD
发明人： AISSAOUI HAMED , CLOZEL MARTINE , MUELLER CLAUS , SCHERZ MICHAEL , WELLER THOMAS , BINKERT CHRISTOPH , MATHYS BORIS , NAYLER OLIVER , VELKER JOERG
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101 , C07D , A61K , A61P

52. 发明专利

NO20042844A 未知
公开(公告)号：NO20042844A
公开(公告)日：2004-08-23
申请号：NO20042844
申请日：2004-07-05
申请人： ACTELION PHARMACEUTICALS LTD
发明人： AISSAOUI HAMED , WELLER THOMAS , VELKER JORG , BINKERT CHRISTOPH , CLOZEL MARTINE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , SCHERZ MICHAEL
IPC分类号： A61K31/4709 , A61P9/02 , C07D20060101 , C07D401/12 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14

53. 发明专利

AU2002304733A1 Amino-aza-cyclohexanes for the treatment of malaria 未知
公开(公告)号：AU2002304733A1
公开(公告)日：2002-10-28
申请号：AU2002304733
申请日：2002-04-09
申请人： ACTELION PHARMACEUTICALS LTD
发明人： FISCHLI WALTER , BINKERT CHRISTOPH , RICHARD-BILDSTEIN SYLVIA , WELLER THOMAS , MEYER SOLANGE , BOSS CHRISTOPH , STRICKNER PANJA
IPC分类号： A61P33/06 , C07D211/58 , C07D401/12 , A61K31/506
摘要： The invention relates to novel compounds which are substituted amino-aza-cyclohexane derivatives of the general formula (I). The invention also concerns related aspects including pharmaceutical compositions containing one or more compounds of the general formula I and their use as medicaments for the treatment of protozoal infections, especially malaria.

54. 发明专利

CA2623213C PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS 未知
公开(公告)号：CA2623213C
公开(公告)日：2014-01-14
申请号：CA2623213
申请日：2006-10-20
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BINKERT CHRISTOPH , BOSS CHRISTOPH , CORMINBOEUF OLIVIER , GRISOSTOMI CORINNA , MEYER SOLANGE
IPC分类号： C07D295/18 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/54 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58
摘要： The invention relates to novel piperazine derivatives of formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria. wherein X represents -(CH2)o-2 - or -C(=O)-; n represents the integer 0, 1 or 2; R1-R4 as described in claim 1

55. 发明专利

SI1689726T1 DERIVATI 5-(BENZ-(Z)-ILIDEN)-TIAZOLIDIN-4-ONA KOT IMUNOSUPRESIVNA SREDSTVA 未知
公开(公告)号：SI1689726T1
公开(公告)日：2011-01-31
申请号：SI200431556
申请日：2004-11-16
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , SCHERZ MICHAEL , MUELLER CLAUS , MATHYS BORIS , BINKERT CHRISTOPH , NAYLER OLIVER
IPC分类号： C07D277/00 , A61K31/00 , A61K31/426 , A61K31/427 , A61P37/00 , C07D277/20 , C07D417/00 , C07D417/06

56. 发明专利

DE602004029493D1 5-(BENZ- (Z) -YLIDEN) -THIAZOLIDIN-4-ONDERIVATE ALS DAS IMMUNSYSTEM UNTERDRÜCKENDE MITTEL 未知
公开(公告)号：DE602004029493D1
公开(公告)日：2010-11-18
申请号：DE602004029493
申请日：2004-11-16
申请人： ACTELION PHARMACEUTICALS LTD
发明人： BOLLI MARTIN , SCHERZ MICHAEL , MUELLER CLAUS , MATHYS BORIS , BINKERT CHRISTOPH , NAYLER OLIVER
IPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61P37/06 , C07D417/06

57. 发明专利

CA2623213A1 PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS 未知
公开(公告)号：CA2623213A1
公开(公告)日：2007-04-26
申请号：CA2623213
申请日：2006-10-20
申请人： ACTELION PHARMACEUTICALS LTD
发明人： GRISOSTOMI CORINNA , CORMINBOEUF OLIVIER , BOSS CHRISTOPH , MEYER SOLANGE , BINKERT CHRISTOPH
IPC分类号： C07D295/18 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/54 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58
摘要： The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria.

59. 发明专利

ES2254772T3 4-(PIPERIDIL-Y PIRROLIDIL-ALQUIL-UREIDO)-QUINOLEINAS COMO RECEPTORES ANTAGONISTAS DE UROTENSINA II. 未知
公开(公告)号：ES2254772T3
公开(公告)日：2006-06-16
申请号：ES02791749
申请日：2002-12-02
申请人： ACTELION PHARMACEUTICALS LTD
发明人： DR AISSAOUI HAMED , BINKERT CHRISTOPH , CLOZEL MARTINE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER
IPC分类号： A61K31/4709 , A61P9/02 , C07D20060101 , C07D401/12 , C07D401/14 , C07D471/04
摘要： Compuestos de la fórmula general 1, caracterizados porque: Py representa piridin-4-ilo mono-sustituido en la posición 2 con -NR 2 R 3 ; piridin-4-ilo disustituido en la posición 2 con -NR 2 R 3 y en la posición 6 con alquilo C1 - 8 o arilalquilo; quinolin-4-ilo no sustituido; quinolin-4-ilo mono-sustituido en la posición 2 con alquilo C1 - 8; quinolin-4-ilo di-sustituido en la posición 2 con alquilo C1 - 8 y en la posición 6, 7, ó 8 con halógeno, alquilo C1 - 8, o arilalquilo; 2-hidroximetil-quinolin-4-ilo; 7-metil-[1, 8]naftiridin-4-ilo; 5, 6, 7, 8-tetrahidro-[1, 8]naftiridin-4-ilo; 8-bencil-5, 6, 7, 8-tetrahidro-[1, 8]naftiridin-4-ilo; 8-metil-5, 6, 7, 8-tetrahidro-[ 1, 8]naftiridin-4-ilo; 2, 3-dihidro-1H-pirrolo[2, 3-b]piridin-4-ilo; 1-metil-2, 3-dihidro-1H-pirrolo[2, 3-b]piridin-4-ilo; 1- bencil-2, 3-dihidro-1H-pirrolo[2, 3-b]piridin-4-ilo; X representa arilo; arilo-O-; arilalquilo-; alquilo C1 - 8-SO2NR 2 -; arilo-SO2NR 2 -; arilalquilo-SO2NR 2 -; alquilo C1 - 8-CONR 2 -; arilo-CONR 2-; arilalquilo-CONR 2 -; alquilo C1 - 8-NR 3 CONR 2 -; arilo-NR 3 CONR 2 -; arilalquilo-NR 3 CONR 2 -; arilo-CO-; arilalquilo-CO-; alquilo C1 - 8-NR 2 CO-; arilo-NR 2 CO-; arilalquilo-NR 2 CO-; o X y Z representan junto con el átomo de carbono al cual se conectan un enlace doble exocíclico el cual porta un sustituyente arilo. Y representa -C(R 4 )(R 5 )(CH2)m- ó -(CH2)mC(R 4 )(R 5 )-Z representa hidrógeno; en caso de que X represente arilo o arilalquilo, Z representa hidrógeno, hidroxilo, carbo-xilo, arilo-CONR 2 -, alquilo C1 - 8-NR 2 CO-, arilo-NR 2 CO- o arilalquilo-NR 2 CO-; n representa los números 0 ó 1; m representa los números 1 ó 2; R 1 representa hidrógeno o alquilo C1 - 8; R 2 y R 3 representan independientemente hidrógeno, alquilo C1 - 8, o arilalquilo; en caso de que R 2 y R 3 se conectan al mismo átomo de nitrógeno, R 2 y R 3 juntos forman con el nitrógeno al cual se conectan, un anillo piperidina, pirrolidina o morfolino.

60. 发明专利

DE60205234T2 未知
公开(公告)号：DE60205234T2
公开(公告)日：2006-05-24
申请号：DE60205234
申请日：2002-03-20
申请人： ACTELION PHARMACEUTICALS LTD
发明人： AISSAOUI HAMED , BINKERT CHRISTOPH , CLOZEL MARTINE , MATHYS BORIS , MUELLER CLAUS , NAYLER OLIVER , SCHERZ MICHAEL , WELLER THOMAS , VELKER JOERG
IPC分类号： C07D403/12 , C07D491/056 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/4741 , A61K31/4745 , A61K31/55 , A61K45/00 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/12 , A61P15/10 , A61P21/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/02 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/12 , C07D405/14 , C07D407/14 , C07D471/02 , C07D471/04 , C07D491/04
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

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