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51. 发明专利

CA3099527A1 MULTISPECIFIC BINDERS OF TGF.BETA.-SUPERFAMILY LIGANDS AND USES THEREOF 未知
公开(公告)号：CA3099527A1
公开(公告)日：2019-11-07
申请号：CA3099527
申请日：2019-05-02
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , SAKO DIANNE S , CASTONGUAY ROSELYNE , KUO TZU-HSING
IPC分类号： C07K14/71 , A61K38/00 , A61P21/00 , C07K16/22 , C07K16/46 , C07K19/00
摘要： In certain aspects, the disclosure provides multispecific binders (e.g., ?ctR???:?ßRII heteromultimers comprising an ActRlIA polypeptide and a TfiRU polypeptide). The disclosure further provides that such multispecific binders (e.g., ?ctR???:?ßRII heteromultimer) may be used to treat various disorders or conditions.

52. 发明专利

AU2017338915A1 TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof 未知
公开(公告)号：AU2017338915A1
公开(公告)日：2019-04-18
申请号：AU2017338915
申请日：2017-10-05
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S , CASTONGUAY ROSELYNE
IPC分类号： A61K38/43 , A61P7/00 , A61P7/06 , C07K16/46 , C07K19/00
摘要： In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine/threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine/threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK.6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and/or cells of hematopoietic lineages, including red blood cells. In certain aspects, such soluble polypeptide complexes are can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cellular networks, and endocrine systems.

53. 发明专利

HK1250374A1 ALK4:ACTRIIB異多聚體和其用途未知
公开(公告)号：HK1250374A1
公开(公告)日：2018-12-14
申请号：HK18109789
申请日：2018-07-30
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S , PEARSALL ROBERT SCOTT , CASTONGUAY ROSELYNE
IPC分类号： C07K20060101 , A61K20060101 , A61P20060101

54. 发明专利

HK1225740A1 TGF-β受體II型變體及其用途未知
公开(公告)号：HK1225740A1
公开(公告)日：2017-09-15
申请号：HK16113925
申请日：2016-12-07
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S , CASTONGUAY ROSELYNE , STEEVES RITA
IPC分类号： C07K20060101 , A61K20060101 , A61P20060101

55. 发明专利

CA2980757A1 FOLLISTATIN-RELATED FUSION PROTEINS AND USES THEREOF 未知
公开(公告)号：CA2980757A1
公开(公告)日：2016-09-29
申请号：CA2980757
申请日：2016-03-25
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S
IPC分类号： C12N15/62 , A61K38/18 , A61K39/395 , C07K14/495
摘要： The present disclosure provides compositions and methods for inhibiting activity of TGFß superfamily ligands, particularly ligands such as GDF8, GDF 11, activin A, activin B, activin C and activin E, in vertebrates, including rodents, primates, and particularly in humans. The compositions of the disclosure contain protein complex/fusion comprising a heteromeric Fc interaction pair to which a follistatin related polypeptide is covalently or non-covalently associated. The compositions maybe used to treat or prevent diseases or disorders that are associated with abnormal activity of a follistatin-related polypeptide and/or a follistatin ligand.

56. 发明专利

CA2931309C COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION 未知
公开(公告)号：CA2931309C
公开(公告)日：2022-06-21
申请号：CA2931309
申请日：2014-11-21
申请人： BRIGHAM & WOMENS HOSPITAL INC , ACCELERON PHARMA INC
发明人： YU PAUL , GRINBERG ASYA , SAKO DIANNE S , CASTONGUAY ROSELYNE , STEEVES RITA , KUMAR RAVINDRA
IPC分类号： A61K47/68 , A61P9/00 , A61P9/12 , A61P11/00
摘要： In some aspects, the invention teaches pharmaceutical compositions that include a TGF-beta ligand trap, and methods of using a TGF-beta ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-beta ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-beta signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-beta ligand trap to reduce right ventricular systolic pressure in a subject.

57. 发明专利

MA53400A HÉTÉROMULTIMÈRES ALK7: ACTRIIB ET LEURS UTILISATIONS 未知
公开(公告)号：MA53400A
公开(公告)日：2021-06-02
申请号：MA53400
申请日：2016-04-06
申请人： ACCELERON PHARMA INC
发明人： CASTONGUAY ROSELYNE , DAGON YOSSI , GRINBERG ASYA , KNOPF JOHN , KUMAR RAVINDRA , LI GANG , PEARSALL ROBERT SCOTT , SAKO DIANNE S
IPC分类号： A61K38/00 , A61K38/17 , A61K39/395 , A61P1/16 , A61P3/04 , A61P9/00 , A61P11/00 , A61P13/12 , A61P19/00 , A61P21/00 , A61P25/00 , A61P35/00 , A61P37/00 , C07K14/71 , C07K19/00 , C12N9/12

58. 发明专利

RS61728B1 JEDNOGRANI FUZIONI RECEPTORSKI PROTEINI TIPA I I TIPA II I NJIHOVE UPOTREBE 未知
公开(公告)号：RS61728B1
公开(公告)日：2021-05-31
申请号：RSP20210481
申请日：2016-04-06
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S
IPC分类号： A61P3/00 , A61K38/00 , A61P7/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P43/00 , C07K14/71

59. 发明专利

AU2021200071A1 ALK4:ActRIIB heteromultimers and uses thereof 未知
公开(公告)号：AU2021200071A1
公开(公告)日：2021-03-18
申请号：AU2021200071
申请日：2021-01-07
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S , PEARSALL ROBERT SCOTT , CASTONGUAY ROSELYNE
IPC分类号： C07K14/71 , A61K38/17 , A61K39/395 , A61P13/12 , A61P19/08 , A61P21/06 , C07K19/00
摘要： In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK4 receptor and an extracellular domain of ActRIIB. In certain aspects, such soluble ALK4:ActRIIB complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, and/or cancerous cells. In certain aspects, such ALK4:ActRIIB complexes are can be used to improve muscle formation, bone formation, metabolic parameters, and disorders associated with these tissues, cellular networks, kidney, and endocrine systems.

60. 发明专利

EA037293B1 ГЕТЕРОМУЛЬТИМЕРЫ РЕЦЕПТОРОВ ТИПА I И ТИПА II БЕЛКОВ СУПЕРСЕМЕЙСТВА TGF-БЕТА 未知
公开(公告)号：EA037293B1
公开(公告)日：2021-03-05
申请号：EA201792222
申请日：2016-04-06
申请人： ACCELERON PHARMA INC
发明人： KUMAR RAVINDRA , GRINBERG ASYA , SAKO DIANNE S , PEARSALL ROBERT SCOTT , CASTONGUAY ROSELYNE
IPC分类号： A61K38/18 , A61K39/395 , A61P9/00 , A61P19/00 , A61P21/00 , A61P35/00 , C07K14/71 , C07K19/00
摘要： Внекоторыхаспектахизобретениеотноситсяк растворимымгетеромернымполипептиднымкомплексам, содержащимвнеклеточныйдоменсерин/треониновогокиназногорецепторатипа I белковсемейства TGF-бетаи внеклеточныйдоменсерин/треониновогокиназногорецепторатипа II белковсемейства TGF-бета. Внекоторыхвариантахосуществленияизобретениеотноситсяк растворимымполипептиднымкомплексам, содержащимвнеклеточныйдоменрецепторатипа II, выбранногоиз ActRIIA, ActRIIB, TGFBRII, BMPRII и MISRII. Внекоторыхвариантахосуществленияизобретениеотноситсяк растворимымполипептиднымкомплексам, содержащимвнеклеточныйдоменрецепторатипа I, выбранногоиз ALK1, ALK2, ALK3, ALK4, ALK5, ALK6 и ALK7. Необязательнорастворимыйкомплекспредставляетсобойгетеродимер. Внекоторыхаспектахтакиерастворимыеполипептидныекомплексыможноиспользоватьдлярегуляции (стимуляцииилиингибирования) ростатканейиликлеток, включая, например, мышцу, кость, хрящ, жировуюткань, нервнуюткань, опухоли, злокачественныеклеткии/иликлеткигемопоэтическихростков, включаяэритроциты. Внекоторыхаспектахтакиерастворимыеполипептидныекомплексыможноиспользоватьдляулучшенияобразованиямышц, образованиякостей, гемапоэза, метаболическихпараметрови длянарушений, ассоциированныхс этимитканями, клеточнымисетямии эндокриннымисистемами.

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