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    • 58. 发明公开
    • 어성초 추출물 또는 이로부터 분리된 리그난 계열 화합물인디하이드로구아이아레트산을 유효성분으로 하는심장순환계 질환의 예방 및 치료용 조성물
    • 含有HOUTTUYNIA CORDATA THUNB萃取物的组合物。 或用于预防和治疗心血管疾病的双胍化合物,二氢阿拉伯酸
    • KR1020080032525A
    • 2008-04-15
    • KR1020060098502
    • 2006-10-10
    • 한국생명공학연구원
    • 정태숙이우송박호용김민정
    • C07C43/275C07C43/257
    • A composition for preventing or treating cardiovascular diseases is provided to prevent or treat hyperlipidemia, coronary artery heart disease, atherosclerosis and myocardial infarction caused by oxidation of LDL or synthesis and accumulation of cholesteryl esters. A composition for preventing or treating cardiovascular diseases comprises dihydroguaiaretic acid, a lignan compound represented by the following formula 1, as an active ingredient. The compound is obtained by extraction and isolation from Houttuynia cordata thunb. Particularly, the method for preparing the compound represented by formula 1 comprises the steps of: crushing dried Houttuynia cordata thunb., and extracting the crushed product with a solvent; adding water to the extract of the preceding step and fractioning the water suspension sequentially with n-hexane, chloroform and ethyl acetate to obtain a soluble extract; and separating and purifying the soluble extract.
    • 提供用于预防或治疗心血管疾病的组合物以预防或治疗由高密度脂蛋白氧化引起的高脂血症,冠状动脉心脏病,动脉粥样硬化和心肌梗死或胆固醇酯的合成和积聚。 用于预防或治疗心血管疾病的组合物包含二氢愈耳炎酸,由下式1表示的木酚素化合物作为活性成分。 通过从鱼腥草提取和分离获得化合物。 特别地,制备式1化合物的方法包括以下步骤:粉碎干鱼腥草,并用溶剂萃取破碎的产物; 向前述步骤的提取物中加入水,并依次用正己烷,氯仿和乙酸乙酯分级水悬浮液,得到可溶性提取物; 并分离和纯化可溶性提取物。
    • 60. 发明公开
    • 바이페놀 화합물을 유효성분으로 함유하는 심장순환계질환의 예방 및 치료제
    • 含有苯二酚化合物的治疗药物用于预防和治疗心血管疾病
    • KR1020070110463A
    • 2007-11-19
    • KR1020070060987
    • 2007-06-21
    • 한국생명공학연구원
    • 박호용정태숙이우송오현우박두상서명철한종민
    • A61K31/05A61P9/10
    • A therapeutic agent comprising biphenol compounds is provided to inhibit oxidation of low density lipoproteins and remove DPPH(1,1-diphenyl-2-picrylhydrazyl) radicals without side effects, so that the agent is useful for prevention and treatment of cardiovascular diseases including arteriosclerosis, coronary artery heart disease and myocardial infarction. A therapeutic agent for prevention and treatment of cardiovascular diseases comprises a biphenol compound represented by the formula(2), 3,5,5',5'-tetra-tert-butyl-diphenyl-2,2'-diol, isolated from Mantidis ootheca which is isolated by extracting Mantidis ootheca with water, C1-C4 lower alcohol or a mixed solvent thereof to prepare the crude extract of Mantidis ootheca; suspending the crude extract in water, and fractionating the suspension with n-hexane, chloroform and ethylacetate, sequentially to obtain an ethylacetate fraction; and subjecting the ethylacetate fraction to silica gel chromatography.
    • 提供包含联苯酚化合物的治疗剂以抑制低密度脂蛋白的氧化并除去DPPH(1,1-二苯基-2-苦基肼基)基团,而不会有副作用,因此该试剂可用于预防和治疗心血管疾病,包括动脉硬化, 冠状动脉心脏病和心肌梗塞。 用于预防和治疗心血管疾病的治疗剂包括由Mantidis分离的由式(2),3,5,5',5'-四叔丁基 - 二苯基-2,2'-二醇代表的联苯酚化合物 通过用水,C1-C4低级醇或其混合溶剂提取螳螂is子分离出的卵母细胞以制备螳螂的粗提物; 将粗提物悬浮在水中,并依次用正己烷,氯仿和乙酸乙酯分级悬浮液,得到乙酸乙酯级分; 并将乙酸乙酯级分进行硅胶色谱。