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51. 发明授权

KR101667560B1 이미다졸리움을 가진 고분자 화합물을 유효성분으로 함유하는 항균용 약학적 조성물 및 박테리아 검출용 화학센서 有权
标题翻译：高分子化合物与咪唑鎓作为抗菌药物组合物中的活性成分或用于检测细菌的化学传感器
公开(公告)号：KR101667560B1
公开(公告)日：2016-10-20
申请号：KR1020140044123
申请日：2014-04-14
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 박성수 , 이송이 , 성화 , 슈큉링
IPC分类号： C08F290/06 , C08F281/00 , C08F279/00 , C08G73/06 , C08G69/00 , C08F2/46 , A01N43/48 , G01N33/48 , A61K47/32 , C08F22/40
摘要： 본발명은이미다졸리움을가진고분자화합물을유효성분으로함유하는항균용약학적조성물및 박테리아검출용화학센서에관한것으로, 비색, 흡광및 형광변화를통한박테리아의검출능력뿐아니라, 그람양성세균성박테리아(Gram-positive pathogenic bacteria), 그람음성세균성박테리아(Gram-negative pathogenic bacteria) 및항생제내성을가지는박테리아(antibiotic resistant bacteria)의활성을억제하는효과가우수하므로, 이에따른박테리아감염에대한치료가효과적일것으로예상되어박테리아의검출또는치료용약학적조성물로유용하게사용될수 있다.

52. 发明公开

KR1020160036462A 글루타티온을 선택적으로 검출하여 패혈증을 진단하기 위한 사이아닌 구조 기반의 화합물 有权
标题翻译：通过选择性检测GLUTATHIONE的基于CYANINE SCAFFOLD进行诊断的化合物
公开(公告)号：KR1020160036462A
公开(公告)日：2016-04-04
申请号：KR1020150038035
申请日：2015-03-19
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 윤준 , 김경미 , 김다빈
IPC分类号： C07D403/14 , A61K31/497 , G01N31/22
CPC分类号： C07D403/14 , A61K31/497 , G01N31/22 , G01N2800/26
摘要： 본발명은글루타티온을선택적으로검출하여패혈증을진단하기위한사이아닌구조기반의화합물에관한것으로, 본발명에따른사이아닌구조기반의화합물은세포내 환경에서도그 구조가유지되며시스테인, 호모시스테인, 글루타티온등 싸이올기(R-SH)를포함하는아미노산들중 오직글루타티온과선택적으로반응하여흡광또는형광스펙트럼이변화하므로, 생체시료중에서, 또는생체내에서글루타티온을검출하는용도로사용될수 있을뿐만아니라, 글루타티온의농도변화를유발하는패혈증을진단하는용도로유용하게사용할수 있다.
摘要翻译：本发明涉及通过选择性检测谷胱甘肽来诊断败血病的花青结构化合物。根据本发明的花青结构的化合物将结构保持在细胞内的环境中。此外，该化合物仅与包含硫醇基（R-SH）的氨基酸（如半胱氨酸，高半胱氨酸，谷胱甘肽等）中的谷胱甘肽发生反应，并改变化合物的光吸收或荧光光谱。因此，本发明的化合物可用于检测生物样本或体内的谷胱甘肽，并用于诊断导致谷胱甘肽浓度变化的败血症。本发明化合物由化学式1表示。

53. 发明授权

KR101413589B1 폴리메틴 체인에 메조-반응작용기를 갖는 신규한 시아닌 유도체 및 이의 제조방법 有权
标题翻译：在聚甲炔链上具有内消旋官能团的新型花青衍生物及其制备方法
公开(公告)号：KR101413589B1
公开(公告)日：2014-07-02
申请号：KR1020130126581
申请日：2013-10-23
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 지콴궈
IPC分类号： G01N31/22 , G01N21/78 , C07D403/10
摘要： 본 발명은 폴리메틴 체인에 메조-반응작용기를 갖는 신규한 시아닌 유도체 및 이의 제조방법에 관한 것으로, 본 발명에 따른 메조 위치에 반응 작용기가 치환된 시아닌 유도체는 합성 방법이 매우 간단하여 대량생산에 적합하고, 종래의 신경작용제 검출용 시약이 두 단계의 반응 과정을 거쳐야하는 반면에 본 발명의 시아닌 유도체는 한 단계의 반응 과정만을 거치므로 반응속도가 매우 빠르고 민감도 또한 매우 우수하며, 산성의 pH에서도 활성화 가능하고 수성 환경에서도 사용가능하므로, 산성의 pH에서 활성화 가능한 비율측정 근적외선 프로브(acid pH-activatable ratiometric NIR probe)로 유용할 수 있다.

54. 发明公开

KR1020130124265A 폴리메틴 체인에 메조-반응작용기를 갖는 신규한 시아닌 유도체 및 이의 제조방법 有权
标题翻译：在聚四氟乙烯链上具有MESO反应性官能团的新型氰胺衍生物及其制备方法
公开(公告)号：KR1020130124265A
公开(公告)日：2013-11-13
申请号：KR1020130126581
申请日：2013-10-23
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 지콴궈
IPC分类号： G01N31/22 , G01N21/78 , C07D403/10
摘要： The present invention relates to a novel cyanine derivative having a meso-reactive functional group at a polymethine chain and a method for manufacturing thereof and the cyanine derivative in which a reactive functional group is displaced at the meso position according to the present invention is suited or mass production because a synthesis method is simple. A reagent for nerve agent detection passes two reactive processes, but the cyanine derivative according to the present invention passes a reactive process of one step only. Therefore, in case of the cyanine derivative, a reaction speed is fast and the sensitivity is excellent and the vitalization is possible in acid PH. The cyanine derivative is able to be used in aqueous environment and is able to be used as an acid pH-activatable ratiometric NIR probe.
摘要翻译：本发明涉及一种在聚甲炔链上具有内反应性官能团的新颖花青衍生物及其制备方法，其中反应性官能团在本发明的介观位置上位移的花青衍生物是适用的或大量生产因为合成方法简单。用于神经毒素检测的试剂通过两种反应性方法，但根据本发明的花青衍生物仅通过一步反应过程。因此，在花青衍生物的情况下，反应速度快，灵敏度优异，酸PH可能发生活化。花青衍生物能够在水性环境中使用，并且能够用作酸可pH活化的比率NIR探针。

55. 发明公开

KR1020130085755A 폴리메틴 체인에 메조-반응작용기를 갖는 신규한 시아닌 유도체 및 이의 제조방법 有权
标题翻译：在聚四氟乙烯链上具有MESO反应性官能团的新型氰胺衍生物及其制备方法
公开(公告)号：KR1020130085755A
公开(公告)日：2013-07-30
申请号：KR1020120006796
申请日：2012-01-20
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 지콴궈
IPC分类号： C07D403/10 , C07D209/08 , G01N21/80
CPC分类号： G01N31/221 , C07D209/14 , C07D403/08 , C09B23/0041 , C09B23/0066 , G01N33/84 , Y10T436/163333
摘要： PURPOSE: A novel cyanine derivative having meso-reaction functional group in a polymethine chain is provided to give fast reaction rate and excellent sensitivity by passing through only one-step reaction process and to be useful as acidic pH activatable ratiometric NIR probe. CONSTITUTION: A novel cyanine derivative having meso-reaction functional group in a polymethine chain is presented as a chemical formula 1. A manufacturing method of the above mentioned cyanine derivative comprises a step (step 1) obtaining a compound 2 which has a substituted phthalimide at the meso position of compound 3 by reacting compound 3 and phthalimide potassium in the first solvent; and a step (step 2) obtaining compound 1 which has substituted X is at the meso position of compound 2 by reacting compound 2 manufactured in step 1 and X-NH2 in the second solvent as shown in reaction equation 1. The first solvent is one selected from the group of dimethylformamide, dimethylacetamide, diethylether, tetrahydrofuran, 1,4-dioxane, benzene, and toluene.
摘要翻译：目的：提供一种在聚甲炔链中具有内消旋反应官能团的新颖花青衍生物，通过仅通过一步反应过程提供快速反应速率和极好的灵敏度，可用作酸性pH活化比例的NIR探针。构成：在聚甲炔链中具有内消旋反应官能团的新颖花青衍生物作为化学式1表示。上述花青衍生物的制造方法包括步骤（步骤1）得到具有取代的邻苯二甲酰亚胺的化合物2 通过化合物3和邻苯二甲酰亚胺钾在第一溶剂中反应化合物3的内消旋位置; 得到化合物1的步骤（步骤2），如反应式1所示，通过使在步骤1中制造的化合物2和第二溶剂中的X-NH 2反应，得到化合物2的中间位置的化合物1。第一溶剂为选自二甲基甲酰胺，二甲基乙酰胺，二乙醚，四氢呋喃，1,4-二恶烷，苯和甲苯。

56. 发明公开

KR1020110090417A 티올 선택성을 갖는 플루오레세인 유도체를 포함하는 형광 센서 및 이를 이용한 티올 검출방법 有权
标题翻译：具有THIOL选择性的荧光素衍生物和使用其的VIVO监测THIOL的方法
公开(公告)号：KR1020110090417A
公开(公告)日：2011-08-10
申请号：KR1020100010170
申请日：2010-02-03
申请人： 이화여자대학교 산학협력단 , 연세대학교 산학협력단
发明人： 윤주영 , 첸샤오창
IPC分类号： C07D495/12 , C07D495/02 , C07D495/10
摘要： PURPOSE: A fluorescence sensor containing fluorescein derivatives with thiol selectivity is provided to quantitatively and qualitatively analyze thiol-containing materials. CONSTITUTION: A sensor for detecting thiol contains the compound of chemical formula 1. A method for preparing the compound of chemical formula 1 comprises a step of reacting a compound of chemical formula 2 and a compound of chemical formula 3 under the presence of a solvent. The solvent is selected from the group s consisting of tetrahydrofuran, dichloromethane, and acetonenitrile. A method for detecting thiol comprises a step of reacting the compound of chemical formula 1 with thiol.
摘要翻译：目的：提供含有硫醇选择性的荧光素衍生物的荧光传感器，用于定量和定性分析含硫醇材料。构成：用于检测硫醇的传感器含有化学式1的化合物。化学式1化合物的制备方法包括在溶剂存在下使化学式2的化合物与化学式3的化合物反应的步骤。溶剂选自四氢呋喃，二氯甲烷和丙酮腈组成的组。检测硫醇的方法包括使化学式1的化合物与硫醇反应的步骤。

57. 发明公开

KR1020100134362A ＵＴＰ 또는 ＵＤＰ 선택성 형광 프로브, 이의 제조방법 및이를 이용한 ＵＴＰ 또는 ＵＤＰ 검출방법 有权
标题翻译： UTP或UDP选择性荧光探针，其制备方法和使用其的UTP或UDP的检测方法
公开(公告)号：KR1020100134362A
公开(公告)日：2010-12-23
申请号：KR1020090052958
申请日：2009-06-15
申请人： 이화여자대학교 산학협력단 , 연세대학교 산학협력단
发明人： 윤주영 , 조민정 , 첸샤오창
IPC分类号： C07D403/12 , C12N15/10 , C12N15/12
摘要： PURPOSE: A method for detecting UTP or UDP using selective fluorescence probe is provided to ensure fluorescence variation and to quantitatively measure UTP consumption and UDP generation. CONSTITUTION: A perylene-dpa-Zn compounds are denoted by chemical formula 1 or 2. A method for preparing the compound of chemical formula 2 comprises: a step of reacting a compounds of chemical formulas 3 and 4 to obtain a compound of chemical formula 1; and a step of reacting zinc compounds with the compound of chemical formula 1. A sensor for detecting UTP or UDP contains the compound of chemical formula 2. The glycosylation is measured by detecting UTP or UDP using the sensor. The glycosylation comprises: a step of consuming UTP by UDP-glucose pylophosphorylase; and a step of generating UDP by beta-1,4-galactocotransferase.
摘要翻译：目的：提供使用选择性荧光探针检测UTP或UDP的方法，以确保荧光变化并定量测量UTP消耗和UDP生成。构成：苝-dpa-Zn化合物由化学式1或2表示。化学式2化合物的制备方法包括：使化学式3和化合物4的化合物反应得到化学式1化合物的步骤 ; 以及使锌化合物与化学式1化合物反应的步骤。用于检测UTP或UDP的传感器含有化学式2的化合物。通过使用传感器检测UTP或UDP来测量糖基化。糖基化包括：通过UDP-葡萄糖吡喃磷酰化酶消耗UTP的步骤; 以及通过β-1,4-半乳糖转移酶产生UDP的步骤。

58. 发明公开

KR1020100114681A 신규한 로다민 유도체 및 이를 포함한 차아염소산 검출 센서 有权
标题翻译：新型罗丹明衍生物和传感器，用于检测包含其中的高氯酸
公开(公告)号：KR1020100114681A
公开(公告)日：2010-10-26
申请号：KR1020090033186
申请日：2009-04-16
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 이원재 , 첸샤오창 , 하은미 , 김하나 , 이경아
IPC分类号： C07D495/10 , C07D495/02
CPC分类号： C07D495/10
摘要： PURPOSE: A novel rhodamine derivative and sensor having the same for detecting hypochlorous acid are provided to ensure excellent selectivity and sensitivity. CONSTITUTION: A novel rhodamine derivative is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of hydrolyzing a compound of chemical formula 3 to obtain a compound of chemical formula 4; and a step of reacting the compound of chemical formula 4 with a compound of chemical formula 5. A sensor for detecting hypochlorous acid contains a compound of chemical formula 2. A composition for detecting hypochlorous acid contains the compound of chemical formula 2.
摘要翻译：目的：提供一种具有检测次氯酸的新型罗丹明衍生物和传感器，以确保优异的选择性和灵敏度。构成：化学式1表示新的罗丹明衍生物。化学式1化合物的制备方法包括：水解化学式3的化合物，得到化学式4的化合物的工序; 将化学式4的化合物与化学式5的化合物反应的步骤。检测次氯酸的传感器含有化学式2的化合物。检测次氯酸的组合物含有化学式2的化合物。

59. 发明公开

KR1020100025891A 바이나프틸기를 갖는 로다민 유도체, 이의 제조방법 및 이를 이용한 구리 이온의 검출방법 失效
标题翻译：罗丹明衍生轴承二甲基集团，其制备方法及使用该组合物检测铜离子的方法
公开(公告)号：KR1020100025891A
公开(公告)日：2010-03-10
申请号：KR1020080084637
申请日：2008-08-28
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 첸샤오챵 , 조민정 , 김관묵 , 박성수
IPC分类号： C07D311/88 , C07D209/32
摘要： PURPOSE: A method for detecting copper ion using rhodamine derivative having binaphthyl group is provided to react the rhodamine derivative with copper ion and quantitatively and qualitatively analyze the copper ion. CONSTITUTION: A rhodamine derivative having a binaphthyl group is denoted by chemical formula 1 or 2. A method for preparing the rhodamine derivative having binaphthyl group of chemical formula 1 comprises: a step of adding THF in which potassium hydroxide solution and phenta(ethylene glycol)-ditoxylate are dissolved in 2,2'-dihydroxy-1,1'-binaphtyl-3-carboxadehyde of chemical formula 3 and reacting under reflux condition to obtain 3-formyl-2,2'-binaphthyl-20-crown-6 of chemical formula 4(step 1); a step of adding ethanol solution in which rhodamine B hydrazide of chemical formula 5 in 3-formyl-2,2'-binaphthyl-20-crown-6 of chemical formula 4 and reacting under reflex condition to obtain a compound of chemical formula 1(step 2); and a step of adding ethanol solution and reacting under reflux condition to rhodamine derivative having binaphthyl group of chemical formula 2.
摘要翻译：目的：提供使用具有联萘基的罗丹明衍生物检测铜离子的方法，使罗丹明衍生物与铜离子反应，并定量和定性分析铜离子。构成：具有联萘基的罗丹明衍生物由化学式1或2表示。一种制备具有化学式1的联萘基的罗丹明衍生物的方法包括：加入其中氢氧化钾溶液和苯乙酸（乙二醇）的THF的步骤， - 二氧化物溶于化学式3的2,2'-二羟基-1,1'-联吡啶-3-甲醛中，在回流条件下反应，得到3-甲酰基-2,2'-联萘-20-冠-6 化学式4（步骤1）; 将化学式5的罗丹明B酰肼加入到化学式4的3-甲酰基-2,2'-联萘基-20-冠-6中的乙醇溶液的步骤中，并在反应条件下反应，得到化学式1的化合物第2步）; 并加入乙醇溶液并在回流条件下与具有化学式2的联萘基的罗丹明衍生物反应的步骤。

60. 发明公开

KR1020090128737A ＮＢＤ계 유도체, 이의 제조방법 및 이를 이용한 아연이온의 검출방법 失效
标题翻译：基于NBD的衍生物，其制备方法以及使用该方法检测锌离子的方法
公开(公告)号：KR1020090128737A
公开(公告)日：2009-12-16
申请号：KR1020080054640
申请日：2008-06-11
申请人： 이화여자대학교 산학협력단
发明人： 윤주영 , 츄,차오차오 , 김건희 , 신인재 , 조민정
IPC分类号： C07D403/14 , C07D271/12
摘要： PURPOSE: A method for detecting zinc ion using NBD system derivative is provided to ensure high selectivity to zinc ion under the presence of calcium ion. CONSTITUTION: An NBD(7-nitrobenz-2-oxa-1,3-diazole) system derivative is denoted by chemical formula 1. A method for preparing the NBD system derivative comprises: a step of adding 2-pyridinecarboxaldehyde of chemical formula 2 to methanol solution of ethan-1,2-diamine of chemical formula 2; a step of adding NaBH4 to prepare N,N'-bis(2-pyridylmethyl)-ethan-1,2-diamine of chemical formula 4; a step of adding a compound of chemical formula 4 and NBD-Cl of chemical formula 5 to react at room temperature to produce a compound of chemical formula 6; and a step of adding 2-(bromomethyl)pyridine hydrobromic acid of chemical formula 7 to obtain a compound of chemical formula 1.
摘要翻译：目的：提供使用NBD系统衍生物检测锌离子的方法，以确保在钙离子存在下对锌离子的高选择性。构成：NBD（7-硝基苯并-2-氧杂-1,3-二唑）系统衍生物由化学式1表示。一种制备NBD体系衍生物的方法包括：将化学式2的2-吡啶甲醛加入到化学式2的乙-1,2-二胺的甲醇溶液; 加入NaBH 4以制备化学式4的N，N'-双（2-吡啶基甲基） - 乙-1,2-二胺的步骤; 将化学式5的化合物和化学式5的NBD-Cl的化合物在室温下反应以制备化学式6的化合物的步骤; 和加入化学式7的2-（溴甲基）吡啶氢溴酸的步骤，得到化学式1的化合物。

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