专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20210277084A1 BIOPHARMACEUTICAL AGENTS FOR USE IN REDUCING LIPID CONTENT IN CELLS 有权
公开(公告)号：US20210277084A1
公开(公告)日：2021-09-09
申请号：US17258217
申请日：2019-07-08
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Stefan Franz Thomas WEISS , Tyrone Chad OTGAAR , Eloise VAN DER MERWE , Martin BERNERT , Gavin MORRIS
IPC分类号： C07K14/705 , A61P3/04 , A61P5/50
摘要： A biopharmaceutical agent including a 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in treatment and/or prevention of atherosclerosis and/or obesity and/or insulin resistance and/or diabetes. The biopharmaceutical agent may be encapsulated by functionalized or non-functionalized nanoparticles, and further may be formulated to include a carrier to provide a pharmaceutical composition for parental or non-parental administration. In use, the biopharmaceutical agent reduces lipid content in target cells. Also, a method of decreasing lipid concentration in a target cell of a human or animal subject.

52. 发明授权

US10675592B2 Acid mine drainage treatment means 有权
公开(公告)号：US10675592B2
公开(公告)日：2020-06-09
申请号：US15735628
申请日：2016-05-30
申请人： University of the Witwatersrand, Johannesburg
发明人： Michael Olawale Daramola , Bongile Silinda , Sandile Aubrey Masondo
IPC分类号： B01D61/02 , B01D69/02 , B01D69/06 , B01D69/14 , B01D71/02 , B01D71/68 , C02F1/44 , C02F101/20 , C02F103/10 , B01D67/00
摘要： An acid mine drainage (AMD) treatment means comprising polyethersulfone (PES) having dispersed therein hydroxy-sodalite (H-SOD) so as to form a membrane is described. The PES-H-SOD membrane is suitable for treatment of acid mine drainage (AMD) by providing a filtration means to remove toxic chemicals, including but not limited to heavy metals. The invention extends to a method of manufacturing the acid mine drainage (AMD) treatment means.

53. 发明申请

US20150209275A1 Fast Dissolving Ocular Insert 审中-公开
标题翻译：快速溶解眼部插入物
公开(公告)号：US20150209275A1
公开(公告)日：2015-07-30
申请号：US14427195
申请日：2013-09-11
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Yahya Essop Choonara , Lisa Claire du Toit , Pradeep Kumar , Viness Pillay , Raeesa M. Moosa , Rafeeq Jhetam
IPC分类号： A61K9/00 , A61K31/5377 , A61K31/196 , A61K9/20
CPC分类号： C07H15/02 , A61K9/0051 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/138 , A61K31/196 , A61K31/4196 , A61K31/5377 , A61K45/06
摘要： This invention relates to a pharmaceutical dosage form, particularly to a topical ocular pharmaceutical dosage form comprising a polymeric matrix of polyethylene oxide block copolymer, preferably polyoxyethylene-polyoxypropylene block copolymer and hydroxpropyl cellulose, and a pharmaceutically active ingredient incorporated within the matrix. The invention extends to a method of manufacturing the pharmaceutical dosage form.
摘要翻译：本发明涉及一种药物剂型，特别涉及包含聚环氧乙烷嵌段共聚物，优选聚氧乙烯 - 聚氧丙烯嵌段共聚物和羟丙基纤维素的聚合物基质的局部眼用药物剂型，以及并入基质内的药物活性成分。本发明延伸到制造药物剂型的方法。

54. 发明申请

US20150076056A1 DEVICE FOR USE IN FLUID PURIFICATION 审中-公开
标题翻译：用于流体净化的装置
公开(公告)号：US20150076056A1
公开(公告)日：2015-03-19
申请号：US14490396
申请日：2014-09-18
申请人： University of The Witwatersrand, Johannesburg
发明人： Sunny Esayegbemu Iyuke , Selby Maphutha
IPC分类号： B01D71/68 , B01D71/02 , B01D67/00 , B01D71/38
CPC分类号： B01D71/68 , B01D67/0009 , B01D67/0011 , B01D67/0013 , B01D67/0079 , B01D67/0083 , B01D67/0088 , B01D67/0093 , B01D69/12 , B01D69/148 , B01D71/021 , B01D71/38 , B01D2323/02 , B01D2323/30
摘要： The present disclosure relates to a device for use in fluid purification, particularly to a membrane for use in fluid purification, the membrane comprising a porous basal layer in the form of polysulfone (PSF); a multitude of multi-walled carbon nanotubes (CNTs) dispersed within the basal layer; and a top layer in the form of polyvinyl alcohol (PVA). The disclosure extends to a method of manufacturing the device.
摘要翻译：本公开涉及用于流体净化的装置，特别是用于流体净化的膜，所述膜包括聚砜形式的多孔基底层（PSF）; 分散在基底层内的多个多壁碳纳米管（CNT）; 和聚乙烯醇（PVA）形式的顶层。本公开延伸到制造该装置的方法。

55. 发明申请

US20140148495A1 MONOLITHIC DRUG DELIVERY SYSTEM 审中-公开
标题翻译：单体药物递送系统
公开(公告)号：US20140148495A1
公开(公告)日：2014-05-29
申请号：US14057786
申请日：2013-10-18
申请人： University of the Witwatersrand, Johannesburg
发明人： Sibongile Ruth Sibambo , Viness Pillay , Yahya Essop Choonara
IPC分类号： A61K9/00
CPC分类号： A61K9/2009 , A61K9/0024 , A61K9/204
摘要： An improved monolithic drug delivery dosage form releases a pharmaceutically active agent at a predetermined rate. The dosage form comprises a salted-out or crosslinked polymer and a pharmaceutically active agent. The salted-out or crosslinked polymer functions to polymerically entangle the pharmaceutically active agent but, progressively relaxes on contact with an aqueous medium in use to release the pharmaceutically active agent at a predetermined rate.
摘要翻译：改进的整体药物递送剂型以预定的速率释放药物活性剂。该剂型包含盐析或交联的聚合物和药物活性剂。盐析或交联的聚合物用于使药物活性剂聚合缠结，但是在使用中与水性介质接触时逐渐松弛，以预定的速率释放药物活性剂。

56. 发明申请

US20130184421A1 Supramolecular Functional Materials 审中-公开
标题翻译：超分子功能材料
公开(公告)号：US20130184421A1
公开(公告)日：2013-07-18
申请号：US13789193
申请日：2013-03-07
申请人： University of the Witwatersrand
发明人： Manuel Antonio Fernandes
IPC分类号： C08F130/04 , C07F3/06 , C07F15/06 , C08G79/00
CPC分类号： C08F130/04 , C07F3/06 , C07F15/065 , C08G79/00 , C08G83/008
摘要： The field of this invention relates to supramolecular functional materials, particularly to coordination networks, more particularly to coordination polymers, more particularly to metal based one-dimensional coordination polymers. The metal based one-dimensional coordination polymers comprises a repeat unit [L1-M-L2]n where L1 and L2 are one of a plurality of carboxylate ligands and L1 can be the same as L2, M is a metal, particularly a transition metal, and n is an integer from 1 to infinity. The metal based one-dimensional coordination polymers display one or more physico-chemical properties giving at least one functionality to the supramolecular material. Furthermore, a method of forming the metal based one-dimensional coordination polymers is provided by a chemical reaction between said organic ligand and said metal where said method comprises at least one selectable chemical reaction condition from the group comprising: volume of reaction vessel, material composition of reaction vessel, temperature, pressure, humidity and gas defining an atmosphere inside reaction vessel.
摘要翻译：本发明的领域涉及超分子功能材料，特别涉及配位网络，更具体地涉及配位聚合物，更特别涉及基于金属的一维配位聚合物。基于金属的一维配位聚合物包括重复单元[L1-M-L2] n，其中L1和L2是多个羧酸盐配体之一，L1可以与L2相同，M是金属，特别是过渡金属，n是从1到无穷大的整数。基于金属的一维配位聚合物显示出一种或多种给予超分子材料至少一种官能团的物理化学性质。此外，通过所述有机配体和所述金属之间的化学反应提供形成金属的一维配位聚合物的方法，其中所述方法包括至少一种可选择的化学反应条件，其包括：反应容器的体积，材料组成的反应容器，温度，压力，湿度和气体，限定反应容器内的气氛。

57. 发明授权

US11329809B2 Method and system for hybrid classical-quantum communication 有权
公开(公告)号：US11329809B2
公开(公告)日：2022-05-10
申请号：US16480008
申请日：2018-01-23
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Andrew Forbes , Bienvenu Ndagano , Isaac Nape , Mitchell Cox , Carmelo Rosales-Guzman
IPC分类号： H04B10/70 , H04L9/08 , H04B10/50 , H04B10/66
摘要： This invention relates generally to a method and system for hybrid classical-quantum communication. The method comprises transmitting a single photon having a particular quantum state over a communication medium using a quantum mode set; and transmitting a classical light beam over the same communication medium using a classical mode set, wherein the classical and quantum mode sets comprise non-separable modes in common. The non-separable modes in common may be two degrees of freedom of a single photon or classical light and may thus be spatial modes in one or more indexes, and polarisation. The invention relates also to a system to implement the method accordingly.

58. 发明申请

US20220096529A1 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN (HPBETACD) FOR USE IN THE TREATMENT OF BREAST CANCER 有权
公开(公告)号：US20220096529A1
公开(公告)日：2022-03-31
申请号：US17426780
申请日：2020-01-28
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Mandeep KAUR , Sourav Taru SAHA
IPC分类号： A61K31/724 , A61P35/00
摘要： A method including the step of administering 2-hydroxypropyl-β-cyclodextrin (HPβCD) for use in the treatment of breast cancer. Particularly, this invention relates to HPβCD for use in the treatment of triple negative breast cancer, wherein the HPβCD is for administration to a patient in need thereof. The invention extends to methods of preparing a pharmaceutical composition comprising HPβCD, and further extends to a method of treating breast cancer, typically triple negative breast cancer, by administration of the composition to a patient in need thereof.

59. 发明授权

US10973766B2 Oral pharmaceutical dosage form for the delivery of a peptide and/or protein 有权
公开(公告)号：US10973766B2
公开(公告)日：2021-04-13
申请号：US15739809
申请日：2016-06-27
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Viness Pillay , Lisa Claire Du Toit , Yahya Essop Choonara , Bibi F. Choonara , Pradeep Kumar , Pierre Pavan Demarco Kondiah
IPC分类号： A61K9/20 , A61K9/14 , A61K9/28 , A61K9/19
摘要： The invention relates to an oral polymeric pharmaceutical dosage form which comprises a thermoresponsive eutectic composition which is solid at or about room temperature and fluid at or about body temperature, the eutectic composition mixed together with a crosslinking agent and an active pharmaceutical ingredient (API) to form an API loaded region; and a porous polymeric composition at least partially surrounding the API loaded region to protect the API when the dosage form is in a stomach of the human or animal body, the porous polymeric composition allowing the ingress of water to contact the crosslinking agent thereby facilitating the crosslinking agent to cause crosslinking of the porous polymeric composition, which crosslinked porous polymeric composition allows controlled egress of API via egress of fluid thermoresponsive eutectic composition at the intestine. In a preferred embodiment, the dosage form further comprises a coating there around.

60. 发明授权

US10774391B2 Genetically modified strains of mycobacterium smegmatis 有权
公开(公告)号：US10774391B2
公开(公告)日：2020-09-15
申请号：US16090530
申请日：2017-03-31
申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
发明人： Bavesh Davandara Kana , Edith Erika Machowski
IPC分类号： C12Q1/689 , C07K14/195 , C07K14/31 , C07K14/35 , C12N15/74
摘要： The present invention relates to a recombinant bacterium based on a non-pathogenic bacterium that has a modified genome containing a nucleic acid of interest from a pathogen that is detected by a molecular diagnostic assay and that mimics the diagnostic profile of the pathogen. The invention further relates to a diagnostic control composition comprising the recombinant bacterium and to methods for producing the recombinant bacterium. The recombinant bacterium is a safe, reliable quality control for the detection of pathogens such as Mycobacterium tuberculosis and Staphylococcus aureus. The invention also relates to a kit comprising either the recombinant bacterium, compositions containing the recombinant bacterium or bacteria produced according to the method of the invention.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式