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51. 发明申请

WO2016001471A1 PANTALLAS DE AISLAMIENTO ACÚSTICO CON CUBIERTA VEGETAL ARTIFICIAL 审中-公开
标题翻译：具有人造植物覆盖的声学绝缘屏幕
公开(公告)号：WO2016001471A1
公开(公告)日：2016-01-07
申请号：PCT/ES2015/070521
申请日：2015-07-03
申请人： UNIVERSIDAD DE MURCIA
发明人： VICTORIA NAVAS, Leandro , ARENAS DALLA VECCHIA, Aurelio
IPC分类号： E01F8/00 , E01F8/02
CPC分类号： E01F8/00 , E01F8/02
摘要： La invención comprende una nueva modalidad de pantalla de aislamiento acústico con cubierta vegetal artificial de elevadas prestaciones acústicas que mejora el coeficiente de absorción acústica y el aislamiento acústico con respecto a otras pantallas acústicas monolíticas construidas con diversos materiales paisajísticamente incompatibles, proporcionando una integración de las barreras acústicas en el entorno natural.
摘要翻译：本发明包括一种新型的隔音屏幕，其具有相当大的声学效果的人造植物覆盖物，其改善了与使用与景观不相容的各种材料构建的其它整体声屏幕的隔音和声吸收系数，从而提供隔音屏障进入自然环境。

52. 发明申请

WO2014029669A1 COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS 审中-公开
标题翻译：用于治疗梅毒的组合（卡培他滨和甲基）
公开(公告)号：WO2014029669A1
公开(公告)日：2014-02-27
申请号：PCT/EP2013/066934
申请日：2013-08-13
申请人： UNIVERSIDAD DE MURCIA
发明人： RODRIGUEZ-LOPEZ, Jose Neptuno
IPC分类号： A61K31/353 , A61K31/519 , A61P35/00 , A61K45/06
CPC分类号： A61K31/353 , A61K31/519 , A61K2300/00
摘要： The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.
摘要翻译：本发明提供一种治疗黑素瘤的方法，其包括向有需要的个体施用酪氨酸酶表达增强剂，例如MTX和酪氨酸酶活化的前药如TMECG或TMCG。还提供了一种治疗黑素瘤的方法，包括施用酪氨酸酶活化的前药和将茎状肿瘤细胞分化成需要其的个体的酪氨酸酶生产者的成熟细胞的化合物。还提供了一种治疗黑素瘤的方法，其包括向有需要的个体施用酪氨酸酶表达增强剂和酪氨酸酶活化的前药，其中所述个体具有黑素瘤，其中BRAF，NRAS，p53，GNAQ，EGFR， PDGFR，RAC或c-kit携带突变。

53. 发明申请

WO2012130448A1 A MOLECULAR SCAFFOLD TO MODULATE THROMBIN/ANTITHROMBIN ACTIVITY BY HEPARIN BINDING 审中-公开
标题翻译：通过肝素结合调节血栓素/抗凝血活性的分子通道
公开(公告)号：WO2012130448A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/001370
申请日：2012-03-28
申请人： KARLSRUHER INSTITUT FÜR TECHNOLOGIE , UNIVERSIDAD DE MURCIA , PÉRÉZ-SANCHEZ, Horacio , MELICIANI, Irene , WENZEL, Wolfgang , MARTINEZ-MARTINEZ, Irene , NAVARRO-FERNÁNDEZ, José , CORRAL DE LA CALLE, Javier , GARCIA, Vicente Vicente
发明人： PÉRÉZ-SANCHEZ, Horacio , MELICIANI, Irene , WENZEL, Wolfgang , MARTINEZ-MARTINEZ, Irene , NAVARRO-FERNÁNDEZ, José , CORRAL DE LA CALLE, Javier , GARCIA, Vicente Vicente
IPC分类号： A61K31/6615 , A61P7/02 , A61P9/10
CPC分类号： A61K31/6615
摘要： The present invention relates to D- myo -inositol 3,4,5,6-tetrakisphosphate for use in activating antithrombin in a patient as well as to a pharmaceutical composition containing D- myo -inositol 3,4,5,6-tetrakisphosphate for use in recovery of antithrombin activity in patients with antithrombin deficiency or in prophylaxis for a disease associated with increased blood clotting.
摘要翻译：本发明涉及用于激活患者抗凝血酶的3,4,5,6-四磷酸D-肌醇以及含有D-肌醇3,4,5,6-四磷酸的药物组合物，其用于用于恢复抗凝血酶缺乏患者的抗凝血酶活性或预防与血液凝结增加相关的疾病。

54. 发明申请

WO2010057996A2 USE OF IONIC LIQUIDS FOR IMPLEMENTING A PROCESS FOR THE PREPARATION OF BIODIESEL 审中-公开
标题翻译：离子液体在制备生物柴油过程中的应用
公开(公告)号：WO2010057996A2
公开(公告)日：2010-05-27
申请号：PCT/EP2009/065586
申请日：2009-11-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSIDAD DE MURCIA , LOZANO, Pedro , DE DIEGO, Teresa , IBORRA, José Luis , VAULTIER, Michel
发明人： LOZANO, Pedro , DE DIEGO, Teresa , IBORRA, José Luis , VAULTIER, Michel
IPC分类号： C12P7/64 , C12N9/20
CPC分类号： C12P7/649 , Y02E50/13
摘要： The invention relates to the use of a combination of - at least one ionic liquid which is lipophilic, and non miscible with water, and - at least one enzyme, for the implementation of an esterifϊcation and/or transesterification process of a substrate with at least one alcohol, said substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein said ionic liquid, said substrate, and said alcohol form a single homogeneous liquid phase at the temperature at which the esterifϊcation and/or transesterification process is performed.
摘要翻译：本发明涉及 - 至少一种亲脂性且不与水混溶的离子液体和 - 至少一种酶用于实施酯化的组合物和/或将基质与至少一种醇进行酯交换反应过程，所述基质由油，脂肪，脂肪酸或其混合物组成，其中所述离子液体，所述基质和所述醇在所述温度下形成单一均相液相，进行酯化和/或酯交换过程。

55. 发明申请

WO2010023339A1 SISTEMA INTEGRAL DE CONTROL, SEGURIDAD Y DOMÓTICA EN EDIFICIOS INTELIGENTES 审中-公开
标题翻译：智能建筑的整体控制，安全和家庭自动化系统
公开(公告)号：WO2010023339A1
公开(公告)日：2010-03-04
申请号：PCT/ES2009/070334
申请日：2009-08-05
申请人： UNIVERSIDAD DE MURCIA , GÓMEZ SKARMETA, Antonio Fernando , ZAMORA IZQUIERDO, Miguel Ángel , SANTA LOZANO, José
发明人： GÓMEZ SKARMETA, Antonio Fernando , ZAMORA IZQUIERDO, Miguel Ángel , SANTA LOZANO, José
IPC分类号： H04L12/28
CPC分类号： H04L12/2818 , H04L12/282 , H04L63/0435
摘要： Sistema integral de control, seguridad y domótica para edificios inteligentes, de especial utilidad en el control de viviendas y edificios, cuya arquitectura comprende un modulo de automatización HAM (1) que centraliza el control en el recinto que se va a emplear el sistema de control, diversos paneles de control (2), instalados en distintos lugares del recinto y que sirven de interfaz al usuario para controlar las distintas partes del edificio, una pasarela residencial local (3), conectada al módulo de automatización HAM (1) va una red LAN (12), de manera que esta se ocupa de las labores de comunicación con los distintos dispositivos y actuadores, diversos módulos CAN de control (5), que proporcionan conectividad con diversos dispositivos domóticos, una pasarela residencial remota (13) y un centro de control de alarmas (14).
摘要翻译：用于智能建筑的整体控制，安全和家庭自动化系统，特别适用于住宅和建筑物的控制，其结构包括一个自动化模块HAM（1），集中控制系统将要使用的区域中的控制，各种控制面板（2），其安装在该区域的各个位置并用作用于控制建筑物的各个部分的用户界面;连接到自动化模块HAM（1）的本地住宅网关（3）经由LAN（12）处理与各种设备和致动器进行通信的任务，提供与各种家庭自动化设备的连接的各种CAN控制模块（5），远程住宅网关（13）和报警控制中心（14）。

56. 发明申请

WO2009081275A3 ANTIFOLATE COMPOUNDS FOR THE TREATMENT OF MELANOMA 审中-公开
公开(公告)号：WO2009081275A3
公开(公告)日：2009-07-02
申请号：PCT/IB2008/003727
申请日：2008-12-18
申请人： UNIVERSIDAD DE MURCIA , RODRIGUEZ-LOPEZ, Jose, Neptuno , SANCHEZ DEL CAMPO FERRER, Luis , CABEZAS-HERRERA, Juan , TARRAGA TOMAS, Alberto , SAEZ AYALA, Magali, Maria
发明人： RODRIGUEZ-LOPEZ, Jose, Neptuno , SANCHEZ DEL CAMPO FERRER, Luis , CABEZAS-HERRERA, Juan , TARRAGA TOMAS, Alberto , SAEZ AYALA, Magali, Maria
IPC分类号： A61K31/353 , A61P35/00 , A61P35/04
摘要： This invention relates to compounds of the formula X) or Xl) (X) (XI) wherein: each -R 1 , -R 2 and -R 3 is independently -Q 1 , -OH or -H, where at least one of -R 1 , -R 2 and -R 3 is not -H or -OH; each -R 4 and -R 5 is independently -Q 2 or -H; each -Q 1 is independently selected from: -F, -Cl, -R A , -OR A ,-SH, -SR A , where each -R A is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; and each -Q 2 is selected from: -F, -Cl, -R B , -OR B , -SH, -SR B , where each -R B is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; which are useful in the treatment of melanoma.

57. 发明申请

WO2008031908A1 PROCEDIMIENTO DE OBTENCIÓN DE POLIRRICINOLEATO DE POLIGLICEROL 审中-公开
标题翻译：获得聚甘油多糖的方法
公开(公告)号：WO2008031908A1
公开(公告)日：2008-03-20
申请号：PCT/ES2007/000516
申请日：2007-09-13
申请人： UNIVERSIDAD DE BARCELONA , UNIVERSIDAD DE MURCIA , MANRESA PRESAS, Mª Ángeles , BÓDALO SANTOYO, Antonio , GÓMEZ CARRASCO, José Luis , GÓMEZ GÓMEZ, Elisa , BASTIDA RODRÍGUEZ, Josefa , MÁXIMO MARTÍN, Mª Fuensanta , HIDALGO MONTESINOS, Asunción Mª , MONTIEL MORTE, Mª Claudia
发明人： MANRESA PRESAS, Mª Ángeles , BÓDALO SANTOYO, Antonio , GÓMEZ CARRASCO, José Luis , GÓMEZ GÓMEZ, Elisa , BASTIDA RODRÍGUEZ, Josefa , MÁXIMO MARTÍN, Mª Fuensanta , HIDALGO MONTESINOS, Asunción Mª , MONTIEL MORTE, Mª Claudia
IPC分类号： C12P7/62
CPC分类号： C12P7/62
摘要： El procedimiento comprende la esterificación de ácido polirricinoleico con poliglicerol catalizada por lipasa (libre o inmobilizada). La lipasa proviene de un hongo del género Rhizopus, y más particularmente de Rhizopus oryzae o de Rhizopus arrhizus. El ácido polirricinoleico (o estólido del ácido ricinoleico) de partida se obtiene por condensación de ácido ricinoleico catalizada por lipasa 1,3 inespecífica, libre o inmovilizada, preferiblemente de Candida rugosa. Es útil para fabricar polirricinoleato de poliglicerol ("polyglycerol polyricinoleate", PGPR) de calidad alimentaria, evitando la formación de los subproductos asociados a los procedimientos tradicionales, que utilizan catálisis química y altas temperaturas.
摘要翻译：本发明涉及一种获得聚甘油聚蓖麻油酸酯的方法，其包括用（游离或固定化）脂肪酶催化的聚甘油酯化聚蓖麻油酸。脂肪酶来自根霉属的真菌，特别是米根霉（Rhizopus oryzae）或根霉属（Rhizopus arrhizus）。通过将由游离或固定的1,3-非特异性脂肪酶，优选假丝酵母（Candida rugosa）催化的蓖麻油酸缩合得到起始的多蓖麻油酸（或蓖麻油酸内酯）。本发明可用于生产食品级聚甘油聚蓖麻油酸酯（PGPR），防止与使用化学催化和高温的标准方法相关的副产物的形成。

58. 发明公开

EP3985521A1 SYSTEM AND METHOD FOR PREFETCHING BURSTS ACCESSES TO CONTIGUOUS MEMORY LOCATIONS 有权
公开(公告)号：EP3985521A1
公开(公告)日：2022-04-20
申请号：EP20382900.7
申请日：2020-10-13
申请人： Universidad de Murcia
发明人： CEBRIÁN GONZÁLEZ, Juan Manuel , ROS BARDISA, Alberto , KAXIRAS, Stefanos
IPC分类号： G06F12/0862
摘要： Methods are provided of prefetching memory blocks in a processor system handling accesses to memory. The method comprises processing each access by performing an iteration process with each iteration including: capturing access being currently handled by the processor system; identifying memory block to which the captured access refers; determining whether the memory block identified in current iteration is either coincident or contiguous or non-contiguous with respect to memory block identified in immediately previous iteration; and quitting the iteration process when a predefined number of iterations have been performed or non-contiguity has been determined. The method further comprises verifying, whether one or more contiguities and zero non-contiguities have been determined and, in said case, instructing a cache controller to prefetch a number of next contiguous memory blocks with respect to the memory block identified in last iteration. Computer programs and systems are also provided that are suitable to perform such methods.

59. 发明公开

EP3766542A1 MAGNETIC NANOPARTICLES FOR USE IN ASSISTED REPRODUCTION 审中-实审
公开(公告)号：EP3766542A1
公开(公告)日：2021-01-20
申请号：EP19717959.1
申请日：2019-02-26
申请人： Universidad de Murcia
发明人： GARCIA VAZQUEZ, Francisco Alberto , JIMENEZ MOVILLA, Maria , CABALLERO SASTRE, Maria
IPC分类号： A61P15/08 , A61K9/00 , A61K41/00 , C12N5/075 , C12N15/873 , G01N33/68 , A61K47/69
摘要： The present invention relates to a method of preparing magnetic oocytes and/or embryos by means of nanoparticles for assisted reproduction techniques and to the use in assisted reproduction techniques of non-human oocytes and/or embryos prepared with said method. Said method comprises: a step in which magnetic nanoparticles are conjugated with oviduct recombinant protein, OVGP1r; a step in which it is verified that the nanoparticle-OVGP1r conjugation attaches to the ZP of oocytes/embryos after being incubated together; and a step in which the number of oocytes/embryos having nanoparticles attached to them distributed around the ZP without being endocytosed is verified; and it is assessed if the amount of magnetic nanoparticles attached to the ZP of oocytes/embryos is enough to be attracted by a magnetic field.

60. 发明公开

EP2887937A1 COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS 审中-公开
标题翻译：组合FOR USE IN黑色素瘤的治疗（儿茶素和甲氨蝶呤）
公开(公告)号：EP2887937A1
公开(公告)日：2015-07-01
申请号：EP13750682.0
申请日：2013-08-13
申请人： Universidad de Murcia
发明人： RODRIGUEZ-LOPEZ, Jose Neptuno
IPC分类号： A61K31/353 , A61K31/519 , A61P35/00 , A61K45/06
CPC分类号： A61K31/353 , A61K31/519 , A61K2300/00
摘要： The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.

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