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51. 发明公开

EP2473493A4 METHODS OF TREATING POXVIRAL INFECTIONS 有权
标题翻译：方法POXVIRUSINFEKTIONEN的治疗
公开(公告)号：EP2473493A4
公开(公告)日：2013-01-09
申请号：EP10814414
申请日：2010-09-01
申请人： UNITED THERAPEUTICS CORP , UNIV OXFORD
发明人： RAMSTEDT URBAN , KLOSE BRENNAN , ZITZMANN NICOLE , DWEK RAYMOND A , BUTTERS TERRY D
IPC分类号： A61K31/445 , A61P31/20 , C07D307/48
CPC分类号： A61K31/445 , A61K31/452 , C07D211/46

52. 发明公开

EP3294331A1 DENGUE VACCINES 审中-公开
公开(公告)号：EP3294331A1
公开(公告)日：2018-03-21
申请号：EP16723813
申请日：2016-05-11
申请人： UNIV OXFORD INNOVATION LTD
发明人： REYES SANDOVAL ARTURO , LOPEZ CAMACHO CESAR , BLIGHT JOSHUA
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/51 , A61K2039/5258 , A61K2039/545 , C12N2710/10023 , C12N2770/24134
摘要： The invention relates to a protein comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across all four dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4, and wherein the conserved sequences comprise at least part of a sequence of one or more non-structural proteins of the dengue virus serotypes. The invention further relates to associated peptides, compositions,nucleic acids, viral vectors, virus- like particles, use,prime boost vaccination kits, agents and methods.

53. 发明公开

EP3286594A2 COMPACT MICROSCOPE 有权
公开(公告)号：EP3286594A2
公开(公告)日：2018-02-28
申请号：EP16718898
申请日：2016-04-25
申请人： UNIV OXFORD INNOVATION LTD
发明人： KAPANIDIS ACHILLEFS , JING BO
IPC分类号： G02B21/16 , G02B21/24 , G02B21/36
CPC分类号： G02B21/24 , G02B21/16 , G02B21/361 , G02B21/362
摘要： A compact microscope comprising an enclosure,a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, a sample stage supported on the primary optical support element to support a sample, a return optical system to receive returned light from a sample and transmit returned light to a detection apparatus, wherein the return optical system is mounted on the primary optical support element, and wherein the compact microscope comprises at least one of the following elements; a) an objective lens system, the objective lens system being supported on the primary optical support element, an illumination section and an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a mirror disposed above the sample stage, the illumination optical system being arranged to direct light through the objective lens system to the mirror; b) a temperature-control system, the temperature control system comprising a temperature control circuit comprising a plurality of fluid-carrying channels within at least one of the enclosure and the primary optical support element; and c) the return optical system being operable to separate returned light into at least a first wavelength band and a second wavelength band, and the detection apparatus comprising an imaging apparatus, the return optical system having a first tube lens to focus returned light in a first wavelength band to a first area of the imaging apparatus and a second tube lens to focus returned light in a second wavelength band to a second area of the imaging apparatus.

54. 发明公开

EP3285651A1 PATIENT POSITIONING APPARATUS 审中-公开
公开(公告)号：EP3285651A1
公开(公告)日：2018-02-28
申请号：EP16721494
申请日：2016-04-25
申请人： UNIV OXFORD INNOVATION LTD
发明人： HAMILTON THOMAS , MURRAY DAVID , MELLON STEPHEN , PANDIT HEMANT
IPC分类号： A61B6/04
CPC分类号： A61B6/50 , A61B5/4528 , A61B6/0421 , A61B6/0485 , A61G13/1245
摘要： A patient positioning apparatus for use with a medical imaging device, the patient positioning apparatus comprising a first element and a second element, the first element having a base part and an upper part to engage a knee joint of the patient, the second element comprising a lower leg engagement part to receive a lower leg of the patient to maintain the lower leg in a desired position.

55. 发明授权

EP2349483B1 MAPPING AND CHARACTERIZATION OF CAVITATION ACTIVITY 有权转让
标题翻译： KARTIERUNG UND CHARAKTERISIERUNG VONKAVITITATIONSAKTIVITÄT
公开(公告)号：EP2349483B1
公开(公告)日：2017-05-03
申请号：EP09774917
申请日：2009-11-04
申请人： UNIV OXFORD INNOVATION LTD
发明人： COUSSIOS CONSTANTIN C , GYONGY MIKLOS , ARORA MANISH , ROY RONALD AURELE
IPC分类号： A61N7/02 , A61B8/08 , A61B17/22 , A61B90/00 , A61N7/00
CPC分类号： A61B8/08 , A61B2017/00106 , A61B2017/22008 , A61B2090/378 , A61N7/00 , A61N7/02 , A61N2007/0052

56. 发明公开

EP2858642A4 NOVEL IMINOSUGARS AND THEIR APPLICATIONS 审中-公开
标题翻译：新型IMINO糖及其应用
公开(公告)号：EP2858642A4
公开(公告)日：2015-12-02
申请号：EP13800188
申请日：2013-06-05
申请人： UNITHER VIROLOGY LLC , UNIV OXFORD
发明人： KIAPPES J L , LAING PETER , DWEK RAYMOND , ZITZMANN NICOLE , POLLOCK STEPHANIE
IPC分类号： A61K31/355 , A61K31/445 , A61K31/575 , A61P31/12
CPC分类号： C07D405/12 , C07D211/46 , C07D401/12 , C07J43/003
摘要： Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogs of tocopherol or select analogs of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.

57. 发明公开

EP2675895A4 MOLECULAR SWITCH FOR NEURONAL OUTGROWTH 审中-公开
标题翻译：分子开关的神经生长
公开(公告)号：EP2675895A4
公开(公告)日：2014-07-30
申请号：EP12746843
申请日：2012-02-17
申请人： HARVARD COLLEGE , UNIV OXFORD
发明人： FLANAGAN JOHN G , SHEN YINGJIE , JONES EDITH YVONNE , ARICESCU ALEXANDRU RADU , COLES CHARLOTTE HANNAH
IPC分类号： C12N5/0793 , A61K31/7004 , A61P25/00 , C12N5/02
CPC分类号： A61K31/727 , A61K31/737 , A61K38/177 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

58. 发明公开

EP2473046A4 IMINOSUGARS AND METHODS OF TREATING FILOVIRAL DISEASES 有权
标题翻译：亚氨基糖类和方法FILOVIRUSERKRANKUNGEN的治疗
公开(公告)号：EP2473046A4
公开(公告)日：2013-04-24
申请号：EP10814412
申请日：2010-09-01
申请人： UNITED THERAPEUTICS CORP , UNIV OXFORD
发明人： RAMSTEDT URBAN , KLOSE BRENNAN , ZITZMANN NICOLE , DWEK RAYMOND A , BUTTERS TERRY D
IPC分类号： A01N43/40 , A61K31/445 , A61P31/12
CPC分类号： A61K31/445

59. 发明公开

EP2440205A4 IMINOSUGARS AND METHODS OF TREATING BUNYAVIRAL AND TOGAVIRAL DISEASES 失效转让
标题翻译：亚氨基糖类UDN方法用于治疗和BUNYAVIRALEN TOGAVIRALEN疾病
公开(公告)号：EP2440205A4
公开(公告)日：2013-04-24
申请号：EP10786885
申请日：2010-06-11
申请人： UNITED THERAPEUTICS CORP , UNIV OXFORD
发明人： RAMSTEDT URBAN , KLOSE BRENNAN , ZITZMANN NICOLE , DWEK RAYMOND A , BUTTERS TERRY D
IPC分类号： A61K31/445 , A01N43/40 , A61P31/12
CPC分类号： A61K31/445
摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.

60. 发明公开

EP2400843A4 IMINOSUGARS AND METHODS OF TREATING ARENAVIRAL INFECTIONS 有权
标题翻译：用于治疗ARENAVIRIDAE病症的新药和方法
公开(公告)号：EP2400843A4
公开(公告)日：2012-01-04
申请号：EP10746681
申请日：2010-02-22
申请人： UNITED THERAPEUTICS CORP , UNIV OXFORD
发明人： RAMSTEDT URBAN , KLOSE BRENNAN , ZITZMANN NICOLE , DWEK RAYMOND A , BUTTERS TERRY D
IPC分类号： A01N43/40 , A61K31/445 , A61P31/14
CPC分类号： A61K31/445

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