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51. 发明授权

US07844321B2 Rotating catheter probe using a light-drive apparatus 有权
标题翻译：使用光驱装置旋转导管探头
公开(公告)号：US07844321B2
公开(公告)日：2010-11-30
申请号：US11567244
申请日：2006-12-06
申请人： Thomas E. Milner , Nathaniel J. Kemp
发明人： Thomas E. Milner , Nathaniel J. Kemp
IPC分类号： A61B5/00
CPC分类号： A61B1/00163 , A61B1/0011 , A61B1/00172 , A61B5/0066 , A61B5/6852 , Y10T29/49826
摘要： The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.
摘要翻译：本发明是旋转尖端导管成像探针，其中电磁能量被传送到导管的远端并且使用光驱动装置转换成机械能。然后机械能用于旋转将固定模式的光重定向在样品上的反射镜。光驱装置的旋转元件包含叶片，叶片绕轴线转动并且与轴承一起定位以使摩擦力最小化。腔室包围旋转元件并被设定为真空压力。可以通过改变输送到叶片的光功率，腔室中的真空压力，或通过施加到旋转元件的制动机构来控制导管尖端的旋转速度。叶片可以成形为特定的几何形状以增加来自热驱动气流的叶片上的力。

52. 发明申请

US20100298716A1 METHODS AND COMPOSITIONS TO REDUCE SCATTERING OF LIGHT DURING THERAPEUTIC AND DIAGNOSTIC IMAGING PROCEDURES 有权
标题翻译：在治疗和诊断成像过程中减少光的散射的方法和组合
公开(公告)号：US20100298716A1
公开(公告)日：2010-11-25
申请号：US12780647
申请日：2010-05-14
申请人： Joseph W. Villard , Marc D. Feldman , Thomas E. Milner , JeeHyun Kim , Gregory L. Freeman
发明人： Joseph W. Villard , Marc D. Feldman , Thomas E. Milner , JeeHyun Kim , Gregory L. Freeman
IPC分类号： A61B6/00
CPC分类号： A61B5/14551 , A61B5/0066 , A61B5/0073 , A61B5/14535 , A61B5/14553 , A61B5/416
摘要： Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.
摘要翻译：公开了用于基于光的体内成像和治疗的改进的方法和组合物。所描述的技术涉及在成像和治疗方法中使用低散射，含氧载体的血液代用品，包括OCT成像。本发明在心血管系统和高度血管化或氧依赖性组织中的成像中具有特别的优点。

53. 发明授权

US07801590B2 Optical coherence tomographic detection of cells and killing of the same 有权
标题翻译：光学相干断层扫描检测细胞和杀死相同
公开(公告)号：US07801590B2
公开(公告)日：2010-09-21
申请号：US11784477
申请日：2007-04-06
申请人： Marc D. Feldman , Thomas E. Milner , Jihoon Kim , Junghwan Oh , Pramod Sanghi , Jake Mancuso , Keith P. Johnston , Leo Ma , Stas Emelianov
发明人： Marc D. Feldman , Thomas E. Milner , Jihoon Kim , Junghwan Oh , Pramod Sanghi , Jake Mancuso , Keith P. Johnston , Leo Ma , Stas Emelianov
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/416 , A61N1/403 , A61N2/02 , G01N21/1717 , G01N21/4795
摘要： Provided herein are systems, methods and compositions for the use of optical coherence tomography for detection of cells and for killing detected cells. A detected cell can be killed or injured by contacting a composition comprised by the cell with energy. Energy can be applied to a particle comprised by the cell.
摘要翻译：本文提供了使用光学相干断层摄影术来检测细胞和杀死检测到的细胞的系统，方法和组合物。通过将由细胞组成的组合物与能量接触可以将检测到的细胞杀死或损伤。能量可以应用于由电池组成的颗粒。

54. 发明授权

US07783337B2 OCT using spectrally resolved bandwidth 有权
标题翻译： OCT使用光谱解析带宽
公开(公告)号：US07783337B2
公开(公告)日：2010-08-24
申请号：US11446683
申请日：2006-06-05
申请人： Marc D. Feldman , Thomas E. Milner , Jung Hwan Oh , Eunha Kim , Karthik Kumar , Chris Condit , Robert Grant , Nate Kemp , Jeehyun Kim , Shaochen Chen , Li-Hsin Han
发明人： Marc D. Feldman , Thomas E. Milner , Jung Hwan Oh , Eunha Kim , Karthik Kumar , Chris Condit , Robert Grant , Nate Kemp , Jeehyun Kim , Shaochen Chen , Li-Hsin Han
IPC分类号： A61B5/05
CPC分类号： A61B5/0073 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B5/0066 , A61B5/0084 , A61B5/6852
摘要： An apparatus is disclosed for studying an object based on at least one of polarization, space, position or angle of light that has reflected from the object. An optical tomographic instrumentation of the apparatus includes a light source coupled to a source path, a sample path, a reference path, and a detection path, wherein the light source generates a spectrally resolved bandwidth. The spectrally resolved bandwidth includes a plurality of spectrally resolved cells and a detector in the detection path for analyzing light reflected from an object in the sample path and the light reflected in the reference path based upon at least one of the polarization, spatial relationship, position or angle domains.
摘要翻译：公开了一种用于基于从物体反射的光的偏振，空间，位置或角度中的至少一个来研究物体的装置。该设备的光学断层摄影仪器包括耦合到源路径的光源，采样路径，参考路径和检测路径，其中光源产生频谱分辨的带宽。光谱解析的带宽包括多个光谱分辨的单元和检测路径中的检测器，用于分析从采样路径中的物体反射的光和基准路径中反射的光，基于偏振，空间关系，位置或角域。

55. 发明申请

US20100168587A1 CATHETER IMAGING PROBE AND METHOD 有权
标题翻译：导管成像探针和方法
公开(公告)号：US20100168587A1
公开(公告)日：2010-07-01
申请号：US12638927
申请日：2009-12-15
申请人： Marc D. Feldman , Thomas E. Milner , Shaochen Chen , Jeehyun Kim , Li-Hsin Han , Jung-Hwan Oh , Ho Lee
发明人： Marc D. Feldman , Thomas E. Milner , Shaochen Chen , Jeehyun Kim , Li-Hsin Han , Jung-Hwan Oh , Ho Lee
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B1/00183 , A61B1/3137 , A61B5/0066 , A61B5/6852 , A61B8/12 , A61B8/4461 , A61N2007/0091
摘要： A catheter imaging probe for a patient. The probe includes a conduit through with energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit.
摘要翻译：用于患者的导管成像探针。探头包括通过能量传输的导管。探针包括导管延伸通过的第一部分。探针包括第二部分，其相对于导管旋转以重新引导来自导管的能量。一种用于对患者进行成像的方法。该方法包括将导管插入患者体内的步骤。存在使导管的第二部分相对于延伸穿过导管的第一部分的导管旋转的步骤，其将通过导管传输的能量重定向到患者并且接收从患者反射回第二部分的能量，将反射的能量重定向到导管。

56. 发明授权

US07711413B2 Catheter imaging probe and method 失效
标题翻译：导管成像探头和方法
公开(公告)号：US07711413B2
公开(公告)日：2010-05-04
申请号：US10548982
申请日：2004-04-23
申请人： Marc D. Feldman , Thomas E. Milner , Shaochen Chen , Jeehyun Kim , Li-Hsin Han , Jung-Hwan Oh , Ho Lee
发明人： Marc D. Feldman , Thomas E. Milner , Shaochen Chen , Jeehyun Kim , Li-Hsin Han , Jung-Hwan Oh , Ho Lee
IPC分类号： A61B8/00 , A61B1/06
摘要： A catheter imaging probe for a patient. The probe includes a conduit through which energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit.
摘要翻译：用于患者的导管成像探针。探头包括能量传递通过的导管。探针包括导管延伸通过的第一部分。探针包括第二部分，其相对于导管旋转以重新引导来自导管的能量。一种用于对患者进行成像的方法。该方法包括将导管插入患者体内的步骤。存在使导管的第二部分相对于延伸穿过导管的第一部分的导管旋转的步骤，其将通过导管传输的能量重定向到患者并且接收从患者反射回第二部分的能量，将反射的能量重定向到导管。

57. 发明授权

US06589235B2 Method and apparatus for cartilage reshaping by radiofrequency heating 有权
公开(公告)号：US06589235B2
公开(公告)日：2003-07-08
申请号：US09770799
申请日：2001-01-19
申请人： Brian J. F. Wong , Thomas E. Milner , Emil N. Sobol , Michael W. Keefe
发明人： Brian J. F. Wong , Thomas E. Milner , Emil N. Sobol , Michael W. Keefe
IPC分类号： A61B1804
CPC分类号： A61B18/14 , A61B5/4514 , A61B2018/00791 , A61B2018/00875
摘要： A method and apparatus for reshaping cartilage using radiofrequency heating. The cartilage temperature is raised sufficiently for stress relaxation to occur in the cartilage, but low enough so that significant denaturation of the cartilage does not occur. The RF electrodes may be designed to also function as molds, preses, clamps, or mandrills to deform the cartilage tissue. Changes in various properties of the cartilage associated with stress relaxation in the cartilage may be measured in order to provide the control signal to provide effective reshaping without denaturation.

58. 发明授权

US5814040A Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery 失效
标题翻译：用于热介导手术的生物组织的动态冷却装置和方法
公开(公告)号：US5814040A
公开(公告)日：1998-09-29
申请号：US441930
申请日：1995-05-15
申请人： J. Stuart Nelson , Thomas E. Milner , Lars O. Svaasand
发明人： J. Stuart Nelson , Thomas E. Milner , Lars O. Svaasand
IPC分类号： A61B17/00 , A61B17/32 , A61B18/00 , A61B18/02 , A61B18/18 , A61B18/20 , A61B18/22 , A61F9/007 , A61N5/04 , A61N5/06 , A61N5/067 , A61N7/00
CPC分类号： A61B18/0218 , A61B18/203 , A61N5/062 , A61B17/3203 , A61B18/18 , A61B18/20 , A61B18/22 , A61B2017/00057 , A61B2017/00084 , A61B2017/00154 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/00636 , A61N2005/0644 , A61N2005/067 , A61N5/04 , A61N7/00
摘要： Dynamically cooling the epidermis of a port wine stain patient undergoing laser therapy permits maximization of the thermal damage to the port wine stain while at the same time minimizing nonspecific injury to the normal overlying epidermis. A cryogenic spurt is applied to the skin surface for a predetermined short period of time in the order of tens of milliseconds so that the cooling remains localized in epidermis while leaving the temperature of deeper port wine stain vessels substantially unchanged. The result is that epidermal denaturation and necrosis which normally occurs in uncooled laser irradiated skin sites does not occur and that clinically significant blanching of the port wine stains at the dynamically cooled sites establishes that selective laser photothermolysis of the port wine stain blood vessels is achieved. In addition, dynamic epidermal cooling reduces patient discomfort normally associated with flashlamp-pumped pulsed dye laser therapy.
摘要翻译：动态冷却口腔葡萄酒染色患者进行激光治疗的表皮，可以最大限度地提高口腔葡萄酒染色的热损伤，同时最大限度地减少正常上皮表皮的非特异性损伤。将低温喷雾施加到皮肤表面上预定的几十毫秒数量级的短时间段，使得冷却保持定位在表皮中，同时使更深端的葡萄酒污渍容器的温度基本保持不变。结果是通常在未冷却的激光照射的皮肤部位发生表皮变性和坏死，并且在动态冷却部位的端口葡萄酒污渍的临床显着漂白确定了实现了葡萄酒葡萄酒染色血管的选择性激光光热解。此外，动态表皮冷却减少了通常与闪光灯泵浦脉冲染料激光治疗相关的患者不适。

59. 发明授权

US10219780B2 OCT-IVUS catheter for concurrent luminal imaging 有权
公开(公告)号：US10219780B2
公开(公告)日：2019-03-05
申请号：US12173004
申请日：2008-07-14
申请人： Paul Castella , Nathaniel J. Kemp , Thomas E. Milner , David G. Rosenbaum
发明人： Paul Castella , Nathaniel J. Kemp , Thomas E. Milner , David G. Rosenbaum
IPC分类号： A61B8/12 , A61B5/00 , A61B5/02 , A61B8/08
摘要： The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.

60. 发明授权

US09622706B2 Catheter for in vivo imaging 有权
公开(公告)号：US09622706B2
公开(公告)日：2017-04-18
申请号：US12172922
申请日：2008-07-14
申请人： Larry Dick , Thomas E. Milner , Daniel D. Sims
发明人： Larry Dick , Thomas E. Milner , Daniel D. Sims
IPC分类号： A61B1/04 , A61B5/00 , A61B1/00 , A61B8/12 , A61B8/00
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B8/12 , A61B8/4461
摘要： A catheter for in vivo imaging comprising a monolithic outer sheath terminating in a monolithic atraumatic tip having a guidewire lumen. The catheter for in vivo imaging comprising a rotary drive shaft that passes through a central lumen of the monolithic outer sheath to impart rotary motion.

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