专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明专利

MA45990B1 Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase 未知
公开(公告)号：MA45990B1
公开(公告)日：2020-08-31
申请号：MA45990
申请日：2017-08-14
申请人： SUVEN LIFE SCIENCES LTD
发明人： NIROGI RAMAKRISHNA , SHINDE ANIL KARBHARI , MOHAMMED ABDUL RASHEED , JAYARAJAN PRADEEP , BHYRAPUNENI GOPINADH , JASTI VENKATESWARLU
IPC分类号： A61K31/27 , A61K31/445 , A61K31/5377 , A61K31/55 , A61P25/28
摘要： L'invention concerne la combinaison d'un agoniste inverse du récepteur de l'histamine-3 et d'un inhibiteur de l'acétylcholinestérase. L'invention concerne également un agoniste inverse du récepteur d'histamine-3 (h3r) ou un/des sel(s) pharmaceutiquement acceptable(s) de celui-ci, en combinaison avec, ou comme adjuvant à, un inhibiteur de l'acétylcholinestérase, ainsi que leur utilisation dans le traitement des troubles cognitifs. L'invention concerne encore la composition pharmaceutique contenant ladite combinaison.

52. 发明专利

NZ747797A Triple combination of pure 5-ht6 receptor antagonists, acetylcholinesterase inhibitors and nmda receptor antagonist 未知
公开(公告)号：NZ747797A
公开(公告)日：2020-07-31
申请号：NZ74779716
申请日：2016-08-03
申请人： SUVEN LIFE SCIENCES LTD
发明人： BHYRAPUNENI GOPINADH , JASTI VENKATESWARLU , JAYARAJAN PRADEEP , KAMBHAMPATI RAMASASTRI , NIROGI RAMAKRISHNA , SHINDE ANIL KARBHARI
IPC分类号： A61K31/4045 , A61K31/13 , A61K31/445 , A61K31/496 , A61P25/28
摘要： The present invention relates to a pure 5-HT6 receptor antagonist selected from 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole, 1-[(4-Fluorophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole and 1-[(4-Isopropylphenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole, or a pharmaceutically acceptable salt thereof, in combination with an acetylcholinesterase inhibitor and an N-Methyl-D-aspartate (NMDA) receptor antagonist, and their use in the treatment of cognitive disorders. The present invention further provides the pharmaceutical composition containing said combination and the use of the combination in an improved combination therapy for the treatment of cognitive disorders, such as Alzheimer’s disease, schizophrenia, Parkinson’s disease, Lewy body dementia, vascular dementia or frontotemporal dementia.

53. 发明专利

AU2018313049B2 Fluoropiperidine compounds as pure 5-HT6 receptor antagonists 未知
公开(公告)号：AU2018313049B2
公开(公告)日：2020-07-09
申请号：AU2018313049
申请日：2018-08-06
申请人： SUVEN LIFE SCIENCES LTD
发明人： NIROGI RAMAKRISHNA , SHINDE ANIL KARBHARI , MOHAMMED ABDUL RASHEED , BADANGE RAJESH KUMAR , BOJJA KUMAR , GOYAL VINOD KUMAR , PANDEY SANTOSH KUMAR , THENTU JAGADEESH BABU , JASTI VENKATESWARLU
IPC分类号： C07D413/04 , A61K31/4545 , A61P25/28
摘要： The present invention relates to fluoropiperidine compounds of formula (I), their stereoisomers, isotopic forms or pharmaceutically acceptable salts thereof as 5-HT

54. 发明专利

PT3484467T COMBINAÇÃO DE ANTAGONISTAS PUROS DO RECETOR 5-HT6 COM INIBIDORES DE ACETILCOLINESTERASE 未知
公开(公告)号：PT3484467T
公开(公告)日：2020-06-16
申请号：PT16766622
申请日：2016-08-03
申请人： SUVEN LIFE SCIENCES LTD
IPC分类号： A61K31/31 , A61K31/496 , A61P25/28

55. 发明专利

CY1121253T1 ΜΕΘΟΔΟΣ ΠΑΡΑΓΩΓΗΣ ΜΕΓΑΛΗΣ ΚΛΙΜΑΚΑΣ ΤΟΥ ΔΙΥΔΡΟΧΛΩΡΙΚΟΥ Ν-[4-(1-ΚΥΚΛΟΒΟΥΤΥΛΟΠΙΠΕΡΙΔΙΝ-4-ΥΛΟΞΥ)ΦΑΙΝΥΛ]-2-(ΜΟΡΦΟΛΙΝ-4-ΥΛ)ΑΚΕΤΑΜΙΔΙΟΥ 未知
公开(公告)号：CY1121253T1
公开(公告)日：2020-05-29
申请号：CY181101122
申请日：2018-10-30
申请人： SUVEN LIFE SCIENCES LTD
发明人： NIROGI RAMAKRISHNA , SHINDE ANIL KARBHARI , KAMBHAMPATI RAMASASTRI , JASTI VENKATESWARLU
IPC分类号： C07D413/12
摘要： ΗπαρούσαεφεύρεσηαναφέρεταισεμιαδιαδικασίαπαραγωγήςμεγάληςκλίμακαςτουδιυδροχλωρικούΝ-[4-(1-κυκλοβουτυλοπιπεριδιν-4-υλοξυ)φαινυλ]-2-(μορφολιν-4-υλ)ακεταμιδιουτουΧημικούΤύπου (I).

56. 发明专利

SG11202003284RA HETEROARYL COMPOUNDS AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 未知
公开(公告)号：SG11202003284RA
公开(公告)日：2020-05-28
申请号：SG11202003284R
申请日：2018-10-17
申请人： SUVEN LIFE SCIENCES LTD
发明人： NIROGI RAMAKRISHNA , MOHAMMED ABDUL RASHEED , SHINDE ANIL KARBHARI , RAVELLA SRINIVAS , MIDDEKADI VANAJA , GOYAL VINOD KUMAR , JAYARAJAN PRADEEP , DARIPELLI SAIVISHAL , JASTI VENKATESWARLU
IPC分类号： A61K31/519 , C07D487/04 , A61P25/00
摘要： The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I)

57. 发明专利

CA3116650A1 NEW USES OF A 5-HT4 RECEPTOR AGONIST 未知
公开(公告)号：CA3116650A1
公开(公告)日：2020-04-23
申请号：CA3116650
申请日：2019-10-17
申请人： SUVEN LIFE SCIENCES LTD
发明人： NIROGI RAMAKRISHNA , MOHAMMED ABDUL RASHEED , SHINDE ANIL KARBHARI , GRANDHI VENKATA RAMALINGAYYA , JAYARAJAN PRADEEP , BENADE VIJAY , BHYRAPUNENI GOPINADH , JASTI VENKATESWARLU
IPC分类号： A61K31/454 , A61P25/24 , A61P25/28
摘要： The present invention relates to new uses of a 5-HT4 receptor agonist, specifically Isopropyl-3 - { 5- [ 1 -(3 -methoxypropyl) piperidin-4-yl] - [ 1,3,4] oxadiazol-2-yl } - 1 H- indazole (Compound- 1) or a pharmaceutically acceptable salts thereof, for the treatment of dementia due to menopause, senile dementia, cognitive deficits associated with schizophrenia, depression, chemotherapy-induced cognitive impairment, and behavioral and psychological symptoms of dementia such as apathy/indifference, agitation, aggression, depression, anxiety, irritability/lability, dysphoria, aberrant motor behavior, delusions, hallucinations, elation/euphoria, psychosis, disinhibition, sleep and night time behavior disorders or appetite and eating disorders. The present invention further provides use of the said compounds in the manufacture of medicament intended for the treatment of the disorders described herein.

58. 发明专利

IL272287D0 Fluoropiperidine compounds as pure 5-ht6 receptor antagonists 未知
公开(公告)号：IL272287D0
公开(公告)日：2020-03-31
申请号：IL27228720
申请日：2020-01-27
申请人： SUVEN LIFE SCIENCES LTD
IPC分类号： C07D20060101
摘要： The present invention relates to fluoropiperidine compounds of formula (I), their stereoisomers, isotopic forms or pharmaceutically acceptable salts thereof as 5-HT6 receptor antagonists. In particular the present invention discloses the methods of preparation, pharmaceutical composition, combinations and use of fluoropiperidine compounds, their stereoisomers, isotopic forms or pharmaceutically acceptable salts thereof. In formula (I), R1 represents phenyl or pyridyl; wherein the phenyl or pyridyl is optionally substituted with one or more groups selected from halogen, (C1-6)-alkyl or halo(C1-6 )-alkyl; R2 represents hydrogen or (C1-6)-alkyl; R3 represents hydrogen or (C1-6)-alkyl; or R2 and R3 can combine together to form (C3-6)- cycloalkyl; R4 represents hydrogen, (C1-6)-alkyl or halo(C1-6)-alkyl; R5 represents hydrogen, (C1-6)-alkyl, halo(C1-6)-alkyl or -(CH2)0-3- (C3-6)-cycloalkyl. The compounds can be used in the treatment of cognitive disorder mediated by the 5-Hydroxytryptamine 6 receptor, wherein said cognitive disorder is selected from the group consisting of dementia in Alzheimer's disease, dementia in Parkinson's disease, dementia in Huntington's disease, dementia associated with Down syndrome, dementia associated with Tourette's syndrome, dementia associated with post menopause, frontotemporal dementia, Lewy body dementia, Vascular dementia, dementia in HIV, dementia in Creutzfeldt-Jakob disease, substance-induced persisting dementia, dementia in Pick's disease, dementia in schizophrenia, dementia in general medical conditions and senile dementia.

59. 发明专利

NZ747778A Combination of pure 5-ht6 receptor antagonists with nmda receptor antagonist 未知
公开(公告)号：NZ747778A
公开(公告)日：2020-03-27
申请号：NZ74777816
申请日：2016-08-03
申请人： SUVEN LIFE SCIENCES LTD
发明人： KAMBHAMPATI RAMASASTRI , JAYARAJAN PRADEEP , NIROGI RAMAKRISHNA , SHINDE ANIL KARBHARI , BHYRAPUNENI GOPINADH , JASTI VENKATESWARLU
IPC分类号： A61K31/4045 , A61K31/13 , A61K31/496 , A61P25/28
摘要： The present invention relates to pure 5-HT6 receptor antagonists selected from 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole; 1-[(4-Fluorophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole; or 1-[(4-Isopropylphenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole, or their pharmaceutically acceptable salt(s) thereof, in combination with or as adjunct to a N-Methyl-D-aspartate (NMDA) receptor antagonist and their use in the treatment of cognitive disorders. The invention further relates to the pharmaceutical composition containing the said combination, and the use of the combination in an improved combination therapy for the treatment of cognitive disorders, such as Alzheimer’s disease, schizophrenia, Parkinson’s disease, Lewy body dementia, vascular dementia or frontotemporal dementia.

60. 发明专利

BRPI0417895B1 composto, processo para a preparação de um composto e uso do composto 未知
公开(公告)号：BRPI0417895B1
公开(公告)日：2020-03-03
申请号：BRPI0417895
申请日：2004-12-30
申请人： SUVEN LIFE SCIENCES LTD
发明人： NAGARAJ KANDIKERE VISHWOTTAM , RAMA SASTRI KAMBHAMPATI , VENKATA SATYA NIROGI RAMAKRISHNA , VENKATESWARLU JASTI , VIKAS SHREEKRISHNA SHIRSATH
IPC分类号： C07D487/04 , C07D513/04
摘要： derivado de indeno [2,1a] indeno e isoindolo [2,1-a] índole, processo para a preparação de um composto, composições farmacêuticas, uso do derivado, uso de um radiocomposto identificado e método para um tratamento de prevenção ou um tratamento de desordem. a presente invenção descreve os derivados de indeno[2,la]indeno e de isoindolo[2,1-a] índole tendo a fórmula (i), os seus sais e os seus estéreo isômeros, nos quais x, r~ 1~,r~ 2~, r~ 3~, r~ 4~, r~ 6~, r~ 7~, r~ 8~, r~ 9~, r~ 11~, r~ 12~ , r~ 13~ e r~ 1~ são conforme descritos no relatório descritivo. a invenção também proporciona um método para preparar um composto com a fórmula (1), uma composição farmacêutica contendo tais compostos e um método para fabricar um medicamento. estes compostos são úteis no tratamento de várias desordens do cns, de desordens hematológicas, de desordens de alimentação, de doenças associadas com a dor, de doenças respiratórias, de desordens qenito-urológicas, de doenças cardiovasculares e de câncer.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式