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51. 发明申请

US20130270967A1 METHOD FOR FORMING AN ULTRASONIC TRANSDUCER, AND ASSOCIATED APPARATUS 有权
标题翻译：形成超声波传感器的方法及相关设备
公开(公告)号：US20130270967A1
公开(公告)日：2013-10-17
申请号：US13907046
申请日：2013-05-31
申请人： Research Triangle Institute
发明人： David Dausch , Scott H. Goodwin
IPC分类号： H01L41/047 , H01L41/293
CPC分类号： H01L41/0474 , B06B1/0607 , G10K11/004 , H01L41/0973 , H01L41/29 , H01L41/293 , H01L41/332
摘要： A method is provided for forming a piezoelectric ultrasonic transducer apparatus having a first electrode deposited on a dielectric layer disposed on a primary substrate. A piezoelectric material is deposited between the first electrode and a second electrode, to form a transducer device. At least the piezoelectric material is patterned such that a portion of the first electrode extends laterally outward therefrom. The primary substrate and the dielectric layer are etched to form a first via extending to the laterally outward portion of the first electrode, and a first conductive material is deposited to substantially fill the first via and form an electrically-conductive engagement with the laterally outward portion of the first electrode. The primary substrate is etched to define a second via extending therethrough, wherein the second via is laterally spaced apart from the first via. An associated method and apparatus are also provided.
摘要翻译：提供一种用于形成压电超声换能器装置的方法，该装置具有沉积在设置在初级基底上的电介质层上的第一电极。压电材料沉积在第一电极和第二电极之间，以形成换能器装置。至少压电材料被图案化，使得第一电极的一部分从其横向向外延伸。蚀刻初级衬底和电介质层以形成延伸到第一电极的横向向外部分的第一通孔，并且沉积第一导电材料以基本上填充第一通孔并与横向向外部分形成导电接合的第一电极。蚀刻初级衬底以限定延伸穿过其中的第二通孔，其中第二通孔与第一通路横向间隔开。还提供了相关联的方法和装置。

52. 发明申请

US20130150357A1 HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE 有权
公开(公告)号：US20130150357A1
公开(公告)日：2013-06-13
申请号：US13680710
申请日：2012-11-19
申请人： Research Triangle Institute , Digital Health d/b/a St. Joseph's Hospital and Med , Virginia Commonwealth University
发明人： F. Ivy Carroll , Bruce E. Blough , Hernan A. Navarro , S. Wayne Mascarella , Ana Zamfira Muresan , M. Imad Damaj , Ronald J. Lukas
IPC分类号： C07D265/32
CPC分类号： C07D265/32 , A61K31/5375
摘要： The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

53. 发明申请

US20040147539A1 Spermicidal and/or antifungal composition and methods of using the same 失效
标题翻译：杀精和/或抗真菌组合物及其使用方法
公开(公告)号：US20040147539A1
公开(公告)日：2004-07-29
申请号：US10350232
申请日：2003-01-24
申请人： Research Triangle Institute
发明人： Clarence Edgar Cook , Carol Delta Sloan , Brian Frazier Thomas , Hernan Andres Navarro
IPC分类号： A61K031/473
CPC分类号： A61K31/435 , A61K31/473 , Y02P20/582
摘要： Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
摘要翻译：提供六氢茚基吡啶化合物，其用作杀精剂和/或杀真菌剂，含有它们的杀精和/或杀真菌组合物，以及使用该化合物和组合物杀死活动精子和/或真菌的方法。

54. 发明申请

US20020188003A1 Cocaine receptor binding ligands 失效
标题翻译：可卡因受体结合配体
公开(公告)号：US20020188003A1
公开(公告)日：2002-12-12
申请号：US10155012
申请日：2002-05-28
申请人： Research Triangle Institute
发明人： Michael J. Kuhar , Frank Ivy Carroll , John W. Boja , Anita H. Lewin , Philip Abraham
IPC分类号： C07D413/02 , A61K031/46
CPC分类号： C07D451/02 , A61K51/0448 , A61K2123/00 , C07F7/2208
摘要： Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.
摘要翻译：对于多巴胺转运蛋白具有高结合亲和性和选择性的托烷衍生物在托烷骨架上具有羧酸酯或异恶唑部分以及取代的苯基部分。当一个或多个原子是放射性的时，这些化合物既用作药物也可用作成像剂。

55. 发明申请

US20020040889A1 Plasma furnace disposal of hazardous wastes 失效
标题翻译：等离子体炉处理危险废物
公开(公告)号：US20020040889A1
公开(公告)日：2002-04-11
申请号：US09739748
申请日：2000-12-20
申请人： Research Triangle Institute
发明人： Robert J. Markunas , John B. Posthill , Robert C. Hendry , Raymond Thomas
IPC分类号： B23K010/00
CPC分类号： H05H1/46 , Y10S588/90
摘要： A method and apparatus for plasma waste disposal of hazardous waste material, where the hazardous material is volatilized under vacuum inside a containment chamber to produce a pre-processed gas as input to a plasma furnace including a plasma-forming region in which a plasma-forming magnetic field is produced. The pre-processed gas is passed at low pressure and without circumvention through the plasma-forming region and is directly energized to an inductively coupled plasma state such that hazardous waste reactants included in the pre-processed gas are completely dissociated in transit through the plasma-forming region. Preferably, the plasma-forming region is shaped as a vacuum annulus and is dimensioned such that there is no bypass by which hazardous waste reactants in the pre-processed gas can circumvent the plasma-forming region. The plasma furnace is powered by a high frequency power supply outputting power at a fundamental frequency. The power supply contains parasitic power dissipation mechanisms to prevent non-fundamental, parasitic frequencies from destabilizing the fundamental frequency output power. These power loss mechanisms use either distributed resistance or frequency-selective power-loss devices to prevent parasitic oscillations from instantaneously turning on the high frequency power oscillator at non-fundamental frequencies.
摘要翻译：一种用于危险废物等离子体废物处理的方法和装置，其中危险材料在密封室内在真空下挥发，以产生预处理气体作为等离子体炉的输入，其包括等离子体形成区域，其中等离子体形成区域产生磁场。预处理气体在低压下通过等离子体形成区域而不规避，并被直接通电到感应耦合的等离子体状态，使得包含在预处理气体中的危险废物反应物在运输过程中完全离解通过等离子体 - 形成区域。优选地，等离子体形成区域成形为真空环形区域，其尺寸使得不存在预处理气体中的危险废物反应物可绕过等离子体形成区域的旁路。等离子炉由基频输出功率的高频电源供电。电源包含寄生功率耗散机制，以防止非基波寄生频率不稳定基频输出功率。这些功率损耗机制使用分布式电阻或频率选择性功率损耗器件来防止寄生振荡在非基频处瞬时接通高频功率振荡器。

56. 发明专利

AU1251992A CHEMICAL REACTIONS ON CAMPTOTHECIN OR ANALOGS 未知
公开(公告)号：AU1251992A
公开(公告)日：1993-05-21
申请号：AU1251992
申请日：1991-10-18
申请人： RESEARCH TRIANGLE INSTITUTE
发明人： MONROE E. WALL , MANSUKH C. WANI , CHHAGAN A TELE
IPC分类号： C07D471/12 , C07D471/14

57. 发明申请

US20230067004A1 METHODS AND SYSTEMS FOR REDUCING THE CONCENTRATION OF AMINE IN WASH LIQUID USED IN INDUSTRIAL PROCESSING 有权
公开(公告)号：US20230067004A1
公开(公告)日：2023-03-02
申请号：US17759654
申请日：2021-01-26
申请人： Research Triangle Institute
发明人： Paul MOBLEY , Shaojun James ZHOU , Samuel John THOMPSON , Jak TANTHANA , Aravind Villava Rayer RABINDRAN , Marty LAIL
IPC分类号： C02F1/28 , B01J20/20 , B01J20/28 , B01J20/34 , B01D53/14
摘要： A method for reducing the concentration of amines in a wash liquid stream exiting a wash section in an acid gas scrubbing process includes introducing the wash liquid stream exiting the wash section of the acid gas scrubbing process to an adsorbent material, wherein the wash liquid stream has a first concentration of amines. The wash liquid stream having the first concentration of amines is flowed through the adsorbent material, and the adsorbent material retains at least a portion of the amines thereby providing a wash liquid stream having a second, reduced concentration of amines. The wash stream with reduced concentration of amines is recycled back to the wash section to remove amines more effectively from the acid gas being scrubbed. The adsorbent material can be regenerated for reuse. Amine recovered from the regenerated adsorbent material can be recycled to the process for reuse.

58. 发明申请

US20230039640A1 SOLID-STATE CRYSTALLIZATION OF METAL ORGANIC FRAMEWORKS WITHIN MESOPOROUS MATERIALS METHODS AND HYBRID MATERIALS THEREOF 有权
公开(公告)号：US20230039640A1
公开(公告)日：2023-02-09
申请号：US17962217
申请日：2022-10-07
申请人： Research Triangle Institute
发明人： Ignacio Luz Minguez , Mustapha Soukri , Marty Lail
IPC分类号： C01B39/02 , C01B39/00 , B01J20/22 , B01J20/10 , B01J20/32 , B01J31/16 , B01J29/06 , C01B39/48
摘要： A method, comprising i) contacting an aqueous solution of an organic ligand salt of the formula Ax(L-x) with a mesoporous material (MPM) to form an impregnated mesoporous salt material of the formula Ax(L-x)/MPM, ii) treating the impregnated mesoporous salt material with an aqueous acidic solution to form an impregnated mesoporous acid material of the formula Hx(L- x)/MPM, iii) contacting an aqueous solution of a metal precursor of the formula M+y(B)y with the impregnated mesoporous acid material to form an impregnated mesoporous metal organic framework precursor of the formula [M+y(B)y][Hx(L-x)]/MPM, and iv) at least one of 1) heating the impregnated mesoporous metal organic framework precursor in the absence of a solvent or 2) exposing the impregnated mesoporous metal organic framework precursor to a volatile vapor in the absence of a solvent such that the heating or the exposing forms a hybrid material of the formula (M+yL-x)/MPM, wherein the hybrid material comprises a nano-crystalline metal organic framework (MOF) embedded within the mesoporous material.

59. 发明授权

US11285430B2 Nitrosamine decomposition 有权
公开(公告)号：US11285430B2
公开(公告)日：2022-03-29
申请号：US16748111
申请日：2020-01-21
申请人： Research Triangle Institute
发明人： Marty Lail , Aravind Villava Rayer Rabindran , Samuel John Thompson
IPC分类号： B01D53/14 , B01D53/18
摘要： The disclosure provides methods and systems for decreasing nitrosamine content, e.g., in the context of non-aqueous solvent systems. It includes a method including receiving a non-aqueous solvent system and contacting the non-aqueous solvent system with a composition including one or more alkoxides to give a treated solvent system having a nitrosamine content that is lower than the starting nitrosamine content. Similarly, it includes a system including a first unit configured to remove undesirable components from a gas stream; a second unit holding a composition including one or more alkoxides, and a conduit to connect these units.

60. 发明授权

US11267789B2 Apelin receptor (APJ) agonists and uses thereof 有权
公开(公告)号：US11267789B2
公开(公告)日：2022-03-08
申请号：US16448976
申请日：2019-06-21
申请人： Research Triangle Institute
发明人： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC分类号： C07D231/14 , C07D405/12 , A61K45/06 , A61K31/415 , A61K31/4155 , A61K31/422 , C07D403/12 , A61K31/496 , C07D413/12 , C07D407/12 , C07D403/06 , A61K31/454
摘要： This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

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