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51. 发明授权

US06954667B2 Method for Raman chemical imaging and characterization of calcification in tissue 有权
标题翻译：拉曼化学成像方法和组织钙化表征
公开(公告)号：US06954667B2
公开(公告)日：2005-10-11
申请号：US10185090
申请日：2002-06-28
申请人： Patrick J. Treado , Matthew P. Nelson
发明人： Patrick J. Treado , Matthew P. Nelson
IPC分类号： A61B5/00 , G01N21/65 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/4312 , G01N21/65
摘要： Apparatus and methods for spatially resolved Raman detection of calcification in tissues are disclosed. A region of soft non-arterial biological tissue is illuminated with monochromatic light. A spatially organized first area of calcified tissue is then detected in the region by detecting a Raman shifted light signal. The Raman shifted light signal is spatially resolved in at least one direction.
摘要翻译：公开了用于组织中钙化的空间分辨拉曼检测的装置和方法。柔软的非动脉生物组织的区域用单色光照射。然后通过检测拉曼偏移的光信号在该区域中检测空间组织的钙化组织的第一区域。拉曼移动的光信号在至少一个方向上被空间分辨。

52. 发明授权

US08269174B2 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
标题翻译：用于多物体采样的紧凑型光谱仪的方法和装置
公开(公告)号：US08269174B2
公开(公告)日：2012-09-18
申请号：US12719904
申请日：2010-03-09
申请人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
发明人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
IPC分类号： G01J5/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0256 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/6456 , G01N21/6486 , G01N21/65
摘要： A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.
摘要翻译：一种用于评估样品中的试剂的发生的方法和便携式装置。用便携式设备发出的光子照射样品，以产生从具有确定的几何关系的样品中的一组多个点反射，发射或吸收的光子。便携式设备用于同时照亮样品并使用包括红外，荧光和紫外/可见光在内的光谱方法分析从该组多个点反射，发射或吸收的光子。所评估的试剂可以包括危险剂，化学试剂，生物制剂，微生物，细菌，原生动物，病毒及其组合。

53. 发明申请

US20120072122A1 Forensic Integrated Search Technology 审中-公开
标题翻译：法医综合搜索技术
公开(公告)号：US20120072122A1
公开(公告)日：2012-03-22
申请号：US13246906
申请日：2011-09-28
申请人： Robert Schweitzer , Patrick J. Treado , Jason Neiss
发明人： Robert Schweitzer , Patrick J. Treado , Jason Neiss
IPC分类号： G06F19/00
CPC分类号： G06F16/2462 , G16C20/20 , G16C20/90
摘要： A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported.
摘要翻译：搜索光谱数据库并识别未知材料的系统和方法。提供了包括子库的库，每个子库包含对应于已知材料的多个参考数据集。提供测试数据集，是未知材料的特征。每个测试数据集由一个或多个光谱数据产生装置产生。搜索每个子图书馆，并产生相应的一组分数，指示匹配的可能性。对于每个搜索的子图库计算相对概率值。所有相对概率值被融合，产生一组最终概率值，用于确定未知材料是否通过库中的已知材料表示。与最小置信度值相比，选择最高最终概率值。如果概率值大于或等于最小置信度值，则报告已知材料。

54. 发明授权

US08078268B2 System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像的系统和方法来确定手术期间的组织边缘
公开(公告)号：US08078268B2
公开(公告)日：2011-12-13
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

55. 发明申请

US20110299071A1 MULTIPOINT METHOD FOR IDENTIFYING HAZARDOUS AGENTS 有权
标题翻译：用于识别危险剂的多点方法
公开(公告)号：US20110299071A1
公开(公告)日：2011-12-08
申请号：US12422360
申请日：2009-04-13
申请人： Patrick J. Treado , Joseph E. Demuth , Robert Schweitzer
发明人： Patrick J. Treado , Joseph E. Demuth , Robert Schweitzer
IPC分类号： G01J3/44 , G01J1/42 , G01J5/02 , G01N21/64 , G01T1/105
CPC分类号： G01N21/65 , G01N21/64 , G01N21/6402 , G01N21/8483 , G01N2021/6417
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本发明涉及通过对样品进行多点光谱分析来评估样品中危险剂的发生的装置和方法。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

56. 发明授权

US07808634B2 Method and apparatus for automated spectral calibration 有权
标题翻译：用于自动光谱校准的方法和装置
公开(公告)号：US07808634B2
公开(公告)日：2010-10-05
申请号：US12273169
申请日：2008-11-18
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01J3/44
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum; and forming a spatially accurate wavelength resolved image of the sample from the first plurality of collected photons.
摘要翻译：一种用于光谱装置的自动光谱校准的方法和装置。在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱; 以及从所述第一多个收集的光子形成所述样品的空间上准确的波长分辨图像。

57. 发明申请

US20100081127A1 System and Method of Chemical Imaging Using Pulsed Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像系统和方法来确定手术中的组织边缘
公开(公告)号：US20100081127A1
公开(公告)日：2010-04-01
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
IPC分类号： C12Q1/70 , C12Q1/06
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

58. 发明申请

US20090303471A1 Chemical imaging explosives (CHIMED) optical sensor 有权
标题翻译：化学成像炸药（CHIMED）光学传感器
公开(公告)号：US20090303471A1
公开(公告)日：2009-12-10
申请号：US11645132
申请日：2006-12-22
申请人： Patrick J. Treado , Matthew P. Nelson
发明人： Patrick J. Treado , Matthew P. Nelson
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01N21/6456 , G01N21/65 , G01N33/227 , G01N2001/024 , G01N2021/6417 , G01N2021/6484
摘要： A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.
摘要翻译：一种检测位于样品上的爆炸性化合物的系统和方法。用动物安全的紫外线辐射照射样品，产生荧光数据组。基于荧光数据集搜索荧光数据库，以识别已知的荧光数据集。如果荧光数据库的搜索识别已知荧光数据集，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样品中的感兴趣区域。用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据集。基于拉曼数据集搜索拉曼数据库，以便识别已知的拉曼数据集。基于通过搜索拉曼数据库识别的已知拉曼数据集来识别感兴趣区域中的爆炸性化合物。

59. 发明授权

US07629591B2 System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing 有权
标题翻译：用于结构化照明和采集的系统和方法，用于改进拉曼光纤阵列光谱翻译器成像和交互式拉曼探测的光学共焦
公开(公告)号：US07629591B2
公开(公告)日：2009-12-08
申请号：US11712917
申请日：2007-03-02
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01N21/64
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译：本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

60. 发明授权

US07548310B2 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
标题翻译：用于多物体采样的紧凑型光谱仪的方法和装置
公开(公告)号：US07548310B2
公开(公告)日：2009-06-16
申请号：US11366660
申请日：2006-03-03
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

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