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51. 发明申请

US20060035719A1 Golf shot improving system 审中-公开
标题翻译：高尔夫射击改进系统
公开(公告)号：US20060035719A1
公开(公告)日：2006-02-16
申请号：US11200340
申请日：2005-08-09
申请人： Mark Wood
发明人： Mark Wood
IPC分类号： A63B69/36
CPC分类号： A63B69/3655 , A63B43/008
摘要： The present invention comprises a special golf ball, configured with a human eye and preferably with the color and shape of the golfer's mother. By placing a human eye, similar to that of a relative on the golf ball, the golfer utilizes his or her instinctive human behavior on making eye contact, thus maintaining eye contact with the ball during swinging, the most fundamental aspect of a proper golf swing. By keeping an eye on the ball, the golfer's head stays down and performance dramatically improves.
摘要翻译：本发明包括一种特殊的高尔夫球，其配置有人眼，并且优选地具有高尔夫球手母亲的颜色和形状。通过放置类似于高尔夫球上的亲戚的人眼，高尔夫球手利用他或她本能的人类行为进行眼神接触，从而在摆动期间保持与球的眼睛接触，适当的高尔夫挥杆的最基本的方面。通过关注球，高尔夫球手的头部停留下来，性能显着提高。

52. 发明授权

US06431844B1 High pressure pump having integral start valve 有权
标题翻译：高压泵具有积分起动阀
公开(公告)号：US06431844B1
公开(公告)日：2002-08-13
申请号：US09639435
申请日：2000-08-14
申请人： Shane Dexter , Allen Palmer , Mark Wood
发明人： Shane Dexter , Allen Palmer , Mark Wood
IPC分类号： F07B4900
CPC分类号： F04B1/02 , F04B1/0404 , F04B49/035
摘要： A high pressure pump suitable for use in devices such as pressure washers or the like is disclosed wherein the pump's head assembly includes an integral start valve for allowing the fluid through the head assembly so the engine may be more easily started. When the pump reaches a predetermined rate of flow of the fluid, the start valve assembly closes to circulate the fluid through said pump assembly.
摘要翻译：公开了一种适用于诸如压力垫圈等的装置的高压泵，其中泵的头部组件包括用于允许流体通过头部组件的整体起动阀，从而可以更容易地启动发动机。当泵达到流体的预定流速时，启动阀组件关闭以使流体循环通过所述泵组件。

53. 发明授权

US09743933B2 Release mechanism for hemostasis clip 有权
公开(公告)号：US09743933B2
公开(公告)日：2017-08-29
申请号：US13231524
申请日：2011-09-13
申请人： Molly Phillips-Hungerford , Mark Wood , Shawn Ryan , Benjamin E. Morris
发明人： Molly Phillips-Hungerford , Mark Wood , Shawn Ryan , Benjamin E. Morris
IPC分类号： A61B17/10 , A61B17/128 , A61B17/122 , A61B90/00
CPC分类号： A61B17/1285 , A61B17/122 , A61B17/1227 , A61B17/128 , A61B90/03
摘要： Release mechanism for medical device includes a bushing having a proximal end, a distal end and a channel extending therethrough. Plurality of extend proximally from the distal end are biased toward a release configuration in which engagement surfaces at distal ends thereof retract radially into the channel. A core pin insertable through the channel applies a radially expansive pressure to move the arms radially outward to a locking configuration. Engagement surfaces of the first and second arms connect to a retaining surface of a tissue treatment device containing capsule, which extends at an angle relative to the engagement surfaces selected so that a first portion of a force transmitted along an axis of the bushing moves the arms radially inward toward the release configuration before a second portion of the force exceeds a threshold level associated with the removal of a tissue treatment device from gripped tissue.

54. 发明授权

US09387104B2 Loading basket for a stent delivery system 有权
标题翻译：装载支架输送系统的篮子
公开(公告)号：US09387104B2
公开(公告)日：2016-07-12
申请号：US13335615
申请日：2011-12-22
申请人： Ra Nam , Mark Wood , John Pereira , Eric M. Schneider , William C. Bertolino , Naroun Suon
发明人： Ra Nam , Mark Wood , John Pereira , Eric M. Schneider , William C. Bertolino , Naroun Suon
IPC分类号： A61F2/06 , A61F2/962 , A61F2/95
CPC分类号： A61F2/962 , A61F2002/9522
摘要： A loading basket is secured at its proximal end to a portion of a delivery device. The stent engages with the interior of the stent basket when loaded onto the delivery device to prevent shifting or movement of the stent during delivery of the stent to a desired location within the bodily lumen. In at least one embodiment, the loading basket has a proximal end, a distal end, and a braided surface. The loading basket comprises a proximal end portion, a proximal transition portion, a body portion, a distal transition portion, a distal end portion, and an angled inward distal end. When loaded onto the delivery device, the outer surface of the stent contacts at least the angled inward distal end of the delivery device and movement of the stent is prevented.
摘要翻译：装载篮在其近端固定到输送装置的一部分。支架在装载到输送装置上时与支架的内部接合，以防止在将支架输送到体腔内的期望位置时支架的移动或移动。在至少一个实施例中，装载篮具有近端，远端和编织表面。装载篮包括近端部分，近端过渡部分，主体部分，远侧过渡部分，远端部分和倾斜的内侧远端。当装载到输送装置上时，支架的外表面至少与输送装置的倾斜的内向远端相接触，并防止了支架的移动。

55. 发明授权

US09155643B2 Apparatus and method for manufacturing a single wire stent 有权
标题翻译：用于制造单丝支架的装置和方法
公开(公告)号：US09155643B2
公开(公告)日：2015-10-13
申请号：US13092762
申请日：2011-04-22
申请人： Claude Clerc , Alexander Turovsky , Michael E. Zupkofska , Christopher Dubois , Mark Wood , Gary Jordan
发明人： Claude Clerc , Alexander Turovsky , Michael E. Zupkofska , Christopher Dubois , Mark Wood , Gary Jordan
IPC分类号： A61F2/90 , D04C1/06 , D04C3/48 , D04C7/00
CPC分类号： A61F2/90 , A61F2230/0078 , A61F2240/001 , A61F2250/0039 , D04C1/06 , D04C3/48 , D04C7/00 , D10B2509/06 , Y10T29/49998
摘要： A mandrel for manufacturing a stent from a single wire includes a cylindrical member having a plurality of pins at a proximal end region, a plurality of pins at a distal end region, and a plurality of indentations between the proximal pins and the distal pins. These indentations form a helical pattern on the outer surface of the cylindrical member. The single wire is wrapped around every proximal pin and distal pin on the mandrel by following the indentations in the mandrel. The single wire is slid through the indentation under any crossing section of wire and over the next crossing section of wire in an under-over pattern.
摘要翻译：用于从单线制造支架的心轴包括：在近端区域具有多个销的圆柱形构件，在远端区域处的多个销以及近端销和远端销之间的多个凹口。这些凹陷在圆柱形构件的外表面上形成螺旋形图案。通过跟随心轴中的凹陷将单根线缠绕在心轴上的每个近端销和远端销上。单根导线在导线的任何交叉部分下滑过穿过凹陷，并且以下面的图案在导线的下一个交叉部分之上滑动。

56. 发明授权

US09126966B2 Cationic lipids and methods of use thereof 有权
标题翻译：阳离子脂质及其使用方法
公开(公告)号：US09126966B2
公开(公告)日：2015-09-08
申请号：US13599220
申请日：2012-08-30
申请人： Alan Martin , James Heyes , Mark Wood
发明人： Alan Martin , James Heyes , Mark Wood
IPC分类号： A61K9/14 , A61K9/127 , C07D319/06 , A61K47/28 , A61K47/22 , A61K31/713 , A61K9/51 , C12N15/88 , B82Y5/00 , A61K48/00
CPC分类号： C07D319/06 , A61K9/127 , A61K9/1272 , A61K9/14 , A61K9/5123 , A61K31/713 , A61K47/22 , A61K47/28 , A61K48/0033 , B82Y5/00 , C12N15/88 , Y10S977/773 , Y10S977/906 , Y10T428/2982
摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译：本发明提供了将治疗剂递送至细胞的组合物和方法。特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

57. 发明授权

US08865675B2 Compositions and methods for silencing apolipoprotein B 有权
标题翻译：沉默载脂蛋白B的组合物和方法
公开(公告)号：US08865675B2
公开(公告)日：2014-10-21
申请号：US13697000
申请日：2011-05-12
申请人： James Heyes , Mark Wood , Alan Martin , Amy C. H. Lee , Adam Judge , Marjorie Robbins , Ian MacLachlan
发明人： James Heyes , Mark Wood , Alan Martin , Amy C. H. Lee , Adam Judge , Marjorie Robbins , Ian MacLachlan
IPC分类号： C12N15/11 , C12Q1/68 , A61K31/713 , C12N15/88 , C12N15/113
CPC分类号： A61K31/713 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译：本发明提供用于递送干扰RNA的组合物和方法，例如在细胞如肝细胞中沉默APOB表达的siRNA。特别地，核酸 - 脂质颗粒提供了核酸的有效包封，并且将体内核酸的活性有效地递送到细胞例如肝细胞。本发明的组合物是非常有效的，从而允许以相对低的剂量有效地击倒APOB。此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

58. 发明授权

US08663314B2 Continuous double layered stent for migration resistance 有权
标题翻译：连续双层支架用于迁移阻力
公开(公告)号：US08663314B2
公开(公告)日：2014-03-04
申请号：US13396088
申请日：2012-02-14
申请人： Mark Wood , Paul Norton , William Bertolino , F. Anthony Headley, Jr.
发明人： Mark Wood , Paul Norton , William Bertolino , F. Anthony Headley, Jr.
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2/848 , A61F2210/0076 , A61F2220/0016
摘要： The present invention relates to stent structures having improved migration resistance. In particular, the invention relates to mesh stents, such as braided or twisted stent designs, where at least a portion of the stent is folded back over itself to form a multi-layered stent device. Such multi-layered portions provide for migration resistance, among other advantages.
摘要翻译：本发明涉及具有改善的耐迁移性的支架结构。特别地，本发明涉及网状支架，例如编织或扭曲支架设计，其中支架的至少一部分自身折回以形成多层支架装置。除了其它的优点之外，这种多层部分提供了耐迁移性。

59. 发明申请

US20130226170A1 ELECTROSURGICAL DEVICE AND SYSTEM 有权
公开(公告)号：US20130226170A1
公开(公告)日：2013-08-29
申请号：US13781222
申请日：2013-02-28
申请人： Dane Seddon , Sean Fleury , Mark Wood , Peter Dayton
发明人： Dane Seddon , Sean Fleury , Mark Wood , Peter Dayton
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/14 , A61B18/1482 , A61B2017/003 , A61B2017/00305 , A61B2017/00314 , A61B2017/00323
摘要： Embodiments of the disclosure include devices and systems for using an end effector. In an embodiment, a medical device may include an articulation section. The articulation section may be operatively associated with an elongate articulation member configured to move the articulation section, wherein the articulation section can be configured to receive part of a conductive member. The medical device may also include an end effector. The end effector may include an electrode and a non-conductive section encasing a junction between the electrode and the conductive member, wherein the non-conductive section can be moveably coupled to the articulation section and can be fixedly coupled to the elongate articulation member.

60. 发明授权

US08466122B2 Trialkyl cationic lipids and methods of use thereof 有权
标题翻译：三烷基阳离子脂质及其使用方法
公开(公告)号：US08466122B2
公开(公告)日：2013-06-18
申请号：US13235253
申请日：2011-09-16
申请人： James Heyes , Mark Wood , Alan Martin
发明人： James Heyes , Mark Wood , Alan Martin
IPC分类号： C12N15/11 , C07H21/02 , A61K9/127
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K47/34 , C07C229/12 , C07C271/20
摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译：本发明提供了将治疗剂递送至细胞的组合物和方法。特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

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