专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US07601752B2 Pyrrolidine derivatives 失效
标题翻译：吡咯烷衍生物
公开(公告)号：US07601752B2
公开(公告)日：2009-10-13
申请号：US11593821
申请日：2006-11-06
申请人： Lilli Anselm , Katrin Groebke Zbinden , Wolfgang Haap , Hans Hilpert , Jacques Himber , Bernd Kuhn , Narendra Panday , Fabienne Ricklin , Stefan Thomi
发明人： Lilli Anselm , Katrin Groebke Zbinden , Wolfgang Haap , Hans Hilpert , Jacques Himber , Bernd Kuhn , Narendra Panday , Fabienne Ricklin , Stefan Thomi
IPC分类号： A61K31/4025 , C07D409/12
CPC分类号： C07D409/14 , C07D413/14
摘要： The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型吡咯烷衍生物，其中X，Y，R 1，R 2和R 3如说明书和权利要求书中所定义，以及其生理上可接受的盐。这些化合物抑制凝血因子Xa，并且可以用作药物。

52. 发明申请

US20090105307A1 2-AMINOOXAZOLINES AS TAAR1 LIGANDS 有权
标题翻译： 2-AMINOOXAZOLINES as TAAR1 LIGANDS
公开(公告)号：US20090105307A1
公开(公告)日：2009-04-23
申请号：US12028028
申请日：2008-02-08
申请人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
IPC分类号： A61K31/421 , C07D263/28 , C07D401/02 , A61P25/00 , A61K31/4439
CPC分类号： C07D263/28 , C07D413/06
摘要： The invention relates to compounds of formula wherein R1, R2, and R3 are as defined herein and to a pharmaceutically suitable acid addition salts thereof for the treatment of CNS disorders.
摘要翻译：本发明涉及下式的化合物，其中R 1，R 2和R 3如本文所定义，及其药学上合适的酸加成盐，用于治疗CNS病症。

53. 发明申请

US20080146523A1 IMIDAZOLE DERIVATIVES 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：US20080146523A1
公开(公告)日：2008-06-19
申请号：US11950449
申请日：2007-12-05
申请人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
IPC分类号： C07D233/54 , C07D413/00 , A61K31/695 , A61K31/4164 , A61K31/4166 , A61K31/5377
CPC分类号： C07D233/64
摘要： The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1.The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compound.The invention further relates to a composition comprising an imidazole derivative as described above, or a pharmaceutically-suitable acid-addition salt thereof, and to processes for preparing such compounds.
摘要翻译：本发明涉及对微量胺相关受体（TAAR）具有良好亲和力的咪唑衍生物，特别是TAAR1。本发明还涉及上述化合物的药学上合适的酸加成盐。本发明还涉及包含如上所述的咪唑衍生物或其药学上合适的酸加成盐的组合物及其制备方法。

54. 发明申请

US20080113980A1 SUBSTITUTED-2-IMIDAZOLES 失效
标题翻译：取代的2-IMIDAZOLES
公开(公告)号：US20080113980A1
公开(公告)日：2008-05-15
申请号：US11931246
申请日：2007-10-31
申请人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
IPC分类号： A61K31/538 , A61K31/4178 , C07D403/02 , C07D413/02
CPC分类号： C07D413/06 , C07D401/06 , C07D403/06
摘要： The present invention relates to compounds of formula I wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from the group consisting of hydrogen and lower alkyl; each R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, phenyloxy, benzyloxy, halogen and lower alkyl substituted by halogen; X is selected from the group consisting of —CH2—, —CH— and —O—; Y is selected from the group consisting of —CH2—, —CH— and a bond with the proviso that, when X is —O—, Y may not be a bond; Z is selected from the group consisting of —CH2— and —CH—; m is 0, 1 or 2; and n is 0, 1 or 2; and to pharmaceutically-acceptable acid addition salts of such compounds. The invention relates also to processes for preparing such compounds, compositions comprising such a compound or a pharmaceutically-acceptable acid addition salt thereof, and a method of treating a disease or disorder in a patient comprising administering such a compound, or pharmaceutically-acceptable acid addition salt thereof, to a patient in need of such treatment.
摘要翻译：本发明涉及式I化合物，其中R 1选自氢和低级烷基; 每个R 2独立地选自氢和低级烷基; 每个R 3独立地选自氢，低级烷基，低级烷氧基，苯氧基，苄氧基，卤素和被卤素取代的低级烷基; X选自-CH 2 - ， - CH-和-O-; Y选自-CH 2 - ， - CH-和键，条件是当X是-O-时，Y可以不是键; Z选自-CH 2 - 和-CH-; m为0,1或2; 且n为0,1或2; 以及这些化合物的药学上可接受的酸加成盐。本发明还涉及制备这种化合物的方法，包含这种化合物或其药学上可接受的酸加成盐的组合物，以及治疗患者疾病或病症的方法，包括给予这种化合物或药学上可接受的酸加成其盐，需要这种治疗的患者。

55. 发明申请

US20070197622A1 Methods for treating CNS disorders with 4-imidazole derivatives 失效
标题翻译：用4-咪唑衍生物治疗CNS障碍的方法
公开(公告)号：US20070197622A1
公开(公告)日：2007-08-23
申请号：US11655539
申请日：2007-01-19
申请人： Guido Galley , Katrin Groebke Zbinden , Marius Hoener , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Marius Hoener , Roger Norcross , Henri Stalder
IPC分类号： A61K31/415 , C07D233/56
CPC分类号： C07D233/64 , C07D405/06
摘要： The present invention relates to methods for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, Ar, R1, R1′, R2, and n are as defined in the specification and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms. The invention also relates to novel compounds of formula I, compositions containing them, and methods for their preparation.
摘要翻译：本发明涉及治疗抑郁症，焦虑障碍，双相情感障碍，注意力缺陷多动障碍，应激相关障碍，精神病性精神病，如帕金森病，神经变性疾病如阿尔茨海默病，癫痫，偏头痛，高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病，其包括给予个体治疗有效量的式I化合物，其中R，Ar，R 1，R 1，R 2，R 2和n 在本说明书中以及其药学活性盐，外消旋混合物，对映异构体，光学异构体和互变异构体形式中所定义。本发明还涉及式I的新化合物，含有它们的组合物及其制备方法。

56. 发明申请

US20070197621A1 Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives 失效
标题翻译：用取代的2-咪唑或咪唑衍生物治疗CNS障碍的方法
公开(公告)号：US20070197621A1
公开(公告)日：2007-08-23
申请号：US11655468
申请日：2007-01-19
申请人： Guido Galley , Katrin Groebke Zbinden , Marius Hoener , Sabine Kolczewski , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Marius Hoener , Sabine Kolczewski , Roger Norcross , Henri Stalder
IPC分类号： A61K31/415 , C07D233/56
CPC分类号： C07D233/06 , A61K31/4164 , A61K31/4178 , C07D233/20 , C07D233/22 , C07D233/56 , C07D233/64 , C07D401/10 , C07D403/06 , C07D405/06 , C07D409/06
摘要： The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.
摘要翻译：本发明涉及治疗抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍，应激相关障碍，精神病如精神分裂症，神经系统疾病如帕金森病，神经变性疾病如阿尔茨海默病，癫痫，偏头痛，高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病，其包括给予个体治疗有效量的式I化合物，其中R，R 1，R 2，A和n如说明书中所定义，并且其药物活性盐。本发明还涉及式I的新型化合物，含有它们的药物组合物及其制备方法。

57. 发明授权

US07056932B2 Heterocyclyl substituted 1-alkoxy acetic acid amides 失效
标题翻译：杂环取代的1-烷氧基乙酰胺
公开(公告)号：US07056932B2
公开(公告)日：2006-06-06
申请号：US11009464
申请日：2004-12-10
申请人： Luca Claudio Gobbi , Katrin Groebke Zbinden , Peter Mohr , Ulrike Obst
发明人： Luca Claudio Gobbi , Katrin Groebke Zbinden , Peter Mohr , Ulrike Obst
IPC分类号： A61K31/454 , A61K31/444 , C07D413/12 , C07D239/70 , C07D271/06
CPC分类号： C07D401/04 , C07D209/46 , C07D209/48 , C07D213/64 , C07D213/74 , C07D213/76 , C07D231/12 , C07D235/16 , C07D249/08 , C07D263/32 , C07D271/06 , C07D401/12 , C07D413/12
摘要： The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新的杂环基取代的1-烷氧基乙酸衍生物，其中R 1至R 6和A如描述中所定义，并且在以及其生理上可接受的盐。这些化合物抑制由因子VIIa和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成，并且可以用作药物。

58. 发明授权

US06642386B2 N-(4-carbamimidoyl-phenyl)-glycine derivatives 失效
标题翻译： N-（4-甲脒基 - 苯基） - 甘氨酸衍生物
公开(公告)号：US06642386B2
公开(公告)日：2003-11-04
申请号：US10350617
申请日：2003-01-24
申请人： Leo Alig , Katrin Groebke Zbinden , Ulrike Obst
发明人： Leo Alig , Katrin Groebke Zbinden , Ulrike Obst
IPC分类号： C07D21140
CPC分类号： C07D211/22 , C07D211/42
摘要： The invention is concerned with water soluble N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I) wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
摘要翻译：本发明涉及式（I）的水溶性N-（4-甲脒基 - 苯基） - 甘氨酸衍生物，其中R 1至R 4和n如说明书和权利要求书中所定义，以及其生理上可接受的盐。这些化合物抑制由因子VIIa和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成，并且可以用作药物。

59. 发明授权

US09452980B2 Substituted benzamides 有权
标题翻译：取代苯甲酰胺
公开(公告)号：US09452980B2
公开(公告)日：2016-09-27
申请号：US12969613
申请日：2010-12-16
申请人： Katrin Groebke Zbinden , Roger Norcross , Philippe Pflieger
发明人： Katrin Groebke Zbinden , Roger Norcross , Philippe Pflieger
IPC分类号： C07D207/09 , C07D207/10 , C07D207/12 , C07D211/26 , C07D241/04 , C07D265/30 , C07D267/08 , C07D295/135 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/40 , A61K31/495 , A61K31/496 , A61K31/454 , A61K31/553 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/22 , A61K9/20
CPC分类号： C07D207/09 , A61K9/2018 , C07D207/10 , C07D207/12 , C07D211/26 , C07D241/04 , C07D263/32 , C07D265/30 , C07D267/08 , C07D267/10 , C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula wherein R, R1, R2, X, and Y are as defined herein and to a pharmaceutically suitable acid addition salt thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
摘要翻译：式I化合物对微量胺相关受体（TAAR）具有良好的亲和力，特别是TAAR1。这些化合物可用于治疗抑郁症，焦虑障碍，双相情感障碍，注意力缺陷多动障碍（ADHD），应激相关疾病，精神病性精神障碍如精神分裂症，神经系统疾病如帕金森病，神经退行性疾病如阿尔茨海默病，癫痫，偏头痛，高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病。

60. 发明授权

US08604061B2 2-aminooxazolines as TAAR1 ligands 有权
标题翻译： 2-氨基恶唑啉作为TAAR1配体
公开(公告)号：US08604061B2
公开(公告)日：2013-12-10
申请号：US13426736
申请日：2012-03-22
申请人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
发明人： Guido Galley , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
IPC分类号： A01N43/40 , A61K31/44 , C07D413/00
CPC分类号： C07D263/28 , C07D413/04 , C07D413/06 , C07D413/12 , C07F7/0812
摘要： The invention relates to compounds of formula I wherein X, Y, R1, R2, and n are as defined herein or to a pharmaceutically suitable acid addition salt thereof. The invention also relates to pharmaceutical compositions containing such compounds and methods for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases include depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
摘要翻译：本发明涉及其中X，Y，R 1，R 2和n如本文所定义或其药学上合适的酸加成盐的式I化合物。本发明还涉及含有这些化合物的药物组合物和用于治疗与微量胺相关受体的生物功能相关的疾病的方法，所述疾病包括抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍，应激相关疾病，精神病，精神分裂症，神经系统疾病，帕金森病，神经变性疾病，阿尔茨海默病，癫痫，偏头痛，药物滥用和代谢紊乱，进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温稳态，睡眠障碍和昼夜节律，以及心血管疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式