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51. 发明申请

WO2007091097A1 MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流体装置
公开(公告)号：WO2007091097A1
公开(公告)日：2007-08-16
申请号：PCT/GB2007/000484
申请日：2007-02-12
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BROWN, Andrew, Anthony , AZZARONI, Omar , HUCK, Wihelm
发明人： BROWN, Andrew, Anthony , AZZARONI, Omar , HUCK, Wihelm
IPC分类号： B01L3/00
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2300/0645 , B01L2300/0681 , B01L2300/0825 , B01L2300/165 , B01L2300/1822 , B01L2300/1827 , B01L2400/0406 , B01L2400/0677 , B01L2400/0688 , B01L2400/086 , F16K99/0001 , F16K99/0036 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T137/0318
摘要： A method of controlling the flow of an aqueous fluid in a microfluidic device, which makes use of a fluid gate comprising a UCST (upper critical solubility temperature) polymer and which allows fluid to flow by raising the temperature of the fluid gate above the USCT. Also provided is a device incorporating such a fluid gate and the use of such a device to detect an analyte in an aqueous fluid sample.
摘要翻译：一种控制微流体装置中的含水流体流动的方法，其利用包括UCST（上临界溶解度温度）聚合物的流体门，并且允许流体通过将流体门的温度升高到USCT上方而流动。还提供了包括这种流体门的装置以及使用这种装置来检测含水流体样品中的分析物。

52. 发明申请

WO2007077218A1 AN OPTICAL SYSTEM; AN OPTICAL CHIP FOR AN OPTICAL SYSTEM AND A METHOD OF USING AN OPTICAL CHIP FOR AN ANALYTICAL OPERATION 审中-公开
标题翻译：光学系统; 用于光学系统的光学芯片和使用光学芯片进行分析操作的方法
公开(公告)号：WO2007077218A1
公开(公告)日：2007-07-12
申请号：PCT/EP2007/000029
申请日：2007-01-03
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BOZHEVOLNYI, Sergey, I , SORENSEN, Mads, Hoy , THOMSEN, Peter, Theilade , HANSEN, Michael , LEOSSON, Kristjan , WILLIAMS, David, Edward
发明人： BOZHEVOLNYI, Sergey, I , SORENSEN, Mads, Hoy , THOMSEN, Peter, Theilade , HANSEN, Michael , LEOSSON, Kristjan , WILLIAMS, David, Edward
IPC分类号： G01N21/03 , G01N21/64
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/6428 , G01N21/648
摘要： The present invention provides an optical system for use in analytical operations. The system comprises an optical chip with a chamber for a sample with a lower refractive index than the material of at least a part of the optical chip defining a transparent window into the chamber. The system also comprises at least one lens, a light source and a detector. The light source is arranged to direct a light beam into the chip- sample interface to generate an evanescent field, and the detector is arranged to collect light (such as fluorescence or scattered light) from objects in the sample induced by the evanescent field via the lens, which is either incorporated into the optical chip or is placed between the optical chip and the detector to collect and direct light to the detector. Also provided are a method of using the optical system and an optical chip.
摘要翻译：本发明提供一种用于分析操作的光学系统。该系统包括光学芯片，该光学芯片具有用于样品的腔室，折射率低于光学芯片的至少一部分的材料，该材料限定了进入腔室的透明窗口。该系统还包括至少一个透镜，光源和检测器。光源被布置成将光束引导到芯片样本界面中以产生ev逝场，并且检测器被布置成从通过经由ev逝场的诱导的样品中的物体收集光（例如荧光或散射光）透镜，其被结合到光学芯片中或者被放置在光学芯片和检测器之间以收集并将光引导到检测器。还提供了使用光学系统和光学芯片的方法。

53. 发明申请

WO2007057704A1 TEST DEVICE 审中-公开
标题翻译：测试设备
公开(公告)号：WO2007057704A1
公开(公告)日：2007-05-24
申请号：PCT/GB2006/004336
申请日：2006-11-21
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , LONG, Nicholas , JOHNSON, Jon
发明人： LONG, Nicholas , JOHNSON, Jon
IPC分类号： G01N33/487 , C12Q1/00 , G01N27/327 , G01N27/30
CPC分类号： G01N33/574 , B01L3/502715 , B01L2200/027 , B01L2200/082 , B01L2300/043 , B01L2300/0825 , B01L2300/0864 , B01L2400/0406
摘要： A disposable test device consists of a first portion (2) having a fluid application port (5) to which a sample of fluid can be applied, and a handle portion (3) hingedly attached to the first portion (2) at a hinge portion (4) and which normally lies in the plane of the first portion. In use the device is held by the handle portion (3) and the first portion inserted into a measuring instrument. The handle is then deflected downwardly e.g. by the finger of a person to supply a drop of fluid to the port (5).
摘要翻译：一次性测试装置由具有流体施加口（5）的第一部分（2）组成，流体可以被施加到流体施加口（5），以及手柄部分（3），铰链部分（3）铰接地附接到第一部分（4），并且其通常位于第一部分的平面中。在使用中，装置由把手部分（3）和插入到测量仪器中的第一部分保持。然后将手柄向下偏转，例如通过人的手指向端口（5）供应一滴液体。

54. 发明申请

WO2006090144A1 FLUIDIC GATING DEVICE 审中-公开
标题翻译：流体感应装置
公开(公告)号：WO2006090144A1
公开(公告)日：2006-08-31
申请号：PCT/GB2006/000619
申请日：2006-02-22
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , PHELAN, Andrew, Peter , KHAN, Aman
发明人： PHELAN, Andrew, Peter , KHAN, Aman
IPC分类号： G01N33/50 , B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2400/0406 , B01L2400/0688 , F16K99/0021 , F16K99/003 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086
摘要： Disclosed is a fluidic gating device having a plurality of test flow paths, each with an end region, the device comprising: a fluid reservoir or sample application region provided upstream from at lease one indicator flow path, wherein the fluid reservoir or sample application region is separated from the indicator flow path/s by at least one obstacle to flow; and wherein the obstacle to flow is operably associated with the end region of a test capillary flow path, such that the presence of the test liquid at the end region of an associated test capillary flow path reduces or abolishes the obstacle to flow, thereby allowing a liquid to flow from the fluid reservoir or sample application region and along an indicator flow path.
摘要翻译：公开了一种流体门控装置，其具有多个测试流动路径，每个具有端部区域，该装置包括：设置在至少一个指示器流动路径上游的流体储存器或样品施加区域，其中流体储存器或样品施加区域是通过至少一个障碍物与指示器流动路径分离; 并且其中所述流动障碍可操作地与测试毛细管流动路径的端部区域相关联，使得在相关联的测试毛细管流动路径的端部区域处的测试液体的存在减少或消除所述障碍物流动，从而允许液体从流体储存器或样品施加区域以及沿着指示器流动路径流动。

55. 发明申请

WO2005071407A3 METHODS OF DIAGNOSING ACUTE CORONARY SYNDROME BY MEASURING UROTENSIN II 审中-公开
公开(公告)号：WO2005071407A3
公开(公告)日：2005-08-04
申请号：PCT/GB2005/000182
申请日：2005-01-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
摘要： The present invention provides a method for screening, diagnosis or prognosis of acute coronary syndrome (ACS) in a mammalian subject, for determining the stage or severity of ACS in a mammalian subject, for identifying a mammalian subject at risk of developing ACS, or for monitoring the effect of therapy administered to a mammalian subject having ACS. The method comprises measuring the level of Urotensin II (UTN) in a sample of bodily fluid from the mammalian subject. The invention also provides a kit, immunoassay or device for carrying out the method.

56. 发明申请

WO2005058500A1 SYSTEM 审中-公开
标题翻译：系统
公开(公告)号：WO2005058500A1
公开(公告)日：2005-06-30
申请号：PCT/GB2004/005334
申请日：2004-12-17
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BURNELL, Simon , MANNEH, Victor
发明人： BURNELL, Simon , MANNEH, Victor
IPC分类号： B01L3/00
CPC分类号： G01N1/34 , B01L3/502746 , B01L3/502753 , B01L2200/0647 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , B01L2400/0487 , B01L2400/086 , G01N2015/0073
摘要： A microfluidic separation system (1) for separating fluid sample medium from cells provided in a sample, for example, a sample of bodily fluid which is to be subjected to further analysis. The system may include a microfluidic structure (2) and a cell aggregation agent. The microfluidic structure may include one or more microfluidic channels (3, 4, 5) operable to separate aggregated cells from fluid sample medium by size exclusion.
摘要翻译：一种微流体分离系统（1），用于从样品中提供的细胞中分离流体样品介质，例如待进一步分析的体液样品。该系统可以包括微流体结构（2）和细胞聚集剂。微流体结构可以包括一个或多个微流体通道（3,4,5），其可操作以通过尺寸排除将聚集的细胞与流体样品介质分离。

57. 发明申请

WO2005043156A1 COAGULATION DETECTION 审中-公开
标题翻译：凝血检测
公开(公告)号：WO2005043156A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004462
申请日：2004-10-21
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DAVIES, Robert, John , HOWELL, Steven , WILLIAMS, David, Edward
发明人： DAVIES, Robert, John , HOWELL, Steven , WILLIAMS, David, Edward
IPC分类号： G01N33/49
CPC分类号： G01N33/4905
摘要： A coagulation detecting apparatus has a structure defining a container for a fluid, and containing particles for movement through the container under the influence of a magnetic field. A magnetic arrangement provides sequential magnetic fields to the container such as to cause the particles to move. A light source illuminates the container and a detector detects optical radiation of the light source after passing through the container, the detector being arranged for optically detecting at least one of presence of the particles at a predetermined location in the fluid and movement of the particles through a predetermined location in the fluid.
摘要翻译：凝固检测装置具有限定用于流体的容器的结构，并且在磁场的影响下容纳用于移动通过容器的颗粒。磁性装置向容器提供顺序的磁场，以使颗粒移动。光源照亮容器并且检测器检测到在通过容器之后光源的光辐射，检测器被布置用于光学检测在流体中的预定位置处的颗粒的存在和颗粒的运动中的至少一种流体中的预定位置。

58. 发明申请

WO2005003787A1 PARTICLE AGGLUTINATION DETECTION METHOD AND DEVICE 审中-公开
标题翻译：粒子分离检测方法和装置
公开(公告)号：WO2005003787A1
公开(公告)日：2005-01-13
申请号：PCT/IL2004/000618
申请日：2004-07-08
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , ROTT, Gennady , SAMUELS, Fred , FISH, Falk
发明人： ROTT, Gennady , SAMUELS, Fred , FISH, Falk
IPC分类号： G01N33/80
CPC分类号： G01N33/80
摘要： Abstract A method for the detection and/or visualization of particle agglutination, comprising: placing a volume of a suspension of the particles on a filter, the filter being constructed so as to permit passage of individual particles; placing a volume of a solution or suspension containing an agglutinating agent at the location of the particle suspension; optionally placing a wash solution at the location of the agglutinating agent; and observing the surface at the location for the presence of particles, such presence indicating that agglutination of the particles occurred. There is also provided a method for detection of agglutination reactions in general and hemagglutination reactions, such as used in blood grouping and cross-matching, in particular. The method is comprised of successive vertical additions of whole blood, blood grouping reagent and wash to a filter. In case of hemagglutination a colored, preferably red or reddish dot becomes visible after washing. A device and a kit based on the invention is also claimed and facilitates blood grouping and matching in non-laboratory environment without the need for laboratory instruments.
摘要翻译：摘要一种用于检测和/或可视化颗粒凝集的方法，包括：将一定体积的颗粒悬浮液放置在过滤器上，所述过滤器构造成允许单个颗粒通过; 将一定体积的含有凝集剂的溶液或悬浮液放置在颗粒悬浮液的位置; 任选地将洗涤溶液置于凝集剂的位置; 并且在该位置处观察颗粒存在的表面，这种存在表明颗粒发生凝集。还提供了一般检测凝集反应的方法，特别是用于血液分组和交叉匹配的血细胞凝集反应。该方法包括连续垂直添加全血，血液分组试剂和洗涤过滤器。在血细胞凝集的情况下，洗涤后可见有色的，优选的红色或微红色点。还要求一种基于本发明的装置和试剂盒，并且在非实验室环境中便于血液分组和匹配，而不需要实验室仪器。

59. 发明申请

WO2004046729A2 BODILY FLUID MARKERS OF TISSUE HYPOXIA 审中-公开
标题翻译：组织缺氧的体液标记物
公开(公告)号：WO2004046729A2
公开(公告)日：2004-06-03
申请号：PCT/GB2003/005113
申请日：2003-11-21
申请人： THE UNIVERSITY OF LEICESTER , INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
CPC分类号： G01N33/6893
摘要： The present invention provides a method and kit for screening, diagnosis or prognosis of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for determining the stage or severity of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for identifying a mammalian subject at risk of developing tissue hypoxia or a clinical syndrome indicative of tissue hypoxia, or for monitoring the effect of therapy administered to a mammalian subject having tissue hypoxia or a clinical syndrome indicative of tissue hypoxia. The level of oxygen regulated protein (ORP150) or a fragment thereof in a sample of bodily fluid from said mammalian subject is measured to provide information as regards the tissue hypoxia or clinical syndrome indicative of tissue hypoxia.
摘要翻译：本发明提供了用于筛选，诊断或预后哺乳动物受试者的组织缺氧或指示组织缺氧的临床综合征的方法和试剂盒，用于确定组织缺氧或者组织缺氧的阶段或严重程度指示哺乳动物受试者中组织缺氧的临床综合征，用于鉴定处于发展中组织缺氧或指示组织缺氧的临床综合征的风险中的哺乳动物受试者，或用于监测施用于具有组织缺氧或临床的哺乳动物受试者的疗法的效果综合征指示组织缺氧。测量来自所述哺乳动物受试者的体液样品中氧调节蛋白（ORP150）或其片段的水平以提供关于组织缺氧或指示组织缺氧的临床综合征的信息。

60. 发明申请

WO2004008140A3 PLASMA UROTENSIN IN HUMAN HEART FAILURE 审中-公开
公开(公告)号：WO2004008140A3
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003011
申请日：2003-07-11
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
摘要： The present invention provides a method for the diagnosis of heart failure in a mammalian subject. The level of urotensin in a sample of bodily fluid from the subject is measured and compared to reference levels typically found in the said bodily fluid of a subject which are indicative of the absence of heart failure. An elevated level of urotensin is indicative of heart failure.

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