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51. 发明授权

EP1897578B1 SHUT-OFF VALVE FOR THE INTERRUPTION TECHNIQUE USED IN THE ANALYSIS OF RESPIRATORY MECHANICS 有权
标题翻译： VALVE插队技术在呼吸力学的分析
公开(公告)号：EP1897578B1
公开(公告)日：2012-03-14
申请号：EP05750159.5
申请日：2005-05-16
申请人： Instituto de Salud Carlos III , Fundacion Para la Investigacion Biomedica Del Hospital Universitario la Paz
发明人： DE LA OLIVA SENOVILLA, Pedro
IPC分类号： A61M16/20
CPC分类号： A61M16/20 , A61M16/0006 , A61M16/202 , A61M16/207 , A61M16/209
摘要： The invention relates to a shut-off valve for the interruption technique used in the analysis of respiratory mechanics. More specifically, the invention relates to a cylindrical valve body (1) comprising two chambers, namely a high-pressure chamber (3) and a low-pressure chamber (4) which are separated by a partition (2) that is traversed by a shaft (7), the two ends of which are topped with pistons (5 and 6) which move inside the respective chambers (3 and 4). According to the invention, upon receiving gas at a suitable pressure, the piston (5) in the high-pressure chamber (3) moves such as to pull the other piston (6) against a spring (8), thereby pulling the piston (6) which is disposed between the inlet (10) for the gas from the respirator and the gas outlet (11) to the patient, so as to provide a very short closure time as well as a hermetic closure during the interruption. The passage of air from the high-pressure source to the high-pressure chamber (3) is controlled by a servo-assisted solenoid valve which is in turn controlled by a computer or an autonomous electronic device.

52. 发明公开

EP2267162A1 Primers, probes and kits for the detection of bacterial species belonging to the genus rickettsia 失效
标题翻译：引物，Sonden und Zusammensetzungen zur Detektion von Bakterien der Gattung立克次体
公开(公告)号：EP2267162A1
公开(公告)日：2010-12-29
申请号：EP10173990.2
申请日：2006-06-15
申请人： Instituto de Salud Carlos III
发明人： Anda Fernandez, Pedro , Escudero Nieto, Raquel , Jado Garcia, Isabel , Rodriguez Moreno, Isabel , Jimenez Alonso, María Isabel
IPC分类号： C12Q1/68 , C07H21/04 , G01N33/569
CPC分类号： G01N33/56911 , C12Q1/689 , C12Q2600/16
摘要： The present invention refers to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions, in particular the 23S-5S ribosomal spacer region, required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to the genera Rickettsia based on Multiple PCR analysis by RLB (Reverse Line Blotting), in addition to providing a kit to carry out said analysis.
摘要翻译：本发明涉及基于DNA分析的不同细菌种类的检测和鉴定，所有这些细菌都引起人畜共患病。更具体地，本发明提供了引物，探针，基因和基因区域，特别是23S-5S核糖体间隔区，其是基于多重PCR分析方法同时检测属于立克次体属的细菌和细菌群体的方法所需的通过RLB（反向线印刷），除了提供用于进行所述分析的试剂盒。

53. 发明公开

EP2175038A1 Probes and methods for the simultaneous detection and identification of multiple viruses that cause respiratory infections in humans 审中-公开
标题翻译：探针及同时检测和数，呼吸道感染的人类同时识别造成病毒的方法，
公开(公告)号：EP2175038A1
公开(公告)日：2010-04-14
申请号：EP09008066.4
申请日：2005-12-23
申请人： Instituto de Salud Carlos III
发明人： Perez Brena, Pilar , Coiras Lopez, Maria Teresa , Casas Flecha, Inmaculada
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q1/6837 , Y02A50/451
摘要： The invention relates to probes and assays which are used for the simultaneous detection, in a single assay sample, of a plurality of nucleic acid sequences of viruses that cause respiratory infections in humans, selected from among influenza virus type A, influenza virus type B, influenza virus type C, human respiratory syncytial virus type A, human respiratory syncytial virus type B, human adenovirus, human parainfluenza virus type 1, human parainfluenza virus type 2, human parainfluenza virus type 3, human parainfluenza virus types 4A and 4B, enterovirus, rhinovirus, human coronavirus type 229E, human coronavirus type OC43, coronavirus that causes severe acute respiratory syndrome (SARS), human metapneumovirus and combinations thereof.
摘要翻译：本发明涉及一种用于同时检测探针和测定法，单个测定样品中的病毒核酸序列的多个没有引起人类呼吸道感染，从A型流感病毒中选择，B型流感病毒，流感病毒C型，人类呼吸道合胞病毒A型，人呼吸道合胞病毒B型，人腺病毒，人副流感病毒1型，人副流感病毒2型，人副流感病毒3型，人副流感病毒类型4A和4B，肠道病毒，鼻病毒，人类冠状病毒229E型，人类冠状病毒OC43型，冠状做的原因严重急性呼吸综合征（SARS），人偏肺病毒和它们的组合。

54. 发明公开

EP2014775A2 Method for the detection of bacterial species of the genera Anaplasma/Ehrlichia and Bartonella 失效
标题翻译：维拉法尼亚·纳赫维斯·冯·巴特里安娜·德·加登恩·阿纳普拉斯玛/埃里希·巴尔多内拉
公开(公告)号：EP2014775A2
公开(公告)日：2009-01-14
申请号：EP07119610.9
申请日：2007-10-30
申请人： Instituto de Salud Carlos III
发明人： Anda Fernández, Pedro , Gil Gil, Horacio , Escudero Nieto, Raquel , Jado García, Isabel , Rodríguez Moreno, Isabel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： The present invention, relating to a method for the detection and identification of bacterial species belonging to the genera Anaplasma/Ehrlichia and Bartonella, is a patent of addition to the Spanish patent application with publication number 2.264.642. In addition to this method, the invention also provides the primers and probes required for its application.
摘要翻译：本发明涉及用于检测和鉴定属于Anaplasma / Ehrlichia和Bartonella属的细菌物种的方法，该专利是西班牙专利申请的专利，其出版号为2.264.642。除了该方法之外，本发明还提供其应用所需的引物和探针。

55. 发明公开

EP1897578A1 SHUT-OFF VALVE FOR THE INTERRUPTION TECHNIQUE USED IN THE ANALYSIS OF RESPIRATORY MECHANICS 有权
标题翻译： ABSPERRVENTILFÜRDIE UNTERBRECHUNGSTECHNIK BEI DER ANALYZE DER ATEMMECHANIK
公开(公告)号：EP1897578A1
公开(公告)日：2008-03-12
申请号：EP05750159.5
申请日：2005-05-16
申请人： Instituto de Salud Carlos III , Fundacion Para la Investigacion Biomedica Del Hospital Universitario la Paz
发明人： DE LA OLIVA SENOVILLA, Pedro
IPC分类号： A61M16/20
CPC分类号： A61M16/20 , A61M16/0006 , A61M16/202 , A61M16/207 , A61M16/209
摘要： It is based on a cylindrical valve body (1) comprising two chambers, namely a high-pressure chamber (3) and a low-pressure chamber (4) which are separated by a partition (2) that is traversed by a shaft (7), the two ends of which are topped with pistons (5 and 6) which move inside the respective chambers (3) and (4), such that upon receiving gas at a suitable pressure, the piston (5) in the high-pressure chamber (3) moves such as to pull the other piston (6) against a spring (8), thereby pulling the piston (6) which is disposed between the inlet (10) for the gas from the respirator and the gas outlet (11) to the patient, so as to provide a very short closure time as well as a hermetic closure during the interruption. The passage of air from the high-pressure source to the high-pressure chamber (3) is controlled by a servo-assisted solenoid valve which is in turn controlled by a computer or an autonomous electronic device.
摘要翻译：它是基于一个圆柱形阀体（1），它包括两个腔室，即高压腔室（3）和低压腔室（4），它们由一个由轴（7）穿过的隔板（2）分开，），其两端顶上在相应的腔室（3）和（4）内移动的活塞（5和6），使得在适当的压力下接收气体时，活塞（5）处于高压室（3）移动以将另一活塞（6）拉靠在弹簧（8）上，从而拉动设置在来自呼吸器的气体的入口（10）和气体出口（11）之间的活塞（6）），以便在中断期间提供非常短的闭合时间以及气密闭合。空气从高压源向高压室（3）的通过由伺服辅助电磁阀控制，伺服辅助电磁阀又由计算机或自主电子设备控制。

56. 发明公开

EP1837403A2 PROBES AND METHODS FOR THE SIMULTANEOUS DETECTION AND IDENTIFICATION OF MULTIPLE VIRUSES THAT CAUSE RESPIRATORY INFECTIONS IN HUMANS 审中-公开
标题翻译：用于同时检测及多的同时识别探针和方法，在人类呼吸道感染引起的病毒，
公开(公告)号：EP1837403A2
公开(公告)日：2007-09-26
申请号：EP05850035.6
申请日：2005-12-23
申请人： Instituto de salud carlos III
发明人： PEREZ BREÑA, Pilar , COIRAS LOPEZ, Maria Teresa , CASAS FLECHA, Inmaculada
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q1/6837 , Y02A50/451
摘要： The invention relates to probes and assays which are used for the simultaneous detection, in a single assay sample, of a plurality of nucleic acid sequences of viruses that cause respiratory infections in humans, selected from among influenza virus type A, influenza virus type B, influenza virus type C, human respiratory syncytial virus type A, human respiratory syncytial virus type B, human adenovirus, human parainfluenza virus type 1, human parainfluenza virus type 2, human parainfluenza virus type 3, human parainfluenza virus types 4A and 4B, enterovirus, rhinovirus, human coronavirus type 229E, human coronavirus type OC43, coronavirus that causes severe acute respiratory syndrome (SARS), human metapneumovirus and combinations thereof.
摘要翻译：本发明涉及一种用于同时检测探针和测定法，单个测定样品中的病毒核酸序列的多个没有引起人类呼吸道感染，从A型流感病毒中选择，B型流感病毒，流感病毒C型，人类呼吸道合胞病毒A型，人呼吸道合胞病毒B型，人腺病毒，人副流感病毒1型，人副流感病毒2型，人副流感病毒3型，人副流感病毒类型4A和4B，肠道病毒，鼻病毒，人类冠状病毒229E型，人类冠状病毒OC43型，冠状做的原因严重急性呼吸综合征（SARS），人偏肺病毒和它们的组合。

57. 发明申请

WO2015181253A1 NEURAL PROGENITOR CELL POPULATION 审中-公开
标题翻译：神经原细胞群体
公开(公告)号：WO2015181253A1
公开(公告)日：2015-12-03
申请号：PCT/EP2015/061750
申请日：2015-05-27
申请人： FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD , UNIVERSIDAD DE KRAGUJEVAC , INSTITUTO DE SALUD CARLOS III
发明人： STOJKOVIC, Miodrag , LUKOVIC, Dunja , BHATTACHARYA, Shomi S. , ERCEG VUKICEVIC, Slaven
IPC分类号： C12N5/0797 , C12N5/0793 , C12N5/079
CPC分类号： C12N5/0623 , C12N5/0619 , C12N5/0622 , C12N2500/25 , C12N2500/33 , C12N2500/34 , C12N2500/38 , C12N2500/46 , C12N2500/98 , C12N2501/11 , C12N2501/115 , C12N2501/33 , C12N2501/392 , C12N2501/90 , C12N2506/02 , C12N2506/45
摘要： The present invention relates to a new method which includes the use of xeno-free differentiation medium and human extracellular matrix to successfully convert hESCs (human embryonic stem cells) and Adult hi PSC cells (human induced adult pluripotent stem cells) to regional specific and transplantable neural progenitors. These neural progenitor cells are not exclusively characterised by said new method of preparation but also by the fact that they naturally express a specific pattern of markers which can be used to assist with their isolation and expansion. The cells of the invention display an unprecedented capacity for providing, activating and/or inducing repair of damaged neural tissue. These neural progenitor cells may thus be used as therapeutic agents including, without limitation, for the regeneration of tissue, particularly for regeneration of damaged neural tissue.
摘要翻译：本发明涉及一种新的方法，其包括使用不含异种的分化培养基和人细胞外基质成功地将hESC（人类胚胎干细胞）和成人hi PSC细胞（人诱导的成体多能干细胞）转化为区域特异性和可移植的神经祖细胞。这些神经祖细胞并不仅仅是通过所述新的制备方法来表征，而且还通过它们自然地表达可用于辅助其分离和扩增的特异性标记图案。本发明的细胞显示出前所未有的用于提供，激活和/或诱导损伤的神经组织修复的能力。因此，这些神经祖细胞可以用作治疗剂，包括但不限于组织的再生，特别是用于再生损伤的神经组织。

58. 发明申请

WO2014154930A1 ANTICUERPO ANTI-FACTOR B, COMPOSICIÓN FARMACÉUTICA ÚTIL PARA EL TRATAMIENTO DE ENFERMEDADES DEL COMPLEMENTO Y SUS APLICACIONES 审中-公开
标题翻译：抗体B抗体，可用于治疗补体系统疾病的药物组合物及其用途
公开(公告)号：WO2014154930A1
公开(公告)日：2014-10-02
申请号：PCT/ES2014/070236
申请日：2014-03-27
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , INSTITUTO DE SALUD CARLOS III
发明人： RODRÍGUEZ DE CÓRDOBA, Santiago , DOMÍNGUEZ RODRÍGUEZ, Mercedes
IPC分类号： C07K16/42 , A61K39/395 , C12P21/08 , A61P37/00
CPC分类号： C07K16/18
摘要： La presente invención describe un anticuerpo anti-factor B que bloquea la generación de la convertasa del C3 de la vía alternativa útil para prevenir o modular la activación o amplificación de la activación del complemento. Una forma concreta de este anticuerpo es el anticuerpo monoclonal anti-factor B producido por el hibridoma FB-28.4.2 depositado en ACECC el 13 de noviembre de 2012 con la referencia 12111301. Además, proporciona una composición farmacéutica útil para el tratamiento de enfermedades asociadas del complemento como por ejemplo, el síndrome hemolítico urémico atípico (aHUS) o la hemoglobinuria paroxística nocturna (HPN). Igualmente, se proporciona un complejo biotecnológico útil para la realización de ensayos para la identificación y diseño de medicamentos o composiciones farmacéuticas inhibidoras del complemento.
摘要翻译：本发明涉及阻止可用于预防或调节补体系统活化的活化或扩增的替代补体途径C3转化酶的抗因子B抗体。该抗体的特定形式是由2012年11月13日在ECACC保藏的杂交瘤FB-28.4.2产生的单克隆抗体抗因子B，参考号为12111301.此外，本发明涉及可以使用的药物组合物用于治疗与补体系统相关的疾病，例如非典型溶血性尿毒综合征（aHUS）或阵发性夜间血红蛋白尿（PNH）。本发明还涉及可用于进行测试以便鉴定和设计抑制补体系统的药物或药物组合物的生物技术复合物。

59. 发明申请

WO2013021087A1 ANALISIS INFRARROJO DE FRACCIONES DE SANGRE PERIFERICA OBTENIDA PARA INDICAR DESARROLLO COGNITIVO ASOCIADO A LA ENFERMEDAD DE ALZHEIMER 审中-公开
标题翻译：获得与阿尔茨海默病相关的认知发展的外周血液红细胞分析
公开(公告)号：WO2013021087A1
公开(公告)日：2013-02-14
申请号：PCT/ES2012/070613
申请日：2012-08-07
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , INSTITUTO DE SALUD CARLOS III , FUNDACIÓN CIEN , FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO 12 DE OCTUBRE , CARMONA HERNÁNDEZ, Pedro , TOLEDANO GASCA, Adolfo , CALERO LARA, Miguel , MARTÍNEZ MARTÍN, Pablo , BERMEJO PAREJA, Félix
发明人： CARMONA HERNÁNDEZ, Pedro , TOLEDANO GASCA, Adolfo , CALERO LARA, Miguel , MARTÍNEZ MARTÍN, Pablo , BERMEJO PAREJA, Félix
IPC分类号： G01N21/35
CPC分类号： G01N33/49 , G01N21/3577 , G01N2800/2821
摘要： La presente invención se refiere a un método de análisis espectroscópico infrarrojo de transmisión para determinar el grado de deterioro global cognitivo asociado a la enfermedad de Alzheimer basado en analizar la región 3100-1300 cm -1 del espectro de infrarrojo de una muestra de sangre previamente obtenida y fraccionada. Preferentemente, la muestra de sangre fraccionada a analizar es una fracción de leucocitos. Asimismo, es también objeto de la presente invención el empleo de dicho método para obtener una indicación de una condición de enfermedad de Alzheimer y/o una indicación del grado de deterioro cognitivo asociado a dicha enfermedad.
摘要翻译：本发明涉及一种用于确定与阿尔茨海默氏病有关的全球认知衰退程度的透射红外光谱的方法，该方法是基于先前获得的和分级的血液样品的红外光谱的3100-1300cm -1区域的分析。待分析的分级血液样品优选为白细胞级分。同样，本发明涉及所述方法用于获得阿尔茨海默病状态的指示和/或与所述疾病相关的认知恶化程度的指示。

60. 发明申请

WO2012136831A1 NON-REPLICATIVE VIRIONS OF HUMAN IMMUNODEFICIENCY VIRUS AND THERAPEUTIC APPLICATIONS THEREOF 审中-公开
标题翻译：人类免疫缺陷病毒的非替代性病毒及其治疗应用
公开(公告)号：WO2012136831A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056385
申请日：2012-04-09
申请人： FUNDACIÓ CLINIC PER A LA RECERCA BIOMÈDICA , INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER , INSTITUTO DE SALUD CARLOS III , SÁNCHEZ-PALOMINO, Sonsoles , PLANA PRADES, Monserrat , ALCAMI PERTEJO, José
发明人： SÁNCHEZ-PALOMINO, Sonsoles , PLANA PRADES, Monserrat , ALCAMI PERTEJO, José
IPC分类号： A61K39/21 , C07K14/16 , C12N7/04 , C12N15/867 , A61K39/12 , C12N7/00 , C12N15/86
CPC分类号： A61K39/12 , A61K39/21 , A61K2039/5252 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16043 , C12N2740/16062 , C12N2740/16222
摘要： The present invention relates to the development of viral vectors comprising a human immunodeficiency virus (HIV) genome and non-replicative virions comprising said viral vectors. Said viral vectors and non-replicative virions are useful for use in medicine, specifically for use in generating vaccines and more specifically for treating AIDS. The present invention further relates to a method for obtaining a customized vaccine.
摘要翻译：本发明涉及包含人免疫缺陷病毒（HIV）基因组和包含所述病毒载体的非复制病毒粒子的病毒载体的开发。所述病毒载体和非复制病毒粒子可用于医药，特别用于产生疫苗，更具体地用于治疗AIDS。本发明还涉及获得定制疫苗的方法。

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