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51. 发明公开

US20230384625A1 Creation of Single Photons 审中-公开
公开(公告)号：US20230384625A1
公开(公告)日：2023-11-30
申请号：US18032013
申请日：2021-10-14
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Falk Eilenberger , Tobias Vogl
IPC分类号： G02F1/015 , H01S5/14 , H01S5/04
CPC分类号： G02F1/0154 , H01S5/141 , H01S5/041 , G02F2203/15
摘要： A method is proposed for generating single photons with a predetermined wavelength fV, with the following steps:

i) generating a single photon, preferably in a source and a resonator, wherein the single photon has a resonator wavelength fR and a resonator bandwidth fBR,
ii) measuring the resonator wavelength fR, preferably in a wavelength standard, wherein the single photon is guided from the resonator to the wavelength standard via a beam guide,
iii) comparing the resonator wavelength fR with the predetermined wavelength fV and generating a control signal on the basis of the comparison, preferably in a controller,
iv) adjusting the resonator using the control signal in order to change the resonator wavelength fR toward or to the predetermined wavelength fV,
v) repeating steps i to iv) until the resonator wavelength fR corresponds to the predetermined wavelength fV and then coupling out.

52. 发明公开

US20230218536A1 NANOPARTICLES CONTAINING COMPLEXES OF NUCLEIC ACIDS AND CATIONIC COPOLYMERS, PROCESS FOR PREPARING THEM AND THEIR USE FOR GENE TRANSFER IN CELLS 审中-公开
公开(公告)号：US20230218536A1
公开(公告)日：2023-07-13
申请号：US17996435
申请日：2021-04-14
申请人： FRIEDRICH-SCHILLER-UNIVERSITÄT JENA (FSU)
发明人： Jana Ines SOLOMUN , Anja TRÄGER
IPC分类号： A61K9/51
CPC分类号： A61K9/5146 , A61K9/5192
摘要： The invention relates to nanoparticles containing complexes constituted by nucleic acids and cationic copolymers containing the recurring structural units of formulae (Ia) and (Ib) wherein R1 and R6 independently represent hydrogen, alkyl or —COOR9, R2 and R7 independently represent hydrogen or alkyl, R3 is selected from the group consisting of —O—R10—, —COO—R10, —CONH—R10- or —R10—, R4 represents hydrogen, alkyl, cycloalkyl, aryl, aralkyl or alkylaryl, R5 represents hydrogen, alkyl, cycloalkyl, aryl, aralkyl, alkylaryl or —(alkylene-NH—)malkyl, or R4 and R5 together with the nitrogen atom they have in common form a heterocyclic ring, R8 is selected from the group consisting of —O—R11, —COO—R11, —CONH—R11 or —R11, R9 and R11 independently represent hydrogen or a monovalent organic residue, R10 represents a bivalent organic residue, and m is an integer from 1 to 5, with the proviso that the nanoparticles have a diameter (z-average) of less than or equal to 900 nm as determined by dynamic light scattering and that the molar ratio of nitrogen atoms in the copolymer to the phosphate groups in the nucleic acid ranges between 1 and 200. The nanoparticles according to the invention allow the transfer of nucleic acids into cells with great efficiency.

53. 发明申请

US20230129245A1 METHOD AND SYSTEM FOR LASER WELDING OF A SEMICONDUCTOR MATERIAL 有权
公开(公告)号：US20230129245A1
公开(公告)日：2023-04-27
申请号：US18010550
申请日：2021-06-15
申请人： Friedrich-Schiller-Universität Jena , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Maxime CHAMBONNEAU , Stefan NOLTE , Qingfeng LI
IPC分类号： B23K26/21 , B23K26/046
摘要： The invention relates to a method for welding a first workpiece (11) to a second workpiece (12) by means of a laser. It is an object of the invention to provide a reliable, repeatable and reproducible approach for laser welding of two workpieces one of which consists of a semiconductor material. The method proposed by the invention comprises the following steps: Irradiating the first workpiece (11) with a beam of pulsed laser radiation, wherein the first workpiece (11) consists of a semiconductor material which is transparent at the wavelength of the laser radiation, so that the beam enters the first workpiece (11) through an entrance surface and leaves it through an exit surface, the geometric focus of the beam being positioned in the plane of the exit surface; determining a delocalization of the focus caused by nonlinear interaction of the laser radiation with the semiconductor material; placing the second workpiece (12) against the first workpiece (11); and, again, irradiating the first workpiece (11) with the laser beam of pulsed laser radiation, the focus of the laser radiation being positioned along the beam direction taking into account the determined delocalization so that the intensity maximum is located in the plane of the exit surface forming the interface of the two workpieces (11, 12), whereby the first workpiece (11) is welded to the second workpiece (12). Moreover, the invention relates to a system for welding a first workpiece (11) to a second workpiece (12).

54. 发明申请

US20230071288A1 METHOD AND APPARATUS FOR CONTACTLESS MEASURING OF AN OBJECT SURFACE 有权
公开(公告)号：US20230071288A1
公开(公告)日：2023-03-09
申请号：US17759902
申请日：2021-02-05
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
发明人： Martin Landmann , Patrick Dietrich , Stefan Heist , Peter KÜHMSTEDT , Gunther Notni
IPC分类号： G01B11/25
摘要： The invention relates to an apparatus (1) and a method for contactless measuring of an object surface (2). In the proposed method, a temporally variable temperature distribution on the object surface (2) is generated by serially imprinting a plurality of thermal patterns (9) on the object surface (2). Subsequently, a thermal image of the object surface (2) is recorded by at least one thermal imaging camera (16, 17) at each of a plurality of successive recording instants, so that a respective sequence of thermal image values is acquired for points in an image plane (18, 19) of the thermal imaging camera or each of the thermal imaging cameras (16, 17). Corresponding points (20, 21) are then identified in the image planes (18, 19) of the thermal imaging cameras (16, 17) or in the image plane of the thermal imaging camera and in an image plane associated with the radiation source (6) by maximizing a similarity between the sequences of thermal image values detected or simulated for potentially corresponding points. Then spatial coordinates of the object surface (2) are determined by triangulation based on the points (20, 21) identified as being corresponding. When imprinting the patterns (9), surface elements are spatially limited such that an image of each area irradiated by a single one of the irradiation pulses in the image plane (18, 19) of the thermal imaging camera or each of the thermal imaging cameras (16, 17) is smaller than 5% of a total area of said image plane (18, 19).

55. 发明申请

US20220397707A1 Method for Producing a Diffractive Optical Element and Diffractive Optical Element 有权
$Method for Producing a Diffractive Optical Element and Diffractive Optical Element$
公开(公告)号：US20220397707A1
公开(公告)日：2022-12-15
申请号：US17773669
申请日：2020-12-07
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. , Friedrich-Schiller-Universität Jena
发明人： Ernst-Bernhard Kley , Frank Schrempel , Uwe Detlef Zeitner
IPC分类号： G02B5/18 , G02B1/12
摘要： A method for producing a diffractive optical element and a diffractive optical element are disclosed. In an embodiment a method for producing a diffractive optical element includes generating a surface structure by implanting ions into a material of a substrate, a layer or a layer system, wherein the surface structure includes a structure height of less than 10 nm.

56. 发明申请

US20180365831A1 METHOD, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR PROVIDING PROPERTY MEASUREMENT ON A BIOLOGICAL TISSUE SAMPLE 审中-公开
公开(公告)号：US20180365831A1
公开(公告)日：2018-12-20
申请号：US16062340
申请日：2016-12-13
申请人： Leibniz-Institut für Photonische Technologien e.V. , Friedrich-Schiller-Universität Jena
发明人： JÜRGEN POPP , THOMAS BOCKLITZ , OLGA CHERNAVSKAIA , TOBIAS MEYER
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/10056 , G06T2207/30024 , G06T2207/30028
摘要： Exemplary method, computer-accessible medium and system can be provided for determining the presence or absence of a local and/or global property of a biological tissue sample. Thus, it is possible to obtain at least one image of the sample, search the image(s) for a presence of at least one particular feature that is contained in a pre-defined set of features, and assign, to the particular feature(s). It is possible to compute, with a computer processor, at least one discriminant value that is a function of the pronunciation index that is weighted with a particular weight. The weight of each pronunciation index is a measure for a relevance of the corresponding feature with respect to the property. It is possible to determine whether the property is present in at least one part of the biological tissue sample depending on whether the discriminant value exceeds a pre-defined threshold and/or and optimized threshold.

57. 发明授权

US10106540B2 HDAC6 inhibitors and their uses 有权
公开(公告)号：US10106540B2
公开(公告)日：2018-10-23
申请号：US15329175
申请日：2015-08-04
申请人： Universität Regensburg , Friedrich-Schiller-Universität Jena , Universitätsklinikum Jena
发明人： Siavosh Mahboobi , Andreas Sellmer , Herwig Pongratz , Michel Leonhardt , Oliver Krämer , Frank-Dietmar Böhmer , Gerhard Kelter
IPC分类号： C07D471/18 , A61K31/529 , C07D471/22 , C07D455/03 , C07C259/10 , C07C259/06 , C07D471/14
摘要： The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

58. 发明申请

US20180241065A1 Redox Flow Cell for Storing Electrical Energy and Use Thereof 审中-公开
公开(公告)号：US20180241065A1
公开(公告)日：2018-08-23
申请号：US15750766
申请日：2016-08-03
申请人： JenaBatteries GmbH , Friedrich-Schiller-Universität Jena
发明人： Ulrich Sigmar SCHUBERT , Tobias JANOSCHKA , Norbert MARTIN
IPC分类号： H01M8/18
摘要： The redox flow cell comprises a reaction cell having two electrode chambers for catholyte and anolyte, which are each connected to at least one store for liquid and are separated by an ion-conducting membrane, and which are equipped with electrodes, wherein the electrode chambers are each filled with electrolyte solutions comprising redox-active components dissolved or dispersed in an electrolyte solvent, as well as optionally conducting salts dissolved therein and optionally further additives. The redox flow cell is characterized by the anolyte comprising a redox-active component having one to six residues of formula I in the molecule or having one to six residues of formula II in the molecule and by the catholyte comprising a redox-active component having one to six residues of formula III in the molecule or having iron salts or by the anolyte and the catholyte having a redox-active component comprising one to six residues of formula I or of formula II in combination with one to six residues of formula III in the molecule wherein R1 is a covalent C—C-bond or a divalent bridge group, R2 and R3 independently of one another represent alkyl, alkoxy, haloalkyl, cycloalkyl, aryl, aralkyl, heterocyclyl, halogen, hydroxy, amino, nitro or cyano, X is a q-valent inorganic or organic anion, b and c independently of one another are integers from 0 to 4, q is an integer from 1 to 3, a is a number of value 2/q, and R4, R5, R6 and R7 independently of one another represent alkyl, cycloalkyl, aryl or aralkyl.

59. 发明申请

US20180149472A1 DEVICE AND METHOD FOR SPATIALLY MEASURING SURFACES 审中-公开
公开(公告)号：US20180149472A1
公开(公告)日：2018-05-31
申请号：US15571803
申请日：2016-05-04
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Stefan Heist , Gunther Notni , Kevin Srokos , Peter Lutzke , Ingo Schmidt , Peter Kühmstedt
IPC分类号： G01B11/25
CPC分类号： G01B11/2545 , G01B11/2518 , G01B11/254
摘要： A device, for spatially measuring surfaces, includes a projector for projecting patterns into an object space, two cameras for recording pictures of a surface in the object space, and a control and evaluation unit for activating the cameras and evaluating the pictures. The projector includes a light source, a projection lens, at least one rotatably arranged pattern structure, and a drive for rotating the at least one pattern structure. The control and evaluation unit to: activate the cameras for simultaneously recording a picture at each of a plurality of successive points in time; identify corresponding points in the picture planes of the cameras, by way of evaluating a correlation function between the sequences of brightness values acquired for potentially corresponding points and maximizing a value of the correlation; and determine spatial coordinates of surface points by way of triangulation on the basis of the identified corresponding points.

60. 发明申请

US20170068168A1 Illumination Unit and Device for Lithographic Exposure 审中-公开
标题翻译：照明单元和光刻曝光装置
公开(公告)号：US20170068168A1
公开(公告)日：2017-03-09
申请号：US15258734
申请日：2016-09-07
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Uwe Detlef Zeitner , Tina Weichelt , Yannick Bourgin
IPC分类号： G03F7/20 , G02B26/08 , G02B27/09 , G02B26/10
CPC分类号： G03F7/70075 , G02B26/0833 , G02B26/10 , G02B26/101 , G02B26/105 , G02B27/0944 , G02B27/0955 , G03F7/70158 , G03F7/70583
摘要： An illumination unit for lithographic exposure and a device for lithographic exposure are disclosed. In an embodiment the illumination unit includes a beam source, an electronically drivable beam deflection element for generating a temporally varying two-dimensional beam deflection, a collimation lens, a beam homogenizing element, a Fourier lens and a field lens.
摘要翻译：公开了一种用于光刻曝光的照明单元和用于光刻曝光的装置。在一个实施例中，照明单元包括光束源，用于产生时变二维光束偏转的电子可驱动光束偏转元件，准直透镜，光束均匀化元件，傅里叶透镜和场透镜。

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