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    • 52. 发明授权
    • Screening procedure for neuroactive agents
    • 神经活性剂的筛选程序
    • US5711932A
    • 1998-01-27
    • US718281
    • 1996-09-20
    • Jay HirshChris Martin Yellman
    • Jay HirshChris Martin Yellman
    • A61K49/00G01N31/00
    • A61K49/0004
    • The method of testing the affect of neuroactive agents on cellular receptors is disclosed. The procedures comprise decapitating an invertebrate, in the disclosed tests a Drosophila melanogaster is used. A selected neuroactive agent is applied directly to the severed nerve cord of the invertebrate. The reaction of the invertebrate is observed in response to the application of the agent. The reaction of the invertebrate is an indication of the activities of the cellular receptors which react to the specific agents. The tested agents include dopamine, serotonin and octopamine and vertebrate drugs that act as D1-like receptor agonists, D1-like receptor antagonists, D2-like receptor agonists and D2-like receptor antagonist, and a vertebrate monoamine oxidase inhibitor. Other types of neuroactive agents are also used.
    • 公开了测试神经活性剂对细胞受体的影响的方法。 该方法包括斩首无脊椎动物,在所公开的测试中,使用果蝇。 选择的神经活性剂直接施用于无脊椎动物的切断神经线。 响应于试剂的应用观察无脊椎动物的反应。 无脊椎动物的反应是对具体药物反应的细胞受体的活性的指示。 所测试的试剂包括多巴胺,5-羟色胺和章鱼胺和作为D1样受体激动剂,D1样受体拮抗剂,D2样受体激动剂和D2样受体拮抗剂的脊椎动物药物和脊椎动物单胺氧化酶抑制剂。 也使用其他类型的神经活性剂。