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51. 发明申请

WO1998016547A1 SELECTIVE FACTOR Xa INHIBITORS 审中-公开
标题翻译：选择性因子Xa抑制剂
公开(公告)号：WO1998016547A1
公开(公告)日：1998-04-23
申请号：PCT/US1997018312
申请日：1997-10-10
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , ZHU, Bing-Yan , SCARBOROUGH, Robert, M.
IPC分类号： C07K05/06
CPC分类号： C07K5/06191 , A61K38/00
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：本发明涉及显示抗哺乳动物因子Xa活性的新化合物，其盐及其组合物。这些化合物在体外或体内用于凝血障碍的预防性或治疗性治疗。

52. 发明申请

WO1998016525A1 SELECTIVE FACTOR Xa INHIBITORS 审中-公开
标题翻译：选择性因子Xa抑制剂
公开(公告)号：WO1998016525A1
公开(公告)日：1998-04-23
申请号：PCT/US1997018647
申请日：1997-10-10
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , ZHU, Bing-Yan , SCARBOROUGH, Robert, M.
IPC分类号： C07D417/14
CPC分类号： C07D417/12 , C07F5/025
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：本发明涉及具有抗哺乳动物因子Xa活性的新化合物及其盐和相关组合物。这些化合物在体外或体内可用于预防或治疗凝血病症。

53. 发明申请

WO9816523A2 SELECTIVE FACTOR XA INHIBITORS 审中-公开
标题翻译：选择因子XA抑制剂
公开(公告)号：WO9816523A2
公开(公告)日：1998-04-23
申请号：PCT/US9718291
申请日：1997-10-10
申请人： COR THERAPEUTICS INC
发明人： ZHU BING-YAN , SCARBOROUGH ROBERT M
IPC分类号： A61K38/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07D417/00 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0202 , C07K5/06191
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。该化合物在体外或体内可用于预防或治疗凝血障碍。

54. 发明申请

WO9640743A3 INHIBITORS OF FACTOR XA 审中-公开
标题翻译：因子XA的抑制剂
公开(公告)号：WO9640743A3
公开(公告)日：1997-01-23
申请号：PCT/US9609285
申请日：1996-06-05
申请人： COR THERAPEUTICS INC , MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING YAN
发明人： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC分类号： A61K38/00 , A61P7/02 , C07C279/24 , C07C281/06 , C07C309/30 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , A61K38/55
CPC分类号： C07K5/06095 , A61K38/00 , C07K5/06034 , C07K5/06086 , C07K5/06191
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。该化合物在体外或体内可用于预防或治疗凝血障碍。

55. 发明申请

WO1996000577A1 AGENTS AFFECTING THROMBOSIS HEMOSTASIS 审中-公开
标题翻译：影响血栓形成的药剂
公开(公告)号：WO1996000577A1
公开(公告)日：1996-01-11
申请号：PCT/US1995008368
申请日：1995-06-28
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , WOLF, David, L. , SINHA, Uma
IPC分类号： A61K35/16
CPC分类号： C12N9/6464 , A61K38/00 , C07K14/745 , C12N9/6432 , C12N9/647 , C12Y304/21006 , C12Y304/21069 , Y10S514/834 , Y10S530/83
摘要： Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.
摘要翻译：瞬时失活的血液因子的类似物可用于治疗以血栓形成为特征的疾病。此外，在血清中产生活性血因子但具有延长半衰期的活化血液因子的修饰形式可用于治疗血液病症。血液因子的这些修饰形式可以是在体内缓慢脱酰基化的酰化形式。

56. 发明申请

WO1995002054A2 PLATELET GLYCOPROTEIN V GENE AND USES 审中-公开
标题翻译： PLATELET GLYCOPROTEIN V基因和用途
公开(公告)号：WO1995002054A2
公开(公告)日：1995-01-19
申请号：PCT/US1994007644
申请日：1994-07-07
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , LANZA, François , PHILLIPS, David, R. , CAZENAVE, Jean-Pierre
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： This invention relates to the glycoprotein v gene. Specifically, this invention discloses the sequence and structure of the glycoprotein v gene and the amino acid sequence of the glycoprotein v polypeptide. In addition, the evolutionary relationship of the glycoprotein v gene with other glycoproteins is described and several uses of the isolated glycoprotein v gene are shown.
摘要翻译：本发明涉及糖蛋白v基因。具体地，本发明公开了糖蛋白v基因的序列和结构以及糖蛋白v多肽的氨基酸序列。此外，描述了糖蛋白v基因与其他糖蛋白的进化关系，并显示了分离的糖蛋白v基因的几种用途。

57. 发明申请

WO1994003479A1 THROMBIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：硫蛋白受体拮抗剂
公开(公告)号：WO1994003479A1
公开(公告)日：1994-02-17
申请号：PCT/US1993006428
申请日：1993-07-08
申请人： COR THERAPEUTICS, INC. , SCARBOROUGH, Robert, M.
发明人： COR THERAPEUTICS, INC.
IPC分类号： C07K05/00
CPC分类号： C07K7/06 , A61K38/00 , C07K5/06078 , C07K5/1016 , C07K7/02
摘要： Peptide derivatives serving as thrombin receptor antagonists are disclosed, which bear specificity for the cellular thrombin receptor without interfering with the catalytic activities of thrombin. The derivatives generally have formula (I) in which R1 and R3 are amide linkages, N-alkylamide linkages, or isosteric replacements of such linkages; R2 is either a neutral amino acid side chain or a hydrophobic radical; R4 is hydrophobic radical; R5 is CO, CH2 or SO; X is either of formula (II) in which R6 and R7 are H, alkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl or arylalkyl, and R8 is a hydrophobic radical, or a hydrophobic residue; Y is alkoxy, hydroxy, amino, alkylamino, dialkylamino, in which any of the alkyl groups may be substituted with a basic moiety; Z is an amino acid or peptide residue; and m is zero or one.
摘要翻译：公开了用作凝血酶受体拮抗剂的肽衍生物，其对细胞凝血酶受体具有特异性，而不干扰凝血酶的催化活性。衍生物通常具有式（I），其中R 1和R 3是酰胺键，N-烷基酰胺键或这种键的等排取代基; R2是中性氨基酸侧链或疏水基团; R4是疏水基; R5是CO，CH2或SO; X为式（Ⅱ）中R6和R7为H，烷基，环烷基烷基，烷氧基烷基，烷硫基烷基或芳基烷基，R8为疏水基团或疏水残基; Y是烷氧基，羟基，氨基，烷基氨基，二烷基氨基，其中任何烷基可被碱部分取代; Z是氨基酸或肽残基; m为0或1。

58. 发明申请

WO1992013867A1 DOMAINS OF EXTRACELLULAR REGION OF HUMAN PLATELET DERIVED GROWTH FACTOR RECEPTOR POLYPEPTIDES 审中-公开
标题翻译：人胎盘衍生生长因子受体多肽的细胞外区域
公开(公告)号：WO1992013867A1
公开(公告)日：1992-08-20
申请号：PCT/US1992000730
申请日：1992-01-28
申请人： COR THERAPEUTICS, INC. , ESCOBEDO, Jaime, A. , WILLIAMS, Lewis, T.
发明人： COR THERAPEUTICS, INC. , WOLF, David , TOMLINSON, James, E. , FRETTO, Larry, J. , GIESE, Neill, A.
IPC分类号： C07H15/12
CPC分类号： C07K16/2863 , A61K38/00 , C07K14/71 , C07K2319/00
摘要： Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.
摘要翻译：提供修饰的人血小板衍生生长因子受体多肽的定义构建体。鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用于筛选或配体类似物。

59. 发明申请

WO1990000178A1 PLATELET BLOCKING PEPTIDES 审中-公开
标题翻译：平板阻滞胶囊
公开(公告)号：WO1990000178A1
公开(公告)日：1990-01-11
申请号：PCT/US1989002893
申请日：1989-06-30
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , CHARO, Israel, F. , FITZGERALD, Laurence, A. , PHILLIPS, David, R.
IPC分类号： C07K07/08
CPC分类号： C07K14/70557 , A61K38/00 , C07K2319/00 , C07K2319/33 , Y10S530/806
摘要： Methods and compositions are provided for treating platelet-associated ischemic syndromes utilizing oligopeptides corresponding to regions of the platelet GPIIIa protein. The oligopeptides can be used to block platelet aggregation for numerous applications, and can serve in immunogen to raise receptor-specific antibodies.
摘要翻译：提供了使用对应于血小板GPIIIa蛋白的区域的寡肽来治疗血小板相关缺血综合征的方法和组合物。寡肽可用于阻断多种应用的血小板聚集，并可用于免疫原以产生受体特异性抗体。

60. 发明申请

WO0194331A8 METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES 审中-公开
标题翻译：生产氨基取代的颜料的方法
公开(公告)号：WO0194331A8
公开(公告)日：2003-11-06
申请号：PCT/US0118014
申请日：2001-06-01
申请人： LILLY CO ELI , COR THERAPEUTICS INC , ANTOINE LUC , BOQUEL PASCAL , BORGHESE ALFIA , GORISSEN HUGO , MARTINELLI MICHAEL , MERSCHAERT ALAIN , RUHTER GERD , RYPENS CARINE , SCARBOROUGH ROBERT , SCHOTTEN THEO , VAN HOECK JEAN-PIERRE
发明人： ANTOINE LUC , BOQUEL PASCAL , BORGHESE ALFIA , GORISSEN HUGO , MARTINELLI MICHAEL , MERSCHAERT ALAIN , RUHTER GERD , RYPENS CARINE , SCARBOROUGH ROBERT , SCHOTTEN THEO , VAN HOECK JEAN-PIERRE
IPC分类号： C07D311/58 , C07D311/70 , A61K31/353 , A61P7/02
CPC分类号： C07D311/58
摘要： Disclosed are processes for producing benzopyran compounds, reduced 2-(chroman-2-yl) acetic acid compounds and 2-(6-aminochroman-2-yl)acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
摘要翻译：公开了制备苯并吡喃化合物，还原的2-（色满-2-基）乙酸化合物和2-（6-氨基苯并二氢吡喃-2-基）乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。

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