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51. 发明申请

WO2022165537A1 MICROFLUIDIC DEVICES AND PROCESSES 审中-公开
公开(公告)号：WO2022165537A1
公开(公告)日：2022-08-04
申请号：PCT/US2022/070457
申请日：2022-02-01
申请人： BIO-RAD LABORATORIES, INC. , BIO-RAD EUROPE GMBH
发明人： PETRINI, Lorenzo Franco Teodoro , PEREIRO PEREIRO, Iago , LOVCHIK, Robert Dean , FOMITCHEVA KHARTCHENKO, Anna , ZULJI, Anel , KAIGALA, Govind , BOERO, Cristina , NOËL, Olivier Michel Christian , GUEX, Christophe , GUILLOD, Stéphane , BOLON, Aurélie
IPC分类号： B01L3/00 , B01L99/00 , G01N1/28 , G01N35/08
摘要： A method comprises providing a microfluidic device including a reservoir; an injection nozzle at the bottom of the reservoir, the injection nozzle being wider at its top than at its bottom; an injection channel below the injection nozzle; and a microfluidic channel below the injection channel. The method further comprises placing fluid in the reservoir, and allowing the fluid to passively flow through the injection nozzle and the injection channel.

52. 发明申请

WO2019002935A1 IN SITU SERIAL DILUTION METHOD 审中-公开
公开(公告)号：WO2019002935A1
公开(公告)日：2019-01-03
申请号：PCT/IB2018/000768
申请日：2018-06-22
申请人： BIO-RAD EUROPE GMBH
发明人： GUIGNET, Emmanuel
IPC分类号： G01N33/543
摘要： Provided herein are methods of determining a concentration of an analyte in a sample using in situ serial dilution.

53. 发明申请

WO2018041965A1 PIPETTE TIP CONTAINER 审中-公开
标题翻译：移液器容器
公开(公告)号：WO2018041965A1
公开(公告)日：2018-03-08
申请号：PCT/EP2017/071895
申请日：2017-08-31
申请人： BIO-RAD INNOVATIONS , BIO-RAD EUROPE GMBH
发明人： DAGLAND, Typhaine , VENTURI, Gilles , DOURY, Vincent , FOURNIER, Laurent
IPC分类号： B01L3/00 , B01L3/02 , G01N35/10
摘要： A pipette tip container comprising a pipette tip having a lumen extending between a proximal opening of a first diameter and a distal orifice of a second smaller diameter; a pellet arranged in the lumen of the pipette tip between said proximal opening and distal orifice, the second diameter being too narrow to let the pellet pass; and a retainer arranged between the pellet and the proximal opening and arranged to prevent the pellet from moving past the retainer in the lumen but to let fluid move past the retainer in the lumen; the retainer having a distal end such that a portion of its periphery does not contact the inner wall of the lumen, a proximal end such that a portion of its periphery maintains the retainer in the lumen by friction with the inner wall of the lumen; and a radial opening between the distal and proximal ends.
摘要翻译：移液管尖端容器，其包括移液管尖端，所述移液管尖端具有在第一直径的近侧开口和第二较小直径的远侧开口之间延伸的腔; 布置在所述近端开口和远端孔口之间的移液管尖端的内腔中的小球，所述第二直径太窄而不能使所述小球通过; 以及布置在所述小球和所述近侧开口之间并且布置成防止所述小球移动经过所述管腔中的所述保持器但让流体移动通过所述管腔中的所述保持器的保持器; 所述保持器具有使得其外周的一部分不接触所述内腔的内壁的远端，近端使得其外围的一部分通过与所述内腔的内壁摩擦而将所述保持器保持在所述内腔中; 以及远端和近端之间的径向开口。

54. 发明申请

WO2022165536A1 MICROFLUIDIC PROBES 审中-公开
公开(公告)号：WO2022165536A1
公开(公告)日：2022-08-04
申请号：PCT/US2022/070456
申请日：2022-02-01
申请人： BIO-RAD LABORATORIES, INC. , BIO-RAD EUROPE GMBH
发明人： PEREIRO PEREIRO, Iago , FOMITCHEVA KHARTCHENKO, Anna , LOVCHIK, Robert Dean , KAIGALA, Govind , PETRINI, Lorenzo Franco Teodoro , ZULJI, Anel , BUFFIÈRE, Frédéric M. , GUÉGAN, Johann , RIVALIN, Eliane , VILLARD-SAUSSINE, Sylvie
IPC分类号： B01L3/00 , B01L3/02 , B01L3/14 , B01L99/00
摘要： In one implementation, a microfluidic probe has a non-planar processing surface and an inlet aperture. The shape of the surface may be selected to produce a specific velocity gradient profile across a surface onto which fluid is deposited using the microfluidic probe, for example a constant velocity gradient or a velocity gradient that decreases linearly with distance from the inlet aperture. The microfluidic probe may define and overflow notch in a perimeter edge of the processing surface.

55. 发明申请

WO2022081564A1 SYSTEM AND METHOD FOR TARGET DETECTION WITH APPLICATIONS IN CHARACTERIZING FOOD QUALITY AND IMPROVING FOOD SAFETY 审中-公开
公开(公告)号：WO2022081564A1
公开(公告)日：2022-04-21
申请号：PCT/US2021/054562
申请日：2021-10-12
申请人： BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
发明人： HANDIQUE, Kalyan , LEBOFSKY, Ronald , MACKE, Emilie, Celine, Claudie , DIEVART, Rebecca , QUIRING, Christophe , PIERRE, Sophie
IPC分类号： C12M1/34 , B01L3/00 , C12M1/18 , C12M3/00 , G01N33/48 , G01N37/00
摘要： A system, method, and platform for target detection, the system including: a base substrate; a set of sample processing regions defined at a broad surface of the substrate, wherein each of the set of sample processing regions includes: a set of microwell subarrays arranged in a gradient between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions; and a cover substrate configured to mate with the base substrate in a coupled mode, the cover substrate comprising a network of venting channels aligned with the set of sample processing regions upon mating the base substrate with the cover substrate in the coupled mode, the network of venting channels providing gas exchange between the base substrate and an environment surrounding the microwell assembly. The invention(s) can be used for MPN assays.

56. 发明申请

WO2022074463A1 OPTIMAL COMBINATION OF EARLY BIOMARKERS FOR INFECTION AND SEPSIS DIAGNOSIS IN EMERGENCY DEPARTMENT 审中-公开
公开(公告)号：WO2022074463A1
公开(公告)日：2022-04-14
申请号：PCT/IB2021/000715
申请日：2021-10-11
申请人： INSTITUT PASTEUR [FR]/[FR] , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS [FR]/[FR] , SORBONNE UNIVERSITE [FR]/[FR] , BIO-RAD EUROPE GMBH [CH]/[CH]
发明人： CAVAILLON, Jean-Marc , VELLY, Laetitia , HAUSFATER, Pierre , FITTING, Catherine , VOLANT, Stevenn , SALIPANTE, Florian , VALERA, Lionel , FAREH, Jeannette
IPC分类号： G01N33/68 , G01N33/6893
摘要： The present invention allows a rapid and early diagnosis of bacterial or viral infection. Such a diagnosis is highly desired among patients admitted in emergency department to allow the initiation of the appropriate treatment. Although no biomarker alone can offer an appropriate diagnosis with sufficient sensitivity and specificity, the present invention defines optimal combinations of biomarkers allowing the diagnosis of infection.

57. 发明申请

WO2022043725A1 AUTOMATIC SOFTWARE UPDATES 审中-公开
公开(公告)号：WO2022043725A1
公开(公告)日：2022-03-03
申请号：PCT/IB2020/000994
申请日：2020-08-31
申请人： BIO-RAD LABORATORIES, INC. , BIO-RAD EUROPE GMBH
发明人： GABEL, Shlomo , OFFNER, Arie , ISAKOV, Slavik , KHATIB, Abdallah , MILLET, Eric , DILLON, Damien
IPC分类号： G06F8/65 , G06F9/4401 , G06F21/57
摘要： A computer system detects that an external update device (e.g., a USB drive) is connected and adds an update script to its startup event. When the computer system is starting up, it checks to confirm that the external update device is still connected and, if so, runs the update script. The update script executes an update installer on the external update device. The update installer generates a list of software updates to install and installs them using a system account of the computer system. The update installer may restart the computer system if needed to complete installation of the updates.

58. 发明申请

WO2020192972A1 APPARATUS AND METHOD FOR CLASSIFYING PICTURES OF GEL-CARD REACTIONS 审中-公开
公开(公告)号：WO2020192972A1
公开(公告)日：2020-10-01
申请号：PCT/EP2020/025145
申请日：2020-03-26
申请人： BIO-RAD EUROPE GMBH
发明人： PICARD, Thomas , DE-BASTIANI, Bruno , BALLEREAU, Jean-Baptiste , DELAILLE, Stephane , MILLET, Eric , BONY, Pierre , NOEL, Oliver , RAISIN, Yves , FOISSAC, Clément
IPC分类号： G01N21/00 , G16H10/40
摘要： An apparatus for classifying a picture of a reaction of reactants in a predetermined container; the apparatus comprising a first neural network arranged for receiving an input picture of a reaction of reactants in a predetermined container and for providing, for each reaction category of a first plurality of reaction categories, a probability that the input picture shows a reaction that belongs to said reaction category; a second neural network arranged for, if the first neural response provides a highest probability that the input picture shows a reaction that belongs to a predetermined reaction category, receiving a predetermined portion of the input picture and providing, for each reaction category of a second plurality of reaction categories, a probability that said predetermined portion of the input picture shows a reaction that belongs to said reaction category.

59. 发明申请

WO2019121665A1 METHOD AND APPARATUS FOR TESTING A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：WO2019121665A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085468
申请日：2018-12-18
申请人： BIO-RAD EUROPE GMBH
发明人： GUIGNET, Emmanuel , BOMBARD, Stephane
IPC分类号： G01N33/49 , G01N21/07 , G01N15/04
CPC分类号： G01N33/491 , G01N15/042 , G01N15/05 , G01N21/07 , G01N2015/047 , G01N2035/00148 , G01N2035/00495
摘要： A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.

60. 发明申请

WO2019150189A1 MICROFLUIDIC PROBE HEAD WITH ASPIRATION POSTS 审中-公开
公开(公告)号：WO2019150189A1
公开(公告)日：2019-08-08
申请号：PCT/IB2019/000007
申请日：2019-02-05
申请人： URI, Yochanan , BARAK, Itay , LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V. , BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
发明人： URI, Yochanan , BARAK, Itay , LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V.
IPC分类号： B01L3/00 , B01L99/00 , B01L3/02
CPC分类号： B01L3/502707 , B01L3/0293 , B01L3/502761 , B01L99/00 , B01L2200/027 , B01L2200/0642 , B01L2200/0647 , B01L2200/141 , B01L2300/0832
摘要： The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

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