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51. 发明申请

WO2019121937A1 ANIMAL FEED COMPOSITIONS COMPRISING MURAMIDASE AND USES THEREOF 审中-公开
公开(公告)号：WO2019121937A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085875
申请日：2018-12-19
申请人： DSM IP ASSETS B.V. , NOVOZYMES A/S
发明人： AURELI, Raffaella , LOPEZ-ULIBARRI, Rual , PEREZ CALVO, Estefania , CARDOSO BITTENCOURT, Leticia
IPC分类号： A23K20/189 , A23K50/00 , C12N9/36 , A23K50/20 , A23K50/70 , A23K50/75 , A23K50/30 , A23K50/10 , A23K50/80 , A61K38/47
CPC分类号： C12Y302/01017 , A23K20/189 , A23K50/00 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/70 , A23K50/75 , A23K50/80 , C12N9/2462
摘要： The present invention relates to animal feed compositions comprising polypeptides having muramidase activity and uses thereof. In the Examples it is shown that feeding muramidase to broiler chicken increased apparent ileal digestibility of crude protein and crude fat.

52. 发明申请

WO2015086755A1 NOVEL USE OF BIOTIN AND NATURAL ESSENTIAL OILS FOR BOVINE ANIMALS FOR THE PREVENTION AND TREATMENT OF KETOSIS 审中-公开
标题翻译：生物医药和自然基础油用于预防和治疗卡特西斯的牛血清动物的新用途
公开(公告)号：WO2015086755A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077399
申请日：2014-12-11
申请人： DSM IP ASSETS B.V.
发明人： IMMIG, Irmgard , STEINBERG, Wolfgang , MC GRATH, Joseph
IPC分类号： A61K31/4188 , A61K31/11 , A61K31/05 , A23K1/00 , A61P43/00 , A61P3/00
CPC分类号： A61K31/4188 , A23K20/10 , A23K20/158 , A23K20/174 , A23K50/10 , A61K31/05 , A61K31/085 , A61K31/11 , A61K2300/00
摘要： The present invention is made for the prevention of ketosis or minimizing the effects of ketosis in ruminant animals. This purpose is achieved by feeding to the animal biotin in combination with a mixture of at least two essential oil compounds selected from the group consisting of thymol, eugenol, meta-cresol, vaniline and guajacol. The present invention is useful because it is capable of preventing and/or inhibiting ketosis of calving ruminant animals and the subsequent need for veterinary treatment. In a preferred embodiment of a feeding concept for dairy cattle, especially calving dairy cattle, biotin being used in an amount sufficient to provide a daily dosage of 10 mg to 20 mg per head to which it is to be administered. It is at present contemplated that the essential oils are administered in amounts (total dosage ranges of essential oils) of 1 to 1.5 g per head per day.
摘要翻译：本发明是为了预防酮症或使反刍动物中酮症的作用最小化。该目的通过与至少两种选自百里香酚，丁子香酚，间甲酚，香草胺和瓜那醇的精油化合物的混合物联合给动物生物素来实现。本发明是有用的，因为它能够预防和/或抑制产犊反刍动物的酮症和随后的兽医治疗需要。在用于奶牛，特别是犊牛奶牛的喂养概念的优选实施方案中，生物素的用量足以提供每日10mg剂量至每头给予10mg。目前预期精油以每天头数为1至1.5g的量（精油的总剂量范围）施用。

53. 发明申请

WO2013104526A1 USE OF DANIELONE AND DERIVATIVES THEREOF IN SKIN CARE 审中-公开
标题翻译：丹尼酮及其在皮肤护理中的衍生物的使用
公开(公告)号：WO2013104526A1
公开(公告)日：2013-07-18
申请号：PCT/EP2012/077014
申请日：2012-12-28
申请人： DSM IP ASSETS B.V.
发明人： CAMPICHE, Remo , GEOTTI-BIANCHINI, Piero , ZIEGLER, Hugo
IPC分类号： A61K8/35 , A61Q19/02
CPC分类号： A61K8/35 , A61K8/97 , A61K2800/10 , A61Q17/04 , A61Q19/02
摘要： The present invention relates to a novel composition comprising danielone and derivatives thereof as well as to the use of such compositions in skin lightening. More particularly, the present invention relates to danielone and derivatives thereof for use in topical compositions for smoothening skin color irregularities, for reducing melanin formation in the human skin, for lightening/brightening human skin and/or for treatment of pigmentation disorders which comprises topically administering an effective amount of danielone and derivatives thereof to the appropriate skin area of a person in need of such beautifying agent, or treatment.
摘要翻译：本发明涉及一种包含丹尼酮及其衍生物的新型组合物，以及这些组合物在减轻皮肤中的用途。更具体地说，本发明涉及用于局部用于平滑皮肤颜色不规则的局部用组合物的丹尼酮及其衍生物，用于减少人皮肤黑色素形成，减轻/增亮人体皮肤和/或治疗色素沉着病，其包括局部施用有效量的丹尼酮及其衍生物可用于需要这种美容剂的人的适当皮肤区域或治疗。

54. 发明申请

WO2013079388A1 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DIETARY WEIGHT LOSS 审中-公开
标题翻译：单一核苷酸多态性与食物重量损失相关
公开(公告)号：WO2013079388A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/073330
申请日：2012-11-22
申请人： DSM IP ASSETS B.V.
发明人： SORENSEN, Thorklid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156
摘要： The present invention relates to genetic polymorphisms associated with obesity nd obesity-related phenotypes and their use in predicting if an individual looses weight during a dietary weight loss intervention program.
摘要翻译：本发明涉及与肥胖相关的遗传多态性和肥胖相关表型，以及它们在预测饮食减肥干预方案中个体是否减肥时的用途。

55. 发明申请

WO2013072521A2 USE OF ACID STABLE PROTEASES IN ANIMAL FEED, PREFERABLY TO INCREASE PERFORMANCE OF COCCI-VACCINATED BROILER CHICKENS 审中-公开
标题翻译：在动物饲料中使用酸性稳定的蛋白质，优先提高COCCI-VACCINATED BROILER CHICKENS的性能
公开(公告)号：WO2013072521A2
公开(公告)日：2013-05-23
申请号：PCT/EP2012/072979
申请日：2012-11-19
申请人： DSM IP ASSETS B.V.
发明人： WARD , Nelson , KNAP, Inge
CPC分类号： A61K38/48 , A23K10/14 , A23K10/18 , A23K20/10 , A23K20/174 , A23K20/189 , A23K20/22 , A23K20/24 , A23K20/26 , A23K20/28 , A23K20/30 , A23K50/70 , A23K50/75 , A23V2002/00 , A61K38/47 , A61K39/012 , A61K2039/543 , A61K2039/552 , C12Y302/00 , C12Y302/01004 , C12Y302/01008 , C12Y304/00 , C12Y304/21014 , A23V2200/32
摘要： The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of "cocci"-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serin proteases improve the performance of vaccinated broiler chickens, in particular the use of serin proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds.
摘要翻译：本发明涉及至少一种酸稳定蛋白酶在家禽饲料中的用途，与禽鸟的抗球虫疫苗接种相结合以增加接种疫苗的动物的性能。已经令人惊奇地发现，根据本发明的至少一种酸稳定蛋白酶向“球菌”灭蚊鸟类的饮食中添加了动物性能的显着改善。本发明人发现特别是使用丝氨酸蛋白酶改善了接种的鸡肉的性能，特别是丝氨酸蛋白酶的使用增加了体重增加并改善了接种鸡的饲料转化率（FCR）。

56. 发明申请

WO2012168473A2 FUSION OF BIOACTIVE MOLECULES 审中-公开
标题翻译：生物活性分子的融合
公开(公告)号：WO2012168473A2
公开(公告)日：2012-12-13
申请号：PCT/EP2012/061003
申请日：2012-06-11
申请人： DSM IP ASSETS B.V. , SCHYNS, Ghislain , DUVAL, Stephane , BRELIN, Aurelie
发明人： SCHYNS, Ghislain , DUVAL, Stephane , BRELIN, Aurelie
IPC分类号： A23J3/14 , C12N9/16
CPC分类号： C12N9/16 , A23K20/147 , A23K20/174 , A23K20/189 , A23K20/30 , A23K50/30 , A23K50/75 , A23K50/80 , A23L33/18 , C07K14/32 , C07K14/335 , C07K2319/00 , C12Y301/03008 , C12Y301/03026
摘要： Fusion-proteins containing an enzyme, preferably a feed or food enzyme, coupled to a gut surface-binding domain are presented. The fusion-proteins can be used to promote feed utilization in animals. In a particular example, a Fusion enzyme according to the invention comprising a gut-surface-binding polypeptide segment linked to a phytase show an increased resident time in the gut, which leads to an increased amount of time given to the enzyme to catalyse the corresponding reaction which finally leads to improved feed utilisation.
摘要翻译：提供了含有与肠表面结合域偶联的酶，优选饲料或食物酶的融合蛋白。融合蛋白可用于促进动物的饲料利用。在具体实例中，包含与肌醇六磷酸酶连接的肠表面结合多肽片段的根据本发明的融合酶显示在肠中增加的停留时间，这导致增加的时间量给酶以催化相应的最终导致饲料利用率提高的反应。

57. 发明申请

WO2012104145A1 DIHYDROCHALCONE PURIFICATION PROCESS 审中-公开
标题翻译： DIHYDROCHALCONE净化工艺
公开(公告)号：WO2012104145A1
公开(公告)日：2012-08-09
申请号：PCT/EP2012/050756
申请日：2012-01-19
申请人： DSM IP ASSETS B.V. , BOEHLENDORF, Bettina , HUG, Hubert , KAMMERER, Judith , KILPERT, Claus , CARLE, Reinhold
发明人： BOEHLENDORF, Bettina , HUG, Hubert , KAMMERER, Judith , KILPERT, Claus , CARLE, Reinhold
IPC分类号： C07H1/08 , C07H15/203 , C12P19/44
CPC分类号： C07H15/20 , C07H1/08 , C07H15/203
摘要： The present invention relates to an improved process for the preparation of an extract enriched in dihydrochalcones, and more specifically enriched in phlorizin, starting from a polyphenolic fraction originating from industrial apple processing. The invention also relates to a dihydrochal-cone extract obtainable by this process, and to a food or a nutraceutical product comprising a dihydrochalcone extract of the present invention.
摘要翻译：本发明涉及一种制备富含二氢查耳酮的提取物，更具体地富含根皮苷的提取方法，起始于工业苹果加工的多酚馏分。本发明还涉及通过该方法可获得的二氢沙锥提取物，以及包含本发明的二氢查耳酮提取物的食品或营养制品。

58. 发明申请

WO2012084624A1 COMPOSITIONS OF FAT-SOLUBLE ACTIVE INGREDIENTS CONTAINING PLANT PROTEIN-SOY POLYSACCHARIDE COMPLEXES 审中-公开
标题翻译：含有植物蛋白多糖复合物的脂肪可溶性活性成分的组合物
公开(公告)号：WO2012084624A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/072690
申请日：2011-12-14
申请人： DSM IP ASSETS B.V. , DENG, Wei , LEUENBERGER, Bruno , VIDONI, Olivia , YAO, Ping , YIN, Baoru
发明人： DENG, Wei , LEUENBERGER, Bruno , VIDONI, Olivia , YAO, Ping , YIN, Baoru
IPC分类号： A23L1/052 , A23L1/275 , A23L1/30 , A23L1/303 , A23L1/305 , A23L2/52 , A23L2/66 , B01J13/14 , A23K1/16
CPC分类号： A23K20/158 , A23K20/147 , A23K20/174 , A23K20/179 , A23L2/52 , A23L2/66 , A23L5/44 , A23L29/206 , A23L33/115 , A23L33/155 , A23L33/185
摘要： The present invention relates to compositions comprising a) 0.1 to 70 weight-% based on the composition of one or more fat-soluble active ingredients; b) one or more plant protein(s) chosen from the group of proteins suitable for food application; and c) one or more soy soluble polysaccharide(s); wherein the sum of the amount of protein(s) and the amount of polysaccharide(s) represents 10 to 85 weight-% based on the composition in dry matter and, wherein the weight ratio of protein(s) to polysaccharide(s) is chosen like 1 : b with the proviso that b is comprised between 0.5 and 15.
摘要翻译：本发明涉及包含a）0.1至70重量％的组合物，基于一种或多种脂溶性活性成分的组合物; b）一种或多种选自适合食品应用的蛋白质组的植物蛋白质; 和c）一种或多种大豆可溶性多糖; 其中蛋白质的量和多糖的总量相对于干物质中的组成为10至85重量％，并且其中蛋白质与多糖的重量比为选择为1：b，条件是b为0.5至15。

59. 发明申请

WO2012059286A1 CAROTENOID COMPOSITIONS CONTAINING OCTENYL SUCCINATE ANHYDRIDE-MODIFIED GUM ACACIA 审中-公开
标题翻译：含有OCTENYL SUCCINATE ANHYDRIDE改性GAC ACACIA的CAROTENOID组合物
公开(公告)号：WO2012059286A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/067256
申请日：2011-10-04
申请人： DSM IP ASSETS B.V. , HITZFELD, Andrea , LEUENBERGER, Bruno H. , VIDONI, Olivia
发明人： HITZFELD, Andrea , LEUENBERGER, Bruno H. , VIDONI, Olivia
IPC分类号： A23L1/053 , A23L1/275 , A23L2/58 , A61K8/97 , A61K31/07
CPC分类号： A61K8/73 , A23L2/52 , A23L2/58 , A23L5/44 , A23L29/25 , A23L33/10 , A23L35/10 , A23V2002/00 , A61K8/31 , A61K8/97 , A61K47/06 , A61K47/36 , A61K2800/10 , A61K2800/42 , A61K2800/92 , A61Q19/00 , A23V2250/5022 , A23V2250/211
摘要： The present invention relates to compositions comprising octenyl-succinic anhydride- modified gum acacia and carotenoids. It has been found that the compositions according to the invention allow to produce emulsions having a very high color intensity, and color stability with a low turbidity. These compositions can be used for the enrichment, fortification and/or coloration of food beverages, animal feed, cosmetics or pharmaceutical compositions. The present invention furthermore refers to a process for the manufacture of a beverage by mixing the compositions with ingredients of beverages. The present invention also refers to beverages obtainable by this process.
摘要翻译：本发明涉及包含辛烯基 - 琥珀酸酐改性的阿拉伯树胶和类胡萝卜素的组合物。已经发现，根据本发明的组合物允许产生具有非常高的颜色强度和低浊度的颜色稳定性的乳液。这些组合物可用于食品饮料，动物饲料，化妆品或药物组合物的富集，强化和/或着色。本发明还涉及通过将组合物与饮料成分混合来制造饮料的方法。本发明还涉及可通过该方法获得的饮料。

60. 发明申请

WO2011036139A1 METHOD FOR THE EXTRACTION AND DETECTION OF FAT-SOLUBLE COMPONENTS FROM BIOLOGICAL MATERIALS 审中-公开
标题翻译：从生物材料中提取和检测脂肪溶解成分的方法
公开(公告)号：WO2011036139A1
公开(公告)日：2011-03-31
申请号：PCT/EP2010/063855
申请日：2010-09-21
申请人： DSM IP ASSETS B.V. , SCHWEIGERT, Florian, J.
发明人： SCHWEIGERT, Florian, J.
IPC分类号： G01N33/02 , G01N33/92 , A23L1/275 , A61K36/00
CPC分类号： G01N33/92 , G01N1/4055 , G01N2001/4061
摘要： The present invention relates to a method for the analysis of fat-soluble components, in particular dyes, from biological materials, in particular lipid rich foodstuffs, having an enrichment of the components and subsequent analysis. The method comprises a combination of extraction and separation steps and a subsequent analysis step. The invention further relates to an analytical kit and analytical equipment for carrying out the method. The method according to the invention is composed of a plurality of steps. The critical steps which are essential and characterize the invention are: 1.Pre-treatment of the sample to remove lipids. 2.Extracting the dyes into an extraction mixture by a specific solvent or solvent mixture. 3.Destruction of the oxidative sensible ingredients such as carotenoids prior to the final detection and quantification by eye or by optical enhancement.
摘要翻译：本发明涉及从生物材料特别是富含脂肪的食品中分析脂溶性成分，特别是染料的方法，其具有富集组分和随后的分析。该方法包括提取和分离步骤的组合以及随后的分析步骤。本发明还涉及用于实施该方法的分析套件和分析设备。根据本发明的方法由多个步骤组成。本发明所必需的和特征的关键步骤是：1.预处理样品以除去脂质。 2.通过特定溶剂或溶剂混合物将染料萃取到萃取混合物中。 3.在最终检测和眼睛定量之前，通过光学增强来破坏氧化敏感成分如类胡萝卜素。

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