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51. 发明申请

WO2015162216A1 BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS 审中-公开
标题翻译：作为TRPV1配体的二胺或尿素衍生物
公开(公告)号：WO2015162216A1
公开(公告)日：2015-10-29
申请号：PCT/EP2015/058830
申请日：2015-04-23
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DELLA CALABRIA
发明人： BRIZZI, Antonella , AIELLO, Francesca , CORELLI, Federico
IPC分类号： C07D333/58 , C07D333/60 , C07D401/04 , C07D401/12 , C07D209/42 , A61P35/00 , A61K31/381 , A61K31/405 , C07D333/24 , C07D333/28 , C07D409/12 , C07D209/18 , C07D209/40 , A61K31/404 , A61K31/4436 , A61P29/00 , A61P25/00
CPC分类号： C07D333/24 , C07D209/18 , C07D209/40 , C07D209/42 , C07D333/28 , C07D333/58 , C07D333/60 , C07D401/04 , C07D401/12 , C07D409/12
摘要： The present invention relates to high affinity compounds, able to bind the transient receptor potential cation channel, subfamily Vanilloid, type 1 or TRPV1. Being this receptor involved in pain processing and neurogenic inflammatory responses and being up-regulated during chronic pain conditions, the compounds of the invention find particular application in all medical conditions involving said receptors, in particular as agents for pain therapy and/or anti-inflammatory and/or cluster headache therapy and/or anti-oxidant and/or anti-cancer therapy. Moreover, the chemical structure of these compounds provides the opportunity of developing new radiotracers for Positron Emission Tomography (PET) imaging. These radiotracers are of great relevance for mapping TRPV1 receptors in (patho)physiological conditions.
摘要翻译：本发明涉及能够结合瞬时受体潜在阳离子通道的高亲和力化合物，亚科家族1型或TRPV1亚型。作为该受体涉及疼痛加工和神经源性炎症反应并且在慢性疼痛病症期间被上调，本发明的化合物特别适用于涉及所述受体的所有医学病症，特别是用于疼痛治疗和/或抗炎的药剂和/或簇头痛治疗和/或抗氧化和/或抗癌治疗。此外，这些化合物的化学结构提供了为正电子发射断层成像（PET）成像开发新的放射性示踪剂的机会。这些放射性示踪剂与（病态）生理条件下的TRPV1受体的映射有很大关系。

52. 发明申请

WO2014009860A1 NOVEL THERAPY IN THE TREATMENT OF ALKAPTONURIA 审中-公开
标题翻译：治疗阿尔卡派的新治疗方法
公开(公告)号：WO2014009860A1
公开(公告)日：2014-01-16
申请号：PCT/IB2013/055519
申请日：2013-07-05
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
发明人： SANTUCCI, Annalisa , SPREAFICO, Adriano
IPC分类号： A61K31/519 , A61P3/00
CPC分类号： A61K31/519
摘要： The present invention relates to the use of a known compound in the pharmacological treatment of a rare genetic disease called alkaptonuria, and of its complications known as "ochronosis", a pathologic condition of the connective tissues that produces damages in particular to joints, to cardiovascular system, kidneys, skin and glands.
摘要翻译：本发明涉及已知化合物在药理学治疗称为碱性磷酸尿症的罕见遗传疾病中的用途，以及其被称为“异时症”的并发症，特别是关节损伤的结缔组织的病理状况，心血管系统，肾脏，皮肤和腺体。

53. 发明申请

WO2008090583A1 PHOSPHATED DERIVATIVES OF POLYSACCHARIDES AND USES THEREOF 审中-公开
标题翻译：多糖的磷酸衍生物及其用途
公开(公告)号：WO2008090583A1
公开(公告)日：2008-07-31
申请号：PCT/IT2008/000032
申请日：2008-01-22
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , MAGNANI, Agnese , CONSUMI, Marco , ROSSI, Claudio , GRECO, Giuseppe
发明人： MAGNANI, Agnese , CONSUMI, Marco , ROSSI, Claudio , GRECO, Giuseppe
IPC分类号： C08B37/00 , C08B5/00 , A61K31/715 , A61L27/20
CPC分类号： A61L27/34 , A61K31/715 , A61L29/085 , A61L31/10 , C08B5/00 , C08B11/12 , C08B37/00 , C08B37/0072 , C08B37/0084
摘要： The present invention relates to phosphated products with polysaccharide basis, in particular: hyaluronic acid (HA), carboxymethylcellulose (CMC) and alginic acid (AA) and to their use.
摘要翻译：本发明涉及基于多糖的磷酸盐化产品，特别涉及透明质酸（HA），羧甲基纤维素（CMC）和藻酸（AA）及其应用。

54. 发明申请

WO2008038325A1 SCREEN FOR SIMULATING REPETITIVE TRANSCRANIAL MAGNETIC SIMULATION (rTMS) AND DEVICE FOR GIVING AND SIMULATING rTMS PROVIDED WITH SAID SCREEN 审中-公开
标题翻译：用于模拟重复交叉磁化仿真（rTMS）的屏幕和用于提供和模拟提供有屏幕的rTMS的设备
公开(公告)号：WO2008038325A1
公开(公告)日：2008-04-03
申请号：PCT/IT2007/000659
申请日：2007-09-21
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , ROSSI, Simone , FERRO, Marisa
发明人： ROSSI, Simone , FERRO, Marisa
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61N2/006
摘要： The present invention relates to a screen (3) for simulating repetitive transcranial magnetic stimulation (rTMS), said screen being comprised of magnetically inert material, suitable to be coupled with an active element for administering rTMS, comprising electromagnetic means (2, 2') for generating a magnetic field along a direction, the screen (3) having a shape substantially identical to the section of the active element orthogonal to the direction of generation of magnetic field, the screen (3) being characterised in that it comprises at least a pair of electrodes (5, 5') on a surface facing outward. The present invention further relates to the device (1) for administering and simulating repetitive transcranial magnetic stimulation (rTMS) provided with said screen.
摘要翻译：本发明涉及一种用于模拟重复经颅磁刺激（rTMS）的屏幕（3），所述屏幕由磁性惰性材料组成，适于与用于施用rTMS的有源元件耦合，包括电磁装置（2,2'）为了沿着一个方向产生磁场，屏幕（3）的形状基本上与有源元件的与磁场产生方向正交的截面相同，屏幕（3）的特征在于它包括至少一个一对电极（5,5'）在面向外的表面上。本发明还涉及用于施用和模拟设置有所述屏幕的重复经颅磁刺激（rTMS）的装置（1）。

55. 发明申请

WO2005083489A1 IMPROVED INVERTED LIGHT OPTICAL MICROSCOPE 审中-公开
标题翻译：改进的反光光学显微镜
公开(公告)号：WO2005083489A1
公开(公告)日：2005-09-09
申请号：PCT/IT2005/000107
申请日：2005-02-25
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , BACCETTI, Baccio
发明人： BACCETTI, Baccio
IPC分类号： G02B21/00
CPC分类号： G02B21/0088
摘要： The present invention concerns an improved inverted light optical microscope, comprising at least one light source (1), apt to generate white light following at least one optical path having at least one first section (p1) and at least one second section (p2), the light being diverted from the first to the second section through first optical means (7), at least one supporting plane (4), apt to house at least one specimen (3) illuminable by the light generated by said at least one source (1), and at least one objective (5) being placed in succession along said at least one first section (p1) of said at least one optical path, second optical means (9), apt to allow an operator (10) to observe at least one image of at least one specimen (3), being placed at the end of said at least one second section (p2) of said at least one optical path, the microscope being characterised in that it comprises, after said at least one source (1) and before said at least one supporting plane (4), light polarising optical means (11) apt to allow light polarised according to a polarisation direction to pass.
摘要翻译：本发明涉及一种改进的倒置光学光学显微镜，其包括至少一个光源（1），其适于产生白光，跟随至少一个具有至少一个第一部分（p1）和至少一个第二部分（p2）的光路，，所述光通过第一光学装置（7）从第一部分转移到第二部分，至少一个支撑平面（4），其易于容纳由所述至少一个光源产生的光可照亮的至少一个样本（3）（1），并且至少一个物镜（5）沿着所述至少一个光路的所述至少一个第一部分（p1）被连续地放置，所述第二光学装置（9）易于允许操作者（10）观察至少一个样本（3）的至少一个图像，其被放置在所述至少一个光路的所述至少一个第二部分（p2）的末端，其特征在于，其至少包括在至少一个一个源（1），并且在所述至少一个支撑平面（4）之前，光p 适于允许根据偏振方向偏振的光的极化光学装置（11）通过。

56. 发明申请

WO2003025001A1 MULTIPLE ANTIGEN PEPTIDES (MAP) AS ANTIDOTES AGAINST SNAKE NEUROTOXIN INTOXICATION 审中-公开
标题翻译：多抗抗原肽（MAP）作为抗SNAKE神经毒素毒素的抗体
公开(公告)号：WO2003025001A1
公开(公告)日：2003-03-27
申请号：PCT/IT2002/000580
申请日：2002-09-12
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , BRACCI, Luisa , LOZZI, Luisa , LELLI, Barbara , PINI, Alessandro , NERI, Paolo
发明人： BRACCI, Luisa , LOZZI, Luisa , LELLI, Barbara , PINI, Alessandro , NERI, Paolo
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/001 , C07K14/70571
摘要： A Multiple Antigen Peptide comprising: a) a dendritic core basically constituted by at least one bifunctional molecule; b) at least two peptide molecules able to bind snake alphneurotoxins when injected into mammals and neutralize snake neurotoxins toxicity; wherein the dendritic core and peptide molecules are linked by covalent bonds.
摘要翻译：多抗原肽，其包含：a）基本上由至少一个双功能分子构成的树突状核; b）当注射到哺乳动物中时，至少有两种肽分子能够结合蛇形神经毒素并中和蛇神经毒素的毒性; 其中树突核心和肽分子通过共价键连接。

57. 发明专利

IT201800007934A1 METODO PER GENERARE UN SEGNALE DI CONSAPEVOLEZZA DI UN ROBOT COLLABORATIVO E RELATIVO SISTEMA HARDWARE 未知
公开(公告)号：IT201800007934A1
公开(公告)日：2020-02-07
申请号：IT201800007934
申请日：2018-08-07
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , MILANO POLITECNICO
发明人： PRATTICHIZZO DOMENICO , POZZI MARIA , ROCCO PAOLO , ZANCHETTIN ANDREA MARIA
IPC分类号： B25J20060101

58. 发明授权

EP3765454B1 ANTIVIRAL COMPOUNDS AND USE THEREOF 有权
公开(公告)号：EP3765454B1
公开(公告)日：2023-11-08
申请号：EP19711363.2
申请日：2019-03-18
发明人： BOTTA, Maurizio , CANDUCCI, Filippo , CAGNO, Valeria , LEMBO, David , TINTORI, Cristina , BRAI, Annalaura , PALOMBI, Nastasja
IPC分类号： C07D403/06 , A61P31/12 , A61K31/427 , A61K31/515

60. 发明公开

EP2388250A1 4-Pyrimidinone derivatives and their use as anti-HIV agents 审中-公开
标题翻译： 4-Pyrimidinon-Derivate und deren Verwendung als Anti-HIV-Mittel
公开(公告)号：EP2388250A1
公开(公告)日：2011-11-23
申请号：EP11176669.7
申请日：2006-10-13
申请人： UNIVERSITA DEGLI STUDI DI SIENA
发明人： Botta, Maurizio , Corelli, Federico , Petricci, Elena , Radi, Marco , Maga, Giovanni , Mai, Antonello
IPC分类号： C07D239/56 , A61K31/513 , A61P31/18
CPC分类号： C07D239/47 , C07D239/56
摘要： The invention relates to 4-pyrimidinone derivatives of formula V and the use thereof as medicaments in particular for the treatment of HIV infections, the use thereof for preparing pharmaceutical compositions and methods for the preparation thereof.

R 6 is -Y-R 7 or NR 4 R 5 ; Y = S, SO, SO 2 ; R 3 is aryl or aralkyl; R 8 is methyl.
摘要翻译：本发明涉及式Ⅴ的4-嘧啶酮衍生物及其作为特别用于治疗HIV感染的药物的用途，其用于制备药物组合物的用途及其制备方法。 R 6为-Y-R 7或NR 4 R 5; Y = S，SO，SO 2; R 3是芳基或芳烷基; R 8是甲基。

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