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51. 发明授权

US4671123A Methods and apparatus for pipetting and/or titrating liquids using a hand held self-contained automated pipette 失效
标题翻译：使用手持式自给式自动移液管移液和/或滴定液体的方法和设备
公开(公告)号：US4671123A
公开(公告)日：1987-06-09
申请号：US580587
申请日：1984-02-16
申请人： Haakon T. Magnussen, Jr. , Gary L. Smith , Stephen J. Ruskewicz , Anthony K. Wingo
发明人： Haakon T. Magnussen, Jr. , Gary L. Smith , Stephen J. Ruskewicz , Anthony K. Wingo
IPC分类号： B01L3/02 , G01N1/00 , G01N1/14
CPC分类号： B01L3/0227 , B01L2300/027 , Y10T436/116664 , Y10T436/25625 , Y10T436/2575
摘要： A hand held self-contained automated pipette for portable operation having an electrically operated digital linear actuator. The actuator preferably includes a stepper motor driving a rotor. A threaded screw is coaxially positioned within the rotor and is connected to an actuator shaft having elongate grooves slidable in a guide for preventing shaft rotation so that precise linear motion is imparted to the shaft. A pipetting displacement assembly having one of various sizes is removably attached for actuation by a common actuator including programmed movement of a displacing piston in a displacement cylinder to optimize air interface volume, neutralize variations in vacuum pipette effects, and provide an accommodated stroke and readout for improved accuracy while pipetting and/or titrating different ranges of volumes. A control circuit is provided so that the back EMF of the stepper motor coils is recirculated when power is duty-cycled off for power conservation. Conversely, recirculation is switched off when power is duty-cycled on for minimizing losses. Recirculation is switched off when coils are commutated which produces a rapid magnetic field collapse for assuring high torque. Upon calibration the piston undertakes immediate excursion to an end of travel limit and after motor slippage is retracted to a home position. This home position is chosen for optimum preservation of an air interface volume between drawn liquid and the piston tailored with particularity to the displacement assembly being used. Multiple precision modes including pipetting, multiple dispensing, titration, and dilution, are provided. Other features are also disclosed.
摘要翻译：手持式独立自动移液器，用于便携式操作，具有电动数字线性致动器。致动器优选地包括驱动转子的步进马达。螺纹螺杆同轴地定位在转子内并且连接到致动器轴，致动器轴具有可在引导件中滑动的细长槽，用于防止轴旋转，从而将准确的线性运动施加到轴上。具有各种尺寸之一的移液装置可移除地附接以用于通过公共致动器进行致动，该执行器包括位移缸中的置换活塞的编程移动，以优化空气界面体积，中和真空吸管效应的变化，并提供容纳的行程和读数在吸取和/或滴定不同体积范围时提高准确度。提供控制电路，使得当电力被关闭循环以进行功率节省时，步进电动机线圈的反电动势被再循环。相反，当为了使损耗最小化而在上电循环时，再循环被关闭。当线圈换向时，再循环关闭，产生快速的磁场塌陷以确保高扭矩。在校准后，活塞立即偏移到行程极限结束，并且电机滑动回缩到原始位置。选择该起始位置是为了最佳地保持拉伸液体和活塞之间的空气界面体积，特别适用于所使用的位移组件。提供了多种精确模式，包括移液，多次分配，滴定和稀释。还公开了其他特征。

52. 发明授权

US4616514A Replaceable tip assembly for pipette 失效
标题翻译：可移动的吸头组件
公开(公告)号：US4616514A
公开(公告)日：1986-10-14
申请号：US814535
申请日：1985-12-20
申请人： Haakon T. Magnussen, Jr. , Stephen J. Ruskewicz
发明人： Haakon T. Magnussen, Jr. , Stephen J. Ruskewicz
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/0279 , B01L3/0227 , Y10T403/7054 , Y10T403/7077
摘要： A pipette is disclosed which includes a pipette body, a tip locking mechanism, and a disposable pipette tip. The pipette body has a plunger which reciprocates into and out of an interior air filled chamber. This air forces a measured amount of liquid into or out of the tip. After pipetting, an over-stroke of the plunger discharges a blast of air to assure discharge of all the fluid. In one embodiment, a further over-stroke unlocks a mechanism holding the shell in place and actuates tip disposal and replacement. The shell surrounding the pipette body is depressed by the plunger shaft. Fingers formed from the lower end of the shell are pushed outward by cam action with the pipette body. As the fingers spread, the tip falls free. A replacement tip is then attached. The fingers also define a funnel which guides the replacement tip on to the point where it snaps into position. The spring biased shell and fingers apply a uniform force holding the tip against a gasket at the end of the pipette body, and the shell is again locked in place.
摘要翻译：公开了一种移液管，其包括移液管主体，尖端锁定机构和一次性吸头。移液管本体具有往往进入和离开内部充满气室的柱塞。这种空气迫使测量量的液体进入或流出尖端。在移液之后，柱塞的过冲冲排出空气，以确保排出所有流体。在一个实施例中，进一步的超行程解除将壳体保持在适当位置并致动尖端处置和更换的机构。围绕移液管主体的壳体被柱塞轴压下。从外壳的下端形成的手指通过吸液管本体的凸轮作用被向外推动。随着手指的传播，尖端掉落。然后连接更换提示。手指还限定了将替换尖端引导到其卡入到位的位置的漏斗。弹簧偏压的外壳和手指施加均匀的力，将尖端保持在移液管主体端部的垫圈上，并且外壳再次被锁定就位。

53. 发明授权

US4551249A Modular liquid chromatography column apparatus 失效
公开(公告)号：US4551249A
公开(公告)日：1985-11-05
申请号：US584611
申请日：1984-02-29
申请人： Carl L. Shackelford , Kenneth Rainin
发明人： Carl L. Shackelford , Kenneth Rainin
IPC分类号： B01D15/08 , G01N30/52 , G01N30/56 , G01N30/60
CPC分类号： G01N30/56 , G01N30/6021 , G01N30/6026 , G01N30/6039 , G01N2030/522 , G01N30/6004 , G01N30/6017
摘要： A chromatography column apparatus which utilizes sorbant material in a tube which has a first and second end portion. The first end portion of the tube includes a plug having a passage through the same. The plug fits in the same, adjacent the sorbant material, and is movable within the tube. An end fitting is also employed which has a portion that is placed within the tube adjacent the plug. The end fitting has a passage therethrough which communicates with the passage of the plug. A seal is used inside the tube between the plug and the end fitting. The end fitting and plug are held together. The second end portion of the tube is enclosed and also includes a passage from the interior to the exterior of the tube.

54. 外观设计

USD271239S Container and rack for pipette tips or similar article 失效
公开(公告)号：USD271239S
公开(公告)日：1983-11-01
申请号：US250139
申请日：1981-04-03
申请人： David J. Lemieux , Kenneth Rainin
设计人： David J. Lemieux , Kenneth Rainin

55. 发明授权

US6045757A Membrane filter pipette tip 失效
标题翻译：膜过滤器吸头
公开(公告)号：US6045757A
公开(公告)日：2000-04-04
申请号：US885450
申请日：1997-06-30
申请人： Kent G. Moriarty , James S. Petrek , Kenneth Rainin
发明人： Kent G. Moriarty , James S. Petrek , Kenneth Rainin
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0275 , G01N2035/1023
摘要： A membrane filter pipette tip comprising a hollow tube having a relatively large open upper end for seating on a lower end of a pipette tip mounting shaft of a pipette device and having a relatively small lower open end for passing fluid into the lower end of the tube upon operation of the pipette device in an aspiration mode. A porous membrane is secured by a porous plug within the tube across an open channel within the tube extending between the open upper and lower ends thereof and having a fluid initiation/penetration pressure which is greater than the maximum vacuum pressure which the pipette device to which the tube is secured is capable of generating.
摘要翻译：一种膜过滤器吸头，其包括具有相对较大的敞开的上端的中空管，用于放置在移液管装置的移液管末端安装轴的下端，并具有相对较小的下开口端，用于将流体流入管的下端在抽吸模式下操作移液器装置。多孔膜通过管内的多孔塞固定在管内的开放通道内，该通道在其开口的上端和下端之间延伸，并且具有大于最大真空压力的流体引发/穿透压力，吸管装置管被固定能够产生。

56. 发明授权

US6007779A Refill pack for pipette tip racks 失效
标题翻译：移液器吸头架的补充包装
公开(公告)号：US6007779A
公开(公告)日：1999-12-28
申请号：US819795
申请日：1997-03-18
申请人： David J. Lemieux , William D. Homberg , Christopher Kelly , Kent G. Moriarty
发明人： David J. Lemieux , William D. Homberg , Christopher Kelly , Kent G. Moriarty
IPC分类号： B01L9/00 , B65D71/70 , B01L3/02 , B65D55/00
CPC分类号： B65D71/70 , B01L9/543
摘要： A refill pack for storing and dispensing pipette tips into an empty tip rack. The refill rack comprises a hand-gripable carrier for an array of pipette tips releasably secured relative to the carrier such that after hand positioning the array of tips on the empty tip rack, the carrier may be released from the tips which are then free to be seated on a lower end of a pipette and removed from the tip rack.
摘要翻译：用于将移液管尖端存储和分配到空头架中的补充包装。再充填架包括用于可移动吸头阵列的可手动抓握的载体，该移液管尖端相对于载体可释放地固定，使得将手尖阵列手动定位在空的末端齿条上之后，载体可以从尖端释放，坐在移液器的下端并从尖端架上取下。

57. 发明授权

US5849248A Adjustable volume pipette with improved volume adjustment lock mechanism 失效
标题翻译：可调节体积移液器，具有改进的音量调节锁定机构
公开(公告)号：US5849248A
公开(公告)日：1998-12-15
申请号：US611074
申请日：1996-03-05
申请人： William D. Homberg
发明人： William D. Homberg
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/0224 , B01L2300/026
摘要： A volume adjustable pipette for aspirating and dispensing precise volumes of liquid comprising an elongated hollow hand-holdable housing supporting a plunger for turning and for axial movement within the housing the pipette including (i) an upper stop which is axially adjustable within the housing in response to a turning of the plunger to adjust the volume of liquid which may be drawn into a tip secured to a lower end of the housing upon upward axial movement of the plunger to the upper stop and (ii) a manually actuated lock mechanism for locking the plunger against rotation to set the volume adjustment for the pipette and comprising a hand-turnable knob for actuating and releasing the lock mechanism by virtue of two thumb and/or finger engageable wings extending outwardly from diametrically opposite sides of the hand-turnable knob a gripping member for fixedly securing the plunger against turning and being actuated by a turning of the hand-turnable knob to force a cam surface of the knob against a cam surface of the gripping member.
摘要翻译：一种用于抽吸和分配精确体积的液体的体积可调吸管，包括细长的中空手持式壳体，其支撑用于转动的柱塞并且用于在所述壳体内的轴向移动，所述移液管包括（i）响应于轴向可调节的壳体内的上止动件到柱塞的转动以调节液体的体积，以便当柱塞向上止动件向上轴向移动时，该液体的体积可以被拉入到固定到壳体的下端的末端中，以及（ii）手动致动的锁定机构，用于锁定柱塞抵抗旋转以设定用于移液管的体积调节，并且包括用于通过从手动转动旋钮的径向相对侧向外延伸的两个拇指和/或手指接合翼来致动和释放锁定机构的手动转动旋钮，用于固定地固定柱塞以防转动并通过手动转动旋钮的转动来致动的部件，以迫使柱塞的凸轮表面旋钮抵靠夹持构件的凸轮表面。

58. 发明授权

US5792424A Manual pipette with delayed-action home position latch 失效
标题翻译：手动移液器，带有延迟动作原位置锁存器
公开(公告)号：US5792424A
公开(公告)日：1998-08-11
申请号：US658862
申请日：1996-08-15
申请人： William D. Homberg , Christopher Kelly , Kenneth Rainin , Haakon T. Magnussen, Jr.
发明人： William D. Homberg , Christopher Kelly , Kenneth Rainin , Haakon T. Magnussen, Jr.
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/0224 , B01L2300/026 , Y10T436/2575
摘要： A manual pipette including a delayed action home position latch for engaging only after the plunger unit of the pipette has moved downward through its home position to thereafter releasably connect a moveable bottom stop member to the plunger unit to move therewith and upon an upward return of the plunger unit by the pipette's return spring to engage a home position stop to releasably lock the plunger unit in its home position without any downward force being exerted by the pipette user on the plunger unit.
摘要翻译：手动移液器包括用于仅在移液管的柱塞单元之后接合的延迟动作原位锁定器已经向下移动通过其原始位置，此后将可移动的底部止动构件可释放地连接到柱塞单元以随之移动，并且在向上返回时柱塞单元通过移液管的复位弹簧接合原位置止动件以可释放地将柱塞单元锁定在其原始位置，而没有由移液管使用者施加在柱塞单元上的任何向下的力。

59. 发明授权

US5642816A Pipette tip rack refill plate hold down apparatus 失效
标题翻译：移液器支架机架补充板压紧装置
公开(公告)号：US5642816A
公开(公告)日：1997-07-01
申请号：US548233
申请日：1995-10-25
申请人： Christopher Kelly , Kenneth Rainin
发明人： Christopher Kelly , Kenneth Rainin
IPC分类号： B65D85/00 , B01L9/00 , A47F7/00
CPC分类号： B01L9/543
摘要： A reusable pipette tip rack for successively receiving and dispensing arrays of pipette tips and including a manually releasable latch mechanism for securing a support plate carrying an array of pipette tips flat on the top of a support tray of the pipette tip rack with the array of tips seated in an array of openings in the top of the support tray. The latch mechanism comprises a latch including a laterally extending locking surface on one of the support plate or the support tray and a manually releasable locking member extending from the other of the support plate or the support tray. Preferably, the latch mechanism comprises a combination of two such latches each including a locking member and locking surface located at opposite edges of the support tray of the pipette tip rack.
摘要翻译：一种用于连续地接收和分配移液管尖端阵列的可重复使用的移液管末端架，并且包括可手动释放的闩锁机构，用于将携带移液管尖端的平面的支撑板平坦地固定在移液管末端架的支撑托盘的顶部上，坐在支撑盘顶部的开口阵列中。闩锁机构包括闩锁，其包括在支撑板或支撑托盘中的一个上的横向延伸的锁定表面和从支撑板或支撑托盘中的另一个延伸的可手动释放的锁定构件。优选地，闩锁机构包括两个这样的闩锁的组合，每个闩锁包括锁定构件和位于移液管末端支架的支撑托盘的相对边缘处的锁定表面。

60. 发明授权

US5441702A Refill pack for pipette tip racks 失效
标题翻译：移液器吸头架的补充包装
公开(公告)号：US5441702A
公开(公告)日：1995-08-15
申请号：US125019
申请日：1993-09-21
申请人： David J. Lemieux , Paul K. Chadwick , Christopher Kelly , James S. Petrek , Kenneth Rainin , Haakon T. Magnussen, Jr. , William D. Homberg
发明人： David J. Lemieux , Paul K. Chadwick , Christopher Kelly , James S. Petrek , Kenneth Rainin , Haakon T. Magnussen, Jr. , William D. Homberg
IPC分类号： B01L9/00 , B65D71/70 , B01L3/02 , B65D1/34 , B65D55/00
CPC分类号： B65D71/70 , B01L9/543
摘要： A refill pack for storing and dispensing pipette tips into a tip rack, comprising a support plate with an array of holes containing disposable pipette tips arranged in an organized array and a carrier for hand positioning the support plate over the tip rack for release of the array of pipette tips into the tip rack.
摘要翻译：一种用于将移液管尖端存储并分配到尖端架中的补充包，包括具有排列成有组织阵列的一次性移液管尖端的孔阵列的支撑板和用于将支撑板手指定位在尖端齿条上用于释放阵列的载体的移液器尖端进入尖端架。

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