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51. 发明申请

WO2021205403A1 ENDOXIFEN FOR THE TREATMENT OF BIPOLAR I DISORDER 审中-公开
公开(公告)号：WO2021205403A1
公开(公告)日：2021-10-14
申请号：PCT/IB2021/052971
申请日：2021-04-09
申请人： JINA PHARMACEUTICALS, INC.
发明人： AHMAD, Ateeq , AHMAD, Imran , AHMAD, Moghisuddin , ALI, Shoukath M , SHEIKH, Saifuddin
IPC分类号： A61K31/138 , A61P25/18 , A61K33/14 , A61K31/20 , A61K31/55
摘要： A method for managing or decreasing a risk of suicidal behaviour in a patient undergoing treatment of bipolar I disorder is provided. The said method includes maintaining the therapeutically effective concentration of endoxifen by administrating a dose of 2 mg to 16 mg of endoxifen citrate in an enteric coated tablet once per day for at least 21 days.

52. 发明申请

WO2008127358A3 AQUEOUS SYSTEMS FOR THE PREPARATION OF LIPID-BASED PHARMACEUTICAL COMPOUNDS; COMPOSITIONS, METHODS, AND USES THEREOF 审中-公开
标题翻译：用于制备基于脂质的药物化合物的水性体系; 组合物，方法及其用途
公开(公告)号：WO2008127358A3
公开(公告)日：2008-12-24
申请号：PCT/US2007080984
申请日：2007-10-10
申请人： JINA PHARMACEUTICALS INC , ALI SHOUKATH M , AHMAD MOGHIS U , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
发明人： ALI SHOUKATH M , AHMAD MOGHIS U , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1617 , A61K9/1682 , A61K9/19 , A61K9/5123 , A61K31/337 , A61K31/436 , A61K31/704 , A61K31/7048 , A61K47/10 , A61K47/24 , A61K47/541 , A61K47/554
摘要： The present invention relates to a methods of preparing active compounds complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention comprises a composition comprising a complex comprising at least one active compound, e.g., a polyene antibiotic, an immunosuppressant agent such as tacrolimus or a taxane or taxane derivative, and one or more lipids. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising at least one active compound and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.
摘要翻译：本发明涉及使用不含有机溶剂的水性体系制备与脂质复合的活性化合物的方法，以及使用复合物例如治疗受试者疾病的方法。在一些实施方案中，本发明包含包含至少一种活性化合物，例如多烯抗生素，免疫抑制剂如他克莫司或紫杉烷或紫杉烷衍生物的复合物和一种或多种脂质的组合物。在一些实施方案中，本发明提供了一种方法，其包括制备包含至少一种活性化合物和至少一种脂质的脂质复合物并将组合物给予受试者的组合物。在某些实施方案中，受试者是哺乳动物。在某些优选实施方案中，受试者是人。

53. 发明申请

WO2008127358A2 AQUEOUS SYSTEMS FOR THE PREPARATION OF LIPID-BASED PHARMACEUTICAL COMPOUNDS; COMPOSITIONS, METHODS, AND USES THEREOF 审中-公开
标题翻译：用于制备基于脂质的药物化合物的水性体系; 组合物，方法和用途
公开(公告)号：WO2008127358A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/080984
申请日：2007-10-10
申请人： JINA PHARMACEUTICALS, INC. , ALI, Shoukath, M. , AHMAD, Moghis, U. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
发明人： ALI, Shoukath, M. , AHMAD, Moghis, U. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1617 , A61K9/1682 , A61K9/19 , A61K9/5123 , A61K31/337 , A61K31/436 , A61K31/704 , A61K31/7048 , A61K47/10 , A61K47/24 , A61K47/541 , A61K47/554 , Y02A50/409
摘要： The present invention relates to a methods of preparing active compounds complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention comprises a composition comprising a complex comprising at least one active compound, e.g., a polyene antibiotic, an immunosuppressant agent such as tacrolimus or a taxane or taxane derivative, and one or more lipids. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising at least one active compound and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.
摘要翻译：本发明涉及使用不含有机溶剂的水性体系制备与脂质络合的活性化合物的方法，以及使用该络合物的方法，例如用于治疗受试者中的疾病的方法。在一些实施方案中，本发明包含组合物，其包含含有至少一种活性化合物（例如多烯抗生素），免疫抑制剂（例如他克莫司或紫杉烷或紫杉烷衍生物）和一种或多种脂质的复合物。在一些实施方案中，本发明提供一种方法，其包括制备包含脂质复合物的组合物，所述脂质复合物包含至少一种活性化合物和至少一种脂质，并将所述组合物施用于受试者在某些实施方案中，受试者是哺乳动物。在某些优选的实施方案中，受试者是人。

54. 发明公开

EP3681484A2 METHODS OF PREPARING COMPOSITIONS CONTAINING THYMOQUINONE 审中-实审
公开(公告)号：EP3681484A2
公开(公告)日：2020-07-22
申请号：EP18855389.5
申请日：2018-09-12
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath M. , SHEIKH, Saifuddin , AHMAD, Ateeq , AHMAD, Moghis U. , CHEN, Paul , AHMAD, Imran
IPC分类号： A61K9/20

55. 发明公开

EP2088865A4 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 有权
标题翻译： GUGGULPHOSPHOLIPID的方法和组合物
公开(公告)号：EP2088865A4
公开(公告)日：2010-03-17
申请号：EP07864003
申请日：2007-11-06
申请人： JINA PHARMACEUTICALS INC
发明人： AHMAD MOGHIS U , ALI SHOUKATH M , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A01N65/00 , A61K36/328 , C07J7/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J51/00
CPC分类号： C07J13/007 , A61K31/337 , A61K47/554 , A61K47/6907 , A61K47/6911 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0088 , C07J51/00 , C12N15/85

56. 发明公开

EP2432462A4 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES 审中-公开
标题翻译：因多昔芬组合物和方法处理哺乳动物疾病
公开(公告)号：EP2432462A4
公开(公告)日：2013-11-13
申请号：EP10778503
申请日：2010-05-21
申请人： JINA PHARMACEUTICALS INC
发明人： AHMAD ATEEQ , ALI SHOUKATH M , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K31/135 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/19 , A61K31/138 , A61P25/00 , A61P25/28
CPC分类号： A61K9/06 , A61K9/0014 , A61K9/08 , A61K9/19 , A61K31/138
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of a subject having or at risk for psychiatric and neurodegenerative diseases. Specifically, the present invention relates to the composition comprising endoxifen in the treatment of bipolar disorder, schizophrenia, multiple sclerosis (MS), Alzheimer disease, Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), and/or epilepsy by administrating formulations or compositions comprising an effective amount of endoxifen.

57. 发明公开

EP2344198A2 LIPID BASED PHARMACEUTICAL PREPARATIONS FOR ORAL AND TOPICAL APPLICATION; THEIR COMPOSITIONS, METHODS, AND USES THEREOF 有权转让
标题翻译：药物制剂脂质基础口服和外用给药，组合物THEREOF AND METHOD FOR USE
公开(公告)号：EP2344198A2
公开(公告)日：2011-07-20
申请号：EP09816940.2
申请日：2009-09-25
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K47/44 , A61P17/14 , A61K31/58 , A61K31/506
摘要： The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases. The present invention provides a method of preparation of a composition comprising at least one active compound and at least one lipid and administering the composition to a subject by oral or topical delivery. In certain embodiments the subject is a mammal. In certain preferred embodiment, the subject is human.
摘要翻译：本发明涉及包含一种或多种活性剂用于在受试者中治疗疾病或症状的组合物的局部和口服递送。在一些实施方案中，本发明包括一种组合物，其包含至少一种活性化合物，E. G.，非那雄胺或米诺地尔，和一种或多种脂质。在一些实施方案中，本发明涉及制备组合物和方法，用于治疗雄激素性脱发（AGA），预防脱发和女性多毛症的。在一些实施方案中，本发明包括非那雄胺和良性前列腺增生症的治疗中的至少一种脂质组分。在一些实施方案中，本发明包括他克莫司或两性霉素B和用于皮肤或眼睛有关的疾病的治疗中的至少一种脂质组分。本发明提供了制备包含至少一种活性化合物和至少一种脂质和通过口服或局部递送施用组合物至受试者的组合物的方法。在某些实施方案中，受试者是哺乳动物。在某些优选的实施方案中，受试者是人。

58. 发明公开

EP2101731A2 ENDOXIFEN METHODS AND COMPOSITIONS 有权
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGEN MIT ENDOXIFEN
公开(公告)号：EP2101731A2
公开(公告)日：2009-09-23
申请号：EP07871563.8
申请日：2007-11-21
申请人： Jina Pharmaceuticals Inc.
发明人： AHMAD, Ateeq , ALI, Shoukath M. , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/127 , A61K9/12
CPC分类号： A61K31/138 , A61K9/0014 , A61K9/127 , A61K9/19 , A61K31/35 , C07D309/10
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E- guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.
摘要翻译：本发明提供含有内皮素的内含物，制剂和脂质体的组合物，这些药剂和制剂的制备方法，以及这些药剂和制剂用于治疗乳腺癌和其它乳腺疾病和易受内皮素影响的疾病的用途。特别地，本发明的组合物包括脂质体，复合物，囊泡，乳液，胶束和内皮素的混合胶束，其中所述组合物还含有多种中性或带电荷的脂质，并且期望地，胆固醇和胆固醇衍生物，甾醇，Z - 和 - 福古酮，磷脂，脂肪酸，维生素D和维生素E.本发明还提供了内皮素的制备方法。本发明提供了通过施用包含治疗有效量的内皮素的新制剂或组合物来治疗和预防乳腺癌和其它乳腺相关疾病的方法。

59. 发明授权

EP2101731B1 ENDOXIFEN FOR USE IN THE TREATMENT OF CANCER 有权
标题翻译： ENDOXIFEN用于治疗癌症
公开(公告)号：EP2101731B1
公开(公告)日：2018-01-31
申请号：EP07871563.8
申请日：2007-11-21
申请人： Jina Pharmaceuticals Inc.
发明人： AHMAD, Ateeq , ALI, Shoukath M. , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/00 , A61K9/127 , A61K9/19 , A61K31/138 , A61K31/35 , C07D309/10 , A61P35/00
CPC分类号： A61K31/138 , A61K9/0014 , A61K9/127 , A61K9/19 , A61K31/35 , C07D309/10
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

60. 发明授权

EP2076244B1 AQUEOUS SYSTEMS FOR THE PREPARATION OF LIPID-BASED PHARMACEUTICAL COMPOUNDS; COMPOSITIONS, METHODS, AND USES THEREOF 有权
标题翻译：水性体系中医药化合物对基于脂肪，组合物，方法和使用的制备
公开(公告)号：EP2076244B1
公开(公告)日：2016-12-07
申请号：EP07873522.2
申请日：2007-10-10
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath, M. , AHMAD, Moghis, U. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/127 , A61K9/19 , A61K9/00 , A61K47/48 , A61K9/51
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1617 , A61K9/1682 , A61K9/19 , A61K9/5123 , A61K31/337 , A61K31/436 , A61K31/704 , A61K31/7048 , A61K47/10 , A61K47/24 , A61K47/541 , A61K47/554 , Y02A50/409
摘要： The present invention relates to a methods of preparing active compounds complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention comprises a composition comprising a complex comprising at least one active compound, e.g., a polyene antibiotic, an immunosuppressant agent such as tacrolimus or a taxane or taxane derivative, and one or more lipids. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising at least one active compound and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.

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