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51. 发明申请

US20080153879A1 METHOD OF MANAGING OR TREATING PAIN 有权
标题翻译：管理或治疗疼痛的方法
公开(公告)号：US20080153879A1
公开(公告)日：2008-06-26
申请号：US12047388
申请日：2008-03-13
申请人： Peter James Watts , Jonathan David Castile , William Columbus Ian Lafferty , Alan Smith
发明人： Peter James Watts , Jonathan David Castile , William Columbus Ian Lafferty , Alan Smith
IPC分类号： A61K31/445 , A61P29/00
CPC分类号： A61K31/4468 , A61K9/0043 , A61K47/26 , A61K47/36 , A61M11/00 , A61M15/08
摘要： A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii)a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要翻译：用于向动物鼻内递送芬太尼或其药学上可接受的盐的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂：（i）果胶和（ii）泊洛沙姆和壳聚糖或其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与相同剂量的鼻内施用的芬太尼的简单水溶液相比，提供芬太尼（C max max）的峰值血浆浓度为10至80％，其使用简单的芬太尼水溶液以相同的芬太尼剂量鼻内给药。还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。

52. 发明授权

US07323183B2 Vaccine compositions including chitosan for intranasal administration and use thereof 失效
标题翻译：疫苗组合物，包括用于鼻内给药的壳聚糖及其用途
公开(公告)号：US07323183B2
公开(公告)日：2008-01-29
申请号：US10141312
申请日：2002-05-08
申请人： Lisbeth Illum , Steven Neville Chatfield
发明人： Lisbeth Illum , Steven Neville Chatfield
IPC分类号： A61K47/00
CPC分类号： A61K39/39 , A61K2039/543 , A61K2039/55583 , A61K2039/55588
摘要： There is provided vaccine compositions for intranasal administration, which compositions comprise one or more antigens and an effective adjuvant amount of a chitosan.
摘要翻译：提供了用于鼻内给药的疫苗组合物，该组合物包含一种或多种抗原和有效佐剂量的壳聚糖。

53. 发明申请

US20070231269A1 Analgesics 审中-公开
标题翻译：止痛药
公开(公告)号：US20070231269A1
公开(公告)日：2007-10-04
申请号：US11798384
申请日：2007-05-14
申请人： Phillip Birch , Ann Hayes , Peter Watts , Jonathan Castile
发明人： Phillip Birch , Ann Hayes , Peter Watts , Jonathan Castile
IPC分类号： A61K9/00 , A61K47/34 , A61K47/36 , A61K47/38
CPC分类号： A61K31/407 , A61K9/0043 , A61K31/195 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/54 , A61K31/5415 , A61K47/34 , A61K47/36 , A61K47/38
摘要： An analgesic and a delivery agent are combined in a pharmaceutical composition such that, on introduction into the nasal cavity of a patient to be treated, the analgesic may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration, Cther, of 0.2 ng/ml or greater which is maintained for a duration Tmaint of at least 2 hours. The analgesic may be an opioid analgesic or a non-steroidal anti-inflammatory drug.
摘要翻译：镇痛剂和递送剂组合在药物组合物中，使得在引入待治疗的患者的鼻腔中时，止痛剂可以在30分钟内递送到血流中以在治疗血浆浓度C < 其为0.2ng / ml或更大，其维持持续时间为至少2小时。止痛剂可以是阿片样镇痛药或非甾体抗炎药。

54. 发明申请

US20070140981A1 Intranasal compositions 失效
标题翻译：鼻内成分
公开(公告)号：US20070140981A1
公开(公告)日：2007-06-21
申请号：US10596817
申请日：2004-12-23
申请人： Jonathan Castile , Yu-Hui Cheng , Paul Jenkins , Alan Smith , Peter Watts
发明人： Jonathan Castile , Yu-Hui Cheng , Paul Jenkins , Alan Smith , Peter Watts
IPC分类号： A61K9/14 , A61K31/4745
CPC分类号： B82Y5/00 , A61K9/0043 , A61K9/1623 , A61K9/1652 , A61K31/4184 , A61K47/36 , A61K47/40 , A61K47/6951 , Y10S514/923
摘要： The present invention provides compositions for the intranasal administration of zolpidem or a pharmaceutically acceptable salt thereof. Preferred compositions of the invention are in the form of aqueous solutions. Optionally the compositions of the invention comprise a cyclodextrin and/or chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention insomnia or the treatment of neurological disorders such as those arising from brain trauma, stroke and spinocerebellar ataxia or in the treatment of Parkinson's disease.
摘要翻译：本发明提供了用于鼻内施用唑吡旦或其药学上可接受的盐的组合物。本发明的优选组合物是水溶液的形式。任选地，本发明的组合物包含环糊精和/或壳聚糖，其盐或衍生物或壳聚糖衍生物的盐。该组合物可用于治疗或预防失眠或治疗诸如由脑创伤，中风和脊髓小脑共济失调引起的神经障碍或治疗帕金森病。

55. 发明公开

EP2670674A1 IMPROVED CONTAINER 有权转让
标题翻译：改进的容器
公开(公告)号：EP2670674A1
公开(公告)日：2013-12-11
申请号：EP12701771.3
申请日：2012-01-26
申请人： Archimedes Development Limited
发明人： WALSH, Philip , WATTS, Peter
IPC分类号： B65D1/02 , B65D41/34 , B65D50/04 , B65D55/02
CPC分类号： B65D39/10 , B65D1/0246 , B65D41/3404 , B65D50/046 , B65D55/022
摘要： A container (100), comprising a thread (120) arranged around an opening (110) for engaging a corresponding thread (120) of a closure (400), more than four retention members (140) arranged around the opening (110), each retention member (140) having an end-face for abutting a member (510) on an interior surface of the closure (400) to impede unthreading of the closure (400), the retention members (140) being arranged such that a tangent (170) to each end-face of the retention members (140) intersects a plane (160, 350) bisecting the container (100) at an obtuse angle (171), wherein the retention members (140) are arranged in first and second groups, the first group (141, 410) comprising one retention member (140) having an end-face substantially parallel to the plane bisecting the container (100), and the second group (142, 420) comprising two or more retention members (140), the first and second groups being arranged on one side of the plane (160, 350), each in a respective quadrant of the container (100), the teeth of the second group (142, 420) have a first inter-tooth spacing, and a second inter-tooth spacing is provided between an end-face of the retention member of the first group (141, 410) and a first retention member of the second group (142, 420), and the second inter-tooth spacing is larger than the first inter-tooth spacing.

56. 发明授权

EP1641434B1 PHARMACEUTICAL FORMULATIONS FOR INTRANASAL ADMINISTRATION OF PROTEIN COMPRISING CHITOSAN OR A DERIVATIVE THEREOF 有权
标题翻译：配药设备鼻腔给药的含蛋白质的壳聚糖或任意衍生物
公开(公告)号：EP1641434B1
公开(公告)日：2008-12-17
申请号：EP04743222.4
申请日：2004-07-02
申请人： Archimedes Development Limited
发明人： DYER, Ann Margaret Clinical Res. Ctre. Limited , WATTS, Peter James Clinical Res. Ctre. Limited , CHENG, Yu-Hui Clinical Res. Ctre. Limited , SMITH, Alan Clinical Res. Ctre Limited
IPC分类号： A61K9/00 , A61K38/27 , A61P43/00
CPC分类号： A61K9/0043 , A61K9/1652 , A61K38/27 , A61K47/36 , Y10S514/951
摘要： There is provided a powder formulation for nasal delivery comprising a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth hormone.

57. 发明公开

EP1701742A2 INTRANASAL COMPOSITIONS COMPRISING ZOLPIDEM 审中-公开
标题翻译：鼻内唑吡坦组合物
公开(公告)号：EP1701742A2
公开(公告)日：2006-09-20
申请号：EP04806240.0
申请日：2004-12-23
申请人： Archimedes Development Limited
发明人： CASTILE, J. D., West Pharm. Research Centre Ltd. , CHENG, Y.-H., West Pharm. Research Centre Ltd. , JENKINS, P. G., West Pharm. Research Centre Ltd. , SMITH, Alan, West Pharm. Research Centre Ltd. , WATTS, P. J., West Pharm. Research Centre Ltd.
IPC分类号： A61K47/40 , A61K47/36 , A61K9/16
CPC分类号： B82Y5/00 , A61K9/0043 , A61K9/1623 , A61K9/1652 , A61K31/4184 , A61K47/36 , A61K47/40 , A61K47/6951 , Y10S514/923
摘要： The present invention provides compositions for the intranasal administration of zolpidem or a pharmaceutically acceptable salt thereof. Preferred compositions of the invention are in the form of aqueous solutions. Optionally the compositions of the invention comprise a cyclodextrin and/or chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention insomnia or the treatment of neurological disorders such as those arising from brain trauma, stroke and spinocerebellar ataxia or in the treatment of Parkinson's disease.

58. 发明公开

EP1622601A1 PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：药物制剂
公开(公告)号：EP1622601A1
公开(公告)日：2006-02-08
申请号：EP04732650.9
申请日：2004-05-13
申请人： Archimedes Development Limited
发明人： LEANE, Michael , SMITH, Alan, Archimedes, Albert Einstein Centre , ILLUM, Lisbeth
IPC分类号： A61K31/19 , A61K31/722 , A61K9/00
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/205 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/722 , A61K38/00
摘要： The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.

59. 发明授权

EP1035833B1 COMPOSITIONS FOR NASAL ADMINISTRATION 有权
标题翻译：组合物鼻腔给药的
公开(公告)号：EP1035833B1
公开(公告)日：2005-08-31
申请号：EP98955814.3
申请日：1998-11-27
申请人： Archimedes Development Limited
发明人： ILLUM, Lisbeth , WATTS, Peter, James
IPC分类号： A61K9/00 , A61K47/48 , A61P15/10 , A61P25/16
CPC分类号： A61K9/0043 , A61K47/61
摘要： There is provided a composition for the nasal delivery of a drug suitable for the treatment of erectil dysfunction to a mammal wherein the composition is adapted to provide an initial rise in plasma level followed by a sustained plasma level of the drug.

60. 发明公开

EP2340072A1 A DEVICE FOR ADMINISTERING LIQUID ANALGESICS 有权转让
标题翻译： VORRICHTUNG ZUR VERABREICHUNG VON ANALGETIKA
公开(公告)号：EP2340072A1
公开(公告)日：2011-07-06
申请号：EP09740918.9
申请日：2009-09-28
申请人： Archimedes Development Limited
发明人： CASTILE, Jonathan , WATTS, Peter , SMITH, Alan
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0073
摘要： In the field of pain relief and treatment there is a need for a device which is able to administer several predetermined doses of an opioid analgesic in a manner which can be done simply and safely by a patient or carer; in particular in a manner which minimises the risk of administering too great a dose at any one time. A device (10), for administering a predefined number (N) of predefined volume unit doses (Vu) of an opioid analgesic in liquid form, includes a closed container (12) which contains a predetermined fill volume (Vf) of the opioid analgesic, and a dispenser (14) that is connected to the container (12). The dispenser (14) is operable to administer an individual one volume unit dose (Vu) repeatedly said predefined number of times (N). Both the dispenser (14) is adapted, and the concentration of said opioid analgesic is chosen such that said volume unit dose is in the range 0.05 to 0.15 ml.
摘要翻译：在疼痛缓解和治疗领域中，需要能够以可由患者或护理人员简单而安全地进行的方式施用若干预定剂量的阿片类止痛剂的装置; 特别是以最小化在任何一个时间施用太大剂量的风险的方式。用于施用液体形式的阿片样镇痛剂的预定数量（N）预定体积单位剂量（Vu）的装置（10）包括封闭的容器（12），其包含所述阿片样镇痛剂的预定填充体积（Vf）和连接到容器（12）的分配器（14）。分配器（14）可操作以重复地施加单独的一个体积单位剂量（Vu）所述预定次数（N）。适配分配器（14），并且选择所述阿片类镇痛剂的浓度使得所述体积单位剂量在0.05至0.15ml的范围内。

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