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41. 发明申请

WO01021297A1 POLYDISPERSE DOUBLE EMULSION, CORRESPONDING MONODISPERSE DOUBLE EMULSION AND METHOD FOR PREPARING THE MONODISPERSE EMULSION 审中-公开
标题翻译：多相乳液，相应的单相乳液和单体乳液的制备方法
公开(公告)号：WO01021297A1
公开(公告)日：2001-03-29
申请号：PCT/FR2000/002434
申请日：2000-09-04
IPC分类号： A61K9/113 , A61K8/00 , A61K8/06 , A61K8/60 , A61K8/72 , A61K8/73 , A61K8/86 , A61K47/26 , A61K47/34 , A61K47/36 , A61Q1/00 , A61Q1/02 , B01F17/00 , B01F17/42 , B01J13/00
CPC分类号： B01F17/0021 , B01F17/0028 , Y10S516/929 , Y10S516/93
摘要： The invention concerns a fractionable polydisperse stable double oil-in-water emulsion, consisting of 50 to 95 wt.%, relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase; the continuous aqueous phase comprising a polysaccharide thickening agent in a proportion of 1 to 10 wt.% relative to the total weight of the continuous aqueous phase; a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant; and an osmotic pressure balancing agent; the emulsion Ei having a viscosity not higher than the viscosity of the continuous aqueous phase and consisting of 50 to 95 wt.%, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase; the internal aqueous phase comprising at least an active hydrophilic substance; the oily phase comprising polyglycerol polyricinoleate as surfactant. The invention further concerns the corresponding monodisperse double emulsion of the same formulation and the method for preparing it starting from the claimed polydisperse double emulsion.
摘要翻译：本发明涉及可分散的多分散稳定的双重水包油乳液，其相对于双重乳液的总重量为50-95重量％，分散在连续水相中的反转单分散乳液Ei的液滴; 所述连续水相包含相对于连续水相的总重量为1至10重量％的比例的多糖增稠剂; 水溶性环氧乙烷和环氧丙烷嵌段共聚物作为表面活性剂; 和渗透压平衡剂; 乳液Ei的粘度不高于连续水相的粘度，相对于分散在油相中的内部水相的Ei的总重量的50重量％至95重量％组成。所述内部水相包含至少一种活性亲水物质; 油相包含聚甘油聚蓖麻油酸酯作为表面活性剂。本发明还涉及相应制剂的相应的单分散双乳液以及从所要求保护的多分散双乳液开始制备方法。

42. 发明申请

WO1994028939A1 EMULSIONS AS CONTRAST AGENTS AND METHOD OF USE 审中-公开
标题翻译：乳剂作为对照剂和使用方法
公开(公告)号：WO1994028939A1
公开(公告)日：1994-12-22
申请号：PCT/US1994005965
申请日：1994-05-26
申请人： MOLECULAR BIOSYSTEMS, INC.
发明人： MOLECULAR BIOSYSTEMS, INC. , LOHRMANN, Rolf , WIDDER, Kenneth, J. , KRISHNAN, Ashwin, M. , HONG, Dung, K. , MENG, Jialun
IPC分类号： A61K49/00
CPC分类号： A61K49/226 , A61K49/223 , Y10S516/929
摘要： This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer, the emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site-specific imaging as the image-enhancing bubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.
摘要翻译：本发明涉及一种水不溶性气体形成化学品和稳定剂的水包油乳液，该乳液能够在施加超声波能量时形成气体微泡。该组合物允许进行位置特异性成像，因为在需要图像的特定位置处施加超声波能量时可以释放图像增强气泡。

43. 发明申请

WO1993000156A1 MONODISPERSE SINGLE AND DOUBLE EMULSIONS AND PRODUCTION THEREOF 审中-公开
标题翻译：单一和双重乳液及其生产
公开(公告)号：WO1993000156A1
公开(公告)日：1993-01-07
申请号：PCT/JP1991000882
申请日：1991-06-29
申请人： MIYAZAKI-KEN
发明人： MIYAZAKI-KEN , NAKASHIMA, Tadao , SHIMIZU, Masataka , KUKIZAKI, Masato
IPC分类号： B01F03/08
CPC分类号： B01F5/0476 , B01F3/0811 , B01F5/106 , B01F2003/0838 , Y10S516/929
摘要： A monodisperse single emulsion containing particles with a mean diameter within the range of 0.3 to 40 mu m and being substantially free from particles with a diameter as small as 50 % of the mean diameter or less; and a monodisperse double emulsion containing particles with a mean diameter within the range of 0.3 to 40 mu m and an internal phase concentration which is substantially uniformly regulated to be within the range of 1 to 70 %.
摘要翻译：含有平均直径在0.3〜40μm范围内的颗粒并且基本上不含直径小于平均直径的50％或更小的颗粒的单分散单一乳液; 以及含有平均粒径在0.3〜40μm范围内且内相浓度基本均匀调节至1〜70％范围内的单分散双乳液。

44. 发明公开

EP1306083A4 EMULSION OF PERFLUORORGANIC COMPOUNDS FOR MEDICAL PURPOSES, METHOD FOR PRODUCING SAID EMULSION AND METHODS FOR CURING AND PREVENTING DISEASES WITH THE AID OF THE EMULSION 审中-公开
标题翻译：有机FLUOR含乳剂用于医疗目的，方法及其和方法的治疗与预防疾病THROUGH这种乳液
公开(公告)号：EP1306083A4
公开(公告)日：2007-08-29
申请号：EP00970349
申请日：2000-07-20
申请人： PERFTORAN WEST LTD
发明人： MAEVSKY EVGENY ILIICH , IVANITSKY GENRIKH ROMANOVICH , MAKAROV KIRILL NIKOLAEVICH , KULAKOVA GALINA MIKHAILOVNA , ARKHIPOV VLADIMIR VIKTOROVICH , MOROZ VIKTOR VASILIEVICH , STAROVOITOVA LJUDMILA NIKOLAEV , SENINA RAISA YAKOVLEVNA , PUSHKIN SERGEI JURIEVICH , IVASHINA ALBINA IVANOVNA
IPC分类号： C07D295/06 , A61K9/00 , A61K9/10 , A61K9/107 , A61K31/02 , A61K31/025 , A61K31/13 , A61K31/402 , A61K31/445 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/42 , A61K45/06 , A61K47/04 , A61K47/26 , A61K47/34 , A61P7/00 , A61P7/08 , A61P9/08 , A61P9/10 , B01F3/08 , B01F17/42
CPC分类号： A61K9/0026 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/42 , A61K45/06 , Y10S514/824 , Y10S514/832 , Y10S514/833 , Y10S516/929 , A61K2300/00
摘要： The inventive emulsion of perfluororganic compounds (PFOC) has gas-transport properties, used for intravascular injection and comprises perfluorocarbon which is easy to remove from an organism, and perfluortertiary amine which is hard to remove from an organism, in addition to not less than three PFOC additives which are chosen in small quantities. Said additives are close to the main components with respect to the structure and physical and chemical properties thereof, and produce a range of PFOC having gradually fluctuating properties. Said emulsion also comprises minor additives of perfluoroalcane. The composition determines the stability of the emulsion during storage and in the blood flow, in addition to low viscosity of the PFOC emulsion, thereby providing a high dynamic oxygen capacity of the preparation and improving the supply of oxygen to tissues. In order to produce the emulsion, the stabilising agent is heated at a temperature of up to 75 °C. All components are saturated with carbon dioxide and homogenisation is carried out when the carbon dioxide is injected, thereby minimising the occurrence of peroxides and reducing reactogenicity.

45. 发明公开

EP1306083A1 EMULSION OF PERFLUORORGANIC COMPOUNDS FOR MEDICAL PURPOSES, METHOD FOR PRODUCING SAID EMULSION AND METHODS FOR CURING AND PREVENTING DISEASES WITH THE AID OF THE EMULSION 审中-公开
标题翻译：有机FLUOR含乳剂用于医疗目的，方法及其和方法的治疗与预防疾病THROUGH这种乳液
公开(公告)号：EP1306083A1
公开(公告)日：2003-05-02
申请号：EP00970349.7
申请日：2000-07-20
申请人： Otkrytoe Aktsionernoe Obchestvo Nauchno-Proizvodstvennaya Firma "Perftoran"
发明人： MAEVSKY, Evgeny Iliich , IVANITSKY, Genrikh Romanovich , MAKAROV, Kirill Nikolaevich , KULAKOVA, Galina Mikhailovna , ARKHIPOV, Vladimir Viktorovich , MOROZ, Viktor Vasilievich , STAROVOITOVA, Ljudmila Nikolaevna , SENINA, Raisa Yakovlevna , PUSHKIN, Sergei Jurievich , IVASHINA, Albina Ivanovna
IPC分类号： A61K31/02 , A61K31/025 , A61K31/13 , A61K9/107
CPC分类号： A61K9/0026 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/42 , A61K45/06 , Y10S514/824 , Y10S514/832 , Y10S514/833 , Y10S516/929 , A61K2300/00
摘要： An emulsion of perfluoroorganic compounds (PFOCs) with gas-transporting properties for intravascular administration comprises a perfluorocarbon rapidly eliminable from the organism and a perfluorinated tertiary amine slowly eliminable from the organism and further comprises at least three kinds of PFOC admixtures taken in small amounts, which are close in their structure and physicochemical properties to the main components and make up a series of PFOCs with gradually changing properties. The emulsion also contains minor admixtures of H-perfluoroalkanes. Such a composition contributes to the formation of a more homogeneous and stable non-clustered perfluorocarbon phase inside the emulsion particles. The PFOC emulsion is stabilized by a polyoxyethylene-polyoxypropylene copolymer. The formulation of the composition provides stability of the emulsion under storage and on entry into the blood flow, as well as a low viscosity of the PFOC emulsion, which secures a high dynamic oxygen capacity of the preparation and improves the delivery of oxygen to tissues.
When preparing the emulsion, the stabilizing agent is heated at a temperature of up to 75°C, all the components are saturated with carbon dioxide gas, and the homogenization is carried out with feeding carbon dioxide gas, whereby the origination of peroxides is minimized and the reactogenicity is thus reduced.
It is proposed to use PFOC emulsions as a means for treating air-and fat embolism, obliterating vascular injuries of extremities and poisoning with lipophilic poisons, as well as for preventing toxic injuries caused by various xenobiotics.
摘要翻译：全氟化合物（PFOCs）具有用于血管内给药气体传输性能的乳液包含全氟碳从生物体迅速消除的和全氟化的叔胺缓慢消去从生物体和进一步包含至少3种PFOC外加剂以少量，这取在它们的结构和物理化学性质的主要成分接近并配以逐渐改变性质了一系列PFOCs的。所以乳液含有H-全氟烷烃轻微外加剂。这样的组合物有助于实现更均匀和稳定的非群集的全氟化碳相的乳液粒子内部的形成。所述PFOC乳液通过聚氧乙烯 - 聚氧丙烯共聚物稳定化。该组合物的制剂提供下存储并在进入血流，以及所述PFOC乳液的低粘度，这Secure的制剂的高动态氧容量，并提高到组织中的输送氧气的乳液的稳定性。当制备乳液，所述稳定剂在高达75℃的温度下加热，所有组分的饱和与二氧化碳气体，并且均化进行与供给的二氧化碳气体，从而过氧化物的始发被最小化并且的反应原性由此减少。它建议用PFOC乳液作为用于治疗空气和脂肪栓塞，擦掉四肢并用亲脂性毒物中毒血管损伤，以及作为用于防止由各种异生素引起的毒性损伤。

46. 发明授权

EP0802823B1 RECIRCULATING A PORTION OF HIGH INTERNAL PHASE EMULSIONS PREPARED IN A CONTINUOUS PROCESS 失效
标题翻译：与BIG HEARTS相乳液的百分比在连续的过程RETURN
公开(公告)号：EP0802823B1
公开(公告)日：1998-09-30
申请号：EP96905110.1
申请日：1996-01-11
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DesMARAIS, Thomas, Allen
IPC分类号： B01F13/10 , B01F5/10 , B01F3/08
CPC分类号： B01F3/0811 , B01F3/0807 , B01F3/0853 , B01F5/0602 , B01F5/102 , B01F7/00 , B01F13/1025 , B01F2003/0826 , B01F2003/0842 , Y10S516/929 , Y10S516/931
摘要： An improvement in a continuous process for making high internal phase emulsions that are typically polymerized to provide microporous, open-celled polymeric foam materials capable of absorbing aqueous fluids, especially aqueous body fluids such as urine. The improvement involves recirculating a portion (about 50 % or less) of the emulsion withdrawn from the dynamic mixing zone of this continuous process. This increases the uniformity of the emulsion ultimately obtained from this continuous process in terms of having the water droplets homogeneously dispersed in the oil phase. This also improves the stability of the HIPE and expands the temperature range for pouring and curing this HIPE during subsequent emulsion polymerization.

47. 发明授权

EP0701451B1 EMULSIONS AS CONTRAST AGENTS AND METHOD OF USE 失效
标题翻译：乳液作为造影剂及其使用
公开(公告)号：EP0701451B1
公开(公告)日：1998-08-19
申请号：EP94919260.3
申请日：1994-05-26
申请人： MOLECULAR BIOSYSTEMS, INC.
发明人： LOHRMANN, Rolf , WIDDER, Kenneth, J. , KRISHNAN, Ashwin, M. , HONG, Dung, K. , MENG, Jialun
IPC分类号： A61K49/00
CPC分类号： A61K49/226 , A61K49/223 , Y10S516/929
摘要： This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer, the emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site-specific imaging as the image-enhancing bubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.

48. 发明公开

EP0802823A1 RECIRCULATING A PORTION OF HIGH INTERNAL PHASE EMULSIONS PREPARED IN A CONTINUOUS PROCESS 失效
标题翻译：与BIG HEARTS相乳液的百分比在连续的过程RETURN
公开(公告)号：EP0802823A1
公开(公告)日：1997-10-29
申请号：EP96905110.0
申请日：1996-01-11
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DesMARAIS, Thomas, Allen
IPC分类号： B01F3 , B01F5 , B01F13 , B01J13 , B01J20 , C08F2 , B01F7
CPC分类号： B01F3/0811 , B01F3/0807 , B01F3/0853 , B01F5/0602 , B01F5/102 , B01F7/00 , B01F13/1025 , B01F2003/0826 , B01F2003/0842 , Y10S516/929 , Y10S516/931
摘要： An improvement in a continuous process for making high internal phase emulsions that are typically polymerized to provide microporous, open-celled polymeric foam materials capable of absorbing aqueous fluids, especially aqueous body fluids such as urine. The improvement involves recirculating a portion (about 50 % or less) of the emulsion withdrawn from the dynamic mixing zone of this continuous process. This increases the uniformity of the emulsion ultimately obtained from this continuous process in terms of having the water droplets homogeneously dispersed in the oil phase. This also improves the stability of the HIPE and expands the temperature range for pouring and curing this HIPE during subsequent emulsion polymerization.

49. 发明公开

EP0725676A4 ULTRAMULSIONS 失效
标题翻译： ULTRAMULSIONEN
公开(公告)号：EP0725676A4
公开(公告)日：1997-09-17
申请号：EP94931999
申请日：1994-10-25
申请人： WHITEHILL ORAL TECH INC
发明人： HILL IRA D , BROWN DALE GORDON
IPC分类号： A61K8/55 , A61K8/04 , A61K8/06 , A61K8/58 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/90 , A61Q11/00 , B01F17/00 , B01J13/00 , C08J3/03 , C08L83/04 , C11D1/722 , C11D1/76 , C11D3/37 , C11D17/00 , C11D17/08 , C11D1/82
CPC分类号： C08J3/03 , A61K8/06 , A61K8/891 , A61K8/90 , A61Q11/00 , B01F17/00 , C08G77/04 , C08J2383/04 , C08L83/04 , C11D1/76 , C11D3/3707 , C11D3/373 , C11D17/0017 , Y10S516/929 , C08L2666/14
摘要： The present invention relates to water-free, co-solvent free, stable dispersions of certain polydimethylsiloxanes in certain nonionic, polyoxamer surfactants; wherein: a) the dispersed polydimethylsiloxanes, esp. those having the chemical composition (CH3)3SiO[SiO(Ch3)2]nSi(Ch3)3 wherein n is a whole number from between about 10 and about 400, which are insoluble in the surfactant, esp. a nonionic surfactant of the polyoxyethylene-polyoxypropylene block copolymer type, are oriented by the surfactant such that when dispersed in water they are particularly adept at forming oriented, monolayer coatings on various substrates, and b) the particle size of the dispersed polydimethyl-siloxane is from between about 0.5 and about 10 microns, with a particle size distribution such that from between about 80 and 95 % of the dispersed polydimethylsiloxane is within this particle size range. These stable dispersions are described as ultramulsions, which, together with their physical properties (stable when dispersed in water), distinguishes them from emulsions, microemulsions and solutions, and are useful in various products, such as mouthrinses, toothpastes, confectioneries, antacids, mold/release lubricants, plasticizers, cleaners, cosmetics and skin care products.
摘要翻译：本发明涉及某些聚二甲基硅氧烷在某些非离子聚氧乙烯表面活性剂中的无水，无共溶剂，稳定的分散体; 其中：a）分散的聚二甲基硅氧烷，具有化学组成（CH 3）3 SiO [SiO（CH 3）2] n Si（CH 3）3的化合物，其中n为约10-约400的整数，其不溶于表面活性剂中，聚氧乙烯 - 聚氧丙烯嵌段共聚物类型的非离子表面活性剂通过表面活性剂取向，使得当分散在水中时，它们特别适于在各种基材上形成定向的单层涂层，并且b）分散的聚二甲基硅氧烷的粒径为具有约0.5至约10微米的粒度分布，使得分散的聚二甲基硅氧烷的约80至95％在该粒度范围内。这些稳定的分散体被描述为超乳液，其连同其物理性质（当分散在水中时稳定）与乳液，微乳液和溶液区分开来，并且可用于各种产品，例如漱口水，牙膏，糖果，抗酸剂，模具 /释放润滑剂，增塑剂，清洁剂，化妆品和护肤品。

50. 发明授权

EP0569813B1 Verfahren zur Herstellung und Konzentrierung von Kieselsolen 失效
标题翻译：一种生产二氧化硅溶胶和浓度的处理
公开(公告)号：EP0569813B1
公开(公告)日：1996-06-26
申请号：EP93107148.4
申请日：1993-05-03
申请人： BAYER AG
发明人： Brekau, Uwe, Dr. , Nickel, Andreas, Dipl.-Ing. , Block, Hans-Dieter, Dr. , Moretto, Hans-Heinrich, Dr. , Schmidt, Peter, Dr. , Schober, Peter, Dr. , Ludovici, Werner, Dr.
IPC分类号： C01B33/148 , B01D71/00 , B01J13/00
CPC分类号： B01D61/145 , C01B33/148 , C01B33/151 , Y10S516/929

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