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41. 发明申请

US20180217174A1 LABORATORY SAMPLE DISTRIBUTION SYSTEM AND LABORATORY AUTOMATION SYSTEM 审中-公开
公开(公告)号：US20180217174A1
公开(公告)日：2018-08-02
申请号：US15863028
申请日：2018-01-05
申请人： Roche Diagnostics Operations, Inc.
发明人： Michal Malinowski
IPC分类号： G01N35/04 , G01N35/00 , G01R19/25
CPC分类号： G01N35/04 , B65G54/02 , G01N35/00584 , G01N2035/00445 , G01N2035/0475 , G01N2035/0477 , G01R19/2513
摘要： A laboratory sample distribution system is presented. The system comprises carriers to carry sample containers. Each carrier comprises a magnetically active device. The system comprises a transport plane to support the carriers and electro-magnetic actuators stationary arranged below the transport plane. The actuators move the carriers on top of the transport plane by applying a magnetic force to the carriers. The system comprises a control device to control the movement of the carriers on top of the transport plane by driving the actuators such that the carriers move along corresponding transport paths simultaneously and independently from one another and a sensor to measure supply currents and/or supply voltages. The actuators are supplied with electrical energy based on the supply currents and/or the supply voltages. The system comprises a monitoring device coupled to the sensor. The monitoring device monitors the actuators temperature based on the measured supply currents and/or supply voltages.

42. 发明授权

US10012666B2 Sample distribution system and laboratory automation system 有权
公开(公告)号：US10012666B2
公开(公告)日：2018-07-03
申请号：US14665397
申请日：2015-03-23
申请人： Roche Diagnostics Operations, Inc.
发明人： Christian Riether
IPC分类号： G01N35/10 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/1081 , G01N35/0092 , G01N35/02 , G01N2035/00445 , G01N2035/0406 , G01N2035/0462 , G01N2035/0477
摘要： A sample distribution system having a transport surface on which sample container carriers can be moved is presented. The sample distribution system has ambient-condition influencing device in order to influence ambient conditions over a sub-region of the transport surface in such a way that samples can be kept there for a certain time without impairment.

43. 发明申请

US20180156831A1 AUTOMATED STORAGE MODULES FOR DIAGNOSTIC ANALYZER LIQUIDS AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20180156831A1
公开(公告)日：2018-06-07
申请号：US15816773
申请日：2017-11-17
申请人： Abbott Laboratories
发明人： Razvan Raicu , Robert P. Luoma, II
IPC分类号： G01N35/02 , G01N35/10 , B65G1/06 , G01N15/14 , G01N35/00 , B01L9/06 , G01N35/04
CPC分类号： G01N35/026 , B01L9/06 , B65G1/06 , G01N15/1459 , G01N35/0099 , G01N35/025 , G01N35/1011 , G01N35/1081 , G01N2035/00435 , G01N2035/00445 , G01N2035/0405 , G01N2035/0412 , G01N2035/0462 , G01N2035/0465
摘要： Example automated storage modules for analyzer liquids are described herein. An example apparatus includes a refrigerated storage module having a plurality of shelves (to store a plurality of carriers) and a loading bay having an array of slots to receive one or more of the carriers. The loading bay is accessible by a user for manual loading or unloading of the carriers. The example apparatus includes a first carrier transporter coupled to the storage module to transfer the carriers between the shelves and a first transfer location and a second carrier transporter movable along a track connecting the storage module to an automated diagnostic analyzer. The second carrier transporter is to transfer a first carrier between the first transfer location and a slot in the loading bay and a second carrier between the first transfer location and a second transfer location accessible by the automated diagnostic analyzer.

44. 发明申请

US20080286162A1 SAMPLE HANDLING SYSTEM 有权
标题翻译：样品处理系统
公开(公告)号：US20080286162A1
公开(公告)日：2008-11-20
申请号：US12121006
申请日：2008-05-15
申请人： Kuniaki ONIZAWA , Koichi Obari , Junichi Oizumi , Shigemi Oba , Tetsuaki Abe
发明人： Kuniaki ONIZAWA , Koichi Obari , Junichi Oizumi , Shigemi Oba , Tetsuaki Abe
IPC分类号： B01L9/00
CPC分类号： G01N35/026 , G01N2035/00445 , G01N2035/0462
摘要： The present invention provides a sample processing system for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in the thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation of denaturing of the samples and specimens by the unit of a transfer rack. Also it is possible to carry in or out the samples rack by rack according to the necessity.The sample processing system according to the present invention is realized by providing a buffer unit in a cold container having a capability for cold storage and also by accessing a sample rack at random for carrying in or out the rack with a transfer mechanism provided outside the cold container.
摘要翻译：本发明提供了一种用于分析，预处理或进行生物样品如血液或尿素的其它操作的样品处理系统。利用样品处理系统，可以将保存在绝热状态下的样品或在绝热状态下进行精度控制所需的样品存储，以防止样品和样品变性由转印架单元蒸发。还可以根据需要携带或取出样品架。根据本发明的样品处理系统通过在具有冷藏能力的冷容器中提供缓冲单元并且还通过随机地访问样品架来携带或移出带有设置在冷的外部的传送机构的机架容器。

45. 发明授权

US06489094B2 Method and device for drug-drug interaction testing sample preparation 失效
标题翻译：药物相互作用试验样品制备方法和装置
公开(公告)号：US06489094B2
公开(公告)日：2002-12-03
申请号：US09858972
申请日：2001-05-16
申请人： Sean Ekins , Diane Lynn Johnson , Kevin George Kelly
发明人： Sean Ekins , Diane Lynn Johnson , Kevin George Kelly
IPC分类号： C12Q100
CPC分类号： G01N33/5076 , B01L3/50255 , C12Q1/26 , G01N1/4077 , G01N35/028 , G01N35/1074 , G01N2035/00356 , G01N2035/00445 , G01N2035/0422
摘要： A method and device for the automated large scale preparation for testing of drug-drug interactions, particularly with determination of IC50 and Ki, as a screening tool enhancement for determining viability of large numbers of compounds as drug candidates. Small samples of specific probe substrates and new compound inhibitors are automatically dispensed en masse into multi-welled reaction plates which are prefilled with thawed human microsomes, buffer and cofactor. The reaction plates are incubated and the reaction products are tested within degradation time limits, for initial biological determinations of relevant interaction effects of the compounds. The device used for the preparations comprises computer controlled multiple liquid handling cannulas, micropipetting members, refrigeration, freezer and temperature controlled incubator units, vacuum filtration device, bar code tracking of the plates, transport mechanisms for movement and manipulation of multiwell plates and sample mixing elements with coordinated timing of all operations within limited time frame testing parameters.
摘要翻译：用于测定药物 - 药物相互作用的自动化大规模制备的方法和装置，特别是通过测定IC50和Ki作为用于确定作为药物候选物的大量化合物的活力的筛选工具增强。特定探针底物和新化合物抑制剂的小样本被自动分配到预先充满解冻的人微粒体，缓冲液和辅因子的多孔反应板中。将反应板温育，并在降解时间限度内测试反应产物，以初步测定化合物的相互作用效应。用于制备的装置包括计算机控制的多液体处理插管，微量移液构件，制冷，冷冻和温度控制的培养箱单元，真空过滤装置，板的条码跟踪，用于移动和操纵多孔板和样品混合元件的输送机构所有操作的协调定时在有限的时间框架测试参数内。

46. 发明申请

US20010049092A1 Method and device for drug-drug interaction testing sample preparation 失效
标题翻译：药物相互作用试验样品制备方法和装置
公开(公告)号：US20010049092A1
公开(公告)日：2001-12-06
申请号：US09858972
申请日：2001-05-16
申请人： Pfizer Inc.
发明人： Sean Ekins , Diane Lynn Johnson , Kevin George Kelly
IPC分类号： C12Q001/00 , C12M001/34
CPC分类号： G01N33/5076 , B01L3/50255 , C12Q1/26 , G01N1/4077 , G01N35/028 , G01N35/1074 , G01N2035/00356 , G01N2035/00445 , G01N2035/0422
摘要： A method and device for the automated large scale preparation for testing of drug-drug interactions, particularly with determination of IC50 and Ki, as a screening tool enhancement for determining viability of large numbers of compounds as drug candidates. Small samples of specific probe substrates and new compound inhibitors are automatically dispensed en masse into multi-welled reaction plates which are prefilled with thawed human microsomes, buffer and cofactor. The reaction plates are incubated and the reaction products are tested within degradation time limits, for initial biological determinations of relevant interaction effects of the compounds. The device used for the preparations comprises computer controlled multiple liquid handling cannulas, micropipetting members, refrigeration, freezer and temperature controlled incubator units, vacuum filtration device, bar code tracking of the plates, transport mechanisms for movement and manipulation of multiwell plates and sample mixing elements with coordinated timing of all operations within limited time frame testing parameters.
摘要翻译：用于测定药物 - 药物相互作用的自动化大规模制备的方法和装置，特别是通过测定IC50和Ki作为用于确定作为药物候选物的大量化合物的活力的筛选工具增强。特定探针底物和新化合物抑制剂的小样本被自动分配到预先充满解冻的人微粒体，缓冲液和辅因子的多孔反应板中。将反应板温育，并在降解时间限度内测试反应产物，以初步测定化合物的相互作用效应。用于制备的装置包括计算机控制的多液体处理插管，微量移液构件，制冷，冷冻和温度控制的培养箱单元，真空过滤装置，板的条码跟踪，用于移动和操纵多孔板和样品混合元件的输送机构所有操作的协调定时在有限的时间框架测试参数内。

47. 发明授权

US5178835A Biochemical analysis apparatus 失效
标题翻译：生化分析仪
公开(公告)号：US5178835A
公开(公告)日：1993-01-12
申请号：US620447
申请日：1990-12-03
申请人： Tadashi Uekusa , Takashi Koizumi , Yukihide Miyata
发明人： Tadashi Uekusa , Takashi Koizumi , Yukihide Miyata
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/00009 , G01N2035/00019 , G01N2035/00168 , G01N2035/00445 , G01N2035/00455 , G01N2035/1025 , Y10T436/110833
摘要： A biochemical analysis apparatus for applying a liquid sample onto a long test film, incubating the sample-applied film portion by an incubator, and measuring the degree of color formation at the sample-applied portion comprises a cutter provided upstream from the position of sample application for cutting the long test film to a length necessary for a single step of sample application, and a cut-film conveyor for conveying the sample-applied and cut portion of the long test film into the incubator, whereby the long test film is utilized efficiently and processing thereof is facilitated.
摘要翻译：一种用于将液体样品施加到长测试膜上的生化分析装置，通过培养箱孵育样品施加膜部分并测量样品施加部分的颜色形成程度包括设置在样品施加位置上游的切割器用于将长测试膜切割成单次样品施加所需的长度，以及用于将长测试膜的样品施加和切割部分输送到培养箱中的切割式输送机，由此长效测试膜被有效地利用并且其处理方便。

48. 发明授权

US5030418A Biochemical analysis apparatus 失效
标题翻译：生化分析仪
公开(公告)号：US5030418A
公开(公告)日：1991-07-09
申请号：US248017
申请日：1988-09-23
申请人： Yukihide Miyata
发明人： Yukihide Miyata
IPC分类号： G01N35/02 , G01N27/28 , G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00029 , G01N35/00009 , G01N35/0092 , G01N2035/00039 , G01N2035/00089 , G01N2035/00356 , G01N2035/00445 , G01N2035/00455 , G01N2035/00752 , G01N2035/0441 , G01N2035/1025 , G01N35/1004 , G01N35/1083
摘要： A biochemical analysis apparatus comprises a slide conveyor for conveying an electrolyte determination slide to a predetermined position, and a sample applicator for taking up and applying a liquid sample and a reference solution onto the electrolyte determination slide conveyed to the predetermined position. An incubator incubates the electrolyte determination slide on which the liquid sample and the reference solution have already been applied, and a measurement device measures a difference in potential between the liquid sample-applied portion and the reference solution-applied portion of the electrolyte determination slide. The sample applicator is provided with a sample applying nozzle used for both the application of the liquid sample and the application of the reference solution. A washing region is provided for washing the sample applying nozzle.
摘要翻译：生化分析装置包括用于将电解质测定载体输送到预定位置的滑动输送器和用于将液体样品和参考溶液吸收并施加到输送到预定位置的电解质测定滑块上的样品施加器。培养箱孵育其上已经施加有液体样品和参比溶液的电解质测定载玻片，并且测量装置测量液体样品施加部分和电解液测定载玻片的参考溶液施加部分之间的电位差。样品施加器设置有用于液体样品的应用和参考溶液的应用的样品施加喷嘴。提供洗涤区域用于洗涤样品施加喷嘴。

49. 发明授权

US4943416A Automatic urinalysis system 失效
标题翻译：自动尿分析系统
公开(公告)号：US4943416A
公开(公告)日：1990-07-24
申请号：US100224
申请日：1987-09-23
申请人： Makoto Kikuchi , Manabu Harada
发明人： Makoto Kikuchi , Manabu Harada
IPC分类号： G01N1/00 , G01N35/00 , G01N35/10
CPC分类号： G01N35/00029 , G01N2035/00039 , G01N2035/00089 , G01N2035/00118 , G01N2035/00445 , G01N2035/00455 , G01N2035/1025 , G01N35/1095
摘要： An automatic urinalysis system which can be readily installed at an excretion site such as a toilet and by which means a subject itself can test its urine easily at any time and can obtain results of such test. The system comprises a sample collecting means for collecting a sample of urine within a stool or the like at an excretion site, a guiding means for introducing the collected urine sample into a testing area within a body of the system, a urine testing element located within the system body, a contacting means for automatically contacting the urine testing element with the urine sample in the testing area, a urine testing means for automatically testing the urine testing element contacted with the urine sample by the contacting means, a display means for displaying test data from the urine testing means, and a discharging means for discharging the urine sample into the stool after the urine sample has been contacted by the urine testing element.
摘要翻译：一种自动尿分析系统，其可以容易地安装在诸如马桶的排泄部位，并且这意味着受试者本身可以在任何时间容易地测试其尿液并且可以获得这种测试的结果。该系统包括用于在排泄部位的粪便等内收集尿液样本的采集装置，用于将收集的尿液样品引入系统体内的测试区域的引导装置，所述系统主体，用于在所述检查区域中自动接触所述尿液检测元件的接触单元，用于通过所述接触单元自动测试与所述尿液样本接触的尿液检测元件的尿液检查单元，来自尿液检查装置的数据，以及排尿装置，用于在尿液样本与尿液检测元件接触之后将尿液样品排放到粪便中。

50. 发明授权

US4552102A System for improving the starting of diesel engines in cold weather 失效
标题翻译：改善柴油机在寒冷天气启动的系统
公开(公告)号：US4552102A
公开(公告)日：1985-11-12
申请号：US661262
申请日：1984-10-15
申请人： Edward J. Egle
发明人： Edward J. Egle
IPC分类号： B01L3/00 , F02B3/06 , F26B5/06 , G01N35/00 , F02N17/00
CPC分类号： B01L3/5085 , F26B5/06 , F02B3/06 , G01N2035/00445
摘要： A system for improving the starting of indirect and direct injection diesel engines in cold weather, including glowplugs powered by a source of electrical potential for heating the diesel fuel and circuitry for controlling the operation of the glowplugs.
摘要翻译：一种用于在寒冷天气中改进间接和直接喷射柴油发动机的启动的系统，包括由用于加热柴油燃料的电位源供电的辉光球和用于控制辉光球的操作的电路。

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