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41. 发明申请

US20150097120A1 IN-SITU FLUID ANALYSIS SENSOR BOLT 有权
标题翻译：现场流体分析传感器螺栓
公开(公告)号：US20150097120A1
公开(公告)日：2015-04-09
申请号：US14048781
申请日：2013-10-08
申请人： Spectro, Inc.
发明人： Aniruddha S. Weling , Russell S. Girgenti , Matthew B. Fratkin , Patrick F. Henning
IPC分类号： G01N21/85 , G01N21/35
CPC分类号： G01N21/8507 , G01F23/292 , G01F23/2925 , G01N21/3577 , G01N2021/8521 , Y10T29/49117
摘要： A sensor and associated methods wherein a bolt or rod stem includes a flow path through and across the stem. A source of radiation within the stem is configured to direct radiation through the flow path and a detector subsystem in the stem is configured to detect radiation passing through the flow path. A head includes electrical conductors for the radiation source and detector subsystem resulting in a compact, inexpensive sensor.
摘要翻译：一种传感器和相关联的方法，其中螺栓或杆杆包括穿过和穿过杆的流动路径。茎内的辐射源构造成引导辐射通过流动路径，并且杆中的检测器子系统被配置为检测通过流动路径的辐射。头包括用于辐射源和检测器子系统的电导体，导致紧凑且廉价的传感器。

42. 发明申请

US20080087078A1 Logging System and Method for In-Situ Fluids Sensing Through Optical Fiber With Attenuation Compensation 有权
标题翻译：通过具有衰减补偿的光纤传感的现场流体测井系统和方法
公开(公告)号：US20080087078A1
公开(公告)日：2008-04-17
申请号：US11855144
申请日：2007-09-13
申请人： Stephane Vannuffelen , Khalid Ouaaba , Tsutomu Yamate
发明人： Stephane Vannuffelen , Khalid Ouaaba , Tsutomu Yamate
IPC分类号： E21B47/00
CPC分类号： G01J3/433 , E21B47/102 , G01J3/02 , G01J3/0218 , G01J3/0283 , G01J3/0291 , G01J3/0294 , G01J3/0297 , G01J3/42 , G01J3/4338 , G01N21/274 , G01N21/39 , G01N21/8507 , G01N2021/8521 , G01N2021/8528 , G01N2021/855 , G01N2201/06113
摘要： A method for optically sampling characteristics of subsurface fluids within a wellhole using continuous, non-pulsed light transmitted downhole in optical fibers for both sampling and reference light channels for accurate attenuation compensation.
摘要翻译：使用在光纤中透射的用于采样和参考光通道的井下连续的非脉冲光来对井眼内的地下流体的特征进行光学采样的方法，用于精确的衰减补偿。

43. 发明授权

US06764651B2 Fiber-optic dissolution systems, devices, and methods 失效
标题翻译：光纤溶解系统，装置和方法
公开(公告)号：US06764651B2
公开(公告)日：2004-07-20
申请号：US10014270
申请日：2001-11-07
申请人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
发明人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N2101
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

44. 发明申请

US20030086823A1 Fiber-optic dissolution systems, devices, and methods 失效
标题翻译：光纤溶解系统，装置和方法
公开(公告)号：US20030086823A1
公开(公告)日：2003-05-08
申请号：US10014270
申请日：2001-11-07
发明人： C.J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N021/05 , G01N021/63
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

45. 发明授权

US06558957B1 Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form 有权
标题翻译：用于预测来自药物剂型的药物的溶出曲线的检测系统和方法
公开(公告)号：US06558957B1
公开(公告)日：2003-05-06
申请号：US09707498
申请日：2000-11-07
申请人： Kurt Roinestad , Frank S. Cheng , Philip J. Palermo , Kevin Bynum
发明人： Kurt Roinestad , Frank S. Cheng , Philip J. Palermo , Kevin Bynum
IPC分类号： G01N2101
CPC分类号： G01N21/33 , G01N13/00 , G01N21/01 , G01N21/05 , G01N21/359 , G01N21/65 , G01N21/8507 , G01N33/15 , G01N2013/006 , G01N2021/6484 , G01N2021/651 , G01N2021/8521 , G01N2021/8528 , Y10T436/24 , Y10T436/25875
摘要： The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.
摘要翻译：本发明涉及一种检测系统的改进，所述检测系统用于连续地测量药物从包含溶解介质的单一溶出容器或多个溶解容器的药物剂型中释放的检测系统，所述检测系统包括用于检测药物释放量的测量装置在一定时间内，改进包括混合轴和放置在混合轴内或各个溶解容器外部的探针，该探针能够使用UV，IR，近红外，荧光，电化学和拉曼光谱技术测量溶解特性。本发明还涉及一种用于预测由控释药物剂型提供的溶出曲线的方法，包括连续测量药物预期释放的一段时间内从剂型中释放的药物的量并基于获得的值预测溶出曲线的剩余部分。

46. 发明授权

US4980278A Method of effecting immunological analysis and apparatus for carrying out the same 失效
标题翻译：进行免疫学分析的方法及其实施方法
公开(公告)号：US4980278A
公开(公告)日：1990-12-25
申请号：US342589
申请日：1989-04-24
申请人： Takashi Yamada , Nobutaka Kaneko , Takashi Tabara , Takeo Takahashi
发明人： Takashi Yamada , Nobutaka Kaneko , Takashi Tabara , Takeo Takahashi
IPC分类号： G01N21/77 , G01N21/85 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54373 , G01N21/7703 , G01N33/53 , G01N2021/1755 , G01N2021/8521 , Y10S436/805 , Y10S436/807 , Y10S436/81
摘要： A method for analyzing antigen or antibody contained in a sample by introducing a first end surface of at least one measuring light guide member and a second end surface of at least one reference light guide member in the sample. Each of said measuring and reference light guide members being coated with a protection layer except for said first and second end surfaces and an other end surface of respect light guides. Only on said first end surface of the measuring light guide member being fixed an antigen or antibody which is specifically reactive with the antigen or antibody contained in the sample to effect an antigen-antibody reaction. Photoelectrically detecting optical properties of said first and second end surfaces of the measuring and reference light guide members, respectively, by transmitting light through the meauring and reference light guide members to derive detection signals as a measure of antigen or antibody in the sample. Further, when first and second measuring light guide members having A-type antibody and B-type antibody fixed onto one end surfaces thereof are used, a blood type of a blood sample can be determined by detecting the optical condition of the one end surfaces of the first and second measuring light guide members.
摘要翻译：一种通过在样品中引入至少一个测量导光构件的第一端面和至少一个参考光导构件的第二端面来分析样品中所含的抗原或抗体的方法。所述测量和参考光导构件中的每一个涂覆除了所述第一和第二端面之外的保护层和相关光导的另一端面。仅在所述测量光导构件的所述第一端面上固定与所述样品中包含的抗原或抗体特异性反应以进行抗原 - 抗体反应的抗原或抗体。通过透射光通过测量和参考光导构件分别测量测量和参考光导构件的所述第一和第二端面的光学特性，以导出作为样品中抗原或抗体的量度的检测信号。此外，当使用第一和第二测量具有固定在其一个端面上的A型抗体和B型抗体的导向构件时，血液样品的血液类型可以通过检测血液样品的一个端面的光学条件来确定第一和第二测量光导构件。

47. 发明申请

US20180126371A1 Pipette Tip with Integrated Light Guides in the Body and Method of Spectroscopic Analysis Using Same 审中-公开
公开(公告)号：US20180126371A1
公开(公告)日：2018-05-10
申请号：US15813893
申请日：2017-11-15
申请人： Spectrum Perception LLC
发明人： Bradley Lynn Postier , Thomas Michael Spudich, JR.
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0275 , B01L2300/0654 , B01L2300/168 , G01N21/0303 , G01N21/25 , G01N21/253 , G01N21/51 , G01N21/8507 , G01N35/10 , G01N2021/8521 , G01N2035/103 , G01N2035/1062 , G01N2201/0221
摘要： Novel disposable pipette tips that enable spectroscopic analysis of analytes held within the tip while attached to a microspectrometer or microspectrometer which is a micropipette with the functional capability to irradiate an attached tip with light of a defined wavelength and measure the impact of the sample within the tip on the irradiated light as the modified light is directed back to sensors on or within the instrument. Spectroscopic sample analysis is integral to a wide range of research sciences including microbiology, molecular biology, medical, chemistry, environmental, food, and forensics.

48. 发明申请

US20170146450A1 SPECIES SPECIFIC SENSOR FOR EXHAUST GASES AND METHOD THEREOF 审中-公开
公开(公告)号：US20170146450A1
公开(公告)日：2017-05-25
申请号：US15357014
申请日：2016-11-21
申请人： Sentelligence, Inc.
发明人： John Coates
IPC分类号： G01N21/33 , F01N13/00 , F01N11/00 , G01N33/00 , F01N3/28
CPC分类号： G01N21/33 , F01N3/2882 , F01N11/007 , F01N13/008 , F01N2560/021 , F01N2560/026 , F01N2560/027 , F01N2560/12 , G01N21/15 , G01N21/61 , G01N33/0029 , G01N33/0037 , G01N33/0042 , G01N33/0054 , G01N2021/8521 , G01N2201/062 , G01N2201/08 , Y02A50/245 , Y02A50/246 , Y02A50/248
摘要： A species-specific gas sensor and monitor comprising a light source, a sample enclosure or measurement chamber, an optical interface between the light source, the sample and the detection system, electronics that integrate the light source and the detection system, and computational components, such as an onboard microprocessor for calculation of the gas composition and communications between the sensor and the vehicle electronics. The species-specific gas sensor of the present invention can be used to target gases, such as nitric oxide (NO), nitrogen dioxide (NO2) ammonia (NH3), and sulfur dioxide (SO2) which are measurable in the UV spectrum.

49. 发明授权

US09366662B2 Serum sample quality determination 有权
标题翻译：血清样品质量测定
公开(公告)号：US09366662B2
公开(公告)日：2016-06-14
申请号：US14405571
申请日：2013-06-04
申请人： Arthur Babson
发明人： Arthur Babson
IPC分类号： G01N33/48 , G01N33/49 , G01N21/31 , G01N21/85 , G01N21/51
CPC分类号： G01N33/49 , G01N21/31 , G01N21/51 , G01N21/8507 , G01N2021/3129 , G01N2021/3137 , G01N2021/3148 , G01N2021/8514 , G01N2021/8521 , G01N2021/8528 , G01N2021/8535
摘要： A method and device for measuring HIL levels in blood serum samples that are disposed in an automated, clinical chemistry analyzer. The device probe can be attached adjacent to a pipette or sample probe of the analyzer and includes fiber optic bundles and a light-reflecting surface. A cutaway portion is provided between the ends of each of the fiber optic bundles and the light-reflecting surface. One of the four fiber optic bundles is optically coupled to a light-emitting source. Each of the other three fiber optic bundles collects and filters reflected light from the reflecting surface. The light filters correspond to the optimal absorption wavelengths for one of hemoglobin, bilirubin, and triglycerides. A light intensity-measuring device is optically coupled to each of the three fiber optic bundles, to measure the intensity of the filtered, reflected light. A processing device receives output data signal from the light intensity-measuring devices; stores the data; and calculates whether a serum sample has elevated levels of one or more of HIL.
摘要翻译：一种用于测量血液样品中HIL水平的方法和装置，其设置在自动临床化学分析仪中。设备探头可以附在分析仪的移液器或取样探头附近，并包括光纤束和光反射表面。在每个光纤束和光反射表面的端部之间设置切口部分。四个光纤束中的一个光学耦合到发光源。其他三个光纤束中的每一个收集和滤除来自反射表面的反射光。光过滤器对应于血红蛋白，胆红素和甘油三酯之一的最佳吸收波长。光强度测量装置光学耦合到三个光纤束中的每一个，以测量经滤波的反射光的强度。处理装置从光强度测量装置接收输出数据信号; 存储数据; 并计算血清样品是否具有HIL中的一种或多种的升高水平。

50. 发明申请

US20150168371A1 SERUM SAMPLE QUALITY DETERMINATION 有权
标题翻译：血清样品质量测定
公开(公告)号：US20150168371A1
公开(公告)日：2015-06-18
申请号：US14405571
申请日：2013-06-04
申请人： Arhur Babson
发明人： Arhur Babson
IPC分类号： G01N33/49 , G01N21/51
CPC分类号： G01N33/49 , G01N21/31 , G01N21/51 , G01N21/8507 , G01N2021/3129 , G01N2021/3137 , G01N2021/3148 , G01N2021/8514 , G01N2021/8521 , G01N2021/8528 , G01N2021/8535
摘要： A method and device for measuring HIL levels in blood serum samples that are disposed in an automated, clinical chemistry analyzer. The device probe can be attached adjacent to a pipette or sample probe of the analyzer and includes fiber optic bundles and a light-reflecting surface. A cutaway portion is provided between the ends of each of the fiber optic bundles and the light-reflecting surface. One of the four fiber optic bundles is optically coupled to a light-emitting source. Each of the other three fiber optic bundles collects and filters reflected light from the reflecting surface. The light filters correspond to the optimal absorption wavelengths for one of hemoglobin, bilirubin, and triglycerides. A light intensity-measuring device is optically coupled to each of the three fiber optic bundles, to measure the intensity of the filtered, reflected light. A processing device receives output data signal from the light intensity-measuring devices; stores the data; and calculates whether a serum sample has elevated levels of one or more of HIL.
摘要翻译：一种用于测量血液样品中HIL水平的方法和装置，其设置在自动临床化学分析仪中。设备探头可以附在分析仪的移液器或取样探头附近，并包括光纤束和光反射表面。在每个光纤束和光反射表面的端部之间设置切口部分。四个光纤束中的一个光学耦合到发光源。其他三个光纤束中的每一个收集和滤除来自反射表面的反射光。光过滤器对应于血红蛋白，胆红素和甘油三酯之一的最佳吸收波长。光强度测量装置光学耦合到三个光纤束中的每一个，以测量经滤波的反射光的强度。处理装置从光强度测量装置接收输出数据信号; 存储数据; 并计算血清样品是否具有HIL中的一种或多种的升高水平。

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